Medicine and Health Sciences Commons^™

Middle Cerebral O₂ Delivery During The Modified Oxford Maneuver Increases With Sodium Nitroprusside And Decreases During Phenylephrine, Julian M. Stewart, Marvin S. Medow, Andrew Delpozzi, Zachary R. Messer, Courtney Terilli, Christopher E. Schwartz

NYMC Faculty Publications

The modified Oxford maneuver is the reference standard for assessing arterial baroreflex function. The maneuver comprises a systemic bolus injection of 100 μg sodium nitroprusside (SNP) followed by 150 μg phenylephrine (PE). On the one hand, this results in an increase in oxyhemoglobin and total hemoglobin followed by a decrease within the cerebral sample volume illuminated by near-infrared spectroscopy (NIRS). On the other hand, it produces a decrease in cerebral blood flow velocity (CBFv) within the middle cerebral artery (MCA) during SNP and an increase in CBFv during PE as measured by transcranial Doppler ultrasound. To resolve this apparent discrepancy, …

Myelodysplasia: New Approaches, Karen Seiter

NYMC Faculty Publications

The myelodysplastic syndromes (MDS) are a group of clonal hematopoietic disorders characterized by bone marrow failure and a risk of progression to acute myelogenous leukemia (AML). A precise diagnosis is critical, because there is overlap between the clinical and laboratory findings of MDS and other malignant and nonmalignant hematologic disorders. Several prognostic scoring systems (IPSS, WPSS, LR-PSS, and IPSS-R) assess a patient's risk of progression to AML and overall survival. Many patients are elderly, so age and comorbidities are an important consideration. Patients with lower-risk disease are treated with growth factors (erythropoietin stimulating agents and/or G-CSF) and immunomodulatory agents (antithymocyte …

Gene Loss, Thermogenesis, And The Origin Of Birds, Stuart A. Newman, Nadezhda V. Mezentseva, Alexander V. Badyaev

NYMC Faculty Publications

Compared to related taxa, birds have exceptionally enlarged and diversified skeletal muscles, features that are closely associated with skeletal diversification and are commonly explained by a diversity of avian ecological niches and locomotion types. The thermogenic muscle hypothesis (TMH) for the origin of birds proposes that such muscle hyperplasia and the associated skeletal innovations are instead the consequence of the avian clade originating from an ancestral population that underwent several successive episodes of loss of genes associated with thermogenesis, myogenesis, and skeletogenesis. Direct bird ancestors met this challenge with a combination of behavioral strategies (e.g., brooding of nestlings) and acquisition …

Evidence For Novel Aspects Of Nox4 Oxidase Regulation Of Mitochondrial Function And Peroxide Generation In An Endothelial Cell Model Of Senescence, Michael S. Wolin

NYMC Faculty Publications

Observations by Kozieł et al. reported in this issue of the Biochemical Journal suggest the existence of novel regulatory processes associated with new evidence for increased Nox4 (NAPDH oxidase 4) regulation of mitochondrial function in a cultured endothelial cell aging-induced senescence model. Cellular aging appears to promote a Nox4 interaction with mitochondria that disrupts complex I in the electron transport chain and increases the detection of mitochondrial H(2)O(2). Nox4 appears to maintain a highly interconnected mitochondrial network, which may influence mitochondrial fission and/or fusion mechanisms in a manner that could be a contributing factor in the loss of replicative lifespan …

Effect Of Fundamental Frequency At Voice Onset On Vocal Attack Time, Ben C. Watson, R J. Baken, Rick M. Roark, Stephanie Reid, Melissa Ribeiro, Weilyn Tsai

NYMC Faculty Publications

OBJECTIVE: To examine vocal attack time (VAT) values associated with the production of low, mid, and high rates of vocal fold vibration in normal speakers. STUDY DESIGN: Sound pressure (SP) and electroglottographic (EGG) recordings were obtained for eight female and five male subjects while producing multiple tokens of the sustained vowels /ɑ/, /i/, and /u/ at comfortable loudness and at mid, low (-3 semitones), and high (+6 semitones) rates of vocal fold vibration. METHODS: Generalized sinusoidal models of the SP and EGG signals were computed to compare rates of amplitude change. VAT was computed from the time lag of the …

Deconstructing Mtor Complexes In Regulation Of Glioblastoma Multiforme And Its Stem Cells, Meena Jhanwar-Uniyal, Dhruve Jeevan, Jayson Neil, Craig Shannon, Ladislau Albert, Raj Murali

NYMC Faculty Publications

Atypical serine-threonine kinase, mTOR (mechanistic target of Rapamycin; originally coined "mammalian TOR"), exists in two distinct multi-protein complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2), that senses and integrates a variety of environmental signals to control organism growth and homeostasis via non-overlapping signaling pathways. mTOR belongs to the phosphoinositide 3-kinase (PI3-K)-related kinase family, and an aberrant activation of mTORC1 is a potential contributing factor in uncontrolled cell growth, proliferation, and survival of tumor cells via specific effects on cap-dependent translation initiation, as well as in a more sustained manner via advancing ribosome biogenesis. It is thereby shown to be …

Stroke-Associated Differences In Rates Of Activity Of Daily Living Loss Emerge Years Before Stroke Onset, Benjamin Capistrant, Q Wang, Sze Yan Liu, M. Maria Glymour

Department of Public Health Scholarship and Creative Works

Objectives

To compare typical age-related changes in activities of daily living (ADL) independence in stroke-free adults to long-term ADL trajectories before and after stroke.

Study Design, Setting, and Participants

Prospective, observational cohort of 18,441 Health and Retirement Study participants who were stroke-free in 1998 and followed through 2008 (average follow-up=7.9 years).

Measurements

Strokes were assessed with self- or proxy-report of a doctor’s diagnosis and month/year of event. We used logistic regression to compare within-person changes in odds of self-reported independence in 5 ADLs among those who remained stroke free throughout follow-up (n=16,816); those who survived a stroke (n=1,208); and those …

Relationship Of Cellular Topoisomerase Iiα Inhibition To Cytotoxicity And Published Genotoxicity Of Fluoroquinolone Antibiotics In V79 Cells, Gary M. Williams, Klaus D. Brunnemann, Daniel J. Smart, David Molina, Alan M. Jeffrey, Jian-Dong Duan, Niels Krebsfaenger, Andreas Kampkoetter, Gabriele Schmuck

NYMC Faculty Publications

Fluoroquinolone (FQ) antibiotics are bacteriocidal through inhibition of the bacterial gyrase and at sufficient concentrations in vitro, they can inhibit the homologous eukaryotic topoisomerase (TOPO) II enzyme. FQ exert a variety of genotoxic effects in mammalian systems through mechanisms not yet established, but which are postulated to involve inhibition of TOPO II enzymes. To assess the relationship of inhibition of cell nuclear TOPO II to cytotoxicity and reported genotoxicity, two FQ, clinafloxacin (CLFX) and lomefloxacin (LOFX), having available genotoxicity data showing substantial differences with CLFX being more potent than LOFX, were selected for study. The relative inhibitory activities of these …

Mek And The Inhibitors: From Bench To Bedside, Akintunde Akinleye, Muhammad Furqan, Nikhil Mukhi, Pavan Ravella, Delong Liu

NYMC Faculty Publications

Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK inhibitors are in clinical trials. Trametinib is being evaluated by FDA for the treatment of metastatic melanoma with BRAF V600 mutation. Selumetinib has been studied in combination with docetaxel in phase II randomized trial in previously treated patients with advanced lung cancer. Selumetinib group had better response rate and progression-free survival. This review also summarized new MEK inhibitors in clinical development, including pimasertib, refametinib, PD-0325901, TAK733, MEK162 (ARRY 438162), RO5126766, WX-554, RO4987655 (CH4987655), GDC-0973 …

Parasitological Prevalence Of Bovine Trypanosomosis In Kubo Division Of Kwale County Of Coastal: Baseline Survey, N. Mbahin, H. Affognon, J. Andoke, M. Tiberius, D. Mbuvi, J. Otieno, P. Muasa, R. K. Saini

All Peer-Reviewed Publications

Prior to field trials of large scale tsetse repellent technology validation in July 2011, a cross-sectional survey of bovine trypanosomosis and its vectors was carried out to know the disease level in Kwale County of Coastal Kenya. A total of 584 adult cattle were examined at ten different Locations. The trypanosome prevalence in cattle with regard to age, sex, location and apparent tsetse density was investigated. The overall trypanosome prevalence in cattle in Kubo Division of Kwale County was 33.9%. Two types of infections were recorded in various parts of the Division in the following proportions: T. congolense 61.1%, T. …

Anti-Seizure Medications And Estradiol For Neuroprotection In Epilepsy: The 2013 Update, Libor Velisek, Nino Nebieridze, Tamar Chachua, Jana Veliskova

NYMC Faculty Publications

Current epilepsy therapy is still symptomatic using anti-seizure, rather than anti-epileptic, medications. This therapy may control the seizure activity but does not prevent or even cure epilepsy. Treatment strategies that could interfere with the process leading to epilepsy (epileptogenesis) would have significant benefits over the current approaches. Neuronal damage contributing to remodeling of the neuronal networks (such as in the hippocampus during temporal lobe epilepsy) is one of the significant components of ongoing epileptogenesis. Thus, treatment strategies alleviating seizure-induced neuronal damage and network reorganization may become powerful tools fighting the deteriorating process of epileptogenesis. Current anti-seizure medications, especially valproic acid, …

[The Great European Georg Friedrich Nicolai: Physician And Pacifist. Berlin, Germany, 1874 - Santiago, Chile, 1964], Felipe Cabello C

NYMC Faculty Publications

Georg Friedrich Nicolai (1874-1964) was a German physician and physiologist whose pacifism during the First World War led him in 1914 to cosign with W. J. Foerster, A. Einstein and O. Bueck a "Manifesto to the Europeans" against the entry of Germany into the war and the invasion of Belgium. As a result of this appeal and his strong pacifism, Nicolai lost his positions as cardiologist to the German royal family, professor at the University of Berlin and chief of laboratory at the Charite hospital also in Berlin, and was sent as a garrison physician in Graundenz, in today's Poland. …

Messengers Without Borders: Mediators Of Systemic Inflammatory Response In Aki, Brian B. Ratliff, May M. Rabadi, Radovan Vasko, Kaoru Yasuda, Michael S. Goligorsky

NYMC Faculty Publications

The list of signals sent by an injured organ to systemic circulation, so-called danger signals, is growing to include multiple metabolites and secreted moieties, thus revealing a highly complex and integrated network of interlinked systemic proinflammatory and proregenerative messages. Emerging new data indicate that, apart from the well established local inflammatory response to AKI, danger signaling unleashes a cascade of precisely timed, interdependent, and intensity-gradated mediators responsible for development of the systemic inflammatory response. This fledgling realization of the importance of the systemic inflammatory response to the localized injury and inflammation is at the core of this brief overview. It …

Differences And Similarities Between Culture-Confirmed Human Granulocytic Anaplasmosis And Early Lyme Disease, Gary P. Wormser, Maria E. Aguero-Rosenfeld, Mary E. Cox, John Nowakowski, Robert B. Nadelman, Diane Holmgren, Donna Mckenna, Susan Bittker, Lois Zentmaier, Denise Cooper, Dionysios Liveris, Ira Schwartz, Harold W. Horowitz

NYMC Faculty Publications

Lyme disease is transmitted by the bite of certain Ixodes ticks, which can also transmit Anaplasma phagocytophilum, the cause of human granulocytic anaplasmosis (HGA). Although culture can be used to identify patients infected with A. phagocytophilum and is the microbiologic gold standard, few studies have evaluated culture-confirmed patients with HGA. We conducted a prospective study in which blood culture was used to detect HGA infection in patients with a compatible clinical illness. Early Lyme disease was defined by the presence of erythema migrans. The epidemiologic, clinical, and laboratory features of 44 patients with culture-confirmed HGA were compared with those of …

Methyleugenol Hepatocellular Cancer Initiating Effects In Rat Liver, Gary M. Williams, Michael J. Iatropoulos, Alan M. Jeffrey, Jian-Dong Duan

NYMC Faculty Publications

Methyleugenol (MEG), a constituent of plants used in the human diet, is hepatocarcinogenic in rodents. In an experiment to elucidate its mode of action in rat liver, male F344 rats were administered MEG intragastrically at 3 doses per week for up to 16 weeks in an initiation phase, after which half the rats were fed 500 ppm phenobarbital (PB) in the diet to promote liver neoplasia and the other half were maintained on control diet for 24 weeks. At 8 and 16 week interim terminations, (32)P-nucleotide postlabeling assay revealed 3 adducts in livers of all MEG groups. The hepatocellular replicating …

Zanthoxoaporphines A-C: Three New Larvicidal Dibenzo[De,G]Quinolin-7-One Alkaloids From Zanthoxylum Paracanthum (Rutaceae), Fidelis N. Samita, Louis P. Sandjo, Isaiah O. Ndiege, Ahmed Hassanali, Wilber Lwande

All Peer-Reviewed Publications

The bioassay-guided purification of Zanthoxylum paracanthum (Rutaceae) extracts led to the isolation of three new alkaloids, namely 1-hydroxy-10-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxoaporphine A, 2), 1-hydroxy-7H-dibenzo[de,g]quinolin- 7-one (zanthoxoaporphine B, 3) and 1,8-dihydroxy-9-methoxy-7H-dibenzo[de,g]quinolin-7-one (zanthoxaporphine C, 4), and a known lignan identified as sesamin (1). Isolation and purification of the constituent compounds was achieved through conventional chromatographic methods. The chemical structures of the isolated compounds were determined on the basis of UV, IR, NMR and MS data, and confirmed by comparison with those reported in the literature. The larvicidal activity of some of the isolated compounds was investigated by using third-instar Anopheles gambiae larvae. © 2013 …

Serotonin And Dopamine In Essential Hypertension, Charles T. Stier

NYMC Faculty Publications

No abstract provided.

Sex And Hormonal Influences On Seizures And Epilepsy, Jana Velíšková, Kara A. Desantis

NYMC Faculty Publications

Epilepsy is the third most common chronic neurological disorder. Clinical and experimental evidence supports the role of sex and influence of sex hormones on seizures and epilepsy as well as alterations of the endocrine system and levels of sex hormones by epileptiform activity. Conversely, seizures are sensitive to changes in sex hormone levels, which in turn may affect the seizure-induced neuronal damage. The effects of reproductive hormones on neuronal excitability and seizure-induced damage are complex to contradictory and depend on different mechanisms, which have to be accounted for in data interpretation. Both estradiol and progesterone/allopregnanolone may have beneficial effects for …

Lack Of Resveratrol Neuroprotection In Developing Rats Treated With Kainic Acid, L K. Friedman, B Goldstein, A Rafiuddin, P Roblejo, S Friedman

NYMC Faculty Publications

In adult rats, trans-resveratrol attenuates kainic acid (KA)-induced convulsions and the associated hippocampal neurotoxicity. Increased neuronal survival was correlated with reduced lipid peroxidation. Since free radical generation after KA is age dependent and does not correlate with the onset of seizure-induced injury, the present study investigated whether daily trans-resveratrol treatment in development could protect the juvenile hippocampus from seizures and onset of damage at postnatal (P) day 21. Rat pups were treated with daily injections of trans-resveratrol under three dosage regimens (1-15 mg/kg and 20-50mg/kg). Weight, electroencephalography (EEG), histology, and N-methyl-d-aspartate (NMDA) receptor expression were determined. Malondialdehyde (MDA) concentration was …

Phi X 174, David J. Hall

Infectious Pathogens

Phi X 174 database number # 1CD3. Phi X 174 is a virus that infects bacteria and was the first DNA-based genome to be sequenced in 1977. This bacteriophage has a [+] circular single-stranded DNA genome. The assembly of the capsid has been successfully done in vitro and is the focus of many studies on self-assembly, drug delivery and nanotechnology.

Dengue Virus, David J. Hall

Infectious Pathogens

Dengue virus, database # 1THD Dengue fever, is an infectious tropical disease caused by the dengue virus and transmitted by mosquito. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. In a small proportion of cases the disease develops into the life-threatening dengue hemorrhagic fever. Dengue is a positive strand RNA virus that is part of the flavivirus family. Dengue is an enveloped virus meaning it has a nucleocapsid protecting the RNA and the nucleocapsid is surrounded by lipids (hence the name enveloped).

Human Papilloma Virus 16, David J. Hall

Infectious Pathogens

Human Papilloma virus 16, database# 1DZL Infection by most papillomaviruses is either asymptomatic or causes small benign tumors, known as papillomas or warts (e.g. human papillomavirus HPV6 or HPV11). Papillomas caused by some types, however, such as human papillomaviruses 16 and 18, carry a risk of becoming cancerous. Human papilloma virus is a non-enveloped, double stranded, circular DNA virus.

Hepatitis B, David J. Hall

Infectious Pathogens

Hepatitis B, database # 2g33. Hepatitis B is an infectious inflammatory illness of the liver caused by the hepatitis B virus (HBV). Hepatitis B virus (HBV) is a member of the Hepadnavirus family.The virus particle, (virion) consists of an outer lipid envelope and an icosahedral nucleocapsid core composed of protein. These virions are 42 nM in diameter. The nucleocapsid encloses the viral DNA and a DNA polymerase that has reverse transcriptase activity.

Nfib Vs Sebelius: The Political Expediency Of The Roberts Court, Michael K. Gusmano

NYMC Faculty Publications

No abstract provided.

Advances In Hematopoietic Stem Cell Transplantation In Childhood And Adolescent Lymphomas, Mitchell S. Cairo, Willi Woessmann, John Pagel

NYMC Faculty Publications

No abstract provided.

Single-Tier Testing With The C6 Peptide Elisa Kit Compared With Two-Tier Testing For Lyme Disease, Gary P. Wormser, Martin Schriefer, Maria E. Aguero-Rosenfeld, Andrew Levin, Allen C. Steere, Robert B. Nadelman, John Nowakowski, Adriana Marques, Barbara J. Johnson, J Stephen Dumler

NYMC Faculty Publications

For the diagnosis of Lyme disease, the 2-tier serologic testing protocol for Lyme disease has a number of shortcomings including low sensitivity in early disease; increased cost, time, and labor; and subjectivity in the interpretation of immunoblots. In this study, the diagnostic accuracy of a single-tier commercial C6 ELISA kit was compared with 2-tier testing. The results showed that the C6 ELISA was significantly more sensitive than 2-tier testing with sensitivities of 66.5% (95% confidence interval [CI] 61.7-71.1) and 35.2% (95% CI 30.6-40.1), respectively (P < 0.001) in 403 sera from patients with erythema migrans. The C6 ELISA had sensitivity statistically comparable to 2-tier testing in sera from Lyme disease patients with early neurologic manifestations (88.6% versus 77.3%, P = 0.13) or arthritis (98.3% versus 95.6%, P = 0.38). The specificities of C6 ELISA and 2-tier testing in over 2200 blood donors, patients with other conditions, and Lyme disease vaccine recipients were found to be 98.9% and 99.5%, respectively (P < 0.05, 95% CI surrounding the 0.6 percentage point difference of 0.04 to 1.15). In conclusion, using a reference standard of 2-tier testing, the C6 ELISA as a single-step serodiagnostic test provided increased sensitivity in early Lyme disease with comparable sensitivity in later manifestations of Lyme disease. The C6 ELISA had slightly decreased specificity. Future studies should evaluate the performance of the C6 ELISA compared with 2-tier testing in routine clinical practice.

Modulation Of The Axon-Reflex Response To Local Heat By Reactive Oxygen Species In Subjects With Chronic Fatigue Syndrome, Marvin S. Medow, Arun Aggarwal, Ila Baugham, Zachary Messer, Julian M. Stewart

NYMC Faculty Publications

Local cutaneous heating causes vasodilation as an initial first peak, a nadir, and increase to plateau. Reactive oxygen species (ROS) modulate the heat plateau in healthy controls. The initial peak, due to C-fiber nociceptor-mediated axon reflexes, is blunted with local anesthetics and may serve as a surrogate for the cutaneous response to peripheral heat. Chronic fatigue syndrome (CFS) subjects report increased perception of pain. To determine the role of ROS in this neurally mediated response, we evaluated changes in cutaneous blood flow from local heat in nine CFS subjects (16-22 yr) compared with eight healthy controls (18-26 yr). We heated …

Vascular And Heart Diseases In The Incumbent Presidents And Vice Presidents Of The United States Of America: A Medical-Historical Perspective, William H. Frishman, Franklin H. Zimmerman, Robert G. Lerner

NYMC Faculty Publications

Vascular diseases have been the major cause of death and disability in presidents and vice presidents of the United States. Untreated hypertension and cigarette smoking have contributed greatly to this increased morbidity and mortality risk, which has impacted on historical events, especially in the 20th century. In this article, the medical histories of those incumbent Presidents and Vice Presidents who suffered from coronary artery and cerebrovascular diseases will be reviewed. A discussion of how atrial fibrillation has affected the Presidents is also included.

Sleep Experiences Of Hospitalized Antepartum Patients, Andrea M. Erwin

Nursing Dissertations - Archive

For many women, pregnancy can be a time of sleep disturbance. Physiological, hormonal, and emotional changes associated with pregnancy often lead to sleep disturbance. Women who develop antepartum complications frequently are prescribed bed rest and hospitalization. Both pregnancy and hospitalization can influence sleep. This study examined the sleep experience of hospitalized antepartum women. The purposes of this descriptive correlational study were to determine whether being in the hospital affects sleep in pregnant women, gestational age influences sleep while hospitalized, and patient's usual sleep patterns influence sleep during hospitalization. A conceptual model of impaired sleep for the childbearing family provided theoretical …

A Correlational Study Of A Reading Comprehension Program And Attrition Rates Of Esl Nursing Students In Texas, Wendy Morris Donnell

Nursing Dissertations - Archive

Decreasing the attrition rate of nursing students has become an important issue for programs in Texas as a means to alleviate the nursing shortage (THECB, 2009). Programs are admitting a more diverse group of students but attrition has historically been high among minority groups (Gilchrist & Rector, 2007). The purpose of this study was to examine the associations between English as a Second Language (ESL), a reading comprehension program, and attrition rates of nursing students. A secondary analysis of a large database which included nursing students from 27 initial licensure programs in Texas was completed. Jeffreys (2012) NURS model was …