Medicine and Health Sciences Commons^™

An Investigation In The Treatment Of Anisometropia With Orthokeratology Lenses, Cara Finn

Student Theses, Dissertations and Capstones

Purpose: The purpose of this study is to evaluate the treatment and management of anisometropia with orthokeratology lenses compared to traditional spectacle lenses. The present study aimed to quantify the interocular difference in relative corneal refractive power shift and examine its association with the differential axial growth.

Methods: One hundred and two subjects between the ages 8 and 14 years old with over -0.50D of myopia and at least 1D of anisometropia were treated with either orthokeratology lenses or traditional single vision spectacle lenses. Baseline data of axial length, refraction, and corneal topography were taken at the initial visit and …

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …