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Articles 2551 - 2580 of 8080
Full-Text Articles in Medicine and Health Sciences
Increased Micronucleus Count Predicts Malignant Behavior In Pleural Effusion Fluid, Tuba Di̇lay Kökenek Ünal, İpek Çoban
Increased Micronucleus Count Predicts Malignant Behavior In Pleural Effusion Fluid, Tuba Di̇lay Kökenek Ünal, İpek Çoban
Turkish Journal of Medical Sciences
Background/aim: Micronucleus (MN) frequency is used as a biomarker of chromosomal damage, genome instability, and cancer risk. e aim of this study was to evaluate the diagnostic usefulness of MN frequency to di erentiate between malignant and benign pleural e usion samples. Materials and methods: Retrospectively, 78 pleural uid cytology samples (including 20 cases of benign reactive mesothelial cells, 22 cases of suspicious cytology, and 36 cases of malignant cytology) were examined. e number of micronucleated cells in 1000 well- preserved cells was counted. Statistical tests were performed to compare the study groups. Recover operating characteristics (ROC) curve analysis was …
Microbiological And Clinical Data Analysis Of 32 Patients With Nocardia Infections In Yantai, Hong-Xia Yu, Ming Liu, Zeng-Hui Pu, Yan Liu, Mao-Mao Zhao
Microbiological And Clinical Data Analysis Of 32 Patients With Nocardia Infections In Yantai, Hong-Xia Yu, Ming Liu, Zeng-Hui Pu, Yan Liu, Mao-Mao Zhao
Turkish Journal of Medical Sciences
Background/aim: Nocardia is an opportunistic pathogen that mostly a ects hosts with immune de ciencies. Recently, the widespread use of immunosuppressive agents and antitumor drugs has led to an increasing number of Nocardia infections being reported. However, it is di cult to con rm this diagnosis owing to the slow growth of the bacterium and its complex resultant clinical manifestations, potentially delaying treatment and increasing mortality. us, further knowledge on the clinical characteristics of Nocardia infection is required. Hence, this study aimed to review the demographics, comorbidities, clinical presentation, microbiology, treatment, and outcomes of Nocardia infections in Yantai. Materials and …
Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan
Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to report the clinical characteristics and the treatment outcomes of hand infections in diabetic patients and to review the literature. Materials and methods: The medical records of 17 patients with diabetic hand infections admitted to the Diabetic Foot Care Center of two di erent clinics from January 2012 to October 2017 were reviewed. To perform the pooled analysis, published series (32 studies) were searched in two international databases (www.scopus.com and www.pubmed.com). Results: Of the 17 patients (mean age 61.7 ± 8.5 years), 8 (47.1%) were female. All cases were type 2 diabetes mellitus. …
Increased Concentrations Of Serum Nesfatin-1 Levels In Childhood With Idiopathic Chronic Malnutrition, Sezer Acar, Gönül Çatli, Tuncay Küme, Hale Ünver Tuhan, Özlem Gürsoy Çalan, Korcan Demi̇r, Ece Böber, Ayhan Abaci
Increased Concentrations Of Serum Nesfatin-1 Levels In Childhood With Idiopathic Chronic Malnutrition, Sezer Acar, Gönül Çatli, Tuncay Küme, Hale Ünver Tuhan, Özlem Gürsoy Çalan, Korcan Demi̇r, Ece Böber, Ayhan Abaci
Turkish Journal of Medical Sciences
Background/aim: Nesfatin-1, an anorexigenic molecule, seems to play a role in appetite regulation and energy homeostasis. e goal of this study was to evaluate the relation of nesfatin-1 with anthropometric and metabolic (ghrelin, leptin) parameters in children with idiopathic chronic malnutrition. Materials and methods: The study included 37 underweight and 38 healthy children who were similar regarding age, sex, and pubertal status. Anthropometric and biochemical (nesfatin-1, ghrelin, and leptin levels) variables were assessed. Results: A total of 37 underweight subjects (mean age 10.5 ± 2.6 years) and 38 heathy subjects (mean age 10.3 ± 2.3 years) were recruited. Underweight children …
Microdeletion And Mutation Analysis Of The Shox Gene In Patients With Idiopathic Short Stature With Fish And Sequencing, Abdullati̇f Bakir, Meral Yi̇rmi̇beş Karaoğuz, Ferda Emri̇ye Perçi̇n, Esra Tuğ, Peyami̇ Ci̇naz, Mehmet Ali̇ Ergün
Microdeletion And Mutation Analysis Of The Shox Gene In Patients With Idiopathic Short Stature With Fish And Sequencing, Abdullati̇f Bakir, Meral Yi̇rmi̇beş Karaoğuz, Ferda Emri̇ye Perçi̇n, Esra Tuğ, Peyami̇ Ci̇naz, Mehmet Ali̇ Ergün
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the prevalence of the microdeletions and mutations of the SHOX gene in children with idiopathic short stature (ISS) by the usage of uorescence in situ hybridization (FISH) and direct sequencing technique. Materials and methods: Thirty-seven children referred to our clinic because of short stature were classi ed as having ISS a er clinical examination. Chromosome analyses, FISH analysis of the SHOX gene, and direct sequencing of the coding exons of SHOX, through the second to the sixth exon, in 24 of the 37 patients were also performed. Results: All children had …
Comparison Of Percutaneous Nephrostomy And Double J Stent In Symptomatic Pregnancy Hydronephrosis Treatment, Adnan Şi̇mşi̇r, Fuat Kizilay, Mehmet Bülent Semerci̇
Comparison Of Percutaneous Nephrostomy And Double J Stent In Symptomatic Pregnancy Hydronephrosis Treatment, Adnan Şi̇mşi̇r, Fuat Kizilay, Mehmet Bülent Semerci̇
Turkish Journal of Medical Sciences
Background/aim: We aimed to compare the success rate of percutaneous nephrostomy (PCN) and double J stenting (DJS) in the treatment of symptomatic pregnancy hydronephrosis. Materials and methods: Diagnosis and grading of hydronephrosis were performed by urinary ultrasound (USG) and Doppler mode was used for evaluation of renal arterial resistivity index (RI). Patients were divided into two groups according to the method used for the treatment of hydronephrosis: group A (PCN, n = 38) and group B (DJS, n = 46). A P value < 0.05 was considered signi cant. Results: The number of patients requiring second intervention was higher in group B (P = 0.0018) and time to secondary intervention was signi cantly earlier in group B also (P = 0.0025). e number of tertiary intervention was again higher in group B (5/16 vs. 1/6) and the need for tertiary intervention was higher in patients who underwent DJS implantation as a secondary intervention than those who underwent PCN (5/11 vs. 1/11, P = 0.0012). e time to tertiary intervention was longer in patients with PCN than in those with DJS (P = 0.0048). Conclusion: PCN may be preferred to DJS in symptomatic pregnancy hydronephrosis because it requires fewer re-interventions a er longer times.
A Survey On Rectal Bleeding In Children, A Report From Iran, Seyed Mohsen Dehghani, Iraj Shahramian, Maryam Ataollahi, Ali Bazi, Nosaibe Seirfar, Mojtaba Delaramnasab, Ali Reza Sargazi, Mahsa Shariat Razavi
A Survey On Rectal Bleeding In Children, A Report From Iran, Seyed Mohsen Dehghani, Iraj Shahramian, Maryam Ataollahi, Ali Bazi, Nosaibe Seirfar, Mojtaba Delaramnasab, Ali Reza Sargazi, Mahsa Shariat Razavi
Turkish Journal of Medical Sciences
Background/aim: Studies on the epidemiology of rectal bleeding in children are limited in Iran. Our aim was to assess etiologies of rectal bleeding in children in Iran. Materials and methods: We enrolled 730 children with rectal bleeding. All the patients underwent colonoscopy, and 457 were further evaluated with histopathology. Results: According to colonoscopy and histopathology, respectively, in ammatory bowel disease (IBD) (29.4%, 15.8%), nodular hyperplasia (NH) (24.9%, 10%), and juvenile polyposis (JP) (12.6%, 9.9%) were the most common causes of rectal bleeding. Other conditions were solitary rectal ulcer (5.3%), chronic colitis (4.6%), allergic colitis (3.3%), focal colitis (1.3%), and infectious …
Insulin-Like Growth Factor-1 Receptor Expression In Pediatric Tumors: A Comparative Immunohistochemical Study, Resul Karakuş, Esra Karakuş, Suna Emi̇r, Ayper Eri̇bol, Derya Özyörük
Insulin-Like Growth Factor-1 Receptor Expression In Pediatric Tumors: A Comparative Immunohistochemical Study, Resul Karakuş, Esra Karakuş, Suna Emi̇r, Ayper Eri̇bol, Derya Özyörük
Turkish Journal of Medical Sciences
Background/aim: Insulin-like growth factor-1 receptor (IGF-1R) is a pivotal receptor tyrosine kinase involved in the cell cycle and malignant tumor transformation. It is di erentially expressed in various types of tumors. We aimed to determine the expression of IGF- 1R in di erent pediatric tumors and to shed light on possible new indications of anti-IGF-1R treatment approaches. Materials and methods: A total of 147 specimens were analyzed according to their expression of IGF-1R. Specimens included those from rhabdomyosarcomas, Wilms tumors, Ewing sarcoma/primitive neuroectodermal tumors, peripheral neuroblastic tumors, acute lymphoblastic lymphoma, Hodgkin lymphoma, Burkitt lymphoma, retinoblastoma, pleuropulmonary blastoma, Langerhans cell histiocytosis, …
The Relation Between Isolated Micropenis In Childhood With Cag And Ggn Repeat Polymorphisms In The Androgen Receptor Gene, Esra Tuğ, Sezen Günteki̇n Ergün, Mehmet Ali̇ Ergün, Fatma Ni̇hal Di̇lek, Ferda Emri̇ye Perçi̇n
The Relation Between Isolated Micropenis In Childhood With Cag And Ggn Repeat Polymorphisms In The Androgen Receptor Gene, Esra Tuğ, Sezen Günteki̇n Ergün, Mehmet Ali̇ Ergün, Fatma Ni̇hal Di̇lek, Ferda Emri̇ye Perçi̇n
Turkish Journal of Medical Sciences
Background/aim: In micropenis cases accompanied by external genital abnormalities such as hypospadias and cryptorchidism, infertility and spermatogenic failures have been reported to correlate with androgen receptor (AR) gene CAG and GGN repeat polymorphisms. While there is one study on isolated micropenis and CAG repeats, no study related to GGN repeats has been reported. We investigated the relation between CAG and GGN repeats in the AR gene with development of penis length in boys with isolated micropenis. Materials and methods: A total of 24 Turkish boys with isolated micropenis (
A Simplified Cell Culture Model For Research On Intestinal Inflammation, Ayşe Erol, Si̇bel Ti̇ryaki̇, Mustafa Orkan Ergün
A Simplified Cell Culture Model For Research On Intestinal Inflammation, Ayşe Erol, Si̇bel Ti̇ryaki̇, Mustafa Orkan Ergün
Turkish Journal of Medical Sciences
Background/aim: e aim of this study was to combine some easy and economical de ned methods and constitute a comprehensive cell culture model to use in the bowel diseases characterized by in ammation. Materials and methods: Induction of inflammation was performed using lipopolysaccharide (LPS) or a cytokine mixture (TNF-?: 10 ng/mL; IFN-?: 100 ng/mL; IL-1ß: 1 ng/mL). IEC-6 cells were grown to con uence and serum-starved, wounds were constituted, and progress of cell migration into the wounds was photographed at 0, 2, 4, 6, 8, 10, 12, and 24 h in the presence or absence of an in ammatory environment. …
Effects Of Di Erent Drug Treatments On The Proliferation Of Human Ovarian Carcinoma Cell Line Mdah-2774, Şule Ayla, Ayhan Bi̇li̇r, Ahmet Şenol Ertürkoğlu, Gamze Tanriverdi̇, Burak Cem Soner, Kenan Sofuoğlu, Laura Ghisolfi, Gülperi̇ Öktem
Effects Of Di Erent Drug Treatments On The Proliferation Of Human Ovarian Carcinoma Cell Line Mdah-2774, Şule Ayla, Ayhan Bi̇li̇r, Ahmet Şenol Ertürkoğlu, Gamze Tanriverdi̇, Burak Cem Soner, Kenan Sofuoğlu, Laura Ghisolfi, Gülperi̇ Öktem
Turkish Journal of Medical Sciences
Background/aim: In this study, the e ects of resveratrol as a natural polyphenol compound, gemcitabine as an antimetabolite that has nucleoside structure analogous to deoxycytidine, and para-aminophenol-derived paracetamol were investigated with single and combined applications in monolayers of the MDAH-2774 human ovarian cancer cell line. Materials and methods: Drugs were evaluated in cell culture with respect to cell proliferation, cell cytotoxicity (trypan blue dye exclusion test), synthesis phase of cell cycle, and cell structure in 24, 48, 72, and 96 h. Result: Resveratrol and gemcitabine diminished both cell proliferation and cell cycle synthesis phase indication in monolayer cell cultures (P < 0.05). All combination groups showed similar e ects that were mainly more e ective in respect to single usage of resveratrol and gemcitabine in monolayer cell cultures. Conclusion: The effects of gemcitabine, resveratrol, and paracetamol were investigated in monolayers of the MDAH-2774 human ovarian cancer cell line and a decrease in cell number in cell cycle synthesis phase, prevention of cell proliferation, and destruction of cell structure were observed.
The Effects Of Preadministration Of Local Anesthetic On Pulsed Radiofrequency, Tüli̇n Arici, Mustafa Kurçaloğlu, İdri̇s Şevki̇ Köken, Bora Uzuner, Can Eyi̇gör, Meltem Uyar
The Effects Of Preadministration Of Local Anesthetic On Pulsed Radiofrequency, Tüli̇n Arici, Mustafa Kurçaloğlu, İdri̇s Şevki̇ Köken, Bora Uzuner, Can Eyi̇gör, Meltem Uyar
Turkish Journal of Medical Sciences
Background/aim: Pulsed radiofrequency (PRF) has been reported to be a safe and reliable method for the management of a variety of chronic pain syndromes. It is not known whether the preadministration of local anesthetic increases the size of the electrical field. We revealed the effects of administering local anesthetic on PRF and investigated whether they were related to local anesthetic or fluid effects. Materials and methods: Group 1 (n = 18) received PRF to the suprascapular nerve with 1 mL of bupivacaine, group 2 (n = 20) received PRF with 1 mL of physiological saline solution, and group 3 (n …
An Evaluation Of Banana Allergy In Children Living In The Mediterranean Region, Di̇lara Fatma Kocacik Uygun, Serkan Fi̇li̇z, Ayşen Bi̇ngöl
An Evaluation Of Banana Allergy In Children Living In The Mediterranean Region, Di̇lara Fatma Kocacik Uygun, Serkan Fi̇li̇z, Ayşen Bi̇ngöl
Turkish Journal of Medical Sciences
Background/aim: We aimed to apply a double-blind placebo-controlled food challenge (DBPCFC) test to patients who reported a reaction to banana and showed positivity for banana-specific IgE in Turkey. Materials and methods: Medical data of patients who had been analyzed for banana allergy were reviewed, focusing on banana-specific IgE positivity at the Department of Pediatric Allergy-Immunology at the Akdeniz University Faculty of Medicine between the years 2004 and 2012. Patients were called to the clinic for a DBPCFC test. Results: A total of 47 patients participated. We determined reactions in 13% of DBPCFC patients. A cut-off value was determined as 0.66 …
Reliability And Validity Of The Turkish Version Of Thefoot Function Index In Patients With Foot Disorders, Bahar Külünkoğlu, Nesli̇han Firat, Nazim Tolgahan Yildiz, Afra Alkan
Reliability And Validity Of The Turkish Version Of Thefoot Function Index In Patients With Foot Disorders, Bahar Külünkoğlu, Nesli̇han Firat, Nazim Tolgahan Yildiz, Afra Alkan
Turkish Journal of Medical Sciences
Background/aim: The Foot Function Index (FFI) is a valid, reliable, and widely used self-reported questionnaire for the foot. The purpose of this study was to provide evidence for the validity and reliability of the Turkish version of the FFI (FFI-TR) among patients with foot disorders such as plantar fasciitis, hallux valgus, pes planus, and hammertoe deformities. Materials and methods: One hundred and fifty-nine patients with foot disorders were enrolled. The psychometric properties of the previously translated and adapted FFI-TR were assessed. The internal consistency and test-retest reliability were evaluated. Construct validity was examined for correlations with the Short Form-36 (SF-36) …
High Nucleostemin Expression Has A Favorable Prognostic Effect On Gastric Carcinomas, Güneş Deni̇z Yildirim, Deni̇z Arik, Bülent Yildiz, Murat Di̇ncer, Necdet Fati̇h Yaşar, Özgül Paşaoğlu
High Nucleostemin Expression Has A Favorable Prognostic Effect On Gastric Carcinomas, Güneş Deni̇z Yildirim, Deni̇z Arik, Bülent Yildiz, Murat Di̇ncer, Necdet Fati̇h Yaşar, Özgül Paşaoğlu
Turkish Journal of Medical Sciences
Background/aim: Nucleostemin is a nuclear protein that maintains stem cell features and plays a role as a cell proliferation marker. It also participates in cell cycle regulation by interfering with other intracellular proteins. Recent reports have indicated that this protein plays a role in ribosomal biogenesis and genome protection. High expression level of nucleostemin has been reported in some cancer patients. However, the importance of nucleostemin in gastric cancer needs to be addressed. The aim of this study was to investigate nucleostemin expression in gastric cancer and the effects of this expression on prognosis. Materials and methods: Nucleostemin expression was …
Human Immunodeficiency Virus And Tuberculosis Coinfection: Clinical Features And Predictors Of Mortality, Fatma Gümüşer, Merve Altinkaynak, Di̇lek Yildiz Sevgi̇, Özlem Altuntaş Aydin, Bi̇lgül Mete, Alper Gündüz, Hayat Kumbasar Karaosmanoğlu, Si̇bel Bolukçu, Ömer Fehmi̇ Tabak, Mustafa Haluk Vahaboğlu
Human Immunodeficiency Virus And Tuberculosis Coinfection: Clinical Features And Predictors Of Mortality, Fatma Gümüşer, Merve Altinkaynak, Di̇lek Yildiz Sevgi̇, Özlem Altuntaş Aydin, Bi̇lgül Mete, Alper Gündüz, Hayat Kumbasar Karaosmanoğlu, Si̇bel Bolukçu, Ömer Fehmi̇ Tabak, Mustafa Haluk Vahaboğlu
Turkish Journal of Medical Sciences
Background/aim: This study was undertaken to identify subjects with human immunodeficiency virus and tuberculosis (HIV/TB) coinfection in a group of HIV-positive patients followed at five different healthcare centers, and to determine the demographic and clinical characteristics of these subjects as well as the predictors of mortality. Materials and methods: A database search for subjects with TB coinfection was performed among 1475 HIV-positive adult patients and a total of 66 individuals were identified with HIV/TB coinfection. Results: There were 66 patients (4.5%) with TB coinfection. Twenty-one percent (n = 14) of the patients with TB coinfection died during the study period …
The Impact Of Plasma Socs3 Levels And Endometrialleukocytes On Unexplained Infertility, Zehra Sema Özkan, Şükri̇ye Derya Deveci̇, Nusret Akpolat, Nafi̇ye Fulya İlhan, Mehmet Şi̇mşek, Hüseyi̇n Ti̇murkan
The Impact Of Plasma Socs3 Levels And Endometrialleukocytes On Unexplained Infertility, Zehra Sema Özkan, Şükri̇ye Derya Deveci̇, Nusret Akpolat, Nafi̇ye Fulya İlhan, Mehmet Şi̇mşek, Hüseyi̇n Ti̇murkan
Turkish Journal of Medical Sciences
Background/aim: To investigate the possible differences in endometrial leukocyte subtype distribution between women with unexplained infertility and normal fertile women and to determine whether there is a correlation between endometrial leukocyte counts and plasma cytokine levels in unexplained infertility. Materials and methods: This case-control study involved 79 infertile and 40 fertile women. Peripheral venous blood samples and endometrial samples were obtained on day 21 of the menstrual cycle. Plasma interleukin-4 (IL4), IL6, IL10, IL17, IL35, interferongamma (IFN-g), tumor necrosis factor-alpha (TNF-a), transforming growth factor-beta (TGF-b), and suppressor of cytokine signaling-3 (SOCS3) levels were determined by enzyme-linked immunosorbent assay. Endometrial CD8, …
Evaluation Of The Facial Nerve And Internal Auditory Canal Cross-Sectional Areas Onthree-Dimensional Fast Imaging Employing Steady-State Acquisition Magnetic Resonanceimaging In Bell's Palsy, Ebru Ozan Sanhal, Hande Arslan
Evaluation Of The Facial Nerve And Internal Auditory Canal Cross-Sectional Areas Onthree-Dimensional Fast Imaging Employing Steady-State Acquisition Magnetic Resonanceimaging In Bell's Palsy, Ebru Ozan Sanhal, Hande Arslan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the facial nerve (FN) and internal auditory canal (IAC) on three-dimensional fast imaging employing steady-state acquisition (3D-FIESTA) magnetic resonance imaging (MRI) to define possible structural differences in cases of Bell's palsy (BP). Materials and methods: Fifty-six patients presenting with BP were included in this study. The measurements of the diameters and the cross-sectional areas (CSAs) of the FNs and IACs obtained on 3D-FIESTA MRI both on the affected and unaffected sides of all patients were compared. Results: A significant difference was found between affected and unaffected sides of the patients in terms of the …
Anxiety And Depression States Of Adolescents With Polycystic Ovary Syndrome, Hamdi̇ Ci̇han Emeksi̇z, Aysun Bi̇deci̇, Burçi̇n Nalbantoğlu, Ayşi̇n Nalbantoğlu, Cem Çeli̇k, Yasemi̇n Yulaf, Mahmut Orhun Çamurdan, Peyami̇ Ci̇naz
Anxiety And Depression States Of Adolescents With Polycystic Ovary Syndrome, Hamdi̇ Ci̇han Emeksi̇z, Aysun Bi̇deci̇, Burçi̇n Nalbantoğlu, Ayşi̇n Nalbantoğlu, Cem Çeli̇k, Yasemi̇n Yulaf, Mahmut Orhun Çamurdan, Peyami̇ Ci̇naz
Turkish Journal of Medical Sciences
Background/aim: Various studies have shown that adult patients with polycystic ovary syndrome (PCOS) have higher levels of anxiety and depression compared to their normal counterparts. However, it is still unclear whether these mood disorders already exist in adolescents affected by PCOS. The aim of the present study is to assess differences in anxiety and depression levels between adolescents with PCOS and age- and body mass index (BMI)-matched controls and to determine the possible factor(s) impacting these psychological parameters in adolescents with PCOS. Materials and methods: The study included 80 adolescents with PCOS and 50 age- and BMI-matched controls. All participants …
Comparison Of Prognostic Systems In Cirrhotic Patients With Hepatic Encephalopathy, Adnan Taş, Mehmet Suat Yalçin, Bünyami̇n Saritaş, Banu Kara
Comparison Of Prognostic Systems In Cirrhotic Patients With Hepatic Encephalopathy, Adnan Taş, Mehmet Suat Yalçin, Bünyami̇n Saritaş, Banu Kara
Turkish Journal of Medical Sciences
Background/aim: There are various scoring systems for evaluating prognosis in patients hospitalized in intensive care units (ICUs) with hepatic encephalopathy. These include the Child-Turcotte-Pugh (CTP) classification, Model for End-stage Liver Disease (MELD), chronic liver failure-sequential organ failure assessment (CLIF-SOFA), and Acute Physiology and Chronic Health Evaluation II (APACHE II). In this study, we aimed to compare the various scoring systems to determine the best system for showing the prognosis of patients with a prior diagnosis of cirrhosis who were hospitalized for hepatic encephalopathy. Materials and methods: Patients with known cirrhosis hospitalized in the internal medicine ICU of the Adana Numune …
Visfatin Levels In Hormonally Inactive Adrenal Adenoma And Their Association Withmetabolic Parameters, Alp Atasoy, Evri̇m Çakir, Süleyman Ahbab, Yasemi̇n Erdoğan Döventaş, Maci̇t Koldaş, Hayri̇ye Esra Ataoğlu, Mustafa Yeni̇gün
Visfatin Levels In Hormonally Inactive Adrenal Adenoma And Their Association Withmetabolic Parameters, Alp Atasoy, Evri̇m Çakir, Süleyman Ahbab, Yasemi̇n Erdoğan Döventaş, Maci̇t Koldaş, Hayri̇ye Esra Ataoğlu, Mustafa Yeni̇gün
Turkish Journal of Medical Sciences
Background/aim: In parallel with increased frequency and higher quality of imaging techniques, the prevalence of adrenal adenoma has gradually increased. However, despite the growing incidence, the metabolic and tumorigenesis processes involved in its etiology are still unclear. Although visfatin has been reported to be associated with inflammation and tumorigenesis, its role in adrenal adenoma has not yet been investigated. Therefore, the present study was performed with an aim to evaluate visfatin levels and cardiometabolic risk factors in patients with adrenal adenoma. Materials and methods: Thirty patients recently diagnosed with adrenal adenoma along with 30 healthy participants were studied in a …
Saliva Levels Of Caspase-1, Tnf-α, And Ifn-γ In Primary Sjögren's Syndrome: Oralmucosal Abnormalities Revisited, Gonca Karabulut, Gül Ki̇tapçioğlu, Özgün Özçaka, Esi̇n Alpöz, Ayşe Nalbantsoy, Hayri̇ye Koçanaoğullari, Sercan Gücenmez, Gökhan Keser, Yasemi̇n Kabasakal
Saliva Levels Of Caspase-1, Tnf-α, And Ifn-γ In Primary Sjögren's Syndrome: Oralmucosal Abnormalities Revisited, Gonca Karabulut, Gül Ki̇tapçioğlu, Özgün Özçaka, Esi̇n Alpöz, Ayşe Nalbantsoy, Hayri̇ye Koçanaoğullari, Sercan Gücenmez, Gökhan Keser, Yasemi̇n Kabasakal
Turkish Journal of Medical Sciences
Background/aim: Abnormalities in oral mucosal immunity contribute to complex pathogenesis of primary Sjögren's syndrome (pSjS). We aimed to measure saliva and serum levels of caspase-1, tumor necrosis factor-alpha (TNF-α) and interferon gamma (IFN-γ) in patients with pSjS. Materials and methods: We studied 43 pSjS patients fulfilling the AECG criteria and 30 age/sex-matched healthy controls, as well as 39 rheumatoid arthritis (RA) patients as a disease control group. ESSDAI scores were less than seven in all patients with pSjS, indicating low disease activity. Quantitative analyses were made in serum and whole saliva samples. The statistical analysis was performed using SPSS 19.0. …
Positive Correlation Of Galanin With Insulin Resistance And Triglyceride Levels In Obesechildren, Sezer Acar, Ahu Paketçi̇, Tuncay Küme, Korcan Demi̇r, Özlem Gürsoy Çalan, Ece Böber, Ayhan Abaci
Positive Correlation Of Galanin With Insulin Resistance And Triglyceride Levels In Obesechildren, Sezer Acar, Ahu Paketçi̇, Tuncay Küme, Korcan Demi̇r, Özlem Gürsoy Çalan, Ece Böber, Ayhan Abaci
Turkish Journal of Medical Sciences
Background/aim: Galanin is a neuropeptide that is shown to be involved in the regulation of food intake and glucose homeostasis. The objective of this study was to evaluate the relation of serum galanin levels with anthropometric and metabolic parameters in obese and healthy children. Material and methods: The cross-sectional study consisted of 38 obese children (mean age: 11.9 ± 3.0 years) and 30 healthy children (mean age: 11.4 ± 2.0 years). Clinical and biochemical parameters [glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), lipids, galanin, and leptin levels] were assessed. Results: Serum galanin and leptin levels were significantly higher in obese …
Evaluation Of Mesenteric Panniculitis With Computed Tomography: Benign Condition Orparaneoplastic Syndrome?, Ali̇ Küpeli̇, Ayşegül Cansu, Şükrü Oğuz, Süleyman Beki̇rçavuşoğlu, Süha Turkmen, Ali̇ Ahmetoğlu, Gürkan Danişan
Evaluation Of Mesenteric Panniculitis With Computed Tomography: Benign Condition Orparaneoplastic Syndrome?, Ali̇ Küpeli̇, Ayşegül Cansu, Şükrü Oğuz, Süleyman Beki̇rçavuşoğlu, Süha Turkmen, Ali̇ Ahmetoğlu, Gürkan Danişan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the prevalence and association of mesenteric panniculitis (MP) with other diseases and the clinicoradiological features of MP, and to examine computed tomography findings to estimate the presence of malignancy in patients with MP. Materials and methods: Between September 2012 and August 2016, we used a keyword search to identify patients diagnosed with MP. Associated diseases and malignancies of patients were recorded. Cut-off values and diagnostic efficiencies of total MP scores and short and long diameters of the greatest lymph nodes were determined. Results: Out of 22,033 patients, 309 were determined to have MP (prevalence …
Serum Vasohibin-1 And Suppression Of Tumorigenicity-2 Levels In Children Withpredialysis Chronic Kidney Disease, Nuran Çeti̇n, Nadi̇de Meli̇ke Sav
Serum Vasohibin-1 And Suppression Of Tumorigenicity-2 Levels In Children Withpredialysis Chronic Kidney Disease, Nuran Çeti̇n, Nadi̇de Meli̇ke Sav
Turkish Journal of Medical Sciences
Background/aim: Chronic kidney disease (CKD), which is one of the most important health problems worldwide, could be considered as an immune inflammatory disease. A prognostic biomarker may be helpful in determining the progression of CKD in children. We aimed to investigate the serum vasohibin-1 and soluble suppression of tumorigenicity-2 (sST2) levels as potential biomarkers in children with predialysis CKD. Materials and methods: Forty-seven children with stage 2-4 CKD and 20 healthy controls were included in this cross-sectional study. Glomerular filtration rate (GFR) and urinary excretion of protein were measured in 24-h urine samples. Serum vasohibin-1 levels and sST2 were measured. …
Early Postoperative Follow-Up After Craniosynostosis Surgery, Ebru Ati̇ke Ongun, Oğuz Dursun, Mehmet Sai̇m Kazan, Banu Nur, Ercan Mihçi
Early Postoperative Follow-Up After Craniosynostosis Surgery, Ebru Ati̇ke Ongun, Oğuz Dursun, Mehmet Sai̇m Kazan, Banu Nur, Ercan Mihçi
Turkish Journal of Medical Sciences
Background/aim: Declined morbidity rates after craniosynostosis surgery indicate bypassing the pediatric intensive care unit (PICU) course to minimize treatment costs and bed usage. The aim of this study is to examine the incident rates of PICU admission and assess its necessity. Materials and methods: A retrospective analysis of 41 patients (operated on by open surgical techniques) between July 2011 and December 2015 was carried out. Intraoperative/postoperative vital signs, hemodynamic and metabolic parameters, estimated blood loss (EBVloss), blood transfusions, length of PICU, and hospitalizations were recorded. Results: Major and minor events reached 51.2% and 82.9%, respectively. EBVloss within 24 h was …
Perioperative Complications And Short-Term Outcomes Of Abdominal Sacrocolpopexy,Laparoscopic Sacrocolpopexy, Sacrospinous Ligament Fixation,And Iliococcygeus Fixation Procedures, Alper Bi̇ler, İbrahi̇m Egemen Ertaş, Gökhan Tosun, İsmet Hortu, Ahmet Demi̇r, Cüneyt Eftal Taner, Mehmet Özeren, Fati̇h Şendağ
Perioperative Complications And Short-Term Outcomes Of Abdominal Sacrocolpopexy,Laparoscopic Sacrocolpopexy, Sacrospinous Ligament Fixation,And Iliococcygeus Fixation Procedures, Alper Bi̇ler, İbrahi̇m Egemen Ertaş, Gökhan Tosun, İsmet Hortu, Ahmet Demi̇r, Cüneyt Eftal Taner, Mehmet Özeren, Fati̇h Şendağ
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate differences in perioperative complications and short-term outcomes of patients who underwent abdominal sacrocolpopexy/sacrohysteropexy, laparoscopic sacrocolpopexy/sacrohysteropexy, sacrospinous ligament fixation (SSLF), and iliococcygeus fixation due to apical prolapse. Materials and methods: The present retrospective cohort study included 145 patients who underwent apical prolapse surgery performed by the same surgeons between 1/1/2011 and 30/6/2017. There were 68 abdominal sacrocolpopexies (44 sacrocolpopexies and 24 sacrohysteropexies), 13 laparoscopic sacrocolpopexies (10 sacrocolpopexies and 3 sacrohysteropexies), 57 SSLFs, and 7 iliococcygeus fixations. Patients' short-term outcomes, perioperative complications, blood loss, operative time, and hospital stay were analyzed. Results: The mean operating time …
Se33 Locus As A Reliable Genetic Marker For Forensic Dna Analysis Systems, Dr Munir Ahmad Bhinder, Muhammad Yasir Zahoor, Haleema Sadia, Muhammad Qasim, Rukhsana Perveen, Ghulam Murtaza Anjum, Muhammad Iqbal, Najeeb Ullah, Waseem Shehzad, Muhammad Tariq, Ali Muhammad Waryah
Se33 Locus As A Reliable Genetic Marker For Forensic Dna Analysis Systems, Dr Munir Ahmad Bhinder, Muhammad Yasir Zahoor, Haleema Sadia, Muhammad Qasim, Rukhsana Perveen, Ghulam Murtaza Anjum, Muhammad Iqbal, Najeeb Ullah, Waseem Shehzad, Muhammad Tariq, Ali Muhammad Waryah
Turkish Journal of Medical Sciences
Background/aim: Genetic variation, an authentic tool of individual discrimination, is being used for forensic investigations worldwide. A missing result for even one out of 13-17 markers leads to an inconclusive report. Additional reliable markers are required to compensate such deficiencies. The SE33 locus has high genetic variability in different populations and is being used in forensic investigation systems in some countries. The purpose of the study was to assess the viability of use of the SE33 locus as a supportive marker for forensic DNA profiling. Materials and methods: Amplification of the SE33 locus was performed using the PowerPlex ES Monoplex …
Ankaferd Blood Stopper With Antibiofilm Potential Successfully Inhibits The Extracellularmatrix Degradation Enzymes And Promotes Wound Healing Of 3t3 Fibroblasts In Vitro, Ruki̇ye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Ankaferd Blood Stopper With Antibiofilm Potential Successfully Inhibits The Extracellularmatrix Degradation Enzymes And Promotes Wound Healing Of 3t3 Fibroblasts In Vitro, Ruki̇ye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Turkish Journal of Medical Sciences
Background/aim: The potential inhibitory effects of Ankaferd Blood Stopper (ABS) against biofilm formation of oral microorganisms and its capacity for collagenase, hyaluronidase, and elastase inhibitions that have important roles in wound healing have been investigated. Materials and methods: The wound healing potential was determined by its inhibition ability on collagenase, hyaluronidase, and elastase enzyme activities and was evaluated via scratch wound healing assay on murine 3T3 fibroblasts. The antibiofilm activity was tested against eight oral microorganisms using the crystal violet staining method. Results: At 10% ABS successfully inhibited the biofilm formation of the tested microorganisms. Enzyme inhibition analysis revealed that …
Effect Of Phosphodiesterase-5 Inhibition On Joint And Muscle Damage In Rats Withadjuvant Arthritis, Fai̇ze Eli̇f Bahadir, Mustafa Kutay Köroğlu, Meral Yüksel, Feri̇ha Ercan, Yaşar İnci̇ Ali̇can
Effect Of Phosphodiesterase-5 Inhibition On Joint And Muscle Damage In Rats Withadjuvant Arthritis, Fai̇ze Eli̇f Bahadir, Mustafa Kutay Köroğlu, Meral Yüksel, Feri̇ha Ercan, Yaşar İnci̇ Ali̇can
Turkish Journal of Medical Sciences
Background/aim: This study was designed to examine the effect of tadalafil, a phosphodiesterase (PDE)5 inhibitor, on the severity of joint and muscle damage in rats with adjuvant-induced arthritis (AA). Materials and methods: AA was induced by intradermal inoculation into right hind paw of male Sprague Dawley rats (300-450g) with complete Freund's adjuvant (CFA; 0.1 mL). AA rats were treated with either tadalafil (10 mg/kg; per oral) alone or along with the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 10 mg/kg; intraperitoneally). After decapitation on day 16, trunk blood was collected for total oxidant status (TOS) and total antioxidant capacity (TAC) assays. …