Medicine and Health Sciences Commons^™

Clinical Significance Of Liver Enzyme Biomarkers In Chronic Statin Users, Muayad Khaleel Ibrahim, Saad Mahmoud Saeed

Al-Esraa University College Journal for Medical Sciences

It is possible that statins, by their dual capacity to modulate (both stimulate and suppress) immune responses, could play a role in influencing the course of autoimmune diseases. Consequently, our investigation was designed to explore how statins impact both the innate and adaptive branches of the immune system, as well as their effect on the crucial mechanism of self-tolerance. This was achieved through the comprehensive measurement of various antibody profiles, specifically including the detection and quantification of autoantibodies, such as antinuclear antibodies and Creatinine kinase, Aldolase, HMGCR antibody, Albumin and Bilirubin and Alanine transaminase, Aspartate aminotransferase, Our investigation employed a …

Some Pathogenic Agents Isolated From Gento-Urinary Tract Of Females Patients In Baghdad Area, I. M. Al-Saqur, A. N. Al-Thwani, E. M. Abdul Ameer, S. W. Abd-Al-Zhra, M. K. Sahan, H. S. Ferman, A. A. Hassan, H. M. Hassan

Al-Esraa University College Journal for Medical Sciences

The Urinary Tract Infection (UTI) represents a significant global health burden and the pathogens which inhibit the geneto - urinary Tract (GUT) of women cause devastating consume. In this study investigation UGT were carried out through examination of 186 women (183 married and 65 unmarried) who attended Damascus Private Medical Center-Baghdad, through the period from the beginning of January 2023 to the end of August 2023. Detection were conducted according to the standard methods after macroscopically and macroscopically examination of u samples. The results, indicated that 121 (65.05%) were infected and married women had high infection (78.86%) than the unmarried …

Measuring The Concentration Of Heavy Metals In The Serum Of Traffic Police And Their Impact On Heart Disease In The Future, Hanaa Khalil Sacheat

Al-Esraa University College Journal for Medical Sciences

The spread of heavy metals such as lead, cadmium and nickel is a clear danger that threatens the earth and disrupts the ecological balance. In this research, we evaluated the danger of these metals present in the areas of traffic points for traffic policemen who are present for long periods at traffic points. 25 blood samples were collected from traffic policemen present at traffic points, with information about age, date of joining the job, and smoking, The comparison was made with the same number of samples of people who were in a job inside buildings, The results showed a significant …

Tumor–Immune Dynamics With Memory And Time Delay: A Fractional-Order Model With Ctla-4 Regulation, Mutaz Mohammad, Mohyeedden Sweidan, Alexander Trounev, Fathalla Rihan

Mathematical Modelling and Numerical Simulation with Applications

This study develops a fractional-order tumor-immune interaction model incorporating Caputo memory effects, delayed immune activation, and CTLA-4 checkpoint regulation. The model describes the coupled dynamics of tumor cells, CD4$^{+}$ T cells, IFN-$\gamma$, and CTLA-4, and extends classical integer-order tumor-immune models by accounting for hereditary immune responses and biologically motivated latency effects. Theoretical properties, including positivity, boundedness, equilibrium structure, and fractional-order stability, are examined to establish the biological and mathematical consistency of the model. The delayed fractional system is then investigated computationally by comparing several numerical methods, including finite difference discretization, Daubechies wavelet collocation, Euler wavelet collocation, and a predictor-corrector scheme. …

Crispr/Cas9-Based Genome Editing: Understanding Differences In Dna Repair Pathways, Profiles, And Outcomes, Samuel Effah, Shirley Barrera, Nahia Urturi Ortiz, Will Dampier, Michael Nonnemacher, Brian Wigdahl

Kimmel Cancer Center Faculty Papers

Over a decade of advances in Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9)-based technologies have culminated in the first-ever FDA-approved CRISPR/Cas-based therapy. Aside from this approved therapy for sickle cell anemia, several CRISPR/Cas-based therapies are currently under development or testing for a range of chronic diseases, including viral diseases like human immunodeficiency virus type 1 (HIV-1) infection, genetic diseases like familial hypercholesterolemia, and cancer. The success of these therapies hinges on the effective delivery of CRISPR/Cas9 components to target regions, efficient Cas endonuclease editing, repair profiles generated, and their resulting outcomes. Here, we discuss the …

Us Race/Ethnic Disparities In Diabetes Technologies: A Systematic Review And Meta-Analysis Of 950 000 Individuals, Maria L. M. Rego, Maxim Barnett, Maria Helena Siqueira Tavares De Melo, Ana Rivadeneira

Einstein Health Papers

PURPOSE: To provide a descriptive summary and to quantitatively examine racial and ethnic disparities in the use of continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) among people living with diabetes in the United States.

RESEARCH DESIGN AND METHODS: We followed the Cochrane and PRISMA guidelines (PROSPERO: CRD420251124678). Search was conducted on PubMed, Embase, and Cochrane up to August 2025. Observational studies were included if they (1) were conducted in the United States, (2) evaluated the use of CGM/CSII across different races/ethnic groups, and (3) reported odds ratios (ORs) for between-group comparisons. Three-level random-effect meta-analyses examined OR in …

Liver Function Tests, Calcium, And Phosphorus Levels In The Graves' Disease Patients, Munaf Faraj Rashid, Haider Abd. Jabbar Alammar, Abbas Mahdi Rahmah

Al-Qadisiyah Medical Journal

Background: Graves' disease is an autoimmune disorder that affects the thyroid gland, a small butterfly-shaped organ located in the anterior of the neck. In this case, the immune system mistakenly attacks the thyroid, leading to the overproduction of thyroid hormones. The most common result of Graves' disease is an overactive thyroid gland, which produces an excess of thyroid hormones (thyroxine or T4 and triiodothyronine or T3). This can lead to symptoms such as weight loss, rapid heartbeat, anxiety, irritability, heat intolerance, and increased sweating. The thyroid gland may become enlarged, causing a noticeable swelling in the front of the neck. …

Psoriasis Effects On Psychological And Daily Activities In Patients Attending To Outpatient Clinics In Aldiwaniyah Teaching Hospital, Saja Abbas Musa, Hassan Raji Jallab, Akeel Hamid Jabur

Al-Qadisiyah Medical Journal

Background: Psoriasis is a chronic immune-related skin disorder affecting 2–3% globally, linked to heart disease, joint issues, metabolic syndrome, and psychological disorders. It also impacts social life, mental health, and work productivity, with added challenges in Middle Eastern patients due to stigma and limited healthcare access. Aim: To assess the psychological and functional impact of psoriasis on patients attending Al-Diwaniyah Teaching Hospital. It focuses on anxiety, depression, social disengagement, and effects on daily activities like work, exercise, sleep, and hygiene. The study also explores the relationship between disease severity and impairment levels. Material and Methods: The study was conducted at …

Correlation Of Norepinephrine With Some Biochemical Parametric In Patients With Type 2 Diabetes Mellitus, Aqeel Abed Nour Hadi, Ferdous A. Jabir, Muhammad Abd-Alwahab

Al-Qadisiyah Medical Journal

Background: Type 2 diabetes is a chronic metabolic disorder characterized by high blood sugar levels (hyperglycemia) resulting from the body's reduced ability to produce or use insulin effectively. Insulin is a hormone that regulates blood sugar levels, and in type 2 diabetes, the body either does not produce enough insulin or becomes resistant to its effects. This causes a buildup of glucose in the bloodstream, which can eventually harm organs and tissues. This study was carried out on patients who attended the Diabetes and Endocrinology Specialist Center of Marjan City for Medical Education in Babil Province; all patients were diagnosed …

Lipase And Tcf7l2 Polymorphism As Indicators Of Pancreatic Dysfunction In Patients With Breast Cancer, Dhay Ihab Al-Jdooa, Ahmed Ghdhban Al-Ziaydi

Al-Qadisiyah Medical Journal

Background: Pancreatic dysfunction is widely acknowledged as a critical issue in individuals with breast cancer. These biomarkers like insulin, lipase, and amylase or polymorphisms such as TCF7L2 can be correlated in assessing breast cancer in conjunction with other medicine relations such as pancreatic health. Objective: The aim of this particular study is to assess the role of breast cancer in pancreatic dysfunction by assessing the aforementioned biomarkers and gene polymorphisms. Methods: Following ethical guidelines, a case-control study was conducted involving female patients diagnosed with breast cancer and other breast cancer-free women. Various combined diagnostic tests, including ROC curve analysis and …

Ophthalmic Complications In Thalassemia Patients Using Iron Chelating Therapy, Haider Aswad Layikh, Zainab Yousif Ismael, Dheya Nema Kadhum

Al-Qadisiyah Medical Journal

Background:\ Thalassemia's are a group of genetic diseases which are considered as the most common single gene disorder which are usually treated with repeated blood transfusions that may lead to iron accumulations in the body with multi organ complications. Objectives:\ The objectives of this study was to evaluate the most commonly observed ocular signs and complications of beta-thalassemia major, as well as to determine whether there are any significant ocular side effects of the iron chelators taken by many of these patients for the treatment of their condition. Materials & Methods:\ this cross sectional study evaluated the …

Detection Of Uropathogenic Multidrug-Resistant Escherichia Coli And Klebsiella Pneumoniae Isolates In Some Immunocompromised Patients., Alaa Abd Atia, Manal Mohammed Kadhim

Al-Qadisiyah Medical Journal

Background: Multidrug-resistant E. coli and K. pneumoniae isolates are the most common causes of acquired urinary tract infections (UTIs). Objective: Conclude the prevalence of multidrug-resistant E. coli and K. pneumoniae isolates in urine samples from immunocompromised patients with UTIs. Methods: A total of 543 urine samples were collected from patients with supposed UTIs. MacConkey, chromogenic agar, and blood culture were used to cultivate the samples. Disk diffusion on Mueller-Hinton agar was used to select cultures that were positive for testing for antibiotic susceptibility. Excel and SPSS software were used to gather and analyze the data. Results: Of …

Limited Predictive Value Of Vaginal Discharge And Cervical Ectropion For Chlamydia Trachomatis Infection Detected By Direct Immunofluorescence, Dian Novitasari, Willy Sandhika, Ashon Sa'adi, Lusiani Tjandra

Folia Medica Indonesiana

Chlamydia trachomatis is one of the most common sexually transmitted infections, often asymptomatic, yet a major cause of infertility. In clinical practice, vaginal discharge and cervical ectropion are frequently used as syndromic indicators. However, their predictive value for Chlamydia trachomatis infection remains limited, particularly in regions with restricted access to NAAT/PCR, such as Indonesia. This study aimed to evaluate the diagnostic value of vaginal discharge and cervical ectropion as predictors of Chlamydia trachomatis infection using the Direct Immunofluorescence (DIF) method. This study used a cross-sectional design conducted among 93 reproductive-aged women from coastal areas of Jember, East Java, Indonesia, who …

Patterns Recognized In Ayres Sensory Integration®: A Scoping Review, Marica Botha, Janine Van Der Linde, Zoe Mailloux

Department of Occupational Therapy Faculty Papers

Background/Objectives: Associations between scores on tests of sensory integration functions demonstrated in numerous studies over six decades have contributed to the development of Ayres Sensory Integration® (ASI) theory and practice. Understanding these "patterns" aids therapists in their interpretation of assessment results, ensuring appropriate and effective intervention. This study aimed to describe and discuss published research on identified patterns related to constructs in the Ayres Sensory Integration® approach. Methods: Arksey and O'Malley's framework and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews Checklist were used. The literature review search was guided by the following …

Comprehensive Prediction Analysis Of Novel Noncoding Regulatory Variants Identified In The Microrna Binding Regions In Complement System Genes, Anthony Shadid, Haydn E Rich, Kathryn D Hok, Marie-Francoise Doursout, Marcos I Restrepo, Nirmal K Banda, Lavanya Gunamalai, Pooja Shivshankar

The Brown Foundation: Institute of Molecular Medicine

The complement system is a central component of innate immunity that coordinates host defense, immune surveillance, and inflammatory responses through tightly regulated proteolytic cascades. Genetic variation within complement genes contributes substantially to interindividual differences in complement activity and disease susceptibility. While coding variants directly alter complement protein structure and function, the microRNA (miRNA)-mediated control and post-transcriptional regulation is not fully understood in shaping complement gene expression across immune and inflammatory mechanisms. Complement pathway genes exhibit extensive and heterogeneous 3'-untranslated regions (3'UTRs), which serve as primary platforms for miRNA binding and RNA-binding protein interactions. Both common and rare single-nucleotide polymorphisms within …

Liver Function Test (Lfts) Revealed Ameliorative Effect Of Probiotics And Antibiotics As Therapeutic Agents Against Experimentally Induced Enterotoxemia In Goat, Muhammad Mohsen, Jam Kashif Zaman, Amjad Hussain Mirani, Nazeer Hussain Kalhoro, Benazir Sahito

Journal of Bioresource Management

Present study was conducted to evaluate the various liver enzymes in experimentally induced enterotoxemic goat inorder to ensure the therapeutic potential of probiotics and antibiotics. Experiment was conducted at Department of Veterinary Medicine, Sindh Agriculture University Tandojam in which 35 non-descriptive goats were housed and experimenatally induced with enterotoxemia by inoculation of Clostridium perfringens culture surgically by performing laparotomy into intestine. After apperence of positive clinical signs of infection, goats were randomly divided into 5 treatment groups i.e. Group 1 (negative control), Group 2 (positive control), Group 3 (yogurt, 5 % solution, 50 mL/time), Group 4 (Yeast, 5 % solution, …

Male Allyship: What Utahns Need To Know, Susan R. Madsen, Deborah Lin

Marketing and Strategy Faculty Publications

Women do not always have the same opportunities as men, particularly in cultures where more traditional gender norms are embraced. Male allyship can positively impact women’s lives by increasing opportunities (e.g., safety, education attainment, career development, financial security). In addition, understanding and embracing gender differences can optimize women’s participation and leadership contributions. By intentionally removing barriers and encouraging full participation, women’s talents and perspectives can be leveraged. This both expands opportunities for women and enhances innovation, improves decision-making, and contributes to stronger communities.

Modeling Framework To Demonstrate Elimination Of A Vector Population: Tsetse Elimination In Chad, John Hargrove, Mahamat Hissene Mahamat, Moukhtar Aldjibert, Wilfrid Yoni, Djoukzoumka Signaboubo, Justin Darnas, Ernest Salou, Inaki Tirados, Albert Mugenyi, Priscille Barreaux, Philippe Solano, Antoine Marc Gaby Barreaux

All Peer-Reviewed Publications

Every year, over 700,000 people, particularly children under five, die from vector-borne diseases worldwide. Effectively controlling endemics and preventing new outbreaks requires an integrated approach that can lead to the elimination of both vectors and diseases. In the last two decades, integrating medical interventions and vector control has significantly reduced the incidence of Gambian Human African Trypanosomiasis (g-HAT), with the World Health Organization validating eight countries as having eliminated the disease as a public health problem. However, elimination of the tsetse vector has not been confirmed, leaving the possibility of re-emergence. We developed a six-step modeling framework to assess vector …

Tumor-Immune Dynamics With Memory And Time Delay: A Fractional-Order Model With Ctla-4 Regulation, Mutaz Mohammad, Mohyeedden Sweidan, Alexander Trounev, Fathalla Rihan

All Works

This study develops a fractional-order tumor-immune interaction model incorporating Caputo memory effects, delayed immune activation, and CTLA-4 checkpoint regulation. The model describes the coupled dynamics of tumor cells, CD4^+ T cells, IFN-γ, and CTLA-4, and extends classical integer-order tumor-immune models by accounting for hereditary immune responses and biologically motivated latency effects. Theoretical properties, including positivity, boundedness, equilibrium structure, and fractional-order stability, are examined to establish the biological and mathematical consistency of the model. The delayed fractional system is then investigated computationally by comparing several numerical methods, including finite difference discretization, Daubechies wavelet collocation, Euler wavelet collocation, and a predictor-corrector scheme. …

Postural Adaptations In Young Roller Skate Athletes: Effects Of Eight Weeks Of Proprioceptive And Strengthening Training On Static Balance, Widi Arti, Suprianto Suprianto, Hening Laswati Putra, Gadis Meinar Sari, Okky Zubairi Abdillah

Folia Medica Indonesiana

Static and dynamic balance are vital for performance and injury prevention in roller skate athletes. While proprioceptive and strengthening exercises are extensively used, evidence of their combined impact in young athletes is rare. This study evaluated the effects of an eight-week proprioceptive and strengthening program on postural and lower-limb balance parameters in roller skaters aged 11–15 years. The study randomly assigned 30 athletes to an intervention group (n=15) or a control group (n=15). The intervention group trained three times per week with structured exercises, while the control group continued routine skating and endurance activities. Balance outcomes were assessed using the …

Anti-Photoaging Activity Of Kombucha Coffee (Coffea Canephora) Extract Antioxidant Moisturizer On Ultraviolet-B Induced Malondialdehyde In Mice Skin, Renata Prameswari, Lifia Chandra, Dian Ardiana

Folia Medica Indonesiana

Photoaging caused by chronic sun exposure exhibits characteristics similar to intrinsic aging, including skin thinning, moisture loss, roughness, collagen degradation, and wrinkle formation. This process is driven by oxidative stress and the formation of malondialdehyde (MDA) as a result of lipid peroxidation. Topical intervention using antioxidant-based moisturizers could prevent further damage. Robusta coffee (Coffea canephora), high levels of chlorogenic acid and caffeine, is known for its antioxidant properties. When fermented with a Symbiotic Culture of Bacteria and Yeast (SCOBY) to produce kombucha coffee, its bioactive compounds are enhanced, potentially offering additional protection against oxidative stress and photoaging. This …

Effect Of Kebar Leaf (Biophytum Petersianum) Extract On Lh Levels And Ovarian Follicle Development In A Pcos Rat Model, Aprilia Pratiwi Iriani Bahar, Sri Ratna Dwiningsih, Widjiati Widjiati, Sutrisno Sutrisno

Folia Medica Indonesiana

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, commonly characterized by elevated luteinizing hormone (LH) and decreased follicle-stimulating hormone (FSH) levels. These hormonal imbalances impair folliculogenesis and ovulation, often resulting in infertility. This study aimed to evaluate the effects of Biophytum petersianum (Kebar leaf) extract on LH levels and ovarian follicle development in a testosterone propionate-induced rat model of PCOS. A total of 30 adult female white rats (Rattus norvegicus) were randomly assigned to five groups: a negative control (K^–), a positive control with PCOS induction (K⁺), and …

Cracking The Code Of Resistance: Carbapenem-Resistant Urinary Tract Infections In Public And Private Hospitals, Shaista Bakhat, Fakhur Uddin, Muhammad Sohail, Shehla M. Baqai, Naresh Kumar, Saman Nadeem

Folia Medica Indonesiana

This research aimed to analogize the resistance patterns against carbapenem antibiotics in Enterobacterales uropathogens between two healthcare facilities. The authors performed this study at the Basic Medical Sciences Institute, Jinnah Postgraduate Medical Center, and the National Medical Center. A total of 374 UTI patients were enrolled, equally distributed in the two centers (187 each hospital). Molecular assays supplemented phenotypic susceptibility testing to detect carbapenem resistance. Statistical analysis, including multivariate logistic regression, was performed to identify associations between hospital type and carbapenem resistance. Of 374 urine samples, CA-UTIs were found in 86 (23.1%) and 90 (24%), while HA-UTIs occurred in 101 …

Lymphovascular Invasion (Lvi) In Ovarian Epithelial Cancer: A Determinant Of Figo 2014 Stage, Intan Septia. J, Aswiyanti Asri, Puja Agung Antonius, Shinta Ayu Intan, Almurdi Almurdi

Folia Medica Indonesiana

Ovarian epithelial cancer is an ovarian malignancy with the highest mortality rate in gynecologic oncology. Its incidence increases after the age of 50 and is associated with various risk factors. Carcinogenesis is driven by factors such as incessant ovulation, gonadotropin stimulation, and postmenopausal hormonal fluctuations. These factors cause DNA damage in ovarian epithelial cells through specific molecular pathways, resulting in diverse histopathological types and subtypes. Furthermore, the disease's progression and staging are significantly impacted by its pathways of spread via blood vessels and lymphatics known as LVI (Lymphovascular Invasion). This study employed a comparative observational analytical design with a cross-sectional …

Burden And Determinants Of Diarrheal Disease Among Children Under Five In East Java, Indonesia: Findings From Ssgi 2024, Raudia Faridah Humaidy, Soraya Isfandiary Iskandar, Sophia Zahra, Sovia Salamah

Folia Medica Indonesiana

Diarrhea is one of the leading causes of morbidity among children under five in Indonesia and remains a major public health concern, particularly in the province East Java, which has the second-highest disease burden in the country. Unfortunately, evidence for provincial-level predictors of childhood diarrhea using recent national data is limited. This study aimed to estimate the burden of diarrhea among children under five and identify its associated factors to support targeted child health interventions. A cross-sectional analysis was conducted utilizing data from the 2024 Indonesian Nutrition Status Survey (SSGI). Data on children under five residing in East Java with …

Effectiveness Of Laser Acupuncture Therapy Compared With Nsaids On Pain Reduction And Quality Of Life In Patients With Knee Osteoarthritis: A Randomized Controlled Trial, Virgyawan Rizki, Teuku Nanta Aulia, Putri Ade Mueratana, Onarisa Ayu, Muhammad Yusuf

Folia Medica Indonesiana

Knee osteoarthritis (OA) is a major cause of chronic pain and disability, and although NSAIDs are widely used, prolonged therapy may increase the risk of adverse effects. Laser acupuncture has been proposed as a non-invasive option to reduce pain and improve knee-related outcomes. This randomized controlled trial compared laser acupuncture and NSAID therapy in 32 patients with knee OA (Kellgren–Lawrence grade II–III) who were randomized equally to laser acupuncture (n = 16) or NSAIDs (n = 16). The authors assessed pain using the Visual Analog Scale (VAS). Meanwhile, we evaluated knee function and knee-related quality of life using the Knee …

The Effects Of Kombucha Consumption On Obesity And Diabetes Outcomes, Linda Linda, Lina Lukitasari, Rahmad Darmawan, Citrawati Dyah Kencono Wungu, Roikhatul Khusniyah, Ervi Audina Munthe

Folia Medica Indonesiana

Numerous clinical trials have explored the potential of kombucha in addressing obesity and diabetes. Nonetheless, a thorough and integrated analysis of findings from these trials remains lacking. Hence, this review seeks to assess effects of kombucha on metabolic parameters and examine the reliability and quality of available clinical evidence to support its role as a dietary intervention. Studies were sourced from scientific databases: PubMed, Scopus, and Web of Science. This review included studies that reported outcomes related to obesity and diabetes in individuals with either condition who received kombucha as an intervention. There were six clinical trials included. A total …

Extracellular Vesicles In Adult Acute Myeloid Leukemia, Haniatul Qomariya, Fitrotin Azizah, Yetti Hernaningsih

Folia Medica Indonesiana

Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy marked by uncontrolled expansion of immature myeloid cells and disruption of normal hematopoiesis. Beyond genetic abnormalities, accumulating evidence demonstrates that leukemic progression is strongly shaped by intercellular communication within the bone marrow niche. Extracellular vesicles (EVs), including exosomes and microvesicles, have emerged as key mediators of this communication, transporting bioactive molecules that influence leukemic cell behavior, immune responses, and treatment sensitivity. This systematic review synthesizes current findings on EVs in adult AML, focusing on their biogenesis, molecular cargo, roles in disease pathogenesis, diagnostic and prognostic relevance, and therapeutic potential. Following PRISMA …

The Inflammatory Link Between Obesity, Quality Of Life, And Female Sexual Dysfunction: The Role Of Interleukin-6, Amelia Putri Ariyani, Lilik Herawati, Zidni Imanurrohmah Lubis, Alifia Syafira Putri, Adhiratih Ken Sari

Folia Medica Indonesiana

Female sexual dysfunction (FSD) is a common condition that impairs women's quality of life and is frequently associated with obesity. Beyond hormonal and vascular mechanisms, chronic low-grade inflammation, particularly elevated interleukin-6 (IL-6), has been proposed as a biological mediator of this association. This systematic review, registered in PROSPERO (CRD420251046082), aimed to evaluate the role of IL-6 in mediating the association between obesity and FSD. A comprehensive search of PubMed, Scopus, Embase, and Web of Science was conducted for studies published between 2018 and 2025, focusing on obese women, quantitative IL-6 measurements, and validated assessments of sexual function such as the …

Spatio-Temporal And Determinants Of Hiv Incidence Among Msm In Jember Kidul, Indonesia, Siswi Wijayanti, Budi Utomo, Musofa Rusli

Folia Medica Indonesiana

Human immunodeficiency virus (HIV) remains a major public health issue, particularly among men who have sex with men (MSM), who are estimated to have more than 20-fold higher risk of HIV infection than the general population. In Indonesia, MSM are disproportionately affected, with surveillance data showing steady annual increases. In Jember Regency, East Java, HIV cases have risen over the past decade, with MSM contributing significantly to new diagnoses. Despite available therapy and prevention programs, transmission persists, suggesting geographic and social factors play a role. Spatio-temporal analysis using Geographic Information Systems (GIS) and spatial statistics such as Moran's I and …