Medicine and Health Sciences Commons^™

Characterization Of Biological Particles Using An Integrated Hyperspectral Imaging And Machine Learning, Kaeul Lim, Arezoo Ardekani

Graduate Industrial Research Symposium

Hyperspectral imaging (HSI) is a promising modality in medicine with many potential applications. This study focuses on developing a label-free lipid nanoparticle characterization method using a convolutional neural network (CNN) analysis of HSI images. The HSI data, hypercube, consists of a series of images acquired at different wavelengths for the same field of view, providing continuous spectra information for each pixel. Three distinct liposome samples were collected for analysis. Advanced image preprocessing and classification methods for HSI data were developed to differentiate liposomes based on their material compositions. Our machine learning-based classification method was able to distinguish different liposome types …

Measurement And Imaging Of Intra Matrix Igg Diffusion, Riya Debbarma, Antonio C. F. Dos Santos, Diana Milena Ramiez Gutierrez, Fernanda M. Da Cunha, Michael Ladisch

Graduate Industrial Research Symposium

Bovine IgG diffusion measurement by tracking the movement of the protein over time in an in-vitro matrix is motivated by the large number of protein/peptide therapeutics currently under various stages of development in the pharmaceutical industry. Many of these therapeutics are monoclonal antibodies (IgG type proteins) that are candidates for subcutaneous, intra-vitreous and intra-articular administration depending on the target of the therapeutic. Hyaluronic acid (HA) is a major constituent and determines the key attributes of the subcutaneous environment, vitreous humor of the eye and synovial fluid of the knee joint. HA exhibits varying molecular weight at these anatomic locations thereby …

Sepsis Treatment: Reinforced Sequential Decision-Making For Saving Lives, Dipesh Tamboli, Jiayu Chen, Kiran Pranesh Jotheeswaran, Denny Yu, Vaneet Aggarwal

Graduate Industrial Research Symposium

Sepsis, a life-threatening condition triggered by the body's exaggerated response to infection, demands urgent intervention to prevent severe complications. Existing machine learning methods for managing sepsis struggle in offline scenarios, exhibiting suboptimal performance with survival rates below 50%. Our project introduces the "PosNegDM: Reinforcement Learning with Positive and Negative Demonstrations for Sequential Decision-Making" framework utilizing an innovative transformer-based model and a feedback reinforcer to replicate expert actions while considering individual patient characteristics. A mortality classifier with 96.7% accuracy guides treatment decisions towards positive outcomes. The PosNegDM framework significantly improves patient survival, saving 97.39% of patients and outperforming established machine learning …

Comprehensive Analysis Of The Retinal Cell Contributions To The Human Erg, Christopher W. Tyler

MODVIS Workshop

Purpose. Standard electroretinogram (ERG) protocols are largely designed to isolate the responses of the rod and cone retinal pathways, including the use of adapting backgrounds to suppress unwanted off-pathway responses. Here, we record spectral ERGs in the low-to-high mesopic sensitivity range in the absence of any adapting background in order to assess interactions between the pathways.

Methods. We have developed a comprehensive neuroanalytic model of the component structure of the ERG driven by knowledge of the underlying retinal physiology, to enhance its power as a critical diagnostic tool for a broad range of both retinal and systemic dysfunctions. The ERG …

A Note From The Co-Editors, Jada C. Johnson

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

An introduction to the second issue of the third volume of Ideas Magazine, concerning the research and work of M. Adam Howard.

A Note From The Co-Editors, Jada C. Johnson

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

An introduction to the third issue of the third volume of Ideas Magazine, concerning the work and experience of Stone Soup Shakespeare.

A Note From The Co-Editors, Jada C. Johnson

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

An introduction to the fifth issue of the third volume of Ideas Magazine, concerning the thoughts, experience, and work of Dr. Marcelo J.S. de Lemos.

Covid-19 Vaccinations In Brazil, Anastasia Pinopoulos

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

In December 2019, the world watched the city of Wuhan, China enter a lockdown due to an outbreak of COVID-19. This outbreak turned into a pandemic that has transformed all of our lives in various ways. One country that was gaining worldwide attention for how they handled the pandemic was Brazil. Dr. Marcelo J.S. de Lemos, got to experience and live through Brazil’s response. As a society, we can evaluate what Brazil did, both good and bad, to learn how to better prepare for a future pandemic. Vaccines were vital for the prevention of any outbreak and unnecessary deaths.

Covid-19 Pandemic Response In Brazil, Maria P. Ruiz

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

In 2020, the world got struck by a pandemic no one was ready for. Due to the lack of preparation, the world was forced to go into quarantine while scientists tried to create a vaccine. Every country took the actions they thought would be best, however not all of them saw positive outcomes from those decisions. In this paper Brazil’s decision on how to tackle the pandemic is analyzed, specifically how they tried to go for herd immunity, and their outcomes will be compared to the outcomes of the United States, who followed mask and quarantine mandates from specialists.

Covid-19 Pandemic Increases Accessibility To Theatre Performances, Katelyn M. Biggs

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

The pandemic has caused many industries to alter their functionality to stay afloat, specifically the theater. Changes made because of the pandemic have opened the doors for a new audience. This included the theater becoming more accessible financially and for people with disabilities. This article highlights how when transitioning back to a post-pandemic world, these new patrons should be kept in mind.

Lean Six Sigma As An Enabler For Healthcare Operational Excellence In Covid-19, Olivia Mcdermott Dr, Antony Jiju

International Conference on Lean Six Sigma

1. Purpose -This paper aims to present the results of a qualitative research interview study on the utilization and importance of Lean Six Sigma methods in the Healthcare sector in COVID-19 and in pandemics in general.
2. Design/methodology/approach -a qualitative interview approach was utilised by interviewing leading Lean Six Sigma academics and practitioners who are expert in and have experience in Lean Six Sigma.
3. Findings – Lean Six Sigma methods are proven and can be utilised in pandemic situations to improve efficiency and resilience in the healthcare system and readiness for pandemics.
4. Research limitations/implications - One limitation of this research was that …

Application Of Lean Six Sigma To Reduce The Cost Of Regulatory Noncompliance., Reham Nour, Chad Laux

International Conference on Lean Six Sigma

1. Purpose

This research focused on the adoption of Six Sigma within FDA-regulated pharmaceutical companies to create an effective CAPA system for reducing the cost of noncompliance and supporting organizational performance.

2. Design/Methodology/Approach

This study utilized the DMAIC methodology, in a case study, to improve the CAPA process within a medical device company regulated by the FDA. All the critical requirements for compliance CAPA system was being defined from the FDA sources and the DMAIC model was be applied to improve and maintain CAPA performance.

3. Findings

Using the DMAIC approach supported identifying the bottlenecks and process variation. within CAPA. …

A Note From The Editor, Kristina Bross

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

This letter introduces issue five of volume one, Ideas magazine, featuring the work of Dr. Lindsay Bottoms, fencer and sports physiologist.

A Note From The Editor, Daphne Fauber

Ideas: Exhibit Catalog for the Honors College Visiting Scholars Series

This piece is a letter from Daphne Fauber, the editor of this issue of Ideas. In the letter, the editor introduces the work of Dr. Paschalis Gkoupidenis as well as the moment in time in which his Visiting Scholars talk occurs.

Get It From The Source: Identifying Library Resources And Software Used In Faculty Research, Karen S. Alcorn, Erin E. Wentz, Gregory A. Martin, Shanti C. Freundlich, Joanne A. Doucette

Charleston Library Conference

Libraries and Information Technology departments aim to support the educational and research needs of students, researchers, and faculty members. Close matches between the resources those departments provide and the resources the institution’s community members actually use highlight the value of the departments, demonstrate fiscally responsibility, and show attentiveness to the community’s needs. Traditionally, libraries rely on usage statistics to guide collection development decisions, but usage statistics can only imply value. Identifying a resource by name in a publication demonstrates the value of that resource more clearly. This pilot project examined the full-text of articles published in 2016-2017 by faculty members …

Towards Human Retinal Cones Spatial Distribution Modeling, Matteo Paolo Lanaro, Hélène Perrier, David Coeurjolly, Victor Ostromoukhov, Alessandro Rizzi

MODVIS Workshop

No abstract provided.

Modeling Visual Enumeration Using Cumulative Link Regression., Anthony D. Cate Ph.D.

MODVIS Workshop

Based on three core assumptions about mental representations of number, this model of visual enumeration specifies analysis methods that can identify when observers rely on different processes to estimate the numerosity of a visual display. Specifically, the model provides a clear criterion for identifying domains of numerosity that correspond to different perceptual or cognitive processes that have been described in numeracy literature, e.g. subitizing. The model predicts how the requirement to give integer responses in enumeration tasks can produce spurious discontinuities in accuracy measures that can be misidentified as evidence for a subitizing process. It is proposed that cumulative link …

(Poster) Design And Fabrication Of A Custom Wrist Orthosis For Enhanced Patient Comfort, Marko Tasic, Matthew Hansen, Mang Lian, Demetre Mitchell, Rashedul Sarker, Renny Fernandez, Erin Peterson, Joseph Herzog, David Olawale, Najmus Saqib

ASEE IL-IN Section Conference

This custom wrist orthosis project is the continuation of efforts made by students in the R.B Annis School of Engineering during the 2017-2018 academic year. Throughout this project, we have implemented the Design for Six Sigma (DFSS) methodology to guide the design process. Within the R.B. Annis School of Engineering, this methodology has been adapted into guide the DesignSpine process. We have designed a new orthosis that is custom fabricated for enhanced patient comfort. In the occupational therapy field, patients have reportedly not been wearing their prescribed orthoses/braces, which are designed to stabilize injured areas so that they heal properly. …

Improving Access To Clean Water Through Service Learning, Rachel E. Gehr, Tolu Odimayomi, Carolina Tornesi Mackinnon

Engagement & Service-Learning Summit

No abstract provided.

A Comparison Of Student Pharmacist Clinical Interventions During An Internal Medicine Advanced Pharmacy Practice Experience (Appe) In A High-Income Versus Low-Income Setting, Ellen Schellhase, Monica Miller, Shelby Wilkinson, Rakhi Karwa

Engagement & Service-Learning Summit

Objectives: Compare and contrast the number and type of interventions made by student pharmacists who participated in an adult internal medicine APPE in the US to an internal medicine APPE in Kenya.

Methods: A US-based faculty-led, four-week internal medicine APPE with interprofessional team rounding that provides care for underserved patients in an urban setting and hosts 16 students annually was compared to a faculty-led, eight-week internal medicine APPE in Kenya that hosts on average 24 students annually. Starting May 2017 – January 2018 a standard clinical intervention collection form was used by all students on these two APPEs starting …

Assessment Of Intercultural Learning Within An Interdisciplinary Empathy Course Within An Honors College, Ellen Schellhase, Monica Miller

Engagement & Service-Learning Summit

Objective: The objective was to assess the intercultural learning of students enrolled in an interdisciplinary, active learning course with a focus on empathy and healthcare within an Honors College.

Methods:

This 2-credit course met twice weekly for active-learning session for 16 weeks. Topics covered included cultural dimensions, mindfulness, learning styles and four intercultural core competencies. Assignments included an intercultural development plan, on-line discussion board reflections for three required service-learning activities and completion of a Cultural Competence Badge. Students assessed their empathy using several different scales and completed the Intercultural Development Inventory (IDI) assessment at the beginning and end of the …

Construction And Nursing Students, Building A Playground For Bauer Family Services, Daphene Koch, Mary Erin Hoying, Deborah A. Spoerner, Rebecca C. Johnson, Abby Berg

Engagement & Service-Learning Summit

Poster Session

Reimagining Print Materials In A Health Science Context: Creating And Marketing A Wellness Collection, Margaret Ansell, Ariel Pomputius

Charleston Library Conference

In the healthcare field in which out-of-date information can harm patients, the currency and immediacy of digital collections is highly valued. As a result, many health science libraries have deselected much of their print collections (Haapanen, Kultamaa, Ovaska, & Salmi, 2015; Lingle & Robinson, 2009; Tobia & Hunnicutt, 2008; Xiaoli & Kopper, 2005). However, print materials continue to be valued by health science library users for a variety of purposes (Houghton, 2017; Watson, 2016). This paper describes how one academic health science center library found a role for print materials in the context of a wellness initiative, which (1) gave …

Where Are We? Providing Information For The Clinical Enterprise (17th Health Sciences Lively Lunch), Ramune K. Kubilius, Jean Gudenas, Laura Schimming, Jonathan Shank, Vida Vaughn, Neal Nixon

Charleston Library Conference

If the past is prologue to the future, where are we today? Though they are diverse, most academic health sciences libraries have historically described and continue to outline their missions as being directed to serving the education, research, and clinical information needs of their user populations. Over the years, Charleston Conference Health Sciences Lively Lunches have covered many themes, and in 2012, the focus was on the point of care information tools landscape. The 2017 17th Health Sciences Lively Lunch focused on issues and challenges of providing clinicians and clinical affiliates with access not only to point of care tools, …

Mass Spectrometry Image Creator (Msic): Ion Mobility / Mass Spectrometry Imaging Workflow In Python, Stephen Creger, Julia Laskin, Daniela Mesa Sanchez

The Summer Undergraduate Research Fellowship (SURF) Symposium

Mass spectrometry (MS) is a powerful characterization technique that enables identification of compounds in complex mixtures. Acquiring mass spectra in a spatially-resolved manner (i.e. over a grid), allows the data to be used to generate images that show the spatial distribution and relative intensities of every compound in a sample. These images can be used to monitor and identify biomarkers, explore the metabolism of compounds within tissues, and much more. However, the limitations of mass spectrometry can result in ambiguous compound identifications. Another characterization tool, ion mobility spectrometry (IM) can be integrated into existing MS routines to address this problem; …

Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala

The Summer Undergraduate Research Fellowship (SURF) Symposium

The common yeast infection, vulvovaginal candidiasis, affects three out of four women throughout their lifetime and can be spread to their child in the form of oral candidiasis (thrush). This disease is caused by the fungal pathogen Candida albicans, which is also a major cause of systemic candidiasis, a rarer but deadly disease with up to a 49% lethality rate. Current widely-used diagnostic methods include cell cultures, pH tests, and antibody detection, to assist effective treatment. Despite availability of various diagnostic methods, there is no inexpensive, rapid, and accurate way to detect C. albicans infection. This project aims to …

Polyrotaxane Variants And Their Effects On The Cholesterol Efflux In Patients Suffering From Niemann Pick Type C, Sydney Smith, Zach Struzik, David Thompson

The Summer Undergraduate Research Fellowship (SURF) Symposium

Niemann Pick type C disease (NPC) is a rare lysosomal storage disorder characterized by a progressive accumulation of cholesterol in the late endosomal/lysosomes compartment leading to cellular dysfunction and organ failure. Symptoms include ataxia, dysarthria, cognitive dysfunction, and seizures. Although average life expectancy is below 20, there are no FDA approved treatment available making it a serious unmet medical need. Clinical trials with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) has shown promise in cholesterol normalization within NPC cells. However, HP-beta-CD treatment has been shown to cause ototoxicity in NPC patients at high dosages. Supramolecular complexes known as polyrotaxanes have been synthesized in hopes of …

Targeting Pro-Inflammatory Function Of Microglia Using Small Molecules To Combat Neurodegeneration, Gabrielle C. Williams, Priya Prakash, Gaurav Chopra

The Summer Undergraduate Research Fellowship (SURF) Symposium

Microglia are the brain’s resident immune cells that are responsible for maintaining homeostasis in healthy conditions. During injury or infection, resting microglia get activated and produce pro-inflammatory cytokines such as IL-1b, IL-1a, IL-6, etc. along with reactive oxygen species like nitric oxide (NO) to combat neuroinflammatory diseases such as Alzheimer’s disease (AD). Inflammation is characterized by the activation of resident-immune cells in the brain called microglia that respond to the eat-me signals released by the toxic amyloid beta peptides as well as the dying neurons in the microenvironment. Recent studies have shown that activated microglia induce neuronal death by secreting …

Tissue Clearing As A Mechanism To Identify Changes In Fibronectin Structure During Breast Cancer Metastasis, Maryam Nuru, Kelsey Hopkins, Luis Solorio

The Summer Undergraduate Research Fellowship (SURF) Symposium

With metastasis accounting for approximately 90% of breast cancer deaths and an alarming number of over 300,000 new breast cancer cases to be diagnosed by the end of 2018, there is growing need to understand the process of breast cancer. Changes in the extracellular matrix (ECM) of the tumor microenvironment play an essential role in this deadly tumor progression. Specifically, the glycoprotein fibronectin (FN), has been identified to be up-regulated in patients with worse clinical outcomes. During tumor progression fibronectin undergoes conformational changes that aid in metastatic dissemination. In order to analyze the dynamic changes in FN expression and evaluate …

Targeting Neuropeptides To Bone Fractures For Accelerated Healing, Nicholas A. Young, Jeffery J. Nielsen, Philip S. Low

The Summer Undergraduate Research Fellowship (SURF) Symposium

In patients over the age of 65 especially, bone fractures represent a significant disease burden. Non-invasive drug therapies are not available for bone fractures which represents a problem for this population. Vasoactive intestinal peptide (VIP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), two neuromodulator peptides in the glucagon superfamily, have demonstrated positive regulation of osteoblast proliferation and activity. Using acidic oligopeptides, we have developed ligands that target to and accumulate at fracture sites. These targeting ligands can be synthesized in sequence with bone anabolic peptides to minimize off target effects and increase potency at the fracture site to create safer and …