Medicine and Health Sciences Commons^™

In Silico Screening And Molecular Analyses Identify Apigenin From Scutellaria Barbata As A Potent Akt1 Inhibitor In Breast Cancer, Md. Maruf Khan, Md. Arju Hossain, Fatematuz Zohora, Md. Sohel, Md. Faisal Amin, Fatematuz Zuhura Evamoni, M. Nazmul Hoque

School of Integrative Biological & Chemical Sciences Faculty Publications

Breast cancer (BC) remains a leading cause of cancer-related mortality in women worldwide. Scutellaria barbata, a traditional Chinese medicinal herb, possesses recognized anticancer properties, but its mechanistic role in BC is not fully elucidated. This study employed an integrated in silico approach to identify the key flavonoids, targets, and pathways through which S. barbata exerts its anti-BC effects. A multi-step computational methodology incorporating network pharmacology, molecular docking, and dynamics simulations was utilized to profile bioactive compounds from S. barbata. From an initial set of 34 phytocompounds, three flavonoids namely apigenin, 4’-hydroxywogonin, and hispidulin demonstrated favorable drug-likeness, high bioavailability, …

Harmonizing Intervention, Context, And Implementation Strategies With Context-Driven Co-Design (Cd2), Sarah A Birken, Emily R Haines, Cheyenne R Wagi, Bonny B Morris, Kathryn E Weaver, Kathleen M Lisborg, Sara J Landes, Geoffrey M Curran, Miriam Bender, Maria E Fernandez, Ashley Strahley, Kimberly Wiseman, Kristie L Foley

Faculty, Staff and Student Publications

Background: Extant approaches to close the gap between implementation evidence and practice have been unsuccessful due in part to overreliance on researcher engagement. In practice, change is often driven by mid-level managers. We developed Context-Driven Co-Design (CD2) to equip mid-level managers with a theory- and evidence-based approach to implementation planning.

Methods: We used a two-pronged design. First, we engaged six established implementation researchers in a modified Delphi process, involving two hour-long meetings and asynchronous feedback to develop and refine a CD2 prototype. Second, we piloted an in-person CD2 training and conducted an hour-long focus group to solicit feedback from mid-level …

Impact Of Anatomical Changes On Treatment Plan Robustness: A Comparative Study Of Intensity Modulated Proton Therapy And Volumetric Modulated Arc Therapy In Head And Neck Cancer., Jennifer Croft

Masters Projects

Head and neck cancer patients often experience anatomical changes during radiation therapy, including weight loss and tumor regression. These changes can alter planned dose distribution and affect treatment accuracy. Based on the previous understanding, IMPT offers highly conformal dose delivery but is sensitive to the patient’s geometry changes and daily setup uncertainties, while VMAT may provide greater stability under these uncertainties. However, as of today, there is no quantitative analysis and comparison between the two modalities using real clinical data. The purpose of this study is to compare the robustness of IMPT and VMAT for head and neck cancer by …

Tea Polyphenol-Assisted Green Synthesis Of Silver Nanoparticle-Boron-Doped Diamond Nanoparticles For Theophylline Electrochemical Detection, Prastika Krisma Jiwanti, Adira Ainun Tsalsabilla, Angellita Wijaya Gunawan, Siti Wafiroh, Mohammad Kalimanjaro, Mai Tomisaki

Makara Journal of Science

Drug theophylline is a bronchodilator used to treat asthma and chronic obstructive pulmonary disease (COPD), but precise monitoring is required to avoid side effects. Therefore, this study aimed to develop a screen-printed electrode (SPE) modified with a composite of green-synthesized silver nanoparticles and boron-doped diamond nanoparticles using tea polyphenols (Ag-BDDTP/SPE) for detecting theophylline. Formation of AgNPs was confirmed by UV-Vis spectroscopy, which showed a localized surface plasmon resonance peak at ~450 nm. Transmission electron microscopy revealed polydisperse nanoparticles with an average diameter of 39.94 nm. During the electrochemical detection of theophylline, square-wave voltammetry (SWV) was employed to evaluate signal-to-background (S/B) …

Mutation Screening For Confirming Suspected Spinal Muscular Atrophy Using Dried Blood Spotted On In-House Cellulose-Based Cards, Yogik Onky Silvana Wijaya, Farda Tsaqouva Ahza, Annisa Naufal Almaszahra, Mawaddah Ar Rochmah, Dian Kesumapramudya Nurputra

Makara Journal of Science

Early and accurate diagnosis for spinal muscular atrophy (SMA) has gained relevance in an era of emerging therapies to improve patient outcomes. While screening of dried blood spots (DBS) effectively detects deletion-type SMA, non-deletion cases are often missed. Mutation screening from DBS is needed to address this gap. Here, we aimed to evaluate the feasibility of an in-house, cellulose-based card for direct Sanger sequencing for variant hunting, avoiding DNA extraction and offering an alternative to commercial cards. As a proof of concept, sequences obtained from DBSs of 23 healthy individuals were compared with sequences derived from isolated genomic DNA (gDNA). …

Community Perceptions And Hospital Selection In Depok: A Comparative Study Of Rsud Anugerah Sehat Afiat And Competitors Based On The 5a Framework, Iva Nur Faridah, Wahyu Sulistiadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

RSUD Anugerah Sehat Afiat (ASA) Depok faces challenges in enhancing service utilization and competitiveness as a public hospital in the increasingly competitive healthcare environment of eastern Depok City. This study aimed to identify factors influencing community preferences in hospital selection and to determine appropriate positioning strategies for RSUD ASA. A mixed-methods case study design was employed. Quantitative data were collected from 132 respondents aged over 25 years who had visited four hospitals included in the study, using structured questionnaires. Qualitative data were obtained through in-depth interviews with eight key informants representing RSUD ASA management. Data analysis was based on five …

Pengetahuan Dan Motivasi Meningkatkan Penggunaan Aplikasi Mobile Jkn Pada Pasien Bpjs Di Instalasi Rawat Jalan Rsd Idaman Banjarbaru, Salbia Putri Kanzha Khairunnisa, Raziansyah Raziansyah, Fahriadi Fahriadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The development of digital health services encourages the use of the Mobile JKN application to enhance access and service efficiency for BPJS participants. However, its utilization remains inconsistent due to limited knowledge of its functions and low motivation to use it. This study examined the relationship between knowledge and motivation with the use of the Mobile JKN application among BPJS patients at the Outpatient Installation of RSD Idaman Banjarbaru in 2025. This study employed a quantitative approach with a cross-sectional design. The population comprised 10,478 BPJS patients, while the sample consisted of 100 outpatient BPJS patients who used the Mobile …

Exploring The Determinants Of Operating Room Utilization: A Scoping Review Of Influential Factors In Surgical Efficiency, Isma Sari Chumairah, Masyitoh Basabih

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Optimal utilization of the operating room (OR) is a crucial element in improving the efficiency of surgical services and hospital performance. This scoping review aimed to identify and map the factors influencing OR utilization based on recent scientific literature. We conducted a scoping review using the Population–Concept–Context (PCC) framework and reported it according to the PRISMA-ScR guidelines. We systematically searched PubMed, Scopus, and ScienceDirect for articles published between 2015 and 2025. Eligible studies were screened, and information on study characteristics and reported determinants of OR utilization was extracted and summarized descriptively. Forty studies were included. The reported determinants clustered into …

Gambaran Administrasi Rekam Medis Semi-Digital Berdasarkan Pendekatan 5m Dan Poac Di Rsu X Kota Depok Tahun 2025, Dewi Shinta, Risky Kusuma Hartono, Malihah Ramadhani Rum

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Medical record administration is an essential component in supporting healthcare service quality. During the transition toward Electronic Medical Records (EMR), many hospitals still use semi-digital systems that combine conventional and electronic processes. This study aimed to describe semi-digital medical record administration at RSU X, Depok City, based on the Man, Money, Material, Method, and Machine (5M) management elements and the Planning, Organizing, Actuating, and Controlling (POAC) management functions. This study employed a descriptive qualitative approach through in-depth interviews and observations involving five informants. The results showed that the semi-digital system operated through the parallel use of physical medical records and …

Scholarship, Discovery, And The Formation Of Physicians, Anderson Spickard

Cumberland Medica

The launch of Cumberland Medica marks an important milestone for the Thomas F. Frist, Jr. College of Medicine. More than a journal, it reflects something we hope will be deeply woven into our culture: a community of learners committed to discovery, scholarship, and the formation of physicians. This issue showcases the work of our students while also reflecting the scholarship, mentorship, and educational leadership of faculty and staff. More importantly, it reflects our belief that scholarship is not simply about producing knowledge. It is one of the ways physicians learn how to see.

Refining Of An Online Rotator Cuff Related Pain Screening Tool (Orcs): A Mixed Methods Refinement Study, Andrew J. Smythe, Rhiannon Whale, Melanie Farlie, Peter Malliaras

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study is to refine an online rotator cuff related shoulder pain screening tool. Method: A mixed methods item-refinement study was used. The original tool was designed through expert opinion and informal literature review. In this study the original tool was refined over three rounds of cognitive interviews totalling 39 participants. The screening tool consisted of two sections, red flag screening followed by rotator cuff related shoulder pain differential diagnostic items. Results from each round of interviews were summarised and informed a nominal group research panel review process to modify items and develop a finalised version …

Objectively And Subjectively Measured Physical Activity Levels Among Children And Adolescents In Poland (2012–2022): A Systematic Review, Jarosław Herbert, Vasylyna Petrovets

Baltic Journal of Health and Physical Activity

This article aims to provide a comprehensive review of research on physical activity levels among children and adolescents in Poland from 2012 to 2022, considering both objective and subjective assessment methods. A systematic review of the literature was conducted in accordance with the PRISMA reporting recommendations. PubMed, Scopus, Web of Science, Google Scholar databases, as well as Polish scientific databases were searched. The review included studies published from 2012 to 2022, on children and adolescents aged 3–18 living in Poland, assessing physical activity levels using objective and/or subjective methods. This analysis of the selected studies showed that physical activity levels …

Influence Of Peak Height Velocity On The Level Of Motor Skills And Anthropometric Features In Young Male Footballers, Dariusz Tadeusz Skalski, Magdalena Prończuk, Artur Terbalyan, Kinga Łosińska, Adam Maszczyk, Robert Krzysztof Roczniok

Baltic Journal of Health and Physical Activity

Background: This study examines the influence of Peak Height Velocity (PHV) on motor abilities and anthropometric characteristics of young male football players aged 12–16. The research aimed to determine whether PHV significantly affects motor performance beyond the chronological age, providing insights for talent identification and training optimization. Materials and methods: A total of 248 male football players from four professional academies were assessed and categorized into three maturation groups: Pre-PHV (n = 95, 38.3%), Mid-PHV (n = 98, 39.5%), and Post-PHV (n = 55, 22.2%) Anthropometric measurements included height, body mass, BMI, and leg length, while motor tests …

Quality Improvement Project Improving Provider Confidence For Medication Adherence Screening Through Use Of The Medication Adherence Rating Scale (Mars), Tamara Cheek

Doctor of Nursing Practice Projects

Medication nonadherence affects 50% to 70% of individuals with serious mental illness. This contributes to symptom relapses, hospitalization, poor treatment outcomes, and higher healthcare costs. The purpose of this quality improvement project was to evaluate the impact of a competency-based Medication Adherence Rating Scale (MARS) training program on provider confidence and standardized adherence screening in a psychiatric clinic, to improve confidence and increase use of a standardized assessment. Guided by Bandura's Self-Efficacy Theory and Lewin's Change Management Model and implemented using the Plan-Do-Study-Act framework, the project used a quantitative quasi-experimental pre-post design with eight psychiatric mental health nurse practitioners. Data …

Quality Improvement Project: Addressing Appointment Non-Adherence Through Social Needs Screening, Dorathy Anderson

Doctor of Nursing Practice Projects

Mental health care access in the US faces systemic barriers that delay treatment and disrupt care, often worsening patient outcomes. Unmet social needs of health, such as transportation, financial, and housing issues, lead to missed appointments and fragmented care, thereby increasing health disparities. This quality improvement project evaluated whether targeted staff education improved the identification and response to social needs that affect appointment adherence. Adult Learning Theory guided the training, while Lewin’s Theory of Change and the Plan-Do-Study-Act framework informed implementation and evaluation. The intervention population consisted of five clinic staff members. A quasi-experimental pretest-posttest design was used to evaluate …

The Impact Of Telephonic Versus Video Platforms On Nurses’ Intrinsic Motivation: An Evidence-Based Practice Project, Brittney Saldierna

Doctor of Nursing Practice Projects

Ambulatory pediatric nurses frequently rely on telephone-only encounters for telehealth triage and patient education despite the availability of video-enabled technology. Literature demonstrates that the inability to visually assess patients limits clinical assessment accuracy, communication effectiveness, and nurse confidence. The purpose of this evidence-based practice project was to evaluate whether educating ambulatory pediatric nurses on the integration of video-enhanced telehealth encounters impacts intrinsic motivation and perceived competence compared with telephone-only encounters. Guided by the Iowa Model of Evidence-Based Practice and the ADKAR Change Management Model, this quantitative, quasi-experimental project was applied utilizing the PDSA cycle implementation framework in ambulatory pediatric specialty …

Quality Improvement Project: The Impact Of Standardized Handoff Communication In A Home Acute Care Setting, Antonius Devon Speed

Doctor of Nursing Practice Projects

Effective nurse-to-nurse handoff communication is essential in hospital-at-home telehealth care, where remote nurses depend on accurate electronic health record documentation and structured shift-to-shift communication. This quality improvement project evaluated whether education and implementation of a standardized Situation, Background, Assessment, Recommendation (SBAR) workflow improved staff-reported handoff quality and reduced communication-related near-miss events over 8 weeks. Lewin's Change Theory, Rogers's Diffusion of Innovations, and the Plan-Do-Study-Act framework guided implementation and sustainability. A quantitative, quasi-experimental one-group pretest-posttest design was used. The intervention included SBAR education, a workflow checklist, and a handoff template. Outcomes were selected Handover Evaluation Scale (HES) responses and aggregate near-miss …

Assessing Renal Dysfunction Incidence Related To Intravenous Acyclovir Usage, Marwa Said Aljahwari, Mohammad Abobakr Alghazali, Aya Said Alsaidi

Sultan Qaboos University Medical Journal

Objectives: This study aimed to assess the incidence and contributing factors of renal dysfunction among patients receiving intravenous (IV) acyclovir at Khoula Hospital, Muscat, Oman. Specifically, this study aimed to evaluate the incidence of acute kidney injury (AKI) following IV acyclovir administration, associated risk factors and potential preventive strategies to reduce nephrotoxicity. Methods: This retrospective cohort study was conducted at Khoula Hospital and included patients aged 12–80 years who received IV acyclovir between January 2019 and December 2023. Patients with pre-existing renal disease or increased baseline serum creatinine were excluded. The sample size was computed using Daniel's formula, resulting …

Quality Improvement Project: Implementation Of Trauma-Informed Care Education In An Outpatient Psychiatric Clinic, Ornela Claude Ika

Doctor of Nursing Practice Projects

Trauma-informed care (TIC) is an evidence-based approach that promotes safe, patient-centered care for individuals with a history of trauma. Many patients receiving services in psychiatric settings have experienced trauma, placing them at risk for retraumatization during healthcare encounters. Despite the recognized benefits of TIC, the outpatient psychiatric clinic involved in this project lacked a formal trauma-informed care education program for staff. The purpose of this quality improvement project was to determine whether implementation of a structured trauma-informed care educational intervention improved staff attitudes toward trauma-informed care. Lewin’s Change Theory and the Plan-Do-Study-Act framework guided project implementation. A quantitative pre-intervention and …

Quality Improvement Project: Impact Of Adjunct Clinical Faculty Mentorship On Self-Confidence: A Quality Improvement Project, Fairah Solomon

Doctor of Nursing Practice Projects

Novice adjunct clinical faculty transitioning from expert clinicians to nurse educators face many challenges, particularly in understanding their roles, responsibilities, and educational frameworks. Despite an established orientation at the project site, a structured mentorship program to support the role transition is lacking. This quality improvement (QI) project aimed to improve novice adjunct clinical faculty’s self-confidence through the implementation of a structured mentorship intervention. Guided by Lewin's Change Theory and Constructivist Learning Theory, the project utilized a quasi-experimental pre- and post-test design. Implementation was guided by the Plan-Do-Study-Act framework. A purposive sample of seven novice adjunct clinical faculty with less than …

Adaptation Of The Transition Readiness Assessment Questionnaire For Pediatric-Onset Multiple Sclerosis: Protocol For A User-Centered Design Approach, Claudia Gambrah-Lyles, Aaron W Abrams, Sara Loud, Hollie Schmidt, Emily Blosberg, Melissa Wright, Kelsey E Poisson, Kristen S Fisher, Kimberly A O'Neill, Akash Virupakshaiah, John W Rose

Faculty, Staff and Students Publications

Background: Pediatric-onset multiple sclerosis (POMS) is a chronic, progressive neurologic condition requiring lifelong management and coordinated transition from pediatric to adult care. Evidence-based guidelines identify transition readiness assessment as a core component of successful transition; however, most POMS clinics do not formally assess readiness, and existing tools do not address POMS-specific challenges, such as fluctuating disability, complex treatment regimens, and cognitive impairment. This gap underscores the need for a transition readiness measure tailored to POMS.

Objective: This paper aims to describe a stakeholder-engaged, implementation science-guided protocol for adapting the Transition Readiness Assessment Questionnaire (TRAQ) version 6.0 to reflect the unique …

Closing The Gaps: Reforming Maryland Controls On Veterinary Antimicrobial Distribution, Samantha Capaldo, Kerry Mcclaughry

Journal of Food Law & Policy

Antimicrobials have been used in livestock and other food animals in the United States (“U.S.”) since the late 1940s. An antimicrobial is “[a]ny natural, synthetic, or semisynthetic substance that can eradicate or prevent the growth of microbes,” including “[a]ntibacterial, antifungal, antiparasitic, and antiviral medications.” Antimicrobial use in food animals is subject to a complex statutory and regulatory framework at both the state and federal levels. Antimicrobial use in food animals has been widely criticized for contributing to antimicrobial-resistant bacterial infections in humans. In response to this criticism, the U.S. Food and Drug Administration (“FDA”) and several states, including Maryland, have …

Proceedings Of The 25th International Symposium On Adapted Physical Activity: Easy Read Edition Of The Symposium Proceedings, Catherine Carty, Niamh Cronin, Ian Coleman Horgan, Stuart Dodd, Jack Dowling, Lydia Murphy, Alex Nicholls, Yann O'Carroll, Robbie O'Neill, Meabh Rohan, Brandon Rumian, Diarmuid O'Connor, Eamonn Carroll, Gerard O'Carroll, Jasmin Richter, Mary Shanahan, Aaron Doherty, Sasha Fitzgerald, Katie Lyons, Katie Mahoney, Afeefah Memon, Conor Moriarty, Adrian O'Sullivan, Dylan Shine, Michelle Enright, Phil Mcsweeney, Sophie Casey

Publications

This book is the Easy Read Proceedings of the 25th International Symposium of Adapted Physical Activity (ISAPA 2025), hosted by Munster Technological University under the Patronage of UNESCO. A small number of printed books are available in MTU libraries, and there is a digital version available online on the South West Open Research Deposit.

I Cry At Night Before You: Theologies Of Depression In The Psalms, Travis Spillum Osb

Obsculta

This work looks to the Psalms to discover theologies that resonate with experiences of depression. If one struggling with depression feels as if God is angry with them, that their condition is oppressing them, that loved ones have abandoned them, or that God's love for them is wavering, they can utilize the psalmist's words to voice their feelings and express their anguish in prayer to a God who is seemingly deaf to their groaning.

Bridging Gaps In Childhood Systemic Lupus Erythematosus Treated At An Outpatient Clinic, Allen M. Savedra

Walden Dissertations and Doctoral Studies

No abstract provided.

Staff Education Project To Improve Nursing Knowledge And Patient Safety, Njideka Maureen Okeke

Walden Dissertations and Doctoral Studies

No abstract provided.

Continuing Medical Education As A Workforce Learning System For Artificial Intelligence In Clinical Practice, Tim Murphy, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

Artificial intelligence (AI) is increasingly embedded in clinical decision support, documentation, imaging, predictive analytics, and workflow management. However, the educational systems responsible for preparing practicing physicians to use AI have not fully addressed the interpretive, ethical, and organizational demands of AI-supported care. This qualitative case study examined how continuing medical education (CME) shapes physicians’ readiness to integrate AI into clinical practice. Guided by the Unified Theory of Acceptance and Use of Technology (UTAUT) and human resource development (HRD), the study analyzed semi-structured interviews with 14 physicians from diverse specialties within a large academic health system. Organizational artifacts, including CME announcements, …

Improving Procedural Confidence: Outcomes Of A Surgical Skills Workshop For Medical Students, Mary Arden G Guillory, Jennifer Escamilla, Anika Doppalapudi, Ashlyn Holubar, Kaitlyn Ybanez, Mark Manickath, Maci Oestreich, Mckenna Stallworth, Kelsey Baker

School of Medicine Publications

Introduction Introducing surgical skills early in medical training may enhance students' confidence and readiness for clinical training. Simulation-based skill workshops provide students with a comfortable learning environment, resulting in effective learning. The goal of the Surgical Skills Workshop was to provide first- and second-year medical students with hands-on exposure to essential surgical skills. The educational impact on medical students' confidence in performing the respective surgical skills and changes in surgical career interest was assessed.

Methods: First- and second-year medical students at the University of Texas Rio Grande Valley School of Medicine participated in a hands-on surgical skills workshop comprising eight …

From Fly On The Wall To Future Colleagues: Best Practice Recommendations For Medical Student Shadowing Programs, Molly Estes, Danielle Matonis, Mckenna Knych, Brian Barbas, Ronnie Ren, William Dixon, Michael Pasirstein, Xiao C. Zhang, Kaitlin Bowers, Ravi R. Chauhan, Laryssa A. Patti

Department of Emergency Medicine Faculty Papers

BACKGROUND: Physician shadowing is a common component of early medical education and frequently represents students' first exposure to clinical practice. Despite its prevalence, existing guidance primarily targets learners rather than physicians supervising shadowing experiences. This gap is especially relevant in the emergency department (ED), where high patient acuity, workflow demands, and complex clinical environments create challenges for providing safe and meaningful observational learning. We sought to develop consensus-based best practice recommendations for ED faculty supervising medical student shadowing.

METHODS: We conducted a modified Delphi study using an online survey platform to achieve panelist consensus. Ten emergency medicine educators with a …

Reflections On Inclusive Qualitative Research With Autistic Emerging Adults: Lessons Learned And Practical Recommendations, Acadia W. Buro, Heidi Rishel Brakey, Monica F. Asencio Pimentel, Elizabeth Yakes Jimenez

Population Health Research and Scholarship

We explored inclusive qualitative data collection strategies for autistic emerging adults (ages 18–25) to identify nutrition-related resource needs and inform intervention development. We conducted Zoom interviews with autistic emerging adults, their caregivers, and service providers. We co-developed recruitment materials with a community advisory board of autistic advocates and offered and adapted interview accommodations in real time to align with participants’ preferences. Common accommodations included receiving questions in advance and in the chat, having a caregiver present, and simplifying questions. Some techniques used with neurotypical participants translated well to our participants, such as reflective listening, a conversational tone, and allowing pauses; …