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Articles 31 - 60 of 8630
Full-Text Articles in Medicine and Health Sciences
The Fortify Resilience Initiative, Maria Hernandez, Yvette Cantu
The Fortify Resilience Initiative, Maria Hernandez, Yvette Cantu
Research Symposium
The Fortify Resilience Initiative focuses on building and sustaining a culture of wellbeing for Residents and Fellows (R/Fs) at The University of Texas Rio Grande Valley (UTRGV) School of Medicine’s (SOM) Graduate Medical Education (GME) residency and fellowship programs. In order to address the multitude of threats to physician wellness and to mitigate the silent, but pernicious effects of burnout on these physician learners serving in the RGV, this Initiative from the Office of GME will strengthen existing wellbeing pathways while expanding additional solutions that will work to sustain wellbeing. Utilizing a combination of prevention, promotion, and intervention strategies targeted …
The Carcinogenic Effect Of Heavy Metals And Its Association With Epigenetic Changes In Urothelial Bladder Cancer Patients, Ganesh Kumar Verma, A. Sen, S. Saha, A. Mirza, A. Atif
The Carcinogenic Effect Of Heavy Metals And Its Association With Epigenetic Changes In Urothelial Bladder Cancer Patients, Ganesh Kumar Verma, A. Sen, S. Saha, A. Mirza, A. Atif
Research Symposium
Background: According to Global Cancer Observatory (GLOBOCON) 2020, urothelial bladder cancer (UBC) is the 17th most common malignancy in India, and bladder cancer represents a significant health problem due to the potential morbidity and mortality. UBC is commonly associated with industrialized regions and the most accountable risk factors have been tobacco smoke along with occupational chemical exposures including heavy metals. A massive increase in human exposure to heavy metals has been noticed due to industrial activities since last century and an emerging understanding of the carcinogenic effects of certain heavy metals is now being considered as causative agents for UBC. …
Smoking And Drinking Activate Nf-Κb /Il-6 Axis To Promote Inflammation During Cervical Carcinogenesis, Vivek Kumar Kashyap
Smoking And Drinking Activate Nf-Κb /Il-6 Axis To Promote Inflammation During Cervical Carcinogenesis, Vivek Kumar Kashyap
Research Symposium
Background: High-risk strains of HPV are known to cause cervical cancer. Multiple clinical studies have emphasized that smoking and drinking are critical risk factors for cervical cancer and its high-grade precursors. In this study, we investigated the molecular mechanisms involved in the interplay of smoking and/or drinking with HPV infectivity and defined a systematic therapeutic approach for their attenuation in cervical cancer.
Methods: The impact of benzo[a]pyrene (B[a]P) and/or ethanol (EtOH) exposure on cervical cancer cells was assessed by measuring changes in their biophysical, cell migration, and invasion characteristics. Expression of HPV16 E6/E7, NF-κB, cytokines, and inflammation mediators was …
Primary Care Behavioral Health Partnerships Advancing & Transforming Health Sciences (Pcbh Paths), Mayrin Perez, Maria Hernandez
Primary Care Behavioral Health Partnerships Advancing & Transforming Health Sciences (Pcbh Paths), Mayrin Perez, Maria Hernandez
Research Symposium
Primary Care Behavioral Health Partnerships Advancing & Transforming Health Sciences (PCBH PATHS) is a workforce development pipeline project aimed at permanently augmenting UTRGV’s institutional capacity to address shortage of an Integrated Behavioral Health (IBH) competent workforce locally, regionally and nationally. Our initiative, aligned with UTRGV strategic priorities and key initiatives, will integrate basic(model specific strategy and operational elements), mid-level (role identity and profession specific behavioral competencies specific to each health profession), and advanced (behavioral medicine clinical skills) applications of the evidence based PCBH model of delivery. A PCBH focused delivery system (clinical and educational), in which primary care providers (PCPs) …
P22 Viral Capsid Nanocomposites For Enzyme Prodrug Therapy Of Breast Cancer, Astrid Rebeca Luna Rios
P22 Viral Capsid Nanocomposites For Enzyme Prodrug Therapy Of Breast Cancer, Astrid Rebeca Luna Rios
Research Symposium
Background: Current treatment strategies against breast cancer have limitations due to lack in selectivity. Most drugs, such as tamoxifen, require metabolic activation by cytochrome P450 (CYP) enzymes to perform greater anticancer effects. However, the concentration of CYP varies and is low in tumor cells, resulting in side-effects. In enzyme prodrug therapy (EPT), enzymes are targeted to the tumor cells for prodrug transformation, involving the sequential delivery of the enzyme followed by prodrug. However, differences in pharmacokinetics and pharmacodynamics are a major hindrance. Thus, co-delivery of prodrug and enzyme is essential to ensure their favorable interaction at target site.
Results: This …
Novel Nanoformulation Of Sabizabulin (Veru-111) For Pancreatic Cancer Therapy, Vivek Kumar Kashyap
Novel Nanoformulation Of Sabizabulin (Veru-111) For Pancreatic Cancer Therapy, Vivek Kumar Kashyap
Research Symposium
Background: Pancreatic cancer (PanCa) is one of the leading causes of cancer-related mortality in the United States due to very limited therapeutic options. Thus, developing novel therapeutic strategies will help for the management of this disease. We recently identified VERU-111, a novel synthetic molecule which showed potent anti-cancer effect against PanCa via targeting clinically important βIII and βIV tubulin isoforms. In this study, we synthesized and characterized its novel nanoformulation (MNP-VERU) and evaluated its therapeutic effects in vitro and xenograft mouse model.
Methods: MNPs were prepared by chemical precipitation method and loaded with VERU-111 using diffusion method. This formulation was …
Muc13- A Novel Cancer Biomarker For Early Pancreatic Cancer Diagnosis And Imaging, Sheema Khan, Anupam Dhasmana
Muc13- A Novel Cancer Biomarker For Early Pancreatic Cancer Diagnosis And Imaging, Sheema Khan, Anupam Dhasmana
Research Symposium
Pancreatic adenocarcinoma (PDAC) has a very poor survival rate due to late diagnosis. Therefore, identification approaches that aid in early diagnosis are highly desirable. MUC13 is a recently identified high molecular weight glycoprotein that is aberrantly expressed in PDAC and allows its progression via alterations of multiple tumor signaling pathways. Overexpression of MUC13 in PDAC cells leads to enhanced tumorigenic and metastatic phenotypes. These characteristics of PDAC cells are mediated by physical interactions between MUC13 and HER2/Neu. This study elucidates significance of MUC13, as a diagnostic and imaging marker of PDAC. Additionally, a collaborative effort has commenced to investigate the …
Interdisciplinary Integrated Primary And Behavioral Healthcare (I2pbh) Initiative, John Ronnau, Deepu George, Maria Hernandez, Salvador Arellano Iii, Myrna Ruiz
Interdisciplinary Integrated Primary And Behavioral Healthcare (I2pbh) Initiative, John Ronnau, Deepu George, Maria Hernandez, Salvador Arellano Iii, Myrna Ruiz
Research Symposium
Purpose: The Interdisciplinary Integrated Primary and Behavioral Healthcare (I2PBH) Initiative will train University of Texas Rio Grande Valley (UTRGV) mental health graduates to deliver high quality, evidence-based Integrated Behavioral Health (IBH) services in the Rio Grande Valley (RGV) – a high-need, high-demand, medically underserved Hispanic region along the US-Mexico border. Specifically, the I2PBH initiative will train 24 UTRGV mental health graduates annually to deliver high-quality IBH clinical services through the evidence based Primary Care Behavioral Health (PCBH) model. With a training emphasis on basic/advanced theory and clinical skills in the PCBH model, students will serve as Behavioral Health Consultants (BHC) …
Integrative Transcriptomics Data Analysis Of Trpv1 In Hepatocellular Carcinoma, Vivek Kumar Kashyap, Bhuvnesh Sharma, Himanshu Narayan Singh, Deepak Verma, Deepak Parashar, Murali M. Yallapu, Subhash C. Chauhan
Integrative Transcriptomics Data Analysis Of Trpv1 In Hepatocellular Carcinoma, Vivek Kumar Kashyap, Bhuvnesh Sharma, Himanshu Narayan Singh, Deepak Verma, Deepak Parashar, Murali M. Yallapu, Subhash C. Chauhan
Research Symposium
Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective Ca2+ channel protein that is widely expressed and plays a significant role in cancer initiation and progression. However, the biological significance of TRPV1 in HCC has not been systematically and comprehensively investigated. Using deep data mining and transcriptomics analyses, in this study, we described the significance of TRPV1 expression and its association with HCC prognosis.
Methods: TRPV1 mRNA expression in HCC was examined using the Cancer Genome Atlas (TCGA), the Genotype Tissue Expression Atlas (GTEx), the Tumor Immune Estimation …
Icg-Loaded Mesoporous Nanohybrid (Nd-Doped Hydroxyapatite/Fe3o4) For Photonic/Magnetic Hyperthermia And Photodynamic Therapy, Prakhar Sengar, K. Chauhan, A. G. Rodríguez-Hernández, G. A. Hirata
Icg-Loaded Mesoporous Nanohybrid (Nd-Doped Hydroxyapatite/Fe3o4) For Photonic/Magnetic Hyperthermia And Photodynamic Therapy, Prakhar Sengar, K. Chauhan, A. G. Rodríguez-Hernández, G. A. Hirata
Research Symposium
Background: Multimodality nanoplatforms play a crucial role in advancing medical interventions by integrating multiple functionalities into a single system. However, issues like intricate production processes and biocompatibility persist. Herein, a facile synthesis of a biomaterial-based mesoporous nanocarrier, HAp:Nd+SPIONs@mSiO2, loaded with the near-infrared (NIR) emitting dye indocyanine green (ICG) is reported.
Methods: HAp:Nd nanoparticles were synthesized via combustion methods. Thereafter, commercial SPIONs and HAp:Nd were integrated within a mesoporous silica via a modified Stöber approach. HAp:Nd+SPIONs@mSiO2 nanoplatform was characterized for particle size, porosity, and luminescence using TEM, BET, and luminescence spectroscopy. The synthesized nanoplatform was further loaded with ICG dye and …
Integrated Cancer Research Core (Icrc) At The University Of Texas Rio Grande Valley, Iris Enriquez
Integrated Cancer Research Core (Icrc) At The University Of Texas Rio Grande Valley, Iris Enriquez
Research Symposium
Background: The University of Texas Rio Grande Valley-School of Medicine (UTRGV-SOM) has founded the South Texas Centre of Excellence in Cancer Research to address disproportionate cancer related health issues in the Valley. UTRGV-SOM intends to establish an Integrated Cancer Research Core (ICRC) Facility at the UTRGV campus to provide cutting-edge technologies to support cancer research investigators of the Rio Grande Valley.
Methods: The ICRC will house most recent technologies (Flow Cytometry, Image Stream Flow, Droplet Digital PCR, molecular imaging, microPET/CT imaging, etc) to support flow cytometric analyses in cell suspension and tissues, cell sorting, analysis of tumor immune components, microbiome …
Graphene Nanoparticles For Microrna Delivery, Eswara Naga Hanuma Kumar Ghali
Graphene Nanoparticles For Microrna Delivery, Eswara Naga Hanuma Kumar Ghali
Research Symposium
Background: Graphene (G) has been established as an exciting prospect for a broad range of applications owing to its remarkable properties. As the molecular structure of G itself is achiral thus introducing chirality in G by simple attachment of a functional group (a chiral ligand) on the G nanosheet may result in more diverse applications. The recent innovations of G chiral nanosystems have been extended to drug delivery. Herein, we have developed a novel and facile synthesis method for producing chiral G for its application in chirality-dependent microRNA delivery.
Methods: L-graphene and D-graphene were produced in a single step by …
Exploring The Role Of Mucin 13 In Hepatocellular Carcinoma, Shabnam Malik, Mohammed Sikander, Daniel Zubieta
Exploring The Role Of Mucin 13 In Hepatocellular Carcinoma, Shabnam Malik, Mohammed Sikander, Daniel Zubieta
Research Symposium
Background: Hepatocellular carcinoma (HCC) has a poor prognosis due to ineffective therapeutic modality and lack of early diagnostic marker. Accumulating studies have shown that elevated expression of mucin 13 as potential oncogene and predictive biomarker for various cancer. However, very little is known about its expression and function for development and progression of HCC.
Objective: To investigate mucin 13 expression in chemically induced hepatocellular carcinoma model.
Methodology: Diethyl nitrosamine (DEN) and 2-Acetylaminofluorene (2-AAF) induced method was employed for the development of hepatocellular carcinoma in Male Wistar rats. Serum and tissues were collected at regular intervals of time and routinely validated …
Evaluating Who, Cci, And Cfs Performance In Predicting Non-Small Cell Lung Cancer Survival In Finland: Insights Beyond Concord-3, Ville Paappanen
Evaluating Who, Cci, And Cfs Performance In Predicting Non-Small Cell Lung Cancer Survival In Finland: Insights Beyond Concord-3, Ville Paappanen
Research Symposium
Background: Set against the backdrop of the 2018 CONCORD-3 study, our research focuses on Finland's lung cancer survival rates. Despite similar tax-funded and public healthcare systems, these rates lag behind those of other Nordic countries, prompting an investigation into the underlying causes. This research aims to unravel these disparities, particularly in the context of Finland's success in other cancer domains, contributing to broader efforts to elevate lung cancer outcomes to the level of other Nordic cancer success stories.
Study objective: Our study focuses on evaluating clinical performance classification systems like WHO Score, Charlson Comorbidity Index (CCI), and Clinical Frailty Scale …
Embolic Protection During Radical Nephrectomy With Inferior Vena Cava Thrombectomy Using The Protrieve Sheath, Mia Rose Schmolze
Embolic Protection During Radical Nephrectomy With Inferior Vena Cava Thrombectomy Using The Protrieve Sheath, Mia Rose Schmolze
Research Symposium
Renal Cell Carcinoma (RCC) is complicated by inferior vena cava (IVC) involvement in 4-10% of cases with intraoperative tumor embolization associated with 60-75% mortality. Currently, there is no high-level evidence demonstrating which surgical techniques provide optimal outcomes. The Protrieve SheathTM (Inari Medical®) has been used in the vascular setting for complex deep vein thrombosis(DVT) and non-tumor IVC thrombectomy cases. We aim to describe its first use in the setting of RCC with IVC thrombectomy to help prevent intraoperative tumor embolization. The Protrieve SheathTM successfully provided potentially life-saving protection from clot embolization when performing radical nephrectomy with IVC thrombectomy.
Development Of Mirna Therapeutics Targeting Atp Citrate Lyase (Acly) For The Treatment Of Oral Cancer, Uzini Devi Daimary
Development Of Mirna Therapeutics Targeting Atp Citrate Lyase (Acly) For The Treatment Of Oral Cancer, Uzini Devi Daimary
Research Symposium
Background: The global incidence of oral cancer (OC) has seen a consistent rise, with India accounting for nearly one-third of reported cases. Thus, there is an urgent need to gain a comprehensive understanding of the underlying pathophysiology of OC and develop effective and novel therapeutic interventions for the prevention and treatment of this deadly disease. Lipogenesis, a primary metabolic alteration in cancer cells, is linked to ACLY, a key enzyme in lipid biogenesis making it a promising target for OC treatment. Aberrant expression of ACLY regulates vital signaling pathways in tumorigenesis, indicating its potential as a novel therapeutic strategy against …
Development Of Mirna Mimics Targeting Tumor Necrosis Factor-Α Induced Protein Eight (Tnfaip8/Tipe) In Oral Cancer, Aviral Kumar
Development Of Mirna Mimics Targeting Tumor Necrosis Factor-Α Induced Protein Eight (Tnfaip8/Tipe) In Oral Cancer, Aviral Kumar
Research Symposium
Background: The prevalence of oral cancer worldwide is on the rise, with India accounting for almost a third of all documented cases. Despite significant progress in therapeutic approaches, elevated mortality rates and recurrent disease incidences pose a considerable challenge to India’s emerging healthcare sector. Hence, there is an urgent need to comprehend the underlying pathophysiology of oral cancer and devise innovative and effective therapeutic interventions for both prevention and treatment of this lethal ailment. TNFAIP8 is an apoptosis regulator proven to have an important function in the proliferation, invasion, metastasis, and progression of various malignancies. Therefore, targeting TNFAIP8 protein might …
Cucurbitacin B: A Novel Agent For Inducing Tumor-Immune Response., Sahir S. Alvi, Emmanuel Anning, Mudassier Ahmad, Carlos Perez, Mehdi Chaib, Subhash C. Chuahan, Taha Merghoub, Bilal B. Hafeez
Cucurbitacin B: A Novel Agent For Inducing Tumor-Immune Response., Sahir S. Alvi, Emmanuel Anning, Mudassier Ahmad, Carlos Perez, Mehdi Chaib, Subhash C. Chuahan, Taha Merghoub, Bilal B. Hafeez
Research Symposium
Despite the emergence of immunotherapy as a potential breakthrough in cancer treatment, it showed only a marginal response in pancreatic and liver cancers. Thus, novel strategies are highly desirable to take full advantage of immunotherapy in the treatment of these cancers. One of the critical factors that influence the efficacy of immunotherapy is the increased infiltration of myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAM) into tumors that alter the immune landscape and serve as facilitators of tumor proliferation, metastatic growth, and immunotherapy resistance. Thus, we believe that selecting a potent molecule that has the ability to suppress the function …
Assessment Of Cytochrome P450 Isoforms In Colorectal Cancer And Utilization Of Phytochemicals For Their Modulation., Sudha Gahlawat
Assessment Of Cytochrome P450 Isoforms In Colorectal Cancer And Utilization Of Phytochemicals For Their Modulation., Sudha Gahlawat
Research Symposium
Cytochrome P450 (CYPs) belongs to Phase I enzymes and exists in multiple isoforms. CYPs are present in all tissues with the highest concentrations in the liver and small intestine. These are mainly involved in drug detoxification, cellular homeostasis, metabolism of endogenous & exogenous substrates and in the inactivation/ activation of several anticancer drugs. As these CYPs are selectively and differentially expressed in CRC, which could not only provide a mechanism for drug resistance, but also insights into future therapies that may use these enzymes as therapeutic targets. This study is designed to evaluate the differential expression of various CYPs isoforms …
Assessment Of Anti-Cancerous Properties Of Nyctanthes Arbor-Tristis Linn Natural Compounds, Qazi Mohammad Sajid Jamal, Varish Ahmad
Assessment Of Anti-Cancerous Properties Of Nyctanthes Arbor-Tristis Linn Natural Compounds, Qazi Mohammad Sajid Jamal, Varish Ahmad
Research Symposium
Purpose: Nyctanthes arbor-tristis Linn., the lovely and fragrant flowering tree, sometimes called night-blooming jasmine or parijat, is native to Southeast and South Asia. For ages, this has been utilized in traditional medicine. There are claims that its leaves and blossoms have anti-inflammatory, antimicrobial, and anti-diabetic qualities. Plants contain anti-cancer capabilities; however, this has not yet been investigated. Therefore, we propose to explore mechanistic interaction with different cancer targets and active chemicals of this plant through computational methods, which will be further subjected to in vitro/in vivo experimental validation to show its anti-cancerous potentialities.
Description: Nyctanthes arbor-tristis Linn. plant contains several …
A Translational Approach Towards More Cost-Effective Lung Cancer Treatments, Tuula Klaavuniemi, Subhash C. Chauhan, Ville Paappanen, Artturi Mäkinen, Tuomas Rauramaa, Juha Väyrynen, Arja Jukkola, Hanne Kuitunen, Outi Kuittinen
A Translational Approach Towards More Cost-Effective Lung Cancer Treatments, Tuula Klaavuniemi, Subhash C. Chauhan, Ville Paappanen, Artturi Mäkinen, Tuomas Rauramaa, Juha Väyrynen, Arja Jukkola, Hanne Kuitunen, Outi Kuittinen
Research Symposium
Lung cancer, globally the second most common cancer, causes 1.8 million deaths annually with 2 million new cases. It's also one of Finland's deadliest cancers. Chemotherapeutic agents, targeted drugs and radiation therapy have been the mainstay in oncologic treatment for lung cancer patients for decades. Checkpoint inhibitors (e.g. nivolumab, pembrolizumab, atezolizumab) have changed the landscape also in lung cancer. These drugs awake patients own immune system to attack cancer cells. These drugs are widely used in different cancers and they have efficacy also in lung cancer, but only in a minority of patients. Checkpoint inhibitors also induce autoimmune side effects. …
A Novel Exo-Glow Nano-System For Bioimaging, Nycol Cotto, Benilde Adriano, Neeraj Chauhan, Deepak S. Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
A Novel Exo-Glow Nano-System For Bioimaging, Nycol Cotto, Benilde Adriano, Neeraj Chauhan, Deepak S. Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Research Symposium
Background: Milk exosomes are widely used to improve the performance of various small macromolecules, oligonucleotides, and imaging agents for delivery and imaging applications. Indocyanine green (ICG) based Near-Infrared (NIR) fluorescent imaging is an attractive and safer technique used for number of clinical applications. However, ICG tend to have poor photostability, short half-life, non-specific proteins binding, and concentration-dependent aggregation. Therefore, there is an unmet clinical need to develop newer modalities to package and deliver ICG. Bovine milk exosomes are natural, biocompatible, safe, and feasible nanocarriers that facilitate the delivery of micro and macro molecules. Herein, we developed a novel exosomes based …
Lstm-Based Recurrent Neural Network Predicts Influenza-Like-Illness In Variable Climate Zones, Alfred Amendolara, Christopher Gowans, Joshua Barton, David Sant, Andrew Payne
Lstm-Based Recurrent Neural Network Predicts Influenza-Like-Illness In Variable Climate Zones, Alfred Amendolara, Christopher Gowans, Joshua Barton, David Sant, Andrew Payne
Annual Research Symposium
Purpose: Influenza virus is responsible for a recurrent, yearly epidemic in most temperate regions of the world. For the 2021-2022 season the CDC reports 5000 deaths and 100,000 hospitalizations, a significant number despite the confounding presence of SARS-CoV-2. The mechanisms behind seasonal variance in flu burden are not well understood. Based on a previously validated model, this study seeks to expand understanding of the impact of variable climate regions on seasonal flu trends. To that end, three climate regions have been selected. Each region represents a different ecological region and provides different weather patterns showing how the climate variables impact …
What Time Is It? It Is 8-And-A-1/2 Time. A Rare Case About Right Medial Pontine Stroke, Right Ino, Right Facial Colliculus Ischemic Stroke Consistent With Eight-And-A-Half Syndrome., Jessica Marcela Daza, Eunbee Cho, Celia Patricia Daza, Shakirat Ganiyu, Francisco Gomez
What Time Is It? It Is 8-And-A-1/2 Time. A Rare Case About Right Medial Pontine Stroke, Right Ino, Right Facial Colliculus Ischemic Stroke Consistent With Eight-And-A-Half Syndrome., Jessica Marcela Daza, Eunbee Cho, Celia Patricia Daza, Shakirat Ganiyu, Francisco Gomez
Research Symposium
Eight-and-a-half syndrome (EHS) is a rare neuro-ophthalmologic condition characterized by conjugated horizontal gaze palsy, internuclear ophthalmoplegia (INO), and ipsilateral fascicular seventh cranial nerve palsy. Clinical features are attributed to the involvement of the lower pontine, including the abducens nucleus, ipsilateral medial longitudinal fasciculus (MLF), and adjacent facial colliculus. Etiology includes vascular diseases such as pontine infarction or ischemia, demyelinating conditions at the level of the pons, and rarely space-occupying lesions.
Β-Cyclodextrin-Enzalutamide Self-Assembly Complexes For Prostate Cancer Therapy, Meghana Kolli, Rahul Tiwari, Subhash C. Chauhan, Yonghong Zhang, Neeraj Chauhan, Alba C. M, Murali Yallapu
Β-Cyclodextrin-Enzalutamide Self-Assembly Complexes For Prostate Cancer Therapy, Meghana Kolli, Rahul Tiwari, Subhash C. Chauhan, Yonghong Zhang, Neeraj Chauhan, Alba C. M, Murali Yallapu
Research Symposium
Background:Castrate circumstances brought on by therapy give rise to castrationresistant prostate cancer (CRPC), which thereafter develops androgen receptor (AR) resistance. AR inhibitors are frequently used to obstruct AR translocation in cells that overexpress AR and slow the progression of cancer by reducing the number of AR receptors that are accessible. In comparison to Bicalutamide, a first-generation AR inhibitor, the hydrophobic drug Enzalutamide has demonstrated higher effectiveness. We investigate Enzalutamide as a viable option for the formation of self-assembly complexes because AR downregulation is still the major treatment for CRPC.
Methods:Enz-loaded self-assembly complexes (enz-β-CD) formulation was developed using solvent …
Update On The Role Of Muc13 In Pancreatic Cancer: A Promising Early Detection Biomarker, Anupam Dhasmana, Swati Dhasmana, Sheema Khan, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan
Update On The Role Of Muc13 In Pancreatic Cancer: A Promising Early Detection Biomarker, Anupam Dhasmana, Swati Dhasmana, Sheema Khan, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan
Research Symposium
Background: With the rise in pancreatic cancer (PanCa) prevalence and mortality rate, by 2030 it will secure second position among leading causes of cancer-related deaths. Due to poor prognosis of PanCa only 11% of PanCa patients have a 5-year survival rate, resulting in an equal mortality rate and incidence rate. 85% of PanCa are Pancreatic ductal adenocarcinoma (PDAC). The main clinical challenge with PanCa is poor treatment outcomes due the late diagnosis. Currently, there are traditional biomarkers panels available for diagnosis, however, these biomarkers do not have optimal sensitivity and specificity for PanCa. Considering this alarming unmet clinic need, our …
Unveiling The Influence Of Transcription Factor Yb1 In Hepatocellular Carcinoma Cell Lines, Yamile Abuchard, Sophia Leslie, Dennis Kwabiah, Ricardo Pequeno Bracho, Ana Ayala Pazzi, Mohammad Hussain, Manish Tripathi
Unveiling The Influence Of Transcription Factor Yb1 In Hepatocellular Carcinoma Cell Lines, Yamile Abuchard, Sophia Leslie, Dennis Kwabiah, Ricardo Pequeno Bracho, Ana Ayala Pazzi, Mohammad Hussain, Manish Tripathi
Research Symposium
Background: In the Rio Grande Valley (RGV), Hispanics constitute the predominant ethnic group, accounting for over 94% of the population. Projections for 2023 indicate liver cancer to rank fifth in male and seventh in female mortality. Hepatocellular carcinoma (HCC) manifests as a significant concern within the Hispanic community, influenced by a spectrum of factors—biogenetic, social, and cultural—that intertwine with genetic predispositions and dietary practices. The incidence of HCC is intertwined with various illnesses like hepatitis, liver cirrhosis, drug-induced liver injury (DILI), adding to the burden of cancer. Over the years, HCC prevalence in the RGV has surged by over 35%. …
Unraveling Sorafenib Resistance In Hepatocellular Carcinoma: Exploring Key Facets, Dennis Kwabiah, Kyle Doxtater, Yamile Abuchard, Sophia Leslie, Ricardo Pequeno Bracho, Shaibir Hussain, Manish K. Tripathi
Unraveling Sorafenib Resistance In Hepatocellular Carcinoma: Exploring Key Facets, Dennis Kwabiah, Kyle Doxtater, Yamile Abuchard, Sophia Leslie, Ricardo Pequeno Bracho, Shaibir Hussain, Manish K. Tripathi
Research Symposium
Hepatocellular carcinoma (HCC) stands as the prevalent form of primary liver cancer worldwide, diagnosing over half a million new cases annually. Surgical interventions like hepatectomy and liver transplantation offer a potential cure for early-stage HCC. However, the prognosis for advanced stages remains grim due to drug resistance, particularly with high refractoriness rates. Sorafenib, a tyrosine kinase inhibitor, is an approved treatment for advanced HCC. Despite its use, the overall survival extension for these patients remains limited due to the drug's ineffectiveness, and the mechanism behind advanced HCC's resistance to sorafenib remains elusive. TCGA analysis of HCC patient cohorts reveals elevated …
Too Yellow: An Idiopathic Case Of Autoimmune Hemolytic Anemia, Shreel Patel, Kashif Ali, Donnel Dockery-Joseph, Eunbee Cho, Sriharsha Koneru, Taha Al Hassan, Aramide Tijani, Elimar Gonzalez Morales
Too Yellow: An Idiopathic Case Of Autoimmune Hemolytic Anemia, Shreel Patel, Kashif Ali, Donnel Dockery-Joseph, Eunbee Cho, Sriharsha Koneru, Taha Al Hassan, Aramide Tijani, Elimar Gonzalez Morales
Research Symposium
Background: Autoimmune hemolytic anemia is caused by autoantibodies that react with self red blood cells and cause them to be destroyed. Warm AIHA, due to antibodies that are active at body temperature, is the most common type of the AIHA. It is mostly caused by the underlying disease like infections, autoimmune disorders, lymphoproliferative disorders, immunodeficiency or physiologic state like pregnancy. Rarely it happens that there is no underlying cause. Therefore, here we present a case of idiopathic autoimmune hemolytic anemia without any underlying cause.
Case Discussion: A 77 year old lady with known history of the diabetes mellitus type 2, …
Trimeric Antp-Tbp Complexes With Tfiieβ And Exd Modulated The Transcriptional Activity Of Antp, Norma C. Hernández-Bautista, Claudia A. Altamirano-Torres, Ruben Montalvo Mendez, Gustavo Jiménez-Mejía, Diana Reséndez-Pérez
Trimeric Antp-Tbp Complexes With Tfiieβ And Exd Modulated The Transcriptional Activity Of Antp, Norma C. Hernández-Bautista, Claudia A. Altamirano-Torres, Ruben Montalvo Mendez, Gustavo Jiménez-Mejía, Diana Reséndez-Pérez
Research Symposium
Homeoproteins are transcription factors that bind to DNA through a highly conserved binding domain known as the homeodomain (HD), which recognizes short regions rich in A-T. This DNA binding triggers the modulation of multiple target genes responsible for identity in various structures along the A-P axis of D. melanogaster. However, the high similarity of homeodomains and their affinity for widely distributed sites in the genome poses the "Hox paradox," which seeks to explain how homeoproteins acquire functional specificity so precisely. Previous evidence shows that homeoproteins like Antennapedia (Antp) form dimers with cofactors and other transcription factors to modulate their …