Medicine and Health Sciences Commons^™

Virtual Screening Of Erp57 Inhibitors Using Artificial Intelligence, Marwa Dreah, Nuwan De Silva

Three Minute Thesis (3MT)

No abstract provided.

Bridging Health And Function: Integrating Occupational Therapy Into An Urgent Care Campus Health Center, Brooke Mckeon

Three Minute Thesis (3MT)

No abstract provided.

Mocra And The New Cosmetics Gmps, Brandi Reinbold

Oxford ICSB

The Modernization of Cosmetics Regulation Act (MoCRA) enacted by Congress December 29th, 2022, includes provisions for the FDA to publish proposed Good Manufacturing Practice (GMP) regulations by the end of 2024 and a final rule by the end of 2025. In this talk we will explore what the language of MoCRA tells us about what GMPs are likely to be promulgated with a focus on GMPs related to ingredient and finished product identity and purity. MoCRA exempts small cosmetics manufacturers from GMP compliance requirements and directs FDA to “take it easy” on other not-quite-so-small manufacturers. Despite these exemptions, most cosmetics …

The Physiological Demands Of A Division Iii Field Hockey Goalie: A Case Study, Kayla Brady, Sarah Miller-Richards

Student Scholar Showcase

It is essential to evaluate the physiological demands of the sport of field hockey, specifically of a division III field hockey goalie. There has been limited research on this sport, let alone on the position of goalies. Some recent studies have evaluated ice hockey goalies on their anthropometrics, upper and lower body strength, power output, and aerobic capacity. The purpose of this study was to examine the physiological demands and performance profile of a division III field hockey goalkeeper. A division III goalie went through several baseline tests including anthropometrics, resting and maximum heart rate, upper and lower one rep …

Session E Overview Of The U.S. Cosmetics Regulatory Framework, Jannavi Srinivasan

Oxford ICSB

Cosmetic products in the U.S. has been regulated by the Food and Drug Administration (FDA) according to the Federal Food, Drug, and Cosmetic Act which has provided for FDA’s regulation of cosmetics since 1938. The Modernization of Cosmetics Regulation Act (MoCRA), enacted in December of 2022, significantly expanded and reformed regulations overseeing cosmetics in the U.S. Included in MoCRA among other provisions, are facility registration and product listing, reporting of serious adverse events, and a requirement that FDA propose a rule for good manufacturing practices. This presentation will provide an overview of cosmetics regulations including the major provisions of MoCRA …

Impact Of Mocra When Assessing Botanical Safety, Rick Kingston

Oxford ICSB

The Modernization of Cosmetics Regulation Act of 2022 (MoCRA) became effective December 29th, 2023. MoCRA is the most significant expansion of FDA’s authority to regulate cosmetics since the Federal Food, Drug, and Cosmetic (FD&C) Act was enacted in 1938. MoCRA expands the FDA's rulemaking and enforcement authority over cosmetics and creates new compliance obligations for manufacturers. There are six key areas of the legislation including Facility Registration, Product & Ingredient Listing, Safety Substantiation, Cosmetics Labeling, and Adverse Event Reporting and Record Keeping. Each of these areas has significant implications for manufacturers and the ingredients commonly found in cosmetics. Given the …

Short & Long-Term Consequences Of Cannabis Intake & Differences Between Occasional & Chronic Frequent Cannabis Use, Marilyn Huestis

Oxford ICSB

As the medicalization and legalization of the United States continues to increase it is important to understand the short- and long-term consequences of cannabis use. The endogenous cannabinoid neurotransmitter system is critical for the appropriate functioning of survival functions including hunger, body temperature control, memory and reproduction. When individuals use cannabis, they hijack the normal functioning of the system that attempts to maintain homeostasis. The most important short-term consequence of cannabis use is the morbidity and mortality of driving under the influence of cannabis. Also, legalization reduced the perception of risk of using cannabis that leads to higher adolescent and …

A New Way Forward For Cannabidiol (Cbd) And Other Hemp Products, Patrick Cournoyer

Oxford ICSB

The FDA announced that existing regulatory frameworks for foods and supplements are not appropriate for cannabidiol (CBD). Given the available evidence, it is not apparent how CBD products could meet safety standards for dietary supplements or food additives. A new regulatory pathway for CBD is needed that balances individuals’ desire for access to CBD products with the regulatory oversight needed to manage risks.

Opening Remarks For “Cannabis: Current Status And Future Outlook”, Cassandra Taylor

Oxford ICSB

No abstract provided.

Biological Activity Of Essential Oils – Focus On Antibiotic Resistance, Gyorgyi Horvath

Oxford ICSB

No abstract provided.

Natural Products Ireland: From Bioactives To The Bioeconomy - A Systems-Based Approach, Gaia Scalabrino

Oxford ICSB

Natural Products (NP) are on the rise across the world, driven by economic, environmental, health and societal needs. An increasing focus has been placed on the role of boglands within climate change as peatlands store 1/3 of the world’s soil carbon and provide water storage. With our project ‘Unlocking Nature’s Pharmacy’ we aim to increase public awareness and drive Ireland towards a bioeconomy where Natural Product Science (NPS) plays a key role. At the NatPro Centre, the Trinity Centre for Natural Products Research, we use systems-based approaches (SBA), for example looking at the bogs of Ireland, to identify innovative bio-based …

Cold-Water Extract Of Nerium Oleander Leaves Inhibits Cancer: From Bench To Bedside, Thomas Efferth, Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Katrin, Ioannis Ioannis, Ludger A. Wessjohann, Heinz-Herbert Fiebig

Oxford ICSB

Nerium oleander is a well-known medicinal plant used in the Mediterranean region and traditional Indian medicine (Ayurveda) against a variety of diseases, including cancer. We investigated a cold-water extract of N. oleander leaves for their anticancer activities in vitro and in vivo. The cytotoxicity testing in the Oncotest panel of tumor cell lines and concomitant COMPARE analysis showed a high degree of similarity to mitosis-inhibiting compounds. We verified this hypothesis by treating tumor cells transfected with a tubulin-GFP fusion cDNA construct and confocal microscopy as well as a biochemical tubulin polymerization assay. N. oleander showed a similar inhibition of tubulin …

African Plants In Jamaican Farms And Gardens, Thera Edwards

Oxford ICSB

Plants of all growth forms and regeneration strategies were introduced to Jamaica by European slavers and by Enslaved Africans. Some species such as Tamarind used to purify drinking water on ships arrived through purposes of practicality while others that such as yam and plantain were transported as food supplies on the ships or by the Enslaved Africans as tubers for planting in their countries of destination. Tuber crops proved to be invaluable in hurricane prone islands such as Jamaica as the underground tuber was left undamaged by the high winds of the storms. Other crops such as Plantain while not …

Fda Investigational New Drug (Ind) Applications, Cassandra Taylor

Oxford ICSB

Current Federal law requires that a drug be the subject of an approved marketing application before it is transported or distributed across state lines. Because a sponsor will probably want to ship the investigational drug to clinical investigators in many states, it must seek an exemption from that legal requirement. The IND is the means through which the sponsor technically obtains this exemption from the FDA. During a new drug's early preclinical development, the sponsor's primary goal is to determine if the product is reasonably safe for initial use in humans, and if the compound exhibits pharmacological activity that justifies …

Introduction To The Premarket Review Of Human Food Ingredients In The United States And Concepts In The Safety Assessment Of Novel Plant-Derived Ingredients, Troy Hubbard

Oxford ICSB

Premarket regulation of ingredients added to food is a key pillar ensuring the safety of food as it allows the opportunity to address potential safety concerns prior to consumer exposure. In the United States, food and color additives are substances that are intentionally added to food and are subject to pre-market approval by the Food and Drug Administration (FDA) and require a listing in the Code of Federal Regulations, unless the intended use of the substance is generally recognized as safe (GRAS), among qualified experts. GRAS is not an inherent property of a substance, as is often misunderstood; rather, it …

Quality Of Life And Well-Being Of Breast Cancer Patients While Following A Breast Cancer-Related Lymphedema Surveillance Protocol, Madisen L. Prasek

Occupational Therapy Capstone Presentations

With breast cancer being one of the most common cancers in women globally and treatments being one of the greatest risk factors for secondary lymphedema (Eaton et al., 2020; He et al., 2023; Jørgensen et al., 2021), it is essential to understand how a breast cancer diagnosis and treatments affect an individual’s quality of life (QoL) and well-being. This capstone project aimed to gain in-depth clinical skills in lymphedema care, specifically in breast-care related lymphedema (BCRL), and educate on the psychosocial needs of the breast cancer population, with an emphasis on how being at risk for or diagnosed with BCRL …

Natural Products In Food And Agriculture, Stephen O. Duke

Oxford ICSB

Before the National Center for Natural Products Research (NCNPR) existed, I was Director of a USDA weed management lab. Two of my interests were natural products as herbicides and the chemical ecology of weed/crop interactions (allelopathy). Dr. James McChesney and I had several conversations about his vision for the NCNPR on the University of Mississippi campus. I was very interested in becoming a part of this, as his plan was to have a USDA lab that would study natural products for use in food and agriculture as part of the center. The USDA Agricultural Research Service established the Natural Product …

Preventing Ingredient Adulteration To Maintain Botanical Integrity, Katie Banaszewski

Oxford ICSB

The growing popularity of botanical products combined with the challenges of the supply chain to meet the ingredient demand has created opportunities for dishonest companies to take advantage of their clients for financial gain. Suppliers and manufacturers must comply with cGMPs (current Good Manufacturing Practices), specifically when it comes to the basic requirements of properly identifying crude botanicals in whole, cut, or powdered form, as well as botanical extracts and essential oils. Despite this regulatory requirement, a large portion of botanical ingredients and products sold in the marketplace are adulterated. Popular ingredients in high demand are intentionally substituted, diluted, or …

African & Caribbean Herbal Pharmacopieae - Curating Data For Product Development, David Katerere

Oxford ICSB

This presentation aims to provide a comprehensive examination of the Africa Herbal Pharmacopoeia (AHP) and the Caribbean Herbal Pharmacopoeia (CHP), highlighting their respective similarities and differences in the realm of traditional herbal medicine and product development. Both pharmacopoeias are important initiatives in curating indigenous knowledge related to medicinal plants. They are valuable resources for researchers, healthcare practitioners, and industry. This presentation will outline the methodological and logistical approaches employed in putting together monographs and the challenges faced. Furthermore, the comparative analysis will explore the regional nuances that shape the content of each pharmacopoeia, considering factors such as local traditions, ecological …

Chemistry, Biology, And Safety Of Volatile Organics From Aromatic And Medicinal Plants, Nicole Stevens

Oxford ICSB

Introduction Sleep is an important foundation of health, yet the U.S. Centers for Disease Control (CDC) notes that about 30% of adults to not get the recommended minimum of 7 hours’ sleep per night. Prescription treatments may help, but they carry risks such as side-effects, dependency, and medication interaction. Natural botanical extracts are a therapeutic possibility for improving sleep quality, but additional research is needed on their efficacy and safety. A system of natural products based on lavender was developed and tested in a human clinical study to evaluate effect on sleep, blood and safety markers, and gene expression modulation …

Adulteration - Why Does It Still Proliferate?, John Travis

Oxford ICSB

No abstract provided.

A Survey Of Melatonin In Dietary Supplement Products Sold In The U.S., Rahul Pawar

Oxford ICSB

In the United States, melatonin products are widely available to consumers as dietary supplements. During the past few decades, melatonin products have gained increased popularity primarily as a sleep aid, with a variety of product forms available for different age groups of consumers. Recent reports have highlighted a rise in melatonin ingestion among children reported to poison control centers across the U.S. The increased use of melatonin-containing dietary supplements and reported deviation from labeled quantities has emphasized the need for additional research to better understand products in the marketplace.
The objective of this work was to measure the melatonin content …

Challenges Of Building Specifications For Essential Oils: An Industry Perspective, Brett Smith

Oxford ICSB

The rise in essential oil popularity is creating unprecedented demand worldwide. With the increased demand, the worldwide supply chain is challenged with maintaining consistent quality standards. Some essential oil producers may be motivated to use new and innovative methods to alter their products to meet quality standards and extend their current oil supplies. Climate change is also affecting growing season conditions, leading to changes in essential oil composition compared to past harvests. These factors create challenges for industry in establishing updated quality and commerce specifications beyond traditional ISO, AFNOR, and pharmacopoeia standards for essential oils. To meet these supply chain …

Characterization Of Ashwagandha Using A Multi-Detector Approach, Vincent Sica

Oxford ICSB

Botanicals are complex mixtures that present unique analytical challenges. A multi-detector chromatographic approach can provide accurate, constituent-based data to ensure proper identification and quantification of botanicals. These data are often used to help drive in silico safety assessments to identify suspected toxicants and assess the potential for deleterious effects using structure activity relationships. To showcase this approach, ashwagandha extracts were characterized to determine authenticity and to guide the necessary toxicological studies. To ensure the full constituency of the extracts are evaluated, a multi-detector system (UHPLC-PDA-CAD-HRMS) was employed and subjected to a comprehensive chemical constituent identification (CCID) process. All of the …

Understanding Plant To Extract Ratios Of Botanical Extracts And Their Implications In Product Labeling, Maria Monagas, Thomas Brendler, Josef Brinckmann, Steven Dentali, Stefan Gafner, Gabriel Giancaspro, Holly Johnson, James Kababick, Cuiying Ma, Hellen Oketch-Rabah, Pilar Pais, Nandu Sarma, Robin Marles

Oxford ICSB

Dietary supplement current good manufacturing practice (cGMP) in the U.S. requires the establishment of quality parameters for each component used in the manufacture of a dietary supplement to ensure that specifications for the identity, purity, strength, composition, and limits on contaminants are met using scientifically valid methods of analysis. However, specifications for botanical extracts (including fungal and algal extracts) routinely include additional data that are not amenable to verification through analytical methods. Such descriptive information may include Plant to Extract ratios, which are ratios of the quantity of botanical article used in the manufacture of the extract to the quantity …

The True History Of Aloes And Beyond, Ben-Erik Van Wyk

Oxford ICSB

The recorded history of aloes dates back thousands of years, with early recordings in the Papyrus Ebers (ca. 1550 B.C.) and in Dioscorides’s Herbal (1st cent. A.D.). Aloe has been used as a two-in-one medicine, not only by early explorers but also as a material of strategic military importance, with the yellow juice effective against the stomach problems of an army on the march and the white juice (gel) used to treat the wounds of battle. Aloe vera is the correct name for the “true aloe”, as the specific epithet “vera” indicates. The origins of the plant are shrouded in …

One-Class Modeling For The Authentication Of Actaea Racemosa And Evaluation Of The Variation Between Botanical Reference Materials, James Harnly

Oxford ICSB

One-class modeling based on soft independent modeling of class analogy (SIMCA) is a simple but powerful method for comparing the chemical composition of botanical materials using non-targeted chromatograms (GC, LC) or spectra (IR, MS, NIR, NMR). The methodology is available on any commercial chemometric platform. Authentication is based solely on the characteristics of the botanical material of interest. Detection of adulteration is determined for each variable and requires no identification of adulterants. Some highly characterized botanical reference materials (BRMs) may account for species, cultivar, and year and location of harvest while more generic BRMs may have minimal characterization. All of …

Development Of Teacher Training Program, Manual, & Curriculum Guide For Inclusive Dance Studio, From An Occupational Therapy Perspective, Susanna C. Dunn

OTD Capstone Projects

This capstone project was completed in collaboration with MOVE Inclusive Dance, a nonprofit, inclusive dance studio specifically serving individuals of all ages with various disabilities. A needs assessment conducted with the staff at MOVE necessitated a cohesive teacher manual, including teacher training protocol, disability index, safety precautions, sample class activities, curriculum guide, and more. The focus of this capstone was to create and distribute a teacher training manual to dance teachers at MOVE Inclusive Dance. The teacher training manual was created using anonymous pre and post test qualitative and quantitative surveys to assess teacher perceptions regarding feelings of confidence and …

Restoring Effective Sleep Time In Post Cardiac Surgery Patients: A Quality Improvement Project, Brooke Watts Bsn, Rn

Epsilon Sigma at-Large Research Conference

Purpose: Restoring Effective Sleep Time in Post Cardiac Surgery Patients: A Quality Improvement Project

Brooke Watts, BSN, RN, DNP Student, Murray State University

Dr. Kristin Reid, DNP, APRN, ACNS-BC, DNP Program Director/Assistant Professor Murray State University

Aims: This quality improvement project was developed using DNP project guidelines provided through Murray State University and was designed to improve sleep in hospitalized cardiac surgery patients.

Processes: IRB approval was obtained from the healthcare institution and academic institution. This two-phase quality improvement project was designed to analyze the effects of a change in normalized hospital routines on self-reported sleep in post-cardiac surgery patients. …

Development And Evaluation Of Trauma Informed Care Education For Licensed Nurses, Kristina O'Meara

Epsilon Sigma at-Large Research Conference

Trauma informed care nursing education is crucial. Trauma informed care is a method of providing health care which understands the likelihood of past and present traumatic events in patients and families. The experience of past or present trauma often led to chronic diseases, substance abuse disorder, fragmented health care, fears surrounding health care, chronic stress, and other negative health consequences. The purpose of this project is to increase licensed nurses’ awareness and ability to practice trauma informed care in clinical practice, as well as promote policy initiation within the health care facilities. Method planning integrated the Knowledge to Action Cycle. …