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Full-Text Articles in Medicine and Health Sciences
Fluorescein Dye For Exploring Anti-Cancer Drug Dissolution Kinetics, Connor Davis, Tonglei Li, Wei Gao
Fluorescein Dye For Exploring Anti-Cancer Drug Dissolution Kinetics, Connor Davis, Tonglei Li, Wei Gao
The Summer Undergraduate Research Fellowship (SURF) Symposium
Nanocrystalline formulations of anti-tumor drugs have been shown to improve desirable characteristics as well as increase the efficacy of delivery. However, the improvements seen are not strong enough to eradicate tumors and there exists a need to better understand how the drug particles move about and release in the body. The use of fluorophores incorporated into substrates allows for highly sensitive and resolute imaging in the body without the need for radioisotopes. This research aims to utilize quenching characteristics of fluorescein in order to provide pharmacokinetic information to aid in the improvement of nanoparticulate delivery formulations. Nanocrystal formulations of paclitaxel …
Cellular Uptake Of Drug Nanocrystals, Alexandra R. Seybold, Tonglei Li, Yan Chen
Cellular Uptake Of Drug Nanocrystals, Alexandra R. Seybold, Tonglei Li, Yan Chen
The Summer Undergraduate Research Fellowship (SURF) Symposium
Systemic toxicity and poor solubility of existing chemotherapeutic drugs piqued an interest in the use of nanocrystals for chemotherapy. To increase cytotoxicity, surface coating of nanocrystals is of interest to enhance tumor targeting and reduce treatment toxicity. As such, we tested in this project various coated paclitaxel nanocrystals on cancer cells for determining the efficacy of surface coating. An IC50 assay was chosen to determine the cytotoxicity of surface-coated paclitaxel nanocrystals; the lower the IC50 value, the higher the efficacy of the drug. Using the Sulforhodamine B method, paclitaxel, paclitaxel nanocrystals, and polymer coated paclitaxel nanocrystals were tested …