Medicine and Health Sciences Commons^™

Observation And Reflection Of Neighborhood And Community 2026: Education Access/Quality, Economic Stability, Built Environment/Infrastructure And Team Reflection, Alan Carbajo, Samiollah Mohammad, Muhammed Zahriyeh, Grace Drexel, Aster Disbrow, Reagan Recchia

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Observation And Reflection Of Food Availability, Housing, Public Spaces, Recreation, And Healthcare In The Community, Celestino Mangulabnan, Melanie Kajy, Gabriel Hay, George Naguib, Arya Mohanty, Schednah Laraque, Charles Dickson

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Education, Access To Healthy Foods, Neighborhood & Physical Environment, Economic Stability, Taylor Brown, Tanya Bhardwaj, Sara Komaiha, Duncan Mcleod, Jonah Harman, Jai Kukreja, Dominic Marsalese, Elizabeth O'Brien

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Neighborhood & Built Environment, Social & Community Context, Health Care Access & Quality, Courtney Alexander, Sarah Okeke, Bashar Jawich, Joshua Weiss, Shoshana Leflein, Mitchell Finesilver, Liz Ana Palacios

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Sdoh Needs: Food And Community Spaces Reflection, Mohamed Attie, Katie Gahn, Maggie Lomasney, Emerson Woodbury, Muhammad Hatim, Justinas Sapiega, Isaac Agranoff, Braysila Ford

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Income, Education, Food Insecurity And Reflection, Tonia Jones, Habib Serhan, Shriya Karmarkar, Arham Kaiser, Mohammad Turaani, Andre Yazhbin, Jacob Kroll, Jennifer Park

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: The Employment Of Residents In 48203 & Its Impact, Mahmood Sanad, Michelle Wang, Steven Katzman, Nikhil Uppal, Alvin Dong, Yuting Ruan, Makayla Hickmon, Dhara Patel

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: A Reflection On The Limited Resources Available For A Healthy Lifestyle, Jana Hatahet, Steven Jones, Laila Shatela, Pegi Laci, Anushka Dalvi, Michael Becker, Albert Oh, Anthony Marquez

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Provider Availability, Healthcare Coverage, Access To Healthy Food Options, Income, Neighborhood Walkability, And School/Education Reflection, Kayla Hogan, Elizabeth Ajaero, Muhammad Hashem, Alina Ciesielski, Amanda Elashoff, Erik Pedersen, Hamza Mohammad, Tyler Dawson

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Education, Environmental Conditions, And Food Insecurities Reflection, Skylar Hall, Badruddin Mahamed, Jenna Andersen, Evan Robyns, Andrew Singh, Julia Correll, Yousef El-Magharbel, Tiffany Adam

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Observation And Reflection Of Transportation Needs, Aaron Crump, Mohamed El-Souri, Rawan Antar, Sriram Garapati, Olivia Fras, Jai Patel, Lucy Zhang, Laya Dasari

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Food Insecurity, Transportation, Healthcare Access, And Reflection, Mariann Hayek, Noah Weslock, Arya Mashraghy, Mahathi Krothapalli, Abhishek Thakur, Fatima Alemam, Kyle Kramer

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Neighborhood, Environment, And Reflection, Olma Tadesse, Kush Amin, Devon Roe, Anjie Dinakin, Matt Minasian, Arisha Arain, Dave Sreedhar, Ashley Yuran

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Food Desert, Walking Infrastructure, And Primary Care Access Observed In 48203, Christina Barchini, Jad Fawaz, Brayden Moore, Emma Pastoor, Samuel Rest, Hamed Selemani

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Understanding Social Determinants In 48203, Jared Lin, Ryan The, Russell Elkus, Aayushi Jani, Michaela Yamine, Riona O'Donnell, Mariam Duhaini

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Observation And Reflection Of Highland Park, Mohamed Ramadan, Marni Murez, Saatvik Vaishnav, Sathyagopal Siddapureddy, Janiya Brooks

Patient Education Projects

No abstract provided.

Discharge Process Improvement Initiative Using An N-By-T Strategy In A Progressive Care Unit In An Acute Care Setting, Sukhvir Walia

Doctor of Nursing Practice Projects

Background

Timely and efficient patient discharge processes are crucial for enhancing hospital throughput, reducing emergency department boarding, optimizing inpatient bed utilization, and ensuring safe transitions of care. Delayed hospital discharges contribute to prolonged hospitalizations, operational inefficiencies, increased healthcare expenditures, and decreased patient satisfaction. Progressive care units (PCU) are particularly vulnerable to discharge delays because patients frequently require multidisciplinary coordination before safe discharge can occur.

Purpose

The purpose of this quality improvement project was to evaluate the effectiveness of implementing a structured discharge readiness checklist combined with an n-by-T discharge planning strategy during multidisciplinary patient progressive rounds (PPRs) to improve discharge …

A Rare Case Of Gastric Ascariasis, Sharon Pan, Kevin Yu, Blaine A Mathison, Yan Gao, Marc Roger Couturier, Salem Muayad, Violeta Chávez, Ranya Selim

Faculty, Staff and Student Publications

Background: Ascariasis, caused by the parasitic roundworm Ascaris lumbricoides, is one of the most common helminthic infections globally. Spread by contaminated soil through the fecal-oral route, A. lumbricoides typically infects the small intestine and has rarely been reported to infect the stomach.

Case summary: We describe an unusual case of a male in his 30s with a history of neuroendocrine tumor (NET) who immigrated from Colombia and who underwent esophagogastroduodenoscopy (EGD) and colonoscopy for further evaluation of abdominal pain. He was incidentally found to have a female Ascaris worm in his stomach that was retrieved during the EGD.

Conclusion: …

Alternative Abl1 Isoform Expression In Oncogenic Translocations: Implications For Cancer Progression, Jessica Teague

Biological Sciences

Abstract (also on poster): Previous studies in our lab show that an alternate isoform of Bruton’s tyrosine kinase, BTK-C, is required for the survival of several epithelial-derived cancer cells. BTK-C is transcribed from an alternative promoter and includes a 34-amino-acid N- terminal extension with a palmitoylation sequence that alters its subcellular localization. Nine other human kinases have similar alternative N-termini (ANT), often producing palmitoylated or non-palmitoylated isoforms from different transcriptional start sites. Among these, ABL1 is a known oncogenic kinase and key drug target. Translocation mutations at the 5′ end of ABL1 are a major cause of adult leukemias. This …

Towards Dementia-Inclusive Digital Text-Based Health Information: A Multi-Method Investigation Of Cognitive And Affective Accessibility, Margi Engineer

All Dissertations

This dissertation examines the accessibility, readability, emotional tone, and trustworthiness of digital, text‑based dementia information and investigates how older adults with and without dementia cognitively and affectively engage with such content. It further explores the potential of generative AI to improve dementia information delivery through the development of a domain‑specific retrieval‑augmented generation (RAG) large language model (LLM) chatbot designed to deliver accessible, stigma‑free information. The dissertation comprises four studies using complementary quantitative and qualitative methods. Study I conducts a large‑scale content analysis of 300 medical articles, 35 websites, and 50 blogs, applying readability metrics, LIWC‑based linguistic and sentiment analysis, and …

Validation Of The German Version Of The Movement Disorder Society Non-Motor Scale (Mds-Nms), Jonas Bendig, Anika Frank, Adrianna Lipska-Dieck, Kristof Wunderlich, David Geißler-Lösch, Isabel Wurster, Roswitha Kemmner, Kathrin Brockmann, Sheng Luo, Christopher G Goetz, Glenn T Stebbins, Pablo Martinez-Martin, Tiago A Mestre, Alvaro Sanchez-Ferro, Monica M Kurtis, Michelle H S Tosin, Roberta Balestrino, Chi-Ying R Lin, Carmen Gasca-Salas, Heinz Reichmann, Bjoern H Falkenburger

Faculty, Staff and Students Publications

No abstract provided.

Adhesion G Protein-Coupled Receptors, Tobias Langenhan, Garret R Anderson, Demet Araç, Gabriela Aust, Monserrat Avila-Zozaya, Sofie Morsing Bagger, Patrick Barth, Sandra Berndt, Stephen C Blacklow, Beatriz Blanco-Redondo, Antony A Boucard, James P Bridges, Lara-Sophie Brodmerkel, Kathleen M Caron, Yin Kwan Chung, Andrew N Dates, Virginea De Araujo Farias, Daniel Del Toro, Joseph G Duman, Felix B Engel, David M Favara, Caroline J Formstone, Chaoyu Fu, Alain Garcia De Las Bayonas, Anastasia Georgiadi, David E Gloriam, Randy A Hall, Jörg Hamann, Peter W Hildebrand, Cheng-Chih Hsiao, Bill X Huang, Jonathan A Javitch, Hee-Yong Kim, Robert J Kittel, Gunnar Kleinau, Richard Leduc, Ines Liebscher, Hsi-Hsien Lin, Joshua Linnert, Marie-Gabrielle Ludwig, David C Martinelli, Signe Mathiasen, Daniel Matúš, Mariam Melkumyan, Ana L Moreno-Salinas, Jan Mulder, Michael A Nash, Kasturi Pal, Daniel T Pederick, Nicole A Perry-Hauser, Xianhua Piao, Yu-Qi Ping, Dimitris G Placantonakis, Fabian Pohl, Simone Prömel, Mette M Rosenkilde, Laurent Sabbagh, Richard C Sando, Patrick Scheerer, Torsten Schöneberg, Elena Seiradake, Mareike Selcho, Florian Seufert, Abhishek K Singh, Georgios Skiniotis, Katja Spiess, Norbert Sträter, David Strutt, Thomas C Südhof, Jinpeng Sun, Gregory G Tall, Doreen Thor, Douglas G Tilley, Kimberley F Tolias, Mario Vallon, Erwin G Van Meir, Benoit Vanhollebeke, Giselle R Wiggin, Uwe Wolfrum, Jie Yan, Nathan A Zaidman, Yimin Zou, Nicole Scholz

Faculty, Staff and Students Publications

Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive …

Protecting Minors From Medical Malpractice Act: Implications For Otolaryngology-Head & Neck Surgery, Shiven Sharma, Margo K Mckenna, Julina Ongkasuwan, Michael J Brenner

Faculty, Staff and Students Publications

No abstract provided.

Optical Coherence Tomography As An Emerging Technique For Identifying Pediatric Middle Ear Effusion, Roger Neuberger, Jeffrey Carter, Adriana Dives, Ana Sofia C Ibarrola, Maritsa Ixba, Elton Lambert, Yi-Chun Liu, Anna H Messner

Faculty, Staff and Students Publications

Objective: Acute otitis media (AOM) and otitis media with effusion (OME) rely on accurate characterization of middle ear effusion (MEE). Optical coherence tomography (OCT) is a potential modality for noninvasive analysis of MEE, thereby assisting with otitis media diagnosis. This study aims to compare the diagnostic performance of OCT with otoscopy and tympanometry in pediatric patients.

Methods: A prospective convenience sample of 164 pediatric patients aged 6 months to 12 years was recruited from two tertiary care pediatric otolaryngology clinics. During their visit, each child underwent otoscopy, tympanometry, and OCT evaluation. Scans were reviewed by both a fellowship-trained pediatric otolaryngologist …

Most-Favored-Nation Benchmarking Versus Value-Based Contracting: Institutional Fit Of Pharmaceutical Pricing Tools In The United States, Canada, And The United Kingdom, Kola Adegoke, Olajide Alfred Durojaye, Abimbola Adegoke, Adeyinka Adegoke

Health & Biomedical Sciences Faculty Publications

Background: Soaring drug prices pose a significant obstacle to affordable and equitable access to medicines in high-income healthcare systems. This study compares two leading reform tool families, Most Favored Nation (MFN)/international reference pricing (IRP) and value-based contracting (VBC), across the United States, Canada, and the United Kingdom, with attention to cost containment, value-linked incentive design, equity of access, and implementation feasibility. U.S. policy developments (CMS Innovation Center’s GENEROUS, GLOBE, and GUARD models) extend international benchmark-based design options beyond the 2020 MFN rule.

Methods: Guided by institutional and governance theories, we conducted a structured comparative policy analysis using a four-dimensional trade-off …

Lp(A) Has Specific Effects On Coronary Artery Disease Independent Of Ldl-C: A Mendelian Randomization Study, Moa P Lee, Sarah H Koenigsberg, Mohammad Y Anwar, Laura M Raffield, Zhaotong Lin, Anna F Ballou, John N Booth, Thibaut Davy-Mendez, Helina Kassahun, Shia T Kent, J Antonio G López, Keri L Monda, Kari E North, Rina Yarosh, Christie M Ballantyne, Misa Graff, Christy L Avery

Faculty, Staff and Students Publications

Background: Mendelian randomization studies suggest a causal effect of lipoprotein(a) (Lp(a)) on atherosclerotic cardiovascular disease. Noncardiovascular effects (eg, diabetes risk) are inadequately investigated.

Objectives: In this noninterventional phenome-wide association study designed to better understand the potential causal role of Lp(a), direct causal phenotypic effects of exposure to Lp(a) were estimated. Also, the association between LPA null allele rs41272114 with type 2 diabetes was assessed, and ancestry-specific Lp(a) thresholds were determined.

Methods: In the UK Biobank (n = 425,677 adults, 55% female), we studied 1,456 phenotypes spanning 18 classes using 4 ancestry-specific polygenic risk scores and false discovery rate multiple testing …

Plasma Metabolites After 10-Weeks Of Glucose Vs Fructose-Sweetened Beverages In Subjects With Overweight/Obesity, Mélanie Guirette, Danielle E Haslam, Jiantao Ma, Peter J Havel, Kimber L Stanhope, Olga Ilkayeva, Christopher B Newgard, Nicola M Mckeown, Mark A Herman

Faculty, Staff and Students Publications

To identify metabolites as potential biomarkers of fructose vs glucose consumption and related metabolic changes, we conducted exploratory metabolomic profiling of fasting blood samples from participants in a double-blind, parallel-arm trial involving 31 male and female adults with overweight or obesity, both before and after supplementation with glucose- or fructose-sweetened beverages. Orthogonal Partial Least Square Discriminatory Analysis (OPLS-DA) was used to identify metabolites that could discriminate between the 2 intervention groups. Changes in 16 metabolites (5 of which are branched-chain amino acid catabolic pathway metabolites) and the branched chain keto acid (BCKA) composite score showed nominal (FDR adjusted P-value …

Development And Pilot Testing Of Transdiagnostic Exposure Therapy/Behavioral Activation For Autistic Adolescents With Internalizing Disorders, Andrew G Guzick, Elizabeth A Kaplan-Kahn, Jessica Szu-Chi Cheng, Callie Murphy, Ogechi C Onyeka, David Riddle, Tracy Dibbs, Leandra N Berry, Robin P Goin-Kochel, Eric A Storch

Faculty, Staff and Students Publications

Internalizing disorders disproportionately affect autistic adolescents, though limited research has focused on tailoring therapy for this population. The purposes of this paper were (1) to describe the development of a transdiagnostic exposure therapy/behavioral activation intervention for autistic adolescents with internalizing disorders, and (2) to present a pilot test of feasibility, acceptability, and efficacy of the intervention. The development of this therapy is described in detail, which prioritized the following domains: (1) building on the existing evidence base of exposure-based cognitive behavioral therapy for autistic youth with anxiety disorders, (2) involving caregivers considerably, (3) incorporating autism-specific considerations into case conceptualization and …

Stance And Gait Analysis Of Apollo Astronauts On The Moon, Faye Y Chiou-Tan, Conrad Li, Jason P Caffrey, Millard Reschke, Timothy R Macaulay

Faculty, Staff and Students Publications

Introduction/aim: As humans return to the Moon, safe efficient ambulation and fall prevention on the lunar surface are key concerns. The analysis of gait from archived Apollo mission video footage is now possible with pose estimation video analysis software. Thus, this study aims to retrospectively quantify parameters of Apollo astronauts' stance and gait on the Moon.

Methods: Publicly available National Aeronautics and Space Administration (NASA) footage of astronauts ambulating on the Lunar surface was examined using body pose analysis software. Goniometric lower limb joint/torso angles and width of base of stance and gait were derived. Gait cycle stance phase, swing …

Surgical Timing After Acromioclavicular Joint Separation: Association With Clinical Outcomes, Mallory B Lane, Jacob Siahaan, James M Gregory

Faculty, Staff and Student Publications

Background: Treatment of acromioclavicular joint (ACJ) separations continually lacks consensus between providers, and while low-grade injuries generally respond well to conservative management, high-grade injury management is more complex. For patients requiring surgery, the effect of the timing of surgery with respect to the original injury on clinical outcomes remains unclear.

Hypothesis: Clinical outcome measures would worsen as the time between ACJ dislocation injury and surgery increased.

Study design: Cohort study; Level of evidence, 3.

Methods: A large nationwide insurance claims database was queried for patients who had an ACJ dislocation injury using International Classification of Diseases, Ninth and Tenth Revision …