Medicine and Health Sciences Commons^™

What Are The Top 10 Global Research Priorities For Perianal Crohn's Disease? The Global Perianal Crohn's Disease Priority Setting Partnership, Theo Pelly, Parakkal Deepak, Et Al.

2020-Current year OA Pubs

BACKGROUND AND AIMS: Perianal Crohn's disease (pCD) is a debilitating condition with a prevalence of approximately 20% in patients within 10 years of diagnosis of CD. The condition significantly impacts patient quality of life, and there remain a number of unmet needs relating to its optimal management. A global Priority Setting Partnership (PSP) was established to identify the top 10 research priorities for pCD.

METHODS: The PSP followed standard James Lind Alliance (JLA) methodology. An initial survey was circulated to gather unanswered research questions from key stakeholders. From these responses, a longlist of summary questions was formed. These questions were …

Clingen Api Platform For Classification Of Human Genetic Variants, Neethu Shah, Tierra Farris, Arturo Alejandro Zuniga, Andrew R Jackson, Jessie Arce, Kevin Riehle, Christine G Preston, Mark E Mandell, Bryan Wulf, Gloria Cheung, Keyang Yu, Deborah I Ritter, Dubravka Jevtic, Miroslav Milinkov, Novak Martinovic, Nevena Vucinic, Aleksandar Mihajlovic, Alan F Rubin, Melissa S Cline, Marina Distefano, Malachi Griffith, Obi L Griffith, Matt W Wright, Teri E Klein, Sharon E Plon, Aleksandar Milosavljevic

Faculty, Staff and Students Publications

In this commentary, we describe how the Clinical Genome Resource's (ClinGen's) application programming interface-based microservices accelerate growth and dissemination of knowledge about human genetic variation. By exposing findable, accessible, interoperable, reusable, and AI-ready variant data, ClinGen lays a foundation for next-generation software applications, AI systems, and variant classification workflows.

Overlapping Mhc Class I/Ii Epitopes Program Cdc1-Like Differentiation Of Monocyte-Derived Dendritic Cells Via Mtorc1 Signaling Inhibition, S B Amanya, A Murthy, N Bisht, Z N Bullock, K J Ernste, J Vasquez-Perez, W Liu, A Trivedi, D Oyewole-Said, A Paul, L Umokoro, V Akhanov, M Samuel, Z Shi, M H Nguyen, S Huang, M Jeong, P Iakova, K A Jain, K Pham, D C Kraushaar, V Konduri, W K Decker

Faculty, Staff and Students Publications

Viral infection polarizes monocyte-derived dendritic cells (moDC) to initiate type 1 immunity. The availability of overlapping (homologous) MHC class I and II epitopes, an occurrence frequently and primarily associated with intracellular infection, significantly enhances this process; however, the underlying mechanism(s) are unclear. We demonstrate that moDC loaded with homologous MHC epitopes acquire a cDC1-like phenotype in a process governed by mTORC1. mTORC1 pathway inhibition leads to NF-κB-mediated expression of IL-12 and other type I immune polarizing genes. The observed cDC1-like gene signature was also significantly enhanced in clinical moDC vaccine products made through methodologies that enforced class I and II …

Bridging The Gap: At For Those With Physical Or Intellectual Disability, Rebekah Nesbitt

The 2026 Assistive Technology for Persons with Intellectual and Physical Disabilities Conference

No abstract provided.

Challenges And Opportunities To Access Assistive Technology In The Americas Region, Yasmin Garcia Mendez

The 2026 Assistive Technology for Persons with Intellectual and Physical Disabilities Conference

No abstract provided.

2026 Abstract Book (Pdf), School Of Public Health

School of Public Health Delta Omega Honors Day Poster Sessions

The collection of abstracts for the 2026 Delta Omega Honors Day Poster Session.

Protocol For Inducing Focal Striatal Stroke In Mice Using Photothrombosis, Bridget R. Boyle, Eileen Collyer, Andrea P. Berghella, Elena Blanco-Suarez

Department of Neuroscience Faculty Papers

Here, we present a protocol for inducing focal striatal stroke in mice using photothrombosis. We describe steps for photothrombotic striatal surgery, magnetic resonance imaging, open field behavioral assessment of stroke-induced motor deficits, and post-stroke monitoring. We then detail procedures for tissue collection and immunofluorescence. This protocol provides a standardized approach for consistently modeling striatal stroke in mice, enabling mechanistic studies and preclinical therapeutic testing.

Noise-Induced Gains: Are You Damaging Your Hearing While You Train?, Taylor Hitschmann, Lillian Beauvais, Blake Roth, Andrew Gannon

SACAD: Scholarly Activities

This study investigated the potential risk of noise-induced hearing loss (NIHL) among individuals who listen to music during exercise. Survey data were collected alongside sound intensity measurements to better understand listening behaviors in fitness settings. Results indicated that although most participants reported listening at recommended safe levels, a notable proportion exceeded these thresholds, potentially increasing their risk of NIHL. These findings highlight the importance of monitoring listening habits during workouts. Hearing health professionals are encouraged to enhance public awareness and promote safe listening practices to help reduce the likelihood of long-term auditory damage.

Examining Moderators In The Relationship Between Injury/Injury Anxiety And Eating Disturbances In College Women Athletes, Lydia M. Reichley

Undergraduate Theses

Introduction: Injury and injury-related anxiety are common in collegiate athletes and may contribute to maladaptive psychological and behavioral outcomes, including eating disturbances. This study examined the relationship between injury/injury anxiety and eating disturbances, and whether athletic identity, injury self-efficacy, and body shame moderated this relationship. Methods: A cross-sectional design was used with 57 female collegiate and club athletes from Bellarmine University (M age = 19.98 + 1.37). Participants completed an online survey including the Sport Injury Anxiety Scale (SIAS), Athletic Identity Measurement Scale (AIMS), Athletic Injury Self-Efficacy Questionnaire (AISEQ), Eating Attitudes Test (EAT-26), and the Objectified Body Consciousness Scale (OBC; …

Can The Implementation Of The Pause Decrease Death Anxiety And Poor Mental Health In Practicing Nurses?, Lilli Meyer

Undergraduate Theses

Practicing nurses are frequently exposed to patient death, placing them at increased risk for death anxiety and compromised mental health. Despite this, there remains a lack of structured, in-the-moment interventions to support emotional processing within clinical settings. This study evaluates whether the implementation of “The Pause,” a brief moment of silence following a patient’s death, may reduce death anxiety and improve mental health outcomes among practicing nurses. A quantitative survey consisting of eight questions was distributed to nurses in the Louisville, Kentucky area over a three-month period, yielding 26 responses. Findings indicated that 80.8% of participants reported no improvement or …

Is Home Birth A Choice? Racial And Geographic Differences In Unintended Home Births In The U.S., Anna De La Paz

Population Health Research Brief Series

Home births that happen without planning or medical support (i.e., unintended home births) carry a higher likelihood of adverse outcomes, such as low birth weight, preterm birth, and hypothermia. This data slice summarizes findings using data from CDC WONDER (2017–2023) on racial, regional, and metropolitan status differences in home births among women ages 15–44 in the U.S. Findings show that unintended home births are disproportionately concentrated among non-Hispanic Black women, with rates varying substantially by region and metropolitan status.

The Mommy Wine Culture: A Scoping Review Using The Person-Environment-Occupational Model., Sabina Khan

Student Dissertations

Maternal alcohol use as a coping response to parenting-related stress has received growing attention in public health and psychology but remains underexplored within occupational therapy. This gap limits understanding of how daily role demands, environmental pressures, and individual vulnerabilities combine to shape drinking as a functional coping behavior. This dissertation aimed to identify and synthesize factors associated with maternal alcohol use in the context of parenting stress and interpret these determinants using the person–environment–occupation model. A scoping review was conducted following the Arksey and O’Malley framework and reported according to PRISMA-ScR guidelines. Five databases were systematically searched without date or …

Mastering The Ppco Framework: A Guide For Evidence-Based Nursing, Mayra Garcia

PPCO Resources & Education

No abstract provided.

Staff Education To Improve Nursing Knowledge Of Follow-Up Adherence Support Strategies In A Large Outpatient Urology Clinic, Ivette Dieguez

Walden Dissertations and Doctoral Studies

Site monitoring identified inconsistent adherence to scheduled follow-up care as an operational concern, underscoring the need for standardized nursing strategies to enhance follow-up communication. This staff education project aimed to determine whether a focused educational intervention could improve nursing knowledge of adherence support strategies, with confidence measured as a secondary outcome. Guided by the ADDIE instructional design model and the Johns Hopkins evidence-based practice model, the project was implemented in a large outpatient urology clinic with 18 participating registered nurses. Participants completed anonymous paper-based pretests and posttests surrounding a single 45-minute, live group education session. Educational content covered common barriers …

The Impact Of A Mindfulness Meditation Program On Phq-9 Scores In Eskd Clients At The Dialysis Center, Christi Collins Weaver

Student Scholarly Projects

Practice Problem: Patients undergoing hemodialysis for end-stage kidney disease (ESKD) experience high rates of untreated depressive symptoms, which negatively impact quality of life, treatment adherence, and therefore increased hospitalization and higher mortality rates.

PICOT: In adult patients receiving in-center hemodialysis (P), how does the implementation of a structured mindfulness meditation program (I), compared to usual care (C), affect depressive symptoms as measured by the Patient Health Questionnaire-9 (PHQ-9) (O) over an eight-week period (T)?

Evidence: Current literature demonstrates that depression is highly prevalent among individuals with ESKD and is associated with increased morbidity and decreased treatment adherence. Evidence supports mindfulness …

Community As Coping: Mental Illness And Homelessness Within A Tent Camp, Karen A. Snedker, Jennifer Mckinney

Sociology Faculty Articles and Research

"Drawing from interview data with residents of Tent City 3, a sanctioned homeless camp, we illustrate the complex connections between mental illness and homelessness from the residents’ perspectives to understand how living in this tent city helps residents manage mental health."

A Prolonged Nightly Fasting Plus Telehealth Coaching Intervention (Pnf+) For Men On Androgen Deprivation Therapy For Pca: A Pilot Feasibility Randomized Controlled Trial, Kuang-Yi Wen, Julianne Freedman, Kevin K. Zarrabi, Rachel Slamon, Rita Smith, Jessica Liang, Patrick Mille, William J. Tester, William Kevin Kelly

Department of Medical Oncology Faculty Papers

Background/Objectives: This study aimed to assess the feasibility and acceptability of a 3-month health coaching intervention to promote PNF and healthy diet for men on ADT for PCa.

Methods: The study was carried out via a two-armed randomized controlled trial including 40 patients with PCa at a medical center in Philadelphia. During the 3-month period, the intervention group (PNF+) received health coaching utilizing an interactive text message system, and the control group received healthy eating text messages for the same duration. The outcome variables were feasibility and acceptability.

Results: The PNF+ group (n = 27) had high …

Evaluating Pathways Into Health Care Among Healthcare Students In Virginia, Olivette Burroughs

Doctoral Dissertations and Projects

The purpose of this study was to evaluate gaps in healthcare training that lead to healthcare access inequalities and the role of the pathway programs' effectiveness in the pathway process in Virginia. The problem addressed in this study was to assess how healthcare education pathway programs impact access to care in rural and underserved areas of Virginia. The study used the qualitative health belief model by Hochbaum, Rosenstock, Kegeles, and Leventhal to examine pathway program participants' beliefs and perceptions, and the grounded theory by sociologists Barney Glaser and Anselm Strauss, to establish theoretical relationships. The rationale for the study was …

Associate Degree Nursing Students’ Lived Experiences With Simulation: A Qualitative Phenomenological Study, Jamie O'Connor Florez

Doctoral Dissertations and Projects

This qualitative phenomenological study examined the lived experiences of prelicensure associate degree nursing (ADN) students related to skills acquisition and workplace readiness through simulation-based learning at community colleges in California. Skills acquisition and workplace readiness were defined as students’ perceptions of their ability to competently perform nursing skills and prepare for entry into the healthcare workforce. Guided by Kolb’s experiential learning theory, data were collected from 13 ADN students through questionnaires, semi-structured interviews, and reflective journaling and analyzed using Braun and Clarke’s six-phase thematic analysis.

Three themes emerged: varying emotions from excitement to feeling overwhelmed; experiences of collaboration and unprofessionalism …

Empath: A Novel Treatment Modality To Improve Patient Outcomes, Barry Thomas Peade Jr.

Doctoral Dissertations and Projects

In recent years, increasing patient volumes in emergency departments, rising cases of overdoses, and strained resources have heightened the attention paid to behavioral health care in the emergency department setting. Currently, various models of care attempt to streamline the provision of care for behavioral health patients in the emergency department. EmPATH, developed by Dr. Scott Zeller, offers rapid stabilization for psychiatric crises. While preliminary studies show promise, further research is needed. This study aimed to evaluate the impact of EmPATH implementation on patient outcomes, including boarding times, readmission rates, and inpatient admissions. Data was collected before and after implementation of …

A Phenomenological Study Exploring The Role Of Religious Coping In Childhood Interpersonal Trauma Recovery Among Latinx Adults, Christina Mancebo-Torres

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to understand the role religious coping plays in recovery from interpersonal adverse childhood experiences (ACES) among Latinx adults attending Pentecostal churches in New Bedford, Massachusetts. The theory guiding this study was Pargament’s Theory of Religious Coping (1997), which posits that religious coping strategies are ways in which individuals attempt to understand and deal with sacred- related negative life events, including traumatic experiences (Xu, 2015). This study utilized a hermeneutic phenomenology research design. The purposive sample consisted of 12 individuals who self-identified as Latinx, 18 years of age or older, and having a …

Using Somatic Experiencing To Mitigate Symptoms Of Secondary Traumatic Stress In Female Helping Professionals, Jillian Christie Guinta

Doctoral Dissertations and Projects

This phenomenological and quantitative study explored the lived experiences of a dozen women within the veterinary, social work, and nursing communities and how secondary traumatic stress impacts their lives. Faced with unanticipated patient illnesses, facilitating compassionate end-of-life procedures, and rapidly moving from one emotional state to the next between patients, professionals are carrying tremendous unprocessed emotional burdens that can affect them physiologically and psychologically. Somatic Experiencing (SE) indicates tremendous promise in rehabilitating practitioners’ trauma-impacted nervous systems by offering techniques to release emotional stress and re-regulate the nervous system (Kuhfuß et al., 2023). This mixed-methods study explored the world of these …

Oxygen Under Pressure: A Comparative Study Of Maximal Oxygen Uptake In Firefighters And Civilians, Jordan N. Hunt

Doctoral Dissertations and Projects

The purpose of this study aimed to investigate and compare V̇O2max levels between firefighters and age-matched individuals from the general population. This study used a quantitative, comparative, cross-sectional design to assess differences in directly measured V̇O2max with a breath-by-breath portable analyzer between firefighters and matched civilians, determine the percentage of firefighters meeting NFPA recommended fitness thresholds, and examine the accuracy of estimated V̇O2max values. A total sample size of 52 participants (26 per group) participated in this study. Firefighters exhibited significantly higher directly measured V̇O2max and V̇O2peak than age-, sex-, and BMI-matched individuals from the general population. Firefighters in this …

Exploring The Lived Experiences Of Operating Room Nurse Interns Transitioning To Practice: A Qualitative Study, Christina C. Baker

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the essence of the lived experiences of new graduate nurse interns transitioning to the operating room (OR) specialty at a southeastern U.S. university hospital system. Many hospitals have nurse residency programs designed to support and facilitate new nursing graduates’ transition to practice areas. The OR is a highly specialized nursing area requiring training in addition to what is offered in nurse residency programs. The central research question was, what is the lived experience of new graduate OR nurses as they complete their transition to practice programs? The theory guiding this …

Integration Of Aged Brain Multi-Omics Reveals Cross-System Mechanisms Underlying Alzheimer’S Disease Heterogeneity, Lucas P Scheidemantel, Katia De Paiva Lopes, Chris Gaiteri, Vilas Menon, Philip L De Jager, Julie A Schneider, Aron S Buchman, Yanling Wang, Shinya Tasaki, Roberto T Raittz, David A Bennett, Ricardo A Vialle

Faculty, Staff and Student Publications

The molecular correlates of Alzheimer's disease (AD) are increasingly being defined by multi-omics. However, findings from different data types are often difficult to reconcile. Here, we apply a data-driven multi-omics framework integrating seven omics layers from up to 1,358 aged human brain samples from the Religious Orders Study and Rush Memory and Aging Project. We demonstrate sprawling cross-omics biological factors relating to AD phenotypes. The strongest AD-associated factor (factor 8) is characterized by elevated immune activity at the epigenetic level, decreased heat shock gene expression in the transcriptome, and disrupted energy metabolism and cytoskeletal dynamics in the proteome. Unsupervised clustering …

Exploring Lived Experiences Faced By Latina Breast Cancer Survivors, Deborah Fortino

Doctoral Dissertations and Projects

The purpose of the hermeneutic phenomenological study was to explore and understand lived experiences of Latina breast cancer survivors through semi-structured interviews on the Zoom Video Conferencing platform. The theory that guided the study was the Health Belief Model (HBM), a health behavior framework that explored Latina breast cancer survivors' behaviors concerning health (Rosenstock et al., 1988). Furthermore, Fleming et al.’s (2003) five steps of gathering qualitative data and Ajjai and Higgs’s (2007) six stages of data analysis were utilized to acquire the information to explore the phenomenon of Latina breast cancer survivors’ lived experiences. The sample population included nine …

Editorial: Publishing Impact Awarded, Frazer Underwood

South West Clinical School Journal

No abstract provided.

Exploring The Experiences Of Undergraduate Nursing Students Using E-Workbooks: A Qualitative Study, Jo Boote

South West Clinical School Journal

#400words: reasearch report

Interferon-Induced Protein Ifit3 As A Molecular Nexus Of Neuroinflammation In Alzheimer’S Disease And Hiv-Associated Neurocognitive Disorders, Ranjit Kumar Das, Nirakar Sahoo, Deepa Roy, Lauren Nguyen, Hansapani Rodrigo, Asim K. Duttaroy, Jerel Adam Fields, Upal Roy

Health & Biomedical Sciences Faculty Publications

Alzheimer’s disease (AD) and HIV-associated neurocognitive disorder (HAND) are significant global health concerns characterized by cognitive impairment and shared pathological features, including chronic neuroinflammation, amyloid deposition, and immune dysregulation. However, the precise molecular connections between these disorders remain unclear. Here, we identify IFIT3 as a critical shared mediator of neuroinflammatory responses in both AD and HAND. Using complementary approaches, including neuronal and microglial cell cultures, the APP/PS1 mouse model, and human postmortem brain tissues, we demonstrate consistent IFIT3 upregulation in response to amyloid-beta (Aβ) and HIV-1 exposure, with notably enhanced expression under combined conditions. Treatment with combination antiretroviral therapy (cART) …

Emerging Paradigms In Connectome-Guided Neurosurgery For Central Nervous System Tumors: A Narrative Review Of Structural And Functional Connectomics, Tirath Patel, Hamza Yousuf Ibrahim, Muhammad Abbas, Muzna Amir Ali, Sana Sohrab, Kinza Nawaz, Syeda Ramish Zehra Kazmi, Bhumi Daishik Patel, Nikhilesh Anand

School of Medicine Publications

Connectomics is a comprehensive mapping of structural and functional brain networks. It has introduced a paradigm shift in neurosurgery by redefining brain tumors as network disorders rather than isolated lesions. Unlike traditional surgeries, connectome-guided neurosurgery conceptualizes brain tumors as network disorders and aims to preserve brain function in resection. The objective was to study the role of connectome-guided neurosurgery in the management of Central Nervous System tumors and the use of structural and functional connectomics in tumor resection while preserving neurological function. Articles have been identified by searches of PubMed, Scopus and Google scholar from January 2000 to May 2025, …