Medicine and Health Sciences Commons^™

Understanding Qualitative 3d Shape From Texture And Shading, Benjamin Kunsberg, Steven W. Zucker

MODVIS Workshop

No abstract provided.

An Active Efficient Coding Model Of The Development Of Amblyopia, Samuel Eckmann, Lukas Klimmasch, Bertram Shi, Jochen Triesch

MODVIS Workshop

No abstract provided.

Use Of Excel Spreadsheet Calculators In Handling Data Generated From Uv- Spectrometer, Mercy Okezue, Kari Clase, Steve Byrn

BIRS Symposium

To ease the complexities of handling data generated from different analytical procedures, validated excel spreadsheet containing relevant formulas are developed to ensure the process of data handling will consistently produce the expected results. This paper introduces the use of Excel spreadsheets in handling data generated from using a UV-Spectrometer in determination of analyte concentration in various dosage forms

Instituting Process Control Mechanisms In A Quality Control Analytical Chemistry Laboratory, Mercy Okezue, Kari Lynn Clase, Stephen Byrn

BIRS Symposium

Statistical Process Control by means of using control charts was a means of monitoring performance of analytical equipment. Quality control checks on test items using these equipment generated data used for plotting X-bar charts. The charts generated had warning and control limits which helped monitor system performance

Approaches To Integrating Service Learning In The Public Health Administration Course, Sandra Liu, Ali Bianco

Engagement & Service-Learning Summit

No abstract provided.

Pharmacy Practice And Research: The Development Of A University Collaboration In Colombia, Ellen Schellhase

Engagement & Service-Learning Summit

No abstract provided.

Water Supply In Developing Countries, Jason K. Hawes, Ernest R. Blatchley Iii, Audrey Caprio, Andrew T. Kanach

Engagement & Service-Learning Summit

No abstract provided.

Safety And Service-Learning: Engaging Pharmacy Students To Make Safer Communities, Patricia Darbishire, Chelsea Anderson

Engagement & Service-Learning Summit

Poster Abstract

Objective:

To evaluate student perceptions of a service-learning experience for potential implementation in the curriculum.

Method:

A new 3-week intensive elective course was piloted in the Spring of 2017 at Purdue University College of Pharmacy. Seven third professional year students were included in the pilot and were divided into three groups. Each group of 2-3 students was assigned to one of 3 predetermined community partner sites. Students were taught how to perform a needs assessment and then designed a project targeted to improve safety at their site. Students completed a pre-post questionnaire that assessed their perceptions of the …

Implementation Of A Low-Cost Unna Boot Alternative As Adjunctive Treatment For Kaposi Sarcoma, Alexander Robert Mills, Edith Tonui, Sonak Pastakia, Rakhi Karwa, Phelix Were

Engagement & Service-Learning Summit

There are 6 million people living with HIV; 70% reside in Sub-Saharan Africa (SSA). Furthermore, 1.1 million deaths occur due to opportunistic infections (OIs) that can be minimized with antiretroviral therapy. In Kenya, Kaposi Sarcoma (KS) is an especially debilitating OI that presents with dermatologic lesions; magnifying the stigma that patients with HIV face physically and psychosocially. Dermatology research is underway to determine the effectiveness of an unna boot (medicated, layered compression dressing) to speed the healing of these lesions with anecdotal success. Commercially available unna boot products are too expensive and not readily available in SSA. Clinicians from Purdue …

Expansion Of Pharmacy Students’ Involvement In Global Health And International Clinical Rotations, Alice C. Chang, Monica L. Miller, Ellen M. Schellhase

Engagement & Service-Learning Summit

No abstract provided.

Making Music To Enhance Mental Health In Eldoret, Kenya, Michael Peters, Ethan Wahle, Ellen Schellhase

Engagement & Service-Learning Summit

After attending this session, participants will be appreciate the power of music and witness the level of engagement that street youth in a resource-limited country have as they unite behind a common goal. Street youth in Eldoret, Kenya are at a high risk of experiencing psychological conditions like Post-traumatic Stress Disorder with contributing factors including homelessness, an unstable family structure, and exposure to alcoholism and drug abuse in parent figures. Music therapy has shown benefits in children to alleviate and manage some of the symptoms of emotional disturbances. The goal was to create a sustainable music program in Eldoret, Kenya …

Rolling With A Purpose, Ramune K. Kubilius, Deborah Blecic, Greg Randall Watts, Susan B. Clark, Elizabeth Hinton, David Parker, Taney Shondel

Charleston Library Conference

Moderator Deborah Blecic convened this year’s hosted but no holds barred Lively Lunch session, providing a few general remarks and highlighting why this year’s three presentations were all relevant to this year’s conference theme. Time was left for lively discussion between speakers and session attendees.

Temporal Resolution Of Cell Death Signaling Events Induced By Cold Atmospheric Plasma And Electroporation In Human Cancer Cells, Danielle M. Krug, Prasoon K. Diwakar, Ahmed Hassanein

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cancer treatment resistance and their invasive and expensive nature is propelling research towards developing alternate approaches to eradicate cancer in patients. Non-thermal, i.e., cold atmospheric plasma (CAP) and electroporation (EP) applied to the surface of cancerous tissue are new methods that are minimally invasive, safe, and selective. These approaches, both independently and synergistically, have been shown to deplete cancer cell populations, but the signaling mechanisms of death and their timelines of action are still widely unknown. To better understand the timeframe of signaling events occurring upon treatment, human cancer cell lines were treated with CAP, EP, and combined CAP with …

Finding Human Proteins That Bind To A Lassa Virus Protein, Maria Alejandra Pardo Ruge, Veronica J. Heintz, Douglas J. Lacount

The Summer Undergraduate Research Fellowship (SURF) Symposium

Viral hemorrhagic fevers are severe illnesses caused by many different viruses. Lassa Virus is one of these important pathogens in Western Africa, causing hemorrhagic fever and eventually death without early medical treatment. There is no vaccine and there is little information on host-pathogen interactions. Therefore, the interaction between viral proteins and host targets is useful to understand Lassa virus’s lifecycle and pathology, and to develop ways to prevent infection. In this project, we study the nucleoprotein of Lassa virus (NP), which has been reported to have anti-interferon (IFN) activity through elimination of double stranded RNA (dsRNA). These features could be …

Determining The Structure Of Phospholipase C Epsilon, Hannah O'Neill, Monita Sieng, Elisabeth Garland-Kuntz, Angeline Lyon

The Summer Undergraduate Research Fellowship (SURF) Symposium

The phospholipase C (PLC) epsilon subfamily of PLC enzymes are found at highest concentration within the cardiovascular system. Improper functioning of the enzyme, whether due to overstimulation or changes in expression, has far-reaching effects within the human body Stunted heart valve development and cardiac hypertrophy and are two such examples. The mechanisms by which PLC epsilon activity is regulated in these processes remain unknown, as does the physical structure of the enzyme. In this study, we seek to determine the structure of a PLC epsilon fragment that retains enzymatic activity and is amenable to crystallization. Mutagenesis of PLC epsilon cDNA …

Fret Biosensors: Engineering Fluorescent Proteins As Biological Tools For Studying Parkinson’S Disease, Nathan J. Leroy, Jacob R. Norley, Saranya Radhakrishnan, Mathew Tantama

The Summer Undergraduate Research Fellowship (SURF) Symposium

Parkinson’s Disease (PD) is a common neurodegenerative disease with over 200,000 new cases each year. In general, the cause of the disease is unknown, but oxidative stress inside of neurons has been associated with the disease’s pathology for some time. Currently, techniques to study the onset of PD inside of neurons are limited. This makes treatments and causes difficult to discover. One solution to this has been fluorescent protein biosensors. In short, these proteins can be engineered to glow when a certain state is achieved inside a cell. The present research discusses the engineering of a genetically-encoded fluorescent protein (FP) …

Synthesis Of Hydroxybenzylidene-Indolinones, Schiff Bases And N-Substituted Analogs And Their Effects On Bacterial Physiology., Catherine Eliana Cabrera, Neetu Dayal, Moloud Aflaki, Herman Sintim

The Summer Undergraduate Research Fellowship (SURF) Symposium

c-di-AMP is a global stress response regulator involved in some processes of biofilm formation and antibiotic resistance. It has become a candidate target for the development of new antibacterial treatments. Previous studies have shown that hydroxybenzylidene-indolinones can act as c-di-AMP synthase inhibitors. They also act as antibacterial and anti-biofilm inhibitors and re-sensitize resistant bacteria to methicillin and vancomycin. In this project, potent analogs of these compounds, including Schiff bases and N-substituted compounds, have been synthetized. The objective of this work is to explore the effect of these modifications on their biological activity. Base-catalyzed condensation and acid-catalyzed reactions were performed in …

Development Of Self-Assembling Nanoparticles For Drug Delivery Applications, Young Chan Kim, Craig Sweet, Helen Margaret Flynn, David H. Thompson

The Summer Undergraduate Research Fellowship (SURF) Symposium

Bladder cancer is the ninth most common cancer in the world, and occurs in nearly four percent of all men. Although many cases are diagnosed as early stage cancer and the tumor can be removed by surgery, reoccurrence rates are high making treatment difficult and thus one of the most expensive cancers. To address this problem, drugs are injected intravesically after tumor removal to kill any residual cancer that may cause reoccurrence. While this was a significant improvement over surgery alone, high toxicity along with short residence times in the bladder limited its effectiveness. To combat these shortcomings, we will …

Effects Of Stroma On Er+ Breast Cancer Cell Metastasis, Shipeng Xu, Luis Solorio, Sarah Calve

The Summer Undergraduate Research Fellowship (SURF) Symposium

Breast cancer is one of the most wide-spread diseases among women in America. If the cancer is local, it is easily controlled by surgical resection. However, if the cancer cells metastasize, patient survival is significantly reduced. 70% of breast cancers can be targeted through estrogen receptors (ER) on the membrane, with compounds such as tamoxifen. However, tamoxifen shows unreliable outcomes on different patients and it is believed that the ineffectiveness of tamoxifen is related to the epithetical-mesenchymal transition (EMT) of cancer cells. To address this problem, we are designing a system that stimulates metastasis activation with the aim of incorporating …

Three-Dimensional Microfluidic Tumor Vascular Model For Investigating Breast Cancer Metastasis, Anastasiia Vasiukhina, Brian H. Jun, Luis Solorio, Pavlos P. Vlachos

The Summer Undergraduate Research Fellowship (SURF) Symposium

Metastasis is one of the primary reasons for the high mortality rates in female patients diagnosed with breast cancer. It involves the migration of cancer cells into the circulatory system allowing for the dissemination of cancer cells in distal tissues. Understanding the major processes that occur in cells and tissues during metastasis can help improve currently existing therapeutic methods. In order to understand such mechanisms, developing physiologically relevant tissue models is crucial. Advancements in microfluidics have led to the fabrication of 3D culture models with shear stress gradients and flow control that can recapitulate aspects of the tumor microenvironment in …

Computational Drug Design: A Multitargeted Approach In Bladder Cancer, Travis C. Lantz, Joydeb Majumder, Gaurav Chopra

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cancer is a complex, robust disease with multiple redundant disease pathways which lead to tumor development, growth, and eventually even death. Despite known redundancies, cancer therapeutics continue to be developed against a single protein target. Initial disease regression occurs followed by relapse in a drug resistant disease state. In response, combinational drug clinical trial targeting multiple pathways began, and have failed due to increased toxicity caused by adverse drug interactions. Development of a single drug that differentially targets multiple disease pathways will result in a more potent therapeutic while inducing minimal toxicity. This was done computationally through in-lab software packages, …

Computational Modeling Of Contrast Sensitivity And Orientation Tuning In Schizophrenia, Steven M. Silverstein, Docia L. Demmin, James A. Bednar

MODVIS Workshop

Computational modeling is being increasingly used to understand schizophrenia, but, to date, it has not been used to account for the common perceptual disturbances in the disorder. We manipulated schizophrenia-relevant parameters in the GCAL (gain control, adaptation, laterally connected) model (Stevens et al., 2013), run using the Topographica simulator (Bednar, 2012), to model low-level visual processing changes in the disorder. Our models incorporated: separate sheets for retinal, LGN, and V1 activity; gain control in the LGN; homeostatic adaptation in V1 based on a weighted sum of all inputs and limited by a logistic (sigmoid) nonlinearity; lateral excitation and inhibition in …

When You Come To A Fork In The Road, Take It (15th Annual Health Sciences Lively Lunch), Cunera M. Buys, Jean Gudenas, Ramune K. Kubilius, Elizabeth R. Lorbeer

Charleston Library Conference

In this year’s sponsored but no holds barred lunch, participants had the opportunity to contemplate examples of proactive approaches answering the question posed by the 2015 conference theme, “Where Do We Go From Here?” This year’s lunch theme was inspired by a saying of Lawrence Peter “Yogi” Berra (May 12, 1925–September 22, 2015): “When You Come to a Fork in the Road, Take It.” Researchers increasingly must meet various data management requirements and mandates, while educators are challenged by changing trends in providing curricular content. What choices do these challenges provide to libraries and librarians? In the best case scenarios, …

Training A New Librarian In The What, How, Where, And Why Of Health Sciences Collection Management, Susan K. Kendall, Mari Monosoff-Richards

Charleston Library Conference

Collection management for the health sciences, particularly clinical medicine, is an increasingly complex job which, anecdotally, is usually given to experienced librarians. Health sciences libraries tend to delegate collections responsibilities to one librarian who holds all of the institutional collections knowledge. Replacing these people as they retire or move on can be difficult unless new librarians become trained in collections work. At the Michigan State University Libraries, recent search committee experience revealed that an entrylevel health sciences collections position attracted fewer applicants than entry‐level health sciences positions for instruction, liaison, or educational technology. This may reflect the focus of library …

Development Of Standard Criteria To Evaluate The Effectiveness Of Helmets At Decreasing The Risk Of Concussions, Daniel Y. Shyu, Goutham N. Sankaran, Kevin G. Mciver, Nicolas Leiva, Eric A. Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

In many sports, such as American football, accumulations of mild traumatic brain injuries have been suggested as a possible link to neurodegeneration and future mental disorders. With head impacts occurring at all levels of competition and in different sports, it is critical to develop an accurate method for quantifying the effects of head impacts and determining the efficacy of helmets. This study examines the derivation of different dimensionless numbers and ascertains the critical factors needed to predict the effects of head impacts, specifically the resulting accelerations from an impact. Given a known force of impact, parameters such as peak translation …

Cartilage Engineering: Optimization Of Media For Chondrogenic Differentiation In Vitro, Evan Surma, Sherry L. Harbin, Hongji Zhang, Stacy Halum

The Summer Undergraduate Research Fellowship (SURF) Symposium

Lower back pain from intervertebral disc injury affects around 84% of the population at some point in their life, which at its worst may cause total immobilization. This pain can only be temporarily relieved by spinal fusion or intervertebral disc replacement; however, both of these cause loss of natural motion in patients by removing damaged fibrocartilage discs. While these techniques help mitigate pain briefly, no permanent solution exists currently to both relieve pain and preserve natural motion. My work may be a solution by eventually providing patient-specific implants that resemble native tissue in the regeneration process that could be absorbed …

Ball Pressure Correlations With Peak Impact Force And The Potential For Cumulative Mtbi When Heading A Soccer Ball, Nicolas Leiva, Daniel Y. Shyu, Josh Auger, Eric Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

Soccer is a unique sport in which athletes use their heads as tools for gameplay, which may ultimately cause cumulative traumatic brain injuries. Due to rising popularity of soccer in the United States alongside the increased occurrence of CTE and mTBI in other contact sports, there is a growing concern over how to keep the repetitive forces caused by heading, as low as possible. Different variables that can affect the peak force felt when heading a soccer ball can be simulated and compared with in-game data, however, this has never been properly tested before. In the present study two size …

Nanobubbles Provide Theranostic Relief To Cancer Hypoxia, Christopher M. Long, Pushpak N. Bhandari, Joseph Irudayaraj

The Summer Undergraduate Research Fellowship (SURF) Symposium

Hypoxia is a common motif among tumors, contributing to metastasis, angiogenesis, cellular epigenetic abnormality, and resistance to cancer therapy. Hypoxia also plays a pivotal role in oncological studies, where it can be used as a principal target for new anti-cancer therapeutic methods. Oxygen nanobubbles were designed in an effort to target the hypoxic tumor regions, thus interrupting the hypoxia-inducible factor-1α (HIF-1α) regulatory pathway and inhibiting tumor progression. At less than 100nm, oxygen nanobubbles act as a vehicle for site-specific oxygen delivery, while also serving as an ultrasound contrast agent for advanced imaging purposes. Through in vitro and in vivo studies, …

The Role Of Osteocyte Estrogen Receptor Beta (Erβ) In Regulating The Skeletal Response To Mechanical Loading, Julia P. Townsend, Russell P. Main

The Summer Undergraduate Research Fellowship (SURF) Symposium

Estrogen’s biological functions are mediated by estrogen binding to estrogen receptors (ER). Understanding what role both ERα and ERβ have in bone maintenance and formation can contribute to possible treatment of osteoporosis. This study examined osteocyte specific deletion of ERβ in mice. The cross of ERβ-floxed mice with DMP1-8kb-Cre mice provided both experimental knockout mice as well as littermate control mice. At 24 weeks of age the left tibiae of all mice were mechanically loaded five days per week for two weeks to induce bone formation. Analysis of cortical bone was conducted using microcomputed tomography (microCT) to measure load-induced changes …

Leveraging Smart Infusion Pump Data For Workflow, Patient Care And Usability Improvement In Human Factors, Yan Ni Ding, Denny Yu, Poching Delaurentis, Kang-Yu Hsu, Joon Hong Kim

The Summer Undergraduate Research Fellowship (SURF) Symposium

Infusion pumps are medical devices that deliver fluids like medication, and nutrients in a precise, timely, and controlled manner that is critical to patient care. It is widely used in clinical settings especially in hospitals, nursing homes and sometimes at home. Smart infusion pumps technology are supposed to be reduce nurses’ workload, but due to the recurring number of alarms which disrupt the workflow of the infusion process, most nurses prefer to use the traditional infusion pumps or work-around the safety features of the smart pumps. Thus, the aim of this research is to leverage Smart Infusion Pump data to …