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Articles 2131 - 2160 of 8080
Full-Text Articles in Medicine and Health Sciences
Effect Of Variation In Mirna-Binding Site (Rs8176318) Of The Brca1 Gene In Breast Cancer Patients, Mushtaq Ahmad, Fazal Jalil, Muti Ul Haq, Aftab Shah
Effect Of Variation In Mirna-Binding Site (Rs8176318) Of The Brca1 Gene In Breast Cancer Patients, Mushtaq Ahmad, Fazal Jalil, Muti Ul Haq, Aftab Shah
Turkish Journal of Medical Sciences
Background/aim: A variation in the 3 prime untranslated regions (3?-UTRs) affects the binding of microRNA (miRNA) to the breast cancer (BC) susceptibility gene 1 (BRCA1) gene, and thus regulate its expression. In this study, the consequences of a variation in the miRNA-binding site (rs8176318G>T) in the 3?-UTRs of BRCA1 and its association with the risk of BC were investigated.Materials and methods: The selected variation (rs8176318G>T) was genotyped in BC patients (n = 300) and healthy controls (n = 300) using allele-specific polymerase chain reaction (PCR) [tetra-primer amplification refractory mutation system-PCR (T-ARMS-PCR)]. The results of the T-ARMS-PCR were further …
The Effect Of Hypoxia On Hearing Function, Nevreste Di̇dem Sonbay Yilmaz, Cem Saka, Burcu Arslan, Nurdan Aygener Yeşi̇lyurt, Di̇lek Saka, Sadik Ardiç, İstemi̇han Akin
The Effect Of Hypoxia On Hearing Function, Nevreste Di̇dem Sonbay Yilmaz, Cem Saka, Burcu Arslan, Nurdan Aygener Yeşi̇lyurt, Di̇lek Saka, Sadik Ardiç, İstemi̇han Akin
Turkish Journal of Medical Sciences
Background/aim: This study was conducted to determine the critical partial oxygen pressure (pO2) value that would impair hearing function by evaluating the effects of hypoxia on hearing function in subjects diagnosed with chronic obstructive pulmonary disease (CPOD).Materials and methods: The study included 25 male and 5 female patients referred to our clinic who were diagnosed with COPD, according to spirometry and PaO2 values, and who did not show pathology upon autoscopic examination. The control group consisted of 14 female and 16 male patients who had no lung disease and were in the same age range as the COPD group. Results: …
Serum Prolidase Level In Patients With Brucellosis And Its Possible Relationship With Pathogenesis Of The Disease: A Prospective Observational Study, Oğuzhan Sitki Di̇zdar, Ayşe Turunç Özdemi̇r, Osman Başpinar, Derya Koçer, Yavuz Katircilar, İlhami̇ Çeli̇k
Serum Prolidase Level In Patients With Brucellosis And Its Possible Relationship With Pathogenesis Of The Disease: A Prospective Observational Study, Oğuzhan Sitki Di̇zdar, Ayşe Turunç Özdemi̇r, Osman Başpinar, Derya Koçer, Yavuz Katircilar, İlhami̇ Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Changes in collagen metabolism and fibroblastic activity may play a role in the pathogenesis of brucellosis. The prolidase enzyme plays an important role in collagen synthesis. We aimed to investigate the association of prolidase levels with brucellosis.Materials and methods: Serum prolidase levels in 20 patients newly diagnosed with brucellosis were compared with levels in 30 healthy control subjects. Patients with brucellosis were reassessed 3 months later for prolidase, other laboratory measurements, and response to treatment. Results: The levels of serum prolidase were significantly higher in brucellosis patients compared with those of healthy controls. Prolidase, sedimentation, and C-reactive protein levels …
Fabp4 Levels In Hypothyroidism And Its Relationship With Subclinical Atherosclerosis, Mürşi̇de Tan, Hakan Korkmaz, Hüseyi̇n Aydin, Duygu Kumbul Doğuç
Fabp4 Levels In Hypothyroidism And Its Relationship With Subclinical Atherosclerosis, Mürşi̇de Tan, Hakan Korkmaz, Hüseyi̇n Aydin, Duygu Kumbul Doğuç
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to evaluate the relationship between serum fatty acid binding protein 4 (FABP4) levels and carotid intima media thickness (CIMT) in patients with hypothyroidism.Materials and methods: Forty subclinical hypothyroidism patients, 40 overt hypothyroidism patients, and 40 healthy controls were enrolled in the study. Blood pressure, body mass index, CIMT, fasting blood sugar, creatine, alanine aminotransferase, lipid parameters, insulin, free thyroxine, triiodothyronine, thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (anti-TPO), thyroglobulin antibody (anti-TG), high-sensitivity C-reactive protein (Hs-CRP), and FABP4 levels of all participants were measured.Results: Serum FABP4 levels were significantly higher in patients with subclinical and …
Shear Wave Versus Strain Elastography In The Differentiation Of Benign And Malignant Breast Lesions, Aykut Gürüf, Mesut Öztürk, İlkay Koray Bayrak, Ahmet Veysel Polat
Shear Wave Versus Strain Elastography In The Differentiation Of Benign And Malignant Breast Lesions, Aykut Gürüf, Mesut Öztürk, İlkay Koray Bayrak, Ahmet Veysel Polat
Turkish Journal of Medical Sciences
Background/aim: To evaluate and compare the diagnostic performances of shear wave elastography (SWE) and strain elastography (SE) in the differentiation of benign and malignant breast lesions.Materials and methods: The current study included 87 breast lesions in 84 patients. The Breast Imaging Reporting and Data System (BIRADS) categories were determined with ultrasound features. The maximum shear wave velocity (SWV), mean SWV, maximum SWV to fat SWV ratio, and mean SWV to fat SWV ratio were measured using SWE. The strain ratio (SR) was calculated as the ratio of lesion strain to the adjacent fat strain using SE. Receiver operating characteristic (ROC) …
Ultrasound-Guided Pulsed Radiofrequency Neuromodulation Of The Suprascapular Nerve In Partial Rotator Cuff Tears, Ender Si̇r, Sami̇ Eksert
Ultrasound-Guided Pulsed Radiofrequency Neuromodulation Of The Suprascapular Nerve In Partial Rotator Cuff Tears, Ender Si̇r, Sami̇ Eksert
Turkish Journal of Medical Sciences
Background/Aim: Pulsed radiofrequency (PRF) of the suprascapular nerve has been shown to be effective in the treatment of chronic shoulder pain. Ultrasound (US) guidance has gained popularity in regional blocks recently. This study aims to investigate the efficacy of suprascapular nerve pulsed radiofrequency under the guidance of ultrasonography. Materials and methods: This retrospective study included patients treated with PRF of the suprascapular nerve with a diagnosis of partial rotator cuff tears. The patients were assessed with a numeric rating scale (NRS), the Shoulder Pain and Disability Index (SPADI), and a Likert patient satisfaction score before the treatment and 3 weeks …
Seasonal, Sex Variations In Vitamin D Levels And Their Association With Pulmonary Function In Children With Asthma, Şebnem Özdoğan
Seasonal, Sex Variations In Vitamin D Levels And Their Association With Pulmonary Function In Children With Asthma, Şebnem Özdoğan
Turkish Journal of Medical Sciences
Background/aim: We aimed to examine the seasonal and sex variations in vitamin D levels in children with asthma and their associations with lung function. Materials and methods: We conducted a cohort study involving children aged 7?17 years old with asthma. Vitamin D levels were obtained and pulmonary function tests (PFTs) were performed in winter months (December, January, and February) and at the end of summer (August, September, and October). Seasonal and sex variations in vitamin D levels and lung function were examined. Results: A total of 56 children (26 males, mean age: 11.93 ± 1.8) were enrolled. The mean vitamin …
Tracheal Intubation With The Mcgrath Mac X-Blade Videolaryngoscope In Morbidly Obese And Nonobese Patients, Zehra İpek Arslan, Hadi̇ Ufuk Yörükoğlu
Tracheal Intubation With The Mcgrath Mac X-Blade Videolaryngoscope In Morbidly Obese And Nonobese Patients, Zehra İpek Arslan, Hadi̇ Ufuk Yörükoğlu
Turkish Journal of Medical Sciences
Background/aim: Increased body mass index (BMI) and neck circumference are the two independent predictors of difficult intubation. McGrath MAC X-Blade is a videolaryngoscope specifically designed for difficult intubations. Materials and methods: Eighty patients with the American Society of Anesthesiologists (ASA) physical status I?III undergoing elective surgery requiring endotracheal intubation were enrolled in the study. Patients were divided into two groups, nonobese (BMI < 30) and morbidly obese (BMI > 35). All patients were intubated with the McGrath MAC X-Blade in both groups. View optimization and tube insertion maneuvers such as reinsertion of the device, slight removal of the device, cricoid pressure, handling force, 90° anticlockwise rotation of …
Effects Of Phenytoin Injection On Vocal Cord Healing After Mechanical Trauma: An Experimental Study, Si̇bel Ali̇cura Tokgöz, Cem Saka, İstemi̇han Akin, Fatma Fulya Köybaşioğlu, Saffet Kiliçaslan, Murat Çalişkan, Ömer Beşalti, Emel Çadalli Tatar
Effects Of Phenytoin Injection On Vocal Cord Healing After Mechanical Trauma: An Experimental Study, Si̇bel Ali̇cura Tokgöz, Cem Saka, İstemi̇han Akin, Fatma Fulya Köybaşioğlu, Saffet Kiliçaslan, Murat Çalişkan, Ömer Beşalti, Emel Çadalli Tatar
Turkish Journal of Medical Sciences
Background/aim: Phenytoin is an anticonvulsant drug which causes fibroblast proliferation, collagen synthesis, and an increase in epidermal growth factor. Therefore, the aim of the present study is to evaluate the effect of phenytoin injection on the wound healing process in rats with vocal cord injury by histopathological methods. Materials and methods: The vocal cords of 10 albino Wistar rats were damaged bilaterally; the left vocal cord was kept as the control group. Phenytoin was injected in the right vocal cord. Ten rats were sacrificed. The thickness of the lamina propria and density of the fibroblast and collagen were evaluated histopathologically.Results: …
An Old Friend: Uric Acid And Its Association With Fractional Flow Reserve, Sali̇h Topal, Burak Sezenöz, Mustafa Candemi̇r, Eser Açikgöz, Sadik Kadri̇ Açikgöz, Nuri̇ Bülent Boyaci
An Old Friend: Uric Acid And Its Association With Fractional Flow Reserve, Sali̇h Topal, Burak Sezenöz, Mustafa Candemi̇r, Eser Açikgöz, Sadik Kadri̇ Açikgöz, Nuri̇ Bülent Boyaci
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the importance of preprocedural uric acid (UA) level in predicting fractional flow reserve (FFR) results of intermediate coronary lesions in patients with stable coronary artery disease undergoing coronary angiography.Materials and methods: We retrospectively analyzed 293 patients who underwent FFR measurement to determine the significance of intermediate coronary stenosis detected by conventional coronary angiography. Patients were divided into 2 groups: Group 1 (n = 127) included patients with FFR of 0.80 (hemodynamically nonsignificant lesions). Uric acid levels were assessed in both groups with the enzymatic colorimetric method by clinical chemistry autoanalyzer.Results: The …
Assessment Of The Visual Pathways In Patients With Neurofibromatosis-1 By 3s-Space Technique With 3-Tesla Mri, Özge Saraç, Oktay Algin, Mehmet Beyazal, Fatma Banu Anlar, Ali̇ Varan, Adi̇le Tülay Kansu
Assessment Of The Visual Pathways In Patients With Neurofibromatosis-1 By 3s-Space Technique With 3-Tesla Mri, Özge Saraç, Oktay Algin, Mehmet Beyazal, Fatma Banu Anlar, Ali̇ Varan, Adi̇le Tülay Kansu
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the size/tortuosity of the optic nerve (ON) and the dilatation of the ON sheath (ONS) in neurofibromatosis type 1 (NF-1) patients with 3T-MRI, and to assess the usefulness of 3D-SPACE in imaging the optic pathway, ON, and ONS in NF-1 patients. Materials and methods: Twenty consecutive NF-1 patients without optic pathway glioma (OPG) (Group 1), 16 consecutive NF-1 patients with OPG (Group 2), and 19 controls were included in this study. The thickness and tortuosity of the ON and the diameter of the ONS were measured on STIR and 3D-SPACE images. Results: The thickness of …
Clinical Results Of Intradiscal Hydrogel Administration (Gelstix) In Lumbar Degenerative Disc Disease, Ayşegül Ceylan, İbrahi̇m Aşik, Güngör Enver Özgenci̇l, Burak Erken
Clinical Results Of Intradiscal Hydrogel Administration (Gelstix) In Lumbar Degenerative Disc Disease, Ayşegül Ceylan, İbrahi̇m Aşik, Güngör Enver Özgenci̇l, Burak Erken
Turkish Journal of Medical Sciences
Background/aim: Degenerative disc disease (DDD) is one of the main causes of lower back pain. In this study, we evaluate the efficacy of percutaneous intradiscal GelStix administration in patients with discogenic pain due to lumbar DDD who were unresponsive to conservative methods.Materials and methods: A total of 29 patients were included in the study, which took place between 2013 and 2017. Sedation was performed in the prone position in the operating room, and a C-arm was located so as to provide a lateral view of the surgical field. A 22-G, 3.5-inch needle was inserted into the center of the disc …
Pipeline Flex Embolization Device (Ped Flex) For The Treatment Of Intracranial Aneurysms: Periprocedural Outcomes And First-Year Angiographic Results, Şükrü Oğuz, Ömer Naci̇ Tabakci, Ender Uysal, Eser Bulut, Hasan Di̇nç
Pipeline Flex Embolization Device (Ped Flex) For The Treatment Of Intracranial Aneurysms: Periprocedural Outcomes And First-Year Angiographic Results, Şükrü Oğuz, Ömer Naci̇ Tabakci, Ender Uysal, Eser Bulut, Hasan Di̇nç
Turkish Journal of Medical Sciences
Background/aim: The Pipeline Flex Embolization Device (PED Flex) is a new updated version of the PED classic that incorporates a new delivery system to allow facilitation of stent deployment, resheathing, and removal of the capture coil. This study evaluated the PED Flex in terms of the technical aspects of the procedure and first-year follow-up results. Materials and methods: This retrospective study involved prospectively collected data from May 2015 to August 2017. The primary endpoint was technical aspects of the procedure, and the secondary endpoint was first-year follow-up results. Results: Forty-nine patients with 59 target intracranial aneurysms were enrolled. Patients' mean …
Evaluation Of Medial Olivocochlear Efferent System And Hearing Loss In Patients With Primary Sjögren's Syndrome, Bülent Gündüz, Nuri̇ye Yildirim, Serdar Can Güven, Emre Orhan, Recep Karamert, Zafer Günendi̇
Evaluation Of Medial Olivocochlear Efferent System And Hearing Loss In Patients With Primary Sjögren's Syndrome, Bülent Gündüz, Nuri̇ye Yildirim, Serdar Can Güven, Emre Orhan, Recep Karamert, Zafer Günendi̇
Turkish Journal of Medical Sciences
Background/aim: Autoimmune diseases are a remarkable issue for researchers due to their adverse effects on the auditory system, but for primary Sjögren's syndrome (pSS) there is little research on the comprehensive audiological findings in literature. The main objective of this study was to investigate the medial olivocochlear efferent functions of subjects with pSS and to examine the audiological findings.Materials and methods: The study included 36 subjects with pSS and 36 healthy subjects. All the subjects underwent testing including pure tone, speech, and high frequency audiometry; tympanometry and acoustic reflexes; distortion product otoacoustic emissions (DPOAE); and suppression of DPOAE.Results: The hearing …
Initial Regional Evaluation Of The Cystic Fibrosis Newborn Screening Program: Data From The Mediterranean Coast Of Turkey, Abdurrahman Erdem Başaran, Ayşen Başaran, Di̇lara Fatma Kocacik, Özgül Alper, Deni̇z Acican, Ayşen Bi̇ngöl
Initial Regional Evaluation Of The Cystic Fibrosis Newborn Screening Program: Data From The Mediterranean Coast Of Turkey, Abdurrahman Erdem Başaran, Ayşen Başaran, Di̇lara Fatma Kocacik, Özgül Alper, Deni̇z Acican, Ayşen Bi̇ngöl
Turkish Journal of Medical Sciences
Background/ aim: Since January 2015, the Cystic Fibrosis Newborn Screening (CFNS) program has been implemented in Turkey. We aimed to evaluate the demographic, clinical, and laboratory data of cases referred from the CFNS program and to determine the most suitable cut-off value for immunoreactive trypsinogen (IRT)-1 and immunoreactive trypsinogen (IRT-2) that are used in the CFNS program in Turkey. Materials and methods: A total of 156 Turkish Caucasian subjects were determined as positive cases during 3 years, from January 2015 to January 2018, and were referred to the pediatric pulmonology clinics of Akdeniz University Hospital, Antalya, Turkey, for the national …
Neutrophil-To-Lymphocyte Ratio, Monocyte-To-Lymphocyte Ratio, And Platelet-To-Lymphocyte Ratio In Different Etiological Causes Of Thyrotoxicosis, Işilay Taşkaldiran, Tülay Omma, Çağatay Emi̇r Önder, Sevde Nur Firat, Gönül Koç, Mustafa Kemal Kiliç, Şeri̇fe Mehli̇ka Kuşkonmaz, Cavi̇t Çulha
Neutrophil-To-Lymphocyte Ratio, Monocyte-To-Lymphocyte Ratio, And Platelet-To-Lymphocyte Ratio In Different Etiological Causes Of Thyrotoxicosis, Işilay Taşkaldiran, Tülay Omma, Çağatay Emi̇r Önder, Sevde Nur Firat, Gönül Koç, Mustafa Kemal Kiliç, Şeri̇fe Mehli̇ka Kuşkonmaz, Cavi̇t Çulha
Turkish Journal of Medical Sciences
Background/aim: The most common causes of thyrotoxicosis include Graves' disease (GD), toxic multinodular goiter (TMNG), toxic adenoma (TA), and subacute granulomatous thyroiditis (SAT). In our study, we aimed to see whether neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) may be helpful in the differential diagnosis of these diseases.Materials and methods: We retrospectively analyzed the hospital records of the Endocrinology Clinic of our hospital between 2016 and 2019. We included data from 66 GD, 37 TA, and 35 SAT patients. We compared the data with those of 35 healthy subjects as controls.Results: NLR, MLR, …
The Effect Of Pregabalin On Tourniquet-Induced Ischemia-Reperfusion Injury:A Prospective Randomized Study, Ömer Karaca, Hüseyi̇n Ulaş Pinar, Ahmet Fevzi̇ Özgür, Sevsen Kulaksizoğlu, Rafi̇ Doğan
The Effect Of Pregabalin On Tourniquet-Induced Ischemia-Reperfusion Injury:A Prospective Randomized Study, Ömer Karaca, Hüseyi̇n Ulaş Pinar, Ahmet Fevzi̇ Özgür, Sevsen Kulaksizoğlu, Rafi̇ Doğan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the efficacy of pregabalin on ischemia-reperfusion injuries.Materials and methods: Fifty-four patients were randomly assigned into 2 groups. A 150-mg tablet of pregabalin was given the night before and then 1 h before the operation for patients in Group P (pregabalin group, n = 27). A placebo was given to patients in Group C (control group, n = 27) at the same times. After combined spinal-epidural anesthesia was performed, venous blood samples were taken before tourniquet inflation (t1), just before tourniquet deflation (t2), and 20 min after tourniquet deflation (t3) for the …
Does Transrectal Ultrasonography-Guided Biopsy Of The Prostate Lead To Possible Further Metastasis Via Circulating Tumor Cells?, Mustafa Kemal Ati̇lla, Bahatti̇n Avci, Lokman İrkilata, Mustafa Aydin, Alper Bi̇tki̇n, Mevlüt Keleş, İnci̇ Yücel, Mahmut Ulubay
Does Transrectal Ultrasonography-Guided Biopsy Of The Prostate Lead To Possible Further Metastasis Via Circulating Tumor Cells?, Mustafa Kemal Ati̇lla, Bahatti̇n Avci, Lokman İrkilata, Mustafa Aydin, Alper Bi̇tki̇n, Mevlüt Keleş, İnci̇ Yücel, Mahmut Ulubay
Turkish Journal of Medical Sciences
Background/aim: We evaluate whether transrectal ultrasonography (TRUS)-guided prostate biopsy might lead to spillage of tumor cells into peripheral blood as a result of disruption of the epithelial barrier and ultimately result in metastasis. Materials and methods: Eighty-eight patients underwent TRUS-guided prostate needle biopsy due to prostate-specific antigen (PSA) increase or abnormal digital rectal examination at the Samsun Research and Training Hospital (Samsun, Turkey) between April 2016 and September 2018. Approximately 10 mL of whole blood was collected from patients before, 1 week after, and 1 month after biopsy. Samples were analyzed for CD117 positivity and prostate-specific membrane antigen (PSMA) levels …
Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Neck Outcome Score, Şeyda Candeni̇z, Seyi̇t Çitaker, Batuhan Bakirarar
Cross-Cultural Adaptation, Reliability, And Validity Of The Turkish Version Of The Neck Outcome Score, Şeyda Candeni̇z, Seyi̇t Çitaker, Batuhan Bakirarar
Turkish Journal of Medical Sciences
Background/aim: This study aims to determine the validity and reliability of the Turkish version of the Neck OutcOme Score (NOOS).Materials and methods: Two hundred eight patients suffering from nonspecific neck pain participated in the study. Test-retest reliability and internal consistency were assessed using intraclass correlation coefficients (2, 1) and Cronbach's alpha, respectively. The dimensionality was investigated with the factor analysis. The construct validity was determined by testing whether the hypothesis of correlations between NOOS subscales, Short Form-36 subscales, and the Neck Disability Index were met using Spearman's rank correlation coefficient. Ceiling/floor effects and measurement error were tested as well.Results: The …
Is The Asymmetry Between The Vertebral Arteries Related To Cerebral Dominance?, Ahmet Vural, Esma Esi̇n Deri̇n Çi̇çek
Is The Asymmetry Between The Vertebral Arteries Related To Cerebral Dominance?, Ahmet Vural, Esma Esi̇n Deri̇n Çi̇çek
Turkish Journal of Medical Sciences
Background/aim: The two vertebral arteries (VAs) are usually unequal in size; the left one is generally larger than the right one. It was hypothesized that the asymmetry results from the need of the dominant cerebral hemisphere for more glucose and oxygen, i.e. more blood supply. In this study, we aimed to test this hypothesis in patients by evaluating their arterial diameter and hand preference, as it is the most common criterion to determine the dominance of the hemisphere. Materials and methods: The study was performed with 844 participants who consented to participate in the study. We identified the dominant cerebral …
The Turkish Version Of The Modified Falls Efficacy Scale: Reliability And Validity From The Viewpoint Of Balance, Ni̇lüfer Çeti̇şli̇ Korkmaz, Mehmet Duray, Esra Doğru Hüzmeli̇, Hande Şenol
The Turkish Version Of The Modified Falls Efficacy Scale: Reliability And Validity From The Viewpoint Of Balance, Ni̇lüfer Çeti̇şli̇ Korkmaz, Mehmet Duray, Esra Doğru Hüzmeli̇, Hande Şenol
Turkish Journal of Medical Sciences
Background/aim: The factors associated with fall-related self-efficacy should be addressed, especially in the elderly. The Modified Falls Efficacy Scale (MFES) is a simple instrument with good scaling properties and reliability. The aim of the present study was to determine the reliability and the validity of the Turkish version of the MFES from the viewpoint of balance.Materials and methods: In this study, 164 participants aged >65 years were included. The use of walking aids and assistive devices, history and frequency of falls in the previous year, living environment, and exercise habits were noted. Balance and risk of falling were assessed with …
Retrospective Evaluation Of Anesthetic Techniques In Pregnant Women With Renal Transplantation, Asuman Sargin, Semra Karaman, Şeyda Ceylan Ari, Ali̇ Akdemi̇r, İsmet Hortu
Retrospective Evaluation Of Anesthetic Techniques In Pregnant Women With Renal Transplantation, Asuman Sargin, Semra Karaman, Şeyda Ceylan Ari, Ali̇ Akdemi̇r, İsmet Hortu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to evaluate anesthesia management in cesarean operation of pregnant women who underwent renal transplantation and the effects on postoperative renal function, retrospectively.Materials and methods: After obtaining the approval of the ethics committee of our hospital, the records of pregnant women who underwent kidney transplantation and cesarean section between 2007 and 2017 were retrospectively analyzed. The patients' demographic data, concomitant disease history, the treatment received, and type of anesthesia were retrospectively evaluated and recorded in the follow-up form.Results: It was found that a total of 47 women who underwent renal transplantation had 47 live …
Rasch Analysis Of The Neck Bournemouth Questionnaire: Turkish Version, Validity, And Reliability Study, Yasemi̇n Özel Asliyüce, Derya Gökmen, Özlem Ülger
Rasch Analysis Of The Neck Bournemouth Questionnaire: Turkish Version, Validity, And Reliability Study, Yasemi̇n Özel Asliyüce, Derya Gökmen, Özlem Ülger
Turkish Journal of Medical Sciences
Background/aim: The multidimensional evaluation of patients with chronic neck pain is important for planning the treatment program. The aim of this study was to investigate the validity and reliability of the Turkish version of the Neck Bournemouth Questionnaire (NBQ).Materials and methods: The internal construct validity of the NBQ was examined by the fit of the data to the Rasch measurement model. External validity of the NBQ was evaluated by testing for expected associations of Rasch transformed NBQ score with the corresponding variables through the process of convergent validity. The reliability of the NBQ in terms of both internal consistency and …
Does Mammalian Target Of Rapamycin Or Sestrin 1 Protein Signaling Have A Role In Bone Fracture Healing?, Özhan Pazarci, Halef Okan Doğan, Seyran Kilinç, İsmet Yalkin Çamurcu
Does Mammalian Target Of Rapamycin Or Sestrin 1 Protein Signaling Have A Role In Bone Fracture Healing?, Özhan Pazarci, Halef Okan Doğan, Seyran Kilinç, İsmet Yalkin Çamurcu
Turkish Journal of Medical Sciences
Background/aim: Fracture healing is a complex physiological process that involves a well-orchestrated series of biological events. The mammalian target of rapamycin (mTOR) and sestrin 1 (SESN 1) play a central role in cell metabolism, proliferation, and survival. The aim of our study is to present serum mTOR and SESN 1 levels by comparing patients with or without bone fractures. It is also a guide for further research on the roles of these proteins in fracture healing. Materials and methods: A total of 34 patients (10 females, 24 males) with bone fractures and 32 controls (10 females, 22 males) participated in …
Ifn-Γ Stimulated Dental Follicle Mesenchymal Stem Cells Regulate Activated Lymphocyte Response In Rheumatoid Arthritis Patients In Vitro, Noushin Zibandeh, Deni̇z Genç, Güzi̇de Nevsun İnanç, Rafi̇ Haner Di̇reskeneli̇, Tunç Akkoç
Ifn-Γ Stimulated Dental Follicle Mesenchymal Stem Cells Regulate Activated Lymphocyte Response In Rheumatoid Arthritis Patients In Vitro, Noushin Zibandeh, Deni̇z Genç, Güzi̇de Nevsun İnanç, Rafi̇ Haner Di̇reskeneli̇, Tunç Akkoç
Turkish Journal of Medical Sciences
Background/aim: Multipotent mesenchymal stem cells (MSCs) have been investigated in autoimmune diseases such as rheumatoid arthritis (RA) due to their immunomodulatory and regenerative properties. In this study, their immunosuppressive effects on peripheral blood mononuclear cells (PBMC) of RA patients were studied.Materials and methods: Dental follicle stem cells (DFSCs) were isolated from follicle tissue in the orofacial region. Characterization and multipotency analyses were performed. Lymphocytes were isolated from peripheral venous blood of RA patients (n = 5) and healthy individuals (n = 5). DFSCs were preincubated with IFN-γ for 48 h. PBMCs of RA patients and healthy individuals were separately cultured …
The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model, İnayet Güntürk, Cevat Yazici, Sema Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Hanim Yay
The Effect Of N-Acetylcysteine On Inflammation And Oxidative Stress In Cisplatin-Induced Nephrotoxicity: A Rat Model, İnayet Güntürk, Cevat Yazici, Sema Kader Köse, Fatma Dağli, Bi̇lal Yücel, Arzu Hanim Yay
Turkish Journal of Medical Sciences
Background/Aim: Cisplatin is a highly effective chemotherapeutic agent used in the treatment of solid organ cancers. Besides its chemotherapeutic effectiveness, cisplatin administration is associated with numerous side effects. Of those, the most clinically significant and common effect is nephrotoxicity. Recent studies reported that oxidative stress and inflammation are probably the most important mechanisms that contribute to the nephrotoxicity. N-acetylcysteine (NAC) is an antioxidant and antiinflammatory agent. In the present study, the effects of NAC on cisplatin-induced nephrotoxicity were investigated. Materials and methods: Rats were divided into four groups each including eight rats: CONT, NAC-250, CP, and CP+NAC. Rats in experimental …
Urinary Phytate Concentration And Risk Of Fracture Determined By The Frax Index In A Group Of Postmenopausal Women, Angel Arturo Lopez Gonzalez, Felix Grases, Bartolome Mari, Matias Tomas-Salva, Adrian Rodriguez
Urinary Phytate Concentration And Risk Of Fracture Determined By The Frax Index In A Group Of Postmenopausal Women, Angel Arturo Lopez Gonzalez, Felix Grases, Bartolome Mari, Matias Tomas-Salva, Adrian Rodriguez
Turkish Journal of Medical Sciences
Background/aim: This study was designed to evaluate the relationship between urinary phytate concentration and risk of fracture at 10 years, determined by using the FRAX model, in women who had undergone menopause within 5 years of the time of enrollment. Materials and methods: Of the 212 postmenopausal women evaluated, 69 were excluded because they had urinary phytate concentrations between 0.51 and 0.99 mg/L. Of the remaining 143 women, 91 had low (≤0.50 mg/L) and 52 had high (≥1.0 mg/L) urinary phytate concentrations. The 10-year risk of fracture was calculated by using the FRAX model.Results: The risks of major osteoporotic fracture …
Long-Term Monitoring Of Graves' Disease In Children And Adolescents: A Single-Center Experience, Selma Tunç, Özge Köprülü, Hati̇ce Ortaç, Özlem Nalbantoğlu, Ceyhun Di̇zdarer, Korcan Demi̇r, Behzat Özkan
Long-Term Monitoring Of Graves' Disease In Children And Adolescents: A Single-Center Experience, Selma Tunç, Özge Köprülü, Hati̇ce Ortaç, Özlem Nalbantoğlu, Ceyhun Di̇zdarer, Korcan Demi̇r, Behzat Özkan
Turkish Journal of Medical Sciences
Background/aim: Graves' disease (GD) is more severe, requires a more complex treatment, and has a lower probability of achieving remission in children than in adults. There is no consensus on the appropriate duration of antithyroid drug (ATD) treatment. Surgical or radioactive iodine (RAI) treatments are not definitive and generally result in permanent hypothyroidism.This study's goal was examining the effectiveness of ATD treatment in children and adolescents withGD and determining the risk factors of remission and relapse.Materials and methods: This retrospective study included 45 patients (36 females and 9 males, median age 12.5 years) aged 4-18 who were diagnosed with GD …
Seroprevalence Of Hantavirus And Borreliaburgdorferi In Düzce (Turkey) Forest Villages And The Relationship With Sociodemographic Features, Ni̇da Akar, Emel Çalişkan, Ci̇hadi̇ye Eli̇f Öztürk, Handan Ankarali, Özge Kilinçel, Şükrü Öksüz, İdri̇s Şahi̇n
Seroprevalence Of Hantavirus And Borreliaburgdorferi In Düzce (Turkey) Forest Villages And The Relationship With Sociodemographic Features, Ni̇da Akar, Emel Çalişkan, Ci̇hadi̇ye Eli̇f Öztürk, Handan Ankarali, Özge Kilinçel, Şükrü Öksüz, İdri̇s Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: Hantavirus and Borrelia burgdorferi are two zoonotic agents that pose a great risk especially for people living in forest areas. This study aimed to investigate the seroprevalence of hantavirus and B. burgdorferi in forest villages of Düzce and its relationship with sociodemographic features.Materials and methods: The presence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against hantavirus and B. burgdorferi in serum samples was investigated via enzyme-linked immunosorbent assay (ELISA). Hantavirus IgG and B. burgdorferiIgM and IgG positivity was then validated by western blot (WB) method. Results: During the analyses,193 serum samples were tested. Eleven (6%) cases of …
Influence Of Lrp5 (Rs556442) Polymorphism On Insulin Resistance In Healthy Iranian Children And Adolescents, Nima Montazeri Najafabady, Mohammad Hossein Dabbaghmanesh, Rajeeh Mohamadian-Amiri, Marzieh Bakhshayeshkaram, Gholamhossein Ranjbar Omrani
Influence Of Lrp5 (Rs556442) Polymorphism On Insulin Resistance In Healthy Iranian Children And Adolescents, Nima Montazeri Najafabady, Mohammad Hossein Dabbaghmanesh, Rajeeh Mohamadian-Amiri, Marzieh Bakhshayeshkaram, Gholamhossein Ranjbar Omrani
Turkish Journal of Medical Sciences
Background/aim: Genetic aspects play a role in insulin resistance in children. In this study, for the first time, the association of LRP5 (rs556442) polymorphism and insulin resistance in Iranian children and adolescents was investigated.Materials and methods: The study population comprises children and adolescents aged 9-18 years. Anthropometric and biochemical parameters were assessed. Insulin resistance/sensitivity was determined by the quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment-insulin resistance (HOMA-IR), insulin-to-glucose ratio, McAuley index, revised McAuley index, fasting insulin resistance index (FIRI), and Bennett's index. LRP5 (rs566442) single nucleotide polymorphism (SNP) was identified using restriction fragment length polymorphism (RFLP). Linear regression …