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Articles 2581 - 2610 of 8080
Full-Text Articles in Medicine and Health Sciences
Effect Of Cineole, Alpha-Pinene, And Camphor On Survivability Of Skin Flaps, Bi̇lsev İnce, Mehmet Dadaci, İbrahi̇m Kilinç, Pembe Oltulu, Serhat Yarar, Mehmet Uyar
Effect Of Cineole, Alpha-Pinene, And Camphor On Survivability Of Skin Flaps, Bi̇lsev İnce, Mehmet Dadaci, İbrahi̇m Kilinç, Pembe Oltulu, Serhat Yarar, Mehmet Uyar
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the specific component of Rosmarinus officinalis (RO) responsible for increased flap survival and how RO displays its efficacy. Materials and methods: Rectangular random-pattern flaps were elevated from the back of each rat. Group I was the control group. In group II 0.1 mL of cineole, in group III 0.1 mL of alpha-pinene, in group IV 0.1 mL of camphor, in group V 0.1 mL each of alpha-pinene and cineole, in group VI 0.1 mL each of alpha-pinene and camphor, in group VII 0.1 mL each of cineole and camphor, and in …
Investigation Of Phikz Phage Therapy Against Pseudomonas Aeruginosa In Mousepneumonia Model, Kübra Can, Uğur Aksu, Osman Şadi̇ Yenen
Investigation Of Phikz Phage Therapy Against Pseudomonas Aeruginosa In Mousepneumonia Model, Kübra Can, Uğur Aksu, Osman Şadi̇ Yenen
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined. Materials and methods: The systemic, lung-specific, and kidney-specific inflammation levels and the bacterial load in lung tissue and biochemical parameters were investigated after PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the P. aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined by measuring plasma levels of …
Emerging Biomarker For Predicting Acute Kidney Injuryafter Cardiac Surgery: Cystatin C, Onur Saydam, Ercan Türkmen, Oytun Portakal Akçi̇n, Mustafa Arici, Riza Doğan, Meti̇n Demi̇rci̇n, İlhan Paşaoğlu, Mustafa Yilmaz
Emerging Biomarker For Predicting Acute Kidney Injuryafter Cardiac Surgery: Cystatin C, Onur Saydam, Ercan Türkmen, Oytun Portakal Akçi̇n, Mustafa Arici, Riza Doğan, Meti̇n Demi̇rci̇n, İlhan Paşaoğlu, Mustafa Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Cardiopulmonary bypass (CPB)-associated acute kidney injury (AKI) is a common situation and rapid diagnosis and risk classification are important in the prevention and management of AKI. Changes in serum creatinine (SCr) levels in the current consensus criteria do not allow clinicians to diagnose CPB-associated AKI until 48 h after surgery. Materials and methods: We conducted a prospective single center study involving 57 patients who underwent cardiac surgery with CBP to compare serum beta-trace protein (BTP), neutrophil gelatinase-associated lipocalin-2 (NGAL), and cystatin C (CysC) levels with SCr for early diagnosis of CPB associated AKI. We defined AKI according to KDIGO …
Tuberculin Skin Test Response In Patients With Juvenile Idiopathic Arthritis Onanti-Tnf Therapy, Kenan Barut, Sezgi̇n Şahi̇n, Amra Adrovi̇c, Muhammet Köşker, Ömer Kiliç, Yildiz Camcioğlu, Haluk Cezmi̇ Çokuğraş, Necla Akçakaya, Betül Sözeri̇, Özgür Kasapçopur
Tuberculin Skin Test Response In Patients With Juvenile Idiopathic Arthritis Onanti-Tnf Therapy, Kenan Barut, Sezgi̇n Şahi̇n, Amra Adrovi̇c, Muhammet Köşker, Ömer Kiliç, Yildiz Camcioğlu, Haluk Cezmi̇ Çokuğraş, Necla Akçakaya, Betül Sözeri̇, Özgür Kasapçopur
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to evaluate the effect of biologic drugs on the tuberculin skin test in patients with juvenile idiopathic arthritis. Materials and methods: A total of 234 biologic drug-using juvenile idiopathic arthritis patients and 45 healthy controls were enrolled in the study. The tuberculin skin test results of the patients, which had been routinely provided during follow-up, were obtained from the patient files. Tuberculin skin test values of ≥ 5 mm were considered to be positive. Results: The mean diameter of tuberculin skin test induration was 4.99 ± 6.84 mm (IQR: 0-10 mm) and 7.83 …
Diagnostic Value Of Ultrasonography In Peroneal Neuropathy, İlkay Koray Bayrak, Ayşe Oytun Bayrak, Hande Türker, Çeti̇n Kürşad Akpinar, Necdet Bolat
Diagnostic Value Of Ultrasonography In Peroneal Neuropathy, İlkay Koray Bayrak, Ayşe Oytun Bayrak, Hande Türker, Çeti̇n Kürşad Akpinar, Necdet Bolat
Turkish Journal of Medical Sciences
Background/aim: Peroneal neuropathy at the fibular head (PNFH) is one of the most common entrapment neuropathies. Our aim in this study was to analyze the efficiency of ultrasonography in the diagnosis of PNFH. Materials and methods: The study included 15 peroneal nerves of 12 patients with PNFH and 24 peroneal nerves of 12 healthy controls. PNFH confirmation was based on clinical and electrophysiological findings. All patients and controls underwent ultrasonographic evaluations for peroneal nerves. The cross-sectional area (CSA) was measured. Echogenicity of the nerve was evaluated by comparing it with the adjacent connective tissue deep under the subcutaneous fat. Results: …
Pulmonary Valve Replacement In Patients With Repaired Tetralogy Of Fallot: Early Results For Recovery Of Right Ventricular Dilatation And Qrs Duration, Ahmet Arnaz, Ayla Oktay, Serdar Akansel, Di̇lek Altun, Abdullah Doğan, Piotr Serban, Arda Saygili, Yusuf Kenan Yalçinbaş, Ayşe Sarioğlu, Cafer Tayyar Sarioğlu
Pulmonary Valve Replacement In Patients With Repaired Tetralogy Of Fallot: Early Results For Recovery Of Right Ventricular Dilatation And Qrs Duration, Ahmet Arnaz, Ayla Oktay, Serdar Akansel, Di̇lek Altun, Abdullah Doğan, Piotr Serban, Arda Saygili, Yusuf Kenan Yalçinbaş, Ayşe Sarioğlu, Cafer Tayyar Sarioğlu
Turkish Journal of Medical Sciences
Background/aim: Although pulmonary valve replacement (PVR) improves ventricular function and symptoms, the benefit and optimal timing of PVR are controversial. This study aimed to evaluate early response to PVR for right ventricle (RV) dilatation and QRS duration. Materials and methods: Retrospective analysis was performed for 32 patients with repaired tetralogy of Fallot (TOF) between March 2005 and October 2017. The differences between preoperative and postoperative changes in echocardiographic parameters, clinical symptoms, and QRS duration were evaluated. Results: There were no in-hospital or late deaths. Mean age at the time of PVR was 16.57 ± 7.97 years. The interval between TOF …
Investigation Of Syphilis Coinfection And Performance Of The Architect Syphilis Tp Elisa Screening Test In Hiv Positive Patients, Cemi̇le Sönmez, Tüli̇n Demi̇r, Fi̇gen Sezen, Selçuk Kiliç
Investigation Of Syphilis Coinfection And Performance Of The Architect Syphilis Tp Elisa Screening Test In Hiv Positive Patients, Cemi̇le Sönmez, Tüli̇n Demi̇r, Fi̇gen Sezen, Selçuk Kiliç
Turkish Journal of Medical Sciences
Background/aim: Limited data on syphilis coinfection in human immunodeficiency virus (HIV) positive cases exist in Turkey. Our aim is to investigate syphilis coinfection and to evaluate the compatibility of the screening Architect Syphilis Tp ELISA with the fluorescent treponemal antibody absorption (FTA-abs) confirmation test in HIV positive cases. Materials and methods: Totally 519 HIV positive patients were included in the study. Enzyme linked fluorescent assay (ELFA) was used as a screening test and positive samples were confirmed by line immunassay (LIA). In order to discriminate acute HIV infection and false ELISA positivity, HIV-1 RNA PCR was performed in ELFA positive …
Is 72 H Of Antimicrobial Prophylaxis Better Than 24 H In Elective Gastric Cancer Surgery?, Xiang Zia, Gang Zhao, Wei Ling, Fengrong Yu
Is 72 H Of Antimicrobial Prophylaxis Better Than 24 H In Elective Gastric Cancer Surgery?, Xiang Zia, Gang Zhao, Wei Ling, Fengrong Yu
Turkish Journal of Medical Sciences
Background/aim: The optimum duration of antimicrobial prophylaxis in elective gastric cancer surgery is still not yet established. The aim of this study is to evaluate the efficacy of 24 h or 72 h of antimicrobial prophylaxis for preventing postoperative infection. Materials and methods: Between July 2016 and January 2018, 990 gastric cancer patients undergoing surgery with D2 lymphadenectomy in Ren Ji Hospital were classified into 24-h or 72-h antimicrobial prophylaxis groups. The incidence of postoperative infection complications was compared. Results: A total of 990 patients (24-h antimicrobial prophylaxis, 708 cases; 72-h antimicrobial prophylaxis, 282 cases) were analyzed. Surgical site infection …
The Psychometric Evaluation Of The Turkish Version Of The Mann Assessment Of Swallowing Ability In Patients In The Early Period After Stroke, Ebru Karaca Umay, İbrahi̇m Gündoğdu, Eda Gürçay, Erhan Ari̇f Öztürk, Volkan Yilmaz, Özgür Zeli̇ha Karaahmet, Yasemi̇n Eren, Güleser Saylam, Fatma Aytül Çakci
The Psychometric Evaluation Of The Turkish Version Of The Mann Assessment Of Swallowing Ability In Patients In The Early Period After Stroke, Ebru Karaca Umay, İbrahi̇m Gündoğdu, Eda Gürçay, Erhan Ari̇f Öztürk, Volkan Yilmaz, Özgür Zeli̇ha Karaahmet, Yasemi̇n Eren, Güleser Saylam, Fatma Aytül Çakci
Turkish Journal of Medical Sciences
Background/aim: The Mann Assessment of Swallowing Ability (MASA) is an efficient tool that allows physicians to determine the alertness, cooperation, and respiration of patients, which are important factors when assessing swallowing . This study aimed to translate the MASA into Turkish (T-MASA) and to assess its reliability and validity in patients during the early period after a stroke . Materials and methods: The scale was administered to 141 patients in the early period after a stroke. For reliability, both internal consistency (Cronbach's alpha and corrected item-to-total correlations) and interrater reliability were analyzed. The procedures were scored by two blinded independent …
Determinants And Characteristics Of Tuberculosis In Liver Transplant Recipients, Ayli̇n Özgen Alpaydin, Mücahi̇t Özbi̇lgi̇n, Madina Abdullayeva, Selver Seda Mersi̇n, Tufan Egeli̇, Tarkan Ünek, Oğuz Kilinç, İbrahi̇m Kemal Astarcioğlu, Vi̇ldan Avkan Oğuz
Determinants And Characteristics Of Tuberculosis In Liver Transplant Recipients, Ayli̇n Özgen Alpaydin, Mücahi̇t Özbi̇lgi̇n, Madina Abdullayeva, Selver Seda Mersi̇n, Tufan Egeli̇, Tarkan Ünek, Oğuz Kilinç, İbrahi̇m Kemal Astarcioğlu, Vi̇ldan Avkan Oğuz
Turkish Journal of Medical Sciences
Background/aim: Solid organ transplant (SOT) recipients have increased risk of tuberculosis (TB). We aimed to investigate the prevalence and features of TB in liver transplant (LT) recipients at our transplantation canter. Materials and methods: All patients who underwent LT between January 2004 and December 2013 and whose data were accessible were included in the study. Demographic features, tuberculin skin test (TST) results, and TB prevalence were recorded. Characteristics of LT recipients who developed TB were evaluated. Results: A total of 403 patients underwent LT during this period. Mean age was 47.27 ± 11.04 years; 280 (69.47%) were males. The TST …
The Diagnostic Role Of Pentraxin-3 In The Differential Diagnosis Of Pleural Effusions, Fatma Çi̇ftci̇, Gülden Bi̇lgi̇n, Ayşe Naz Özcan, Özlem Doğan, Aycan Yüksel, Serhat Erol, Aydin Çi̇ledağ, Akin Kaya
The Diagnostic Role Of Pentraxin-3 In The Differential Diagnosis Of Pleural Effusions, Fatma Çi̇ftci̇, Gülden Bi̇lgi̇n, Ayşe Naz Özcan, Özlem Doğan, Aycan Yüksel, Serhat Erol, Aydin Çi̇ledağ, Akin Kaya
Turkish Journal of Medical Sciences
Background/aim: Discrimination of pleural effusion etiology is not always easy in clinical practice. Pentraxin-3 (PTX-3) is a new acute- phase protein. The aim of this study was to investigate the role of PTX-3 in the differential diagnosis of pleural effusions. Materials and methods: This prospective study enrolled all consecutive patients from two tertiary hospitals who underwent diagnostic or therapeutic thoracentesis. In a cohort of 149 subjects with pleural effusion, including transudates and malignant (MPE), tuberculous (TPE), and parapneumonic effusion (PPE), serum and pleural effusion PTX-3 concentration measurements were performed using ELISA. Serum and pleural effusion protein, lactate dehydrogenase, C-reactive protein …
The Role Of Soluble Urokinase Plasminogen Activator Receptor (Supar) As An Indicator Of The Severity Of Acute Pancreatitis, Kadi̇r Küçükceran, Mehmet Ergi̇n, İbrahi̇m Kilinç, Adnan Karai̇brahi̇moğlu, Tamer Çolak, Alpay Tuncar, Zerri̇n Defne Dündar, Sedat Koçak, Abdullah Sadik Gi̇ri̇şgi̇n, Mehmet Gül, Başar Cander
The Role Of Soluble Urokinase Plasminogen Activator Receptor (Supar) As An Indicator Of The Severity Of Acute Pancreatitis, Kadi̇r Küçükceran, Mehmet Ergi̇n, İbrahi̇m Kilinç, Adnan Karai̇brahi̇moğlu, Tamer Çolak, Alpay Tuncar, Zerri̇n Defne Dündar, Sedat Koçak, Abdullah Sadik Gi̇ri̇şgi̇n, Mehmet Gül, Başar Cander
Turkish Journal of Medical Sciences
Background/aim: Soluble urokinase plasminogen activator receptor (suPAR) has been reported to have a positive correlation with the activation degree of the immune system. This study's aim is to investigate the efficiency of SuPAR serum levels in acute pancreatitis (AP) patients in determining the severity of disease. Materials and methods: This prospective research involves patients who arrived at the emergency service, were over 18 years old, had nontraumatic abdominal pain and diagnosis of AP, and agreed to join the study. Demographic characteristics, contact information, laboratory and imaging test parameters, Ranson's criteria, the Balthazar Severity Index, the Rapid Acute Physiologic Score (RAPS), …
The Prevalence Of Chest Wall Deformity In Turkish Children, Yücel Akkaş, Nesli̇han Gülay Peri̇, Bülent Koçer, Gülteki̇n Gülbahar, Fatma Nur Baran Aksakal
The Prevalence Of Chest Wall Deformity In Turkish Children, Yücel Akkaş, Nesli̇han Gülay Peri̇, Bülent Koçer, Gülteki̇n Gülbahar, Fatma Nur Baran Aksakal
Turkish Journal of Medical Sciences
Background/aim: This study aimed to identify children who have chest wall deformity, the prevalence of deformity, and the factors affecting the psychological and physical disorders caused by the deformity. Materials and methods: The study was conducted among 14,108 girls and boys aged 11-14 years, who were 5th-8th grade secondary school students in Ankara Province between October 2014 and March 2015. Results: Of the 14,108 students in our study, the mean age of the children was 12.53 ± 1.11 years (median 12.54, 11-14 years) and chest wall deformity was detected in 199 (1.41%) students. Male/female and pectus carinatum/pectus excavatum ratios were …
Impact Of Impaired Glucose Regulation On The Functions Of Large And Small Fibers Of Peripheral Nerves, Na Liu, Jing Zhang, Zhecheng Zhang, Ju Zhu, Li Tian, Qian Li, Xianzhu Zeng
Impact Of Impaired Glucose Regulation On The Functions Of Large And Small Fibers Of Peripheral Nerves, Na Liu, Jing Zhang, Zhecheng Zhang, Ju Zhu, Li Tian, Qian Li, Xianzhu Zeng
Turkish Journal of Medical Sciences
Background/aim: This article analyzes the incidence and characteristics of peripheral neuropathy in patients with impaired glucose regulation (IGR). Materials and methods: A total of 120 IGR patients and 60 healthy controls were enrolled. All subjects underwent nerve conduction study (NCS) of large fibers and skin sympathetic response (SSR) and contact heat pain evoked potential (CHEP) testing of small fibers with a Medtronic Keypoint machine (Medoc Ltd., Israel). IGR patients were evaluated using the Michigan Neuropathy Screening Instrument (MNSI). Results: The abnormal rates (MNSI >2) in IGR patients and NCS and SSR evaluations were 18.3%, 22.5%, and 39.2%, respectively. All abnormal …
The Investigation Of Incidence And Multidetector Computed Tomography Findings Of Median Arcuate Ligament Syndrome, Mustafa Koç, Hakan Artaş, Selami̇ Serhatlioğlu
The Investigation Of Incidence And Multidetector Computed Tomography Findings Of Median Arcuate Ligament Syndrome, Mustafa Koç, Hakan Artaş, Selami̇ Serhatlioğlu
Turkish Journal of Medical Sciences
Background/aim: This study aims to evaluate the incidence and multidetector computed tomography (MDCT) findings of median arcuate ligament syndrome (MALS). Materials and methods: Between January 2010 and September 2016 a total of 4028 patients who underwent angiography for MDCT based on the clinical indications for abdominal pain were retrospectively analyzed. Results: The typical signs of MALS were identified in a total of 141 (3.5%) patients. Among all patients, 84 (59%) were male and 57 (41%) were female. The mean age was 42 years (range: 24 to 71 years). The incidence of celiac artery stenosis was 30% to 50% in 45 …
The Comparison Between Propofol And Dexmedetomidine Infusion On Perioperative Anxiety During Regional Anesthesia, Yong Peng Lim, Nurlia Yahya, Azarinah Izaham, Esa Kamaruzaman, Muhammad Zurrusydi Zainuddin, Wan Rahiza Wan Mat, Shereen Suet Ping Tang, Jaafar Md Zain, Siti Nidzwani Mohamad Mahdi
The Comparison Between Propofol And Dexmedetomidine Infusion On Perioperative Anxiety During Regional Anesthesia, Yong Peng Lim, Nurlia Yahya, Azarinah Izaham, Esa Kamaruzaman, Muhammad Zurrusydi Zainuddin, Wan Rahiza Wan Mat, Shereen Suet Ping Tang, Jaafar Md Zain, Siti Nidzwani Mohamad Mahdi
Turkish Journal of Medical Sciences
Background/aim: Regional anesthesia for surgery is associated with increased anxiety for patients. This study aimed to compare the effect of propofol and dexmedetomidine infusion on perioperative anxiety during regional anesthesia. Materials and methods: Eighty-four patients were randomly divided into two groups receiving either study drug infusion. Anxiety score, level of sedation using the Bispectral Index and Observer's Assessment of Alertness and Sedation, hemodynamic stability, and overall patient's feedback on anxiolysis were assessed. Results: Both groups showed a significant drop in mean anxiety score at 10 and 30 min after starting surgery. Difference in median anxiety scores showed a significant reduction …
Submucous Cleft Palate: From Diagnosis To Management, Mavi̇ş Emel Kulak Kayikci, Şadi̇ye Bacik Tirank, Mert Çaliş, F. Fi̇gen Özgür, Riza Önder Günaydin
Submucous Cleft Palate: From Diagnosis To Management, Mavi̇ş Emel Kulak Kayikci, Şadi̇ye Bacik Tirank, Mert Çaliş, F. Fi̇gen Özgür, Riza Önder Günaydin
Turkish Journal of Medical Sciences
Background/aim : The aim of this study was to investigate submucous cleft palate (SMCP) patients in order to document the age of diagnosis, cause of referral, symptoms and palate findings, objective evaluation of nasalance and velopharyngeal dysfunction (VPD), and intervention type. Material and methods : The archive of Hacettepe University Cleft Lip and Palate, Craniomaxillofacial Anomalies Research, Treatment, and Application Center was reviewed retrospectively, and 166 patients diagnosed with SMCP were documented. Results : The mean age of the patients at the time of initial referral was 10 years and 3 months ± 8 years and 5 months with the …
A Comparison Of The Effects Of Perindopril Arginine And Amlodipine On Choroidal Thickness In Patients With Primary Hypertension, Erel İçel, Hali̇l İbrahi̇m İmamoğlu, Adem Türk, Aykut İçel, Nuretti̇n Akyol
A Comparison Of The Effects Of Perindopril Arginine And Amlodipine On Choroidal Thickness In Patients With Primary Hypertension, Erel İçel, Hali̇l İbrahi̇m İmamoğlu, Adem Türk, Aykut İçel, Nuretti̇n Akyol
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effects of two different medical treatment options on choroidal thickness (CT) in patients with primary hypertension. Materials and methods: Forty newly diagnosed primary hypertension patients and 21 healthy volunteers were included. The patients were randomly divided into two subgroups. Group I started on perindopril arginine and Group II started on amlodipine. Submacular CT using optical coherence tomography (OCT) was measured before treatment and at the third and sixth months after treatment. Results: Initial mean arterial pressure (MAP) values in Groups I and II and the control group were 113.4, 109.8, and 89.4 mmHg, …
Evaluation Of Platelet Parameters And Neutrophil/Lymphocyte Ratio During Omalizumab Treatment In Patients With Severe Chronic Spontaneous Urticaria, Ragip Ertaş, Kemal Özyurt, Çi̇ğdem Karakükcü, Muhammet Reşat Akkuş, Emi̇n Özlü, Atil Avci, Mustafa Atasoy
Evaluation Of Platelet Parameters And Neutrophil/Lymphocyte Ratio During Omalizumab Treatment In Patients With Severe Chronic Spontaneous Urticaria, Ragip Ertaş, Kemal Özyurt, Çi̇ğdem Karakükcü, Muhammet Reşat Akkuş, Emi̇n Özlü, Atil Avci, Mustafa Atasoy
Turkish Journal of Medical Sciences
Background/aim: Spontaneous wheals and/or angioedema lasting longer than six weeks are described as chronic spontaneous urticaria (CSU). Omalizumab is used for the treatment of antihistamine-resistant CSU. The neutrophil-lymphocyte ratio (NLR), platelet- lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) are considered important indicators of inflammation and platelet activation in chronic diseases. We aimed to determine the NLR, PLR, MPV, and PDW levels in patients with CSU compared with healthy controls. We also aimed to investigate the effects of omalizumab therapy on these parameters in CSU patients. Materials and methods: This hospital-based, retrospective study included 143 patients …
Do The Etiological Factors In Artificial Urinary Sphincter Reimplantation Cases Affect Success And Complications?, İsmai̇l Nalbant, Can Tuygun, Ufuk Öztürk, Hasan Nedi̇m Göksel Göktuğ, Ahmet Ni̇hat Karakoyunlu, Volkan Selmi̇, Muhammet Abdurrahi̇m İmamoğlu
Do The Etiological Factors In Artificial Urinary Sphincter Reimplantation Cases Affect Success And Complications?, İsmai̇l Nalbant, Can Tuygun, Ufuk Öztürk, Hasan Nedi̇m Göksel Göktuğ, Ahmet Ni̇hat Karakoyunlu, Volkan Selmi̇, Muhammet Abdurrahi̇m İmamoğlu
Turkish Journal of Medical Sciences
Background/aim: The artificial urinary sphincter (AUS) is still one of the best options for incontinence treatment. It may also have an advantage for revision or reimplantation in the management of complications. In this study we aimed to discuss the etiological factors for AUS reimplantation and effects of these etiological factors on success rates, patient satisfaction rates, time to reimplantation surgery, and complications. Materials and methods: Data from 30 patients for whom AUS reimplantation was performed were analyzed retrospectively. Incontinence due to fluid loss from the cuff or reservoir balloon, inability of the cuff to adequately compress the urethra, and devices …
The Effect Of Generalized Seizure Activity On Ischemia-Induced Cardiac Arrhythmias And Myocardial Injury With Histopathological Evaluation In Anesthetized Rats, Ersöz Gonca, Fi̇gen Barut, Deni̇z Şahi̇n
The Effect Of Generalized Seizure Activity On Ischemia-Induced Cardiac Arrhythmias And Myocardial Injury With Histopathological Evaluation In Anesthetized Rats, Ersöz Gonca, Fi̇gen Barut, Deni̇z Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: Epileptic seizure leads to sudden unexpected death in epilepsy (SUDEP) among affected patients. The causes of SUDEP are still unclear. The aim of this study was to research the effect of epilepsy on myocardial injury and arrhythmias during experimentally induced acute myocardial ischemia. Materials and methods: Wistar albino rats were divided into four groups: sham, pentylentetrazole (PTZ) + sham, ischemia, and PTZ + ischemia groups. PTZ (65 mg/kg, ip) was given 2 h before ischemia. Seizure scoring was conducted by evaluating the PTZ-induced behavioral changes in the rats. The left main coronary artery was ligated in anesthetized rats for …
Investigation Of The Effect Of Combined Use Of Alloplastic-Based Tricalcium Phosphate Bone Graft And Antihemorrhagic Plant Extract (Abs) On Bone Regeneration In Surgically Induced Bone Defects In Nondiabetic Rats: An Experimental Animal Study, Abdulsamet Tani̇k, Arzum Güler Doğru, Veysi̇ Akpolat, Fi̇li̇z Acun Kaya, Ebru Saribaş, Mehmet Gül, Sevgi̇ İrtegün, Engi̇n Deveci̇
Investigation Of The Effect Of Combined Use Of Alloplastic-Based Tricalcium Phosphate Bone Graft And Antihemorrhagic Plant Extract (Abs) On Bone Regeneration In Surgically Induced Bone Defects In Nondiabetic Rats: An Experimental Animal Study, Abdulsamet Tani̇k, Arzum Güler Doğru, Veysi̇ Akpolat, Fi̇li̇z Acun Kaya, Ebru Saribaş, Mehmet Gül, Sevgi̇ İrtegün, Engi̇n Deveci̇
Turkish Journal of Medical Sciences
Background/aim: In this experimental study, we aimed to evaluate the late period effects of the combination of Ankaferd Blood Stopper (ABS), which has bone wound healing effects, and ß-tricalcium phosphate (TCP) on the regeneration of bone tissue through histopathological, immunohistochemical, and radiological (dual energy X-ray absorptiometry - DEXA) methods in nondiabetic rats. Materials and methods: Sixty-four Wistar albino male rats were used. In the calvaria of the rats, a bone defect 7.0 mm in diameter was created. These rats were divided into 4 different groups. Group 1 was the control group without any treatment, a 0.125 mL B-TCP graft was …
Demonstration Of The Effect Of Brivaracetam On An Experimental Epilepsy Model, Mustafa Çeti̇ner, Hasan Emre Aydin
Demonstration Of The Effect Of Brivaracetam On An Experimental Epilepsy Model, Mustafa Çeti̇ner, Hasan Emre Aydin
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effects of valproic acid (VPA) and a new-generation antiepileptic drug called brivaracetam (BRV) on the brain damage occurring after status epilepticus (SE) in rats. Materials and methods: In our study, an experimental animal model of SE, generated by stereotaxically injecting 0.4-2 μg of kainic acid into the rat hippocampus, was used. The laboratory animals were divided into 4 groups: the first group was a sham group that was subjected to anesthesia and SE was not induced; the second group was a SE group, in which SE was induced using kainic …
Expression Changes Of Cd177 And Mpo As Novel Biomarkers In Lung Tissue Ofclp Model Rats, Azadeh Rasooli, Elham Ghafari, Hamed Saeidi, Saba Miri
Expression Changes Of Cd177 And Mpo As Novel Biomarkers In Lung Tissue Ofclp Model Rats, Azadeh Rasooli, Elham Ghafari, Hamed Saeidi, Saba Miri
Turkish Journal of Medical Sciences
Background/aim: Sepsis is an unregulated systemic response to microbial invasion that can lead to multiple organ failure. This study aims at investigating the relationships among myeloperoxidase (MPO) and CD177 in major organ systems including whole blood, liver, and lung tissues in septic rats. Materials and methods: Sepsis was induced by cecal ligation and puncture (CLP) in female Wistar rats. Whole blood, liver, and lung samples were obtained from rats of 3 groups (n = 10 for each group, n total = 30: control as a wild-type group, laparotomy group (LAP), and CLP). Gene expression of MPO and CD177 in targeted …
Vascular Responses Of Aortic, Renal, And Uterine Arteries In Suramin-Induced Preeclampsia-Like Syndrome In Rats, Sebi̇le Güler Çeki̇ç, Edi̇p Güvenç Çeki̇ç, Di̇lek Baydar, Meral Tuncer, Güray Soydan
Vascular Responses Of Aortic, Renal, And Uterine Arteries In Suramin-Induced Preeclampsia-Like Syndrome In Rats, Sebi̇le Güler Çeki̇ç, Edi̇p Güvenç Çeki̇ç, Di̇lek Baydar, Meral Tuncer, Güray Soydan
Turkish Journal of Medical Sciences
Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. We aimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic, renal, and uterine arteries. Materials and methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of saline on days 10 and 11. Blood pressures of rats were observed daily. On the day 20, rats were executed. Protein levels in urine were measured and fetuses, placentas, and kidneys were weighted and evaluated. Thoracic aorta, renal, and uterine arteries were removed for …
Evaluation Of The Performance Of Maldi-Tof Ms And Dna Sequence Analysis In The Identification Of Mycobacteria Species, Işin Akyar, Cengi̇z Çavuşoğlu, Meltem Ayaş, Süheyla Sürücüoğlu, Zeynep Arzu İlki̇, Deni̇z Ece Kaya, Yeşi̇m Beşli̇
Evaluation Of The Performance Of Maldi-Tof Ms And Dna Sequence Analysis In The Identification Of Mycobacteria Species, Işin Akyar, Cengi̇z Çavuşoğlu, Meltem Ayaş, Süheyla Sürücüoğlu, Zeynep Arzu İlki̇, Deni̇z Ece Kaya, Yeşi̇m Beşli̇
Turkish Journal of Medical Sciences
Background/aim: Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry is an alternative way of identifying mycobacteria via the analysis of biomolecules. It is being increasingly used in routine microbiology practice since it permits early, rapid, and cost-effective identification of pathogens of clinical importance. In this study, we aimed to evaluate the efficacy of phenotypic identification of mycobacteria by the MALDI-TOF MS MBT Mycobacteria Library (ML) 4.0 (Bruker, Daltonics) compared to standard sequence analysis. Materials and methods: A total of 155 Mycobacterium clinical and external quality control isolates, comprising nontuberculous mycobacteria (NTM) (n = 95) and the Mycobacterium tuberculosis complex (MTC) (n …
Losartan Inhibits Egfr Transactivation In Vascular Smooth Muscle Cells, Mustafa Kirça, Akin Yeşi̇lkaya
Losartan Inhibits Egfr Transactivation In Vascular Smooth Muscle Cells, Mustafa Kirça, Akin Yeşi̇lkaya
Turkish Journal of Medical Sciences
Background/aim: Angiotensin II (Ang II)-induced molecular signaling pathways play a significant role in the progression of cardiovascular diseases, including hypertension and atherosclerosis. In addition to the well-known effects of Ang II, it may activate epidermal growth factor receptor (EGFR) in a process known as transactivation, which contributes to vascular pathologies. The aim of this study was to determine whether losartan could reduce EGFR transactivation induced by Ang II. Additionally, we evaluated the roles of heparin-binding epidermal-like growth factor (HB-EGF) and matrix metalloproteinases (MMPs) in Ang II-induced EGFR transactivation. Materials and methods: Vascular smooth muscle cells were isolated from a rat …
Neuroendocrine Tumors Detected In Appendectomy Specimens: Ten-Year Single-Center Experience, Fatma Şenel, Hati̇ce Karaman, Hacer Demi̇r
Neuroendocrine Tumors Detected In Appendectomy Specimens: Ten-Year Single-Center Experience, Fatma Şenel, Hati̇ce Karaman, Hacer Demi̇r
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate neuroendocrine tumors (NETs) detected in appendectomy specimens and the incidence and clinicopathologic characteristics of these tumors in our center. Materials and methods: A total of 13,863 patients were evaluated retrospectively. All underwent appendectomy operation in the Kayseri Training and Research Hospital and had a histopathological examination at the Pathology Clinic between January 2007 and March 2017. Age, sex, preoperative clinical findings, operation procedure, and histopathological examination results of the cases reported to be NET are presented. Results: NET was detected in 29 cases (0.2%) in the histopathological examination of 13,863 appendectomy …
Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Cancer Fatigue Scale In Patients With Breast Cancer, Sedef Şahi̇n, Meral Huri̇, Orkun Tahi̇r Aran, Mi̇ne Uyanik
Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Cancer Fatigue Scale In Patients With Breast Cancer, Sedef Şahi̇n, Meral Huri̇, Orkun Tahi̇r Aran, Mi̇ne Uyanik
Turkish Journal of Medical Sciences
Background/aim: The Cancer Fatigue Scale (CFS) was developed to evaluate the severity of fatigue in patients with breast cancer. The aim of this study is to translate and culturally adapt a Turkish version and investigate the validity and reliability of the CFS in Turkish patients with fatigue symptoms. Materials and methods: Eighty participants completed the Turkish version of the CFS for breast cancer and the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire ″Core 30″ (EORTC QLQ-C30). Test-retest reliability was evaluated by repeating the CFS with a 7-day interval. Results: The CFS demonstrated high test-retest …
Does Glycerol Have An E Ect On Pain During Nasal Packing Removal, Sanem Okşan Erkan, Bi̇rgül Tuhani̇oğlu, Zeynel Abi̇di̇n Erkan, Tali̇h Özdaş, Orhan Görgülü
Does Glycerol Have An E Ect On Pain During Nasal Packing Removal, Sanem Okşan Erkan, Bi̇rgül Tuhani̇oğlu, Zeynel Abi̇di̇n Erkan, Tali̇h Özdaş, Orhan Görgülü
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the e cacy of lubricating and moistening of Merocel nasal packs with glycerol on reducing pain and bleeding during nasal packing removal in patients who had undergone endoscopic sinus surgery or with epistaxis. Materials and methods: Fifty patients were included in the study. Glycerol was used on one side while saline was used on the other side of the same patient as a control. All patients were blinded to which side received glycerol and which side received saline. In the glycerol group, glycerol was in ltrated into the Merocel packing in …