Medicine and Health Sciences Commons^™

The Santa Clara, 2018-05-10, Santa Clara University

The Santa Clara

No abstract provided.

Low-Fat Abiraterone Food Effect Is Of Little Consequence, Jill M. Kolesar, Glenn X. Liu

Pharmacy Practice and Science Faculty Publications

No abstract provided.

Data On The Risk Perceptions Of Beach Water Safety In Coastal Georgia, Jeffery A. Jones, Asli Aslan, Rakhi Trivedi, Maria I. Olivas, Mikayla Hoffmann

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

These data reflect the perceptions of beach water quality drawn from a convenience sample of 238 visitors to Georgia (USA) beaches collected in June–July 2017 and are related to the research article entitled “Water quality and the perception of risk: a study of Georgia, USA, beachgoers” (Jones et al., 2018) [1]. Data were collected both via an online survey distributed through Facebook and through in-person questionnaires collected directly on the beaches.

The Santa Clara, 2018-05-03, Santa Clara University

The Santa Clara

No abstract provided.

Metallodithiolate Ligands For Reversing Metal Ion Induced Aggregation Of Beta Amyloid, Eleanor K. Adams, Marilyn Rampersad Mackiewicz

Student Research Symposium

Alzheimer’s Disease (AD) is the sixth leading cause of death in the United States with no known methods to cure, reverse or halt disease progression. The “metal hypothesis” states that Fe^II, Cu^II, Zn^II, and Al^II bind to truncated Aβ peptides and form soluble oligomers which deposit as senile plaques. These plaques play a crucial role in AD pathogenesis. For example, metallated-Aβ aggregates are hypothesized to disrupt membranes or generate a reactive oxygen species (ROS) through redox cycling in the presence of Cu^I/II or Fe^III/II and a reducing agent. ROS can lead …

Dissecting Structure-Encoded Determinants Of Allosteric Cross-Talk Between Post-Translational Modification Sites In The Hsp90 Chaperones, Gabrielle Stetz, Amanda Tse, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

Post-translational modifications (PTMs) represent an important regulatory instrument that modulates structure, dynamics and function of proteins. The large number of PTM sites in the Hsp90 proteins that are scattered throughout different domains indicated that synchronization of multiple PTMs through a combinatorial code can be invoked as an important mechanism to orchestrate diverse chaperone functions and recognize multiple client proteins. In this study, we have combined structural and coevolutionary analysis with molecular simulations and perturbation response scanning analysis of the Hsp90 structures to characterize functional role of PTM sites in allosteric regulation. The results reveal a small group of conserved PTMs …

The Effects Of Surface Pace In Baseball, Jason Farlow

Senior Theses

A baseball travels across different surfaces at different paces. The goal of this experiment is to find a percentage difference in speeds the ball will reflect off a given surface. The energy lost on the turf surface was far more significant than on dirt surface as the turf lost an average of 26% of its energy as compared to just 16% of the energy on dirt. In the Northwest conference, teams play on four turf-based infields and five dirt-based infields. The results of this study suggest that kinetic friction forces are more significant in reducing ball rebound speed than in …

Raman Spectral Analysis For Rapid Screening Of Dengue Infection, Tahir Mahmood, Haq Nawaz, A. Ditta, M.I. Majeed, M.A. Hanif, N. Rashid, H.N. Bhatti, H.F. Nargis, M. Saleem, Franck Bonnier, Hugh Byrne

Articles

Infection with the dengue virus is currently clinically detected according to different biomarkers in human blood plasma, commonly measured by enzyme linked immunosorbent assays, including non-structural proteins (Ns1), immunoglobulin M (IgM) and immunoglobulin G (IgG). However, there is little or no mutual correlation between the biomarkers, as demonstrated in this study by a comparison of their levels in samples from 17 patients. As an alternative, the label free, rapid screening technique, Raman spectroscopy has been used for the characterisation/diagnosis of healthy and dengue infected human blood plasma samples. In dengue positive samples, changes in specific Raman spectral bands associated with …

Epoca House: The Implementation Strategy, Courtney Thomas, Yaffa Fain, Shuxiao Teng, Mingjun Xie

School of Professional Studies

This capstone report provides a written strategic implementation plan for EPOCA House. EPOCA, Ex-Prisoners and Prisoners Organizing for Community Advancement, is a non-profit dedicated to creating better resources and opportunities for prisoners and ex-prisoners in Worcester. The organization’s most recent initiative, EPOCA House, is a transitional facility that will provide reentry services and temporary housing to ex-offenders in and around the Worcester area. Recently, Massachusetts passed a comprehensive criminal justice reform bill that will dramatically reduce the number of people being incarcerated; however, little attention is focused on what will happen to individuals after they leave prison. At the same …

A Guide For Hiring Mature Employees At Ascentria, Binghe Change, Calleigh Leach, Elsie Lu, Hongquiang You, Mengge Wang, Nina Mariotti

School of Professional Studies

This paper will explore existing literature on aspects of an intergenerational workplace in a nonprofit organization and provide recommendations for recruiting and retaining older employees for a human service organization, Ascentria Care Alliance, in Worcester, MA. The paper will review research on trends in the nonprofit industry, a comprehensive breakdown of generational workplace values, reasons people are returning to work and effective marketing strategies that appeal to older generations. Marketing strategies specifically will explore best practices for website design, social media usage, and job descriptions. Additionally, this paper will research case studies of nonprofits with successful intergenerational workforce initiatives, as …

The Relationship Between Stryd Power And Running Economy In Well-Trained Distance Runners 2018, Casey Austin

Master's Theses

A novel running wearable called the Stryd Summit footpod attaches to a runner’s right or left shoe and measures running power output. The developers of the product purport that the footpod’s power and form power measures may correlate with metabolic data gathered in a lab. PURPOSE: Explore the relationship between power output and running economy at threshold pace. METHODS: Seventeen well-trained distance runners, 9 males and 8 females, completed a running protocol at threshold pace. Participants ran two discontinuous four-minute stages: one with their self-selected cadence (SS), and one with cadence lowered by 10% (LC). Metabolic data, power, and form …

Clear The Air: Moving Towards A More Supportive, Welcoming, Tobacco-Free Clark University, Edward Aroko, Simon Elliot, Jackson Espe, Donovan Smith, Michael Spanos

School of Professional Studies

The deleterious health effects of the consumption of tobacco products, especially for youth, have been documented thoroughly and are nearly universally recognized. Numerous federal, state, and local regulations, coupled with health education and tobacco cessation initiatives have been launched to address these effects. Although these pushes have done much to reduce the rates of preventable health conditions and death due to the usage of tobacco, there remains much work to be done at the local level to discourage and disrupt patterns of substance use and abuse. The mission of Clark Clear the Air is to propose various and creative ways …

Inbound Marketing, Hasini Assiriyage, Isabelle Zoeckler, Emmanuel Aghado, Kefu Bu, Xiouyu Jiang, Rajesh Kamble, Yan Wang

School of Professional Studies

This study looks into inbound marketing practice through the process of secondary research. This insight on best practices and market examples have been employed in order to identify the benefits of Inbound Marketing for the School of Professional Studies at Clark University. Through the research, this team has consolidated a number of recommendations for the SPS marketing strategies moving forward. A focus has been placed on identifying solutions, which were effective and financially feasible. The primary solutions are internally sourced; with a future long term recommendation of seeking advice from a third party firm to automate the process.

Adult Learners: A Targeted Marketing Approach, Sarah Baldelli, Camilo Botero, Camille Ferreol, Caleb Horton, Xinyue Ma, Stefan Sprinkmoller

School of Professional Studies

The development of the Adult Learner Capstone Project started with a focus and need to learn more about affinity groups in the Worcester area in order to reach the potential adult learner demographic. Although some partnerships already existed, the Director of Marketing and Communications for Graduate Admissions, Tara Probeck, yearned to explore the potential partnerships and alternative uses of professional organizations to market to the current working professionals. From this idea, our capstone project was introduced in hopes of establishing a comprehensive and exhaustive list of potential organizational partnerships, specific for the School of Professional Studies.

My Choice Greens, Alina Zulfikarova, Amelia Mohr, Hesi Zhang, Ruiqi Huang, Sean Tatar, Yuhao Zhou, Zijun Zhou

School of Professional Studies

My Choice Programs for Independent Living is a nonprofit in Worcester, Massachusetts that helps individuals with special needs. In 2016, My Choice Programs added a branch to their organization called My Choice Greens. My Choice Greens is committed to growing fresh produce in their hydroponic farm. The profit generated from selling their vegetables is put back into direct programming for My Choice Programs. My Choice Greens is the first hydroponic farm in Worcester, but unfortunately not many people are aware of their program. Also, since they are a small nonprofit, they do not have sufficient funding or resources to market …

Optical Heritage Museum: An Interactive Touch, Connor Guerin, Ankur Halwai, Jinzhao Liu, Qi Liu, Yangjing Wang, Yashaswini Bharti

School of Professional Studies

Optical Heritage Museum (OHM) was established in 1983 with the aim to preserve, promote and display historical artifacts of the optics industry and educate all of its vital role optics has played in societal development. Over the years, the museum has grown in its physical space along with exhibit development to engage audiences in innovative, effective methods. Clark University’s School of Professional Studies department and curator of Optical Heritage Museum, Mr. Whitney’s Whitney, have establish a collaboration that has spanned over two semesters with the goal to support and aid in improving OHM. Our capstone group was assigned the task …

Leicester Research A Study In Effective Technology In Education, Jimeshkumar Chauhan, Anna Lakomy, Li Liu, Christina Mccarthy, Scott Mccarthy, Roman Pena, Emilie Smiley

School of Professional Studies

The LPS Research Team has been tasked with researching and recommending a technology plan for a new school that Leicester Public Schools is planning to build. In this paper, we present an overview of the our goals and our client’s goals, an introduction to industry trends, and discuss our findings based on research conducted via interviews with schools that have undergone similar projects. We also outline the conclusions drawn from this research and our analysis of the data we uncovered, and make specific recommendations for technology to be utilized in Leicester’s new school. Finally, we present a 3-part framework that …

Leicester Public Schools Information And Data Portal: Research And Recommendations, Yue Cen, Natalie Bonetti, Rashida Buchanan, Sathark Jain, Yuwei Wong

School of Professional Studies

The purpose of this project is to develop a strategy for the creation of a multifaceted portal to help with the organization and dissemination of information about the Leicester public school district. The functionality of this portal is to provide comparative financial, demographic, and academic data to other relative school districts in the area, both for the parents’ and for the city’s reference. It will be an examination into the best practices for creating a portal, both technological and aesthetic recommendations, as well as research into the value the publication of this data would provide for the parents of current …

Water In Worcester A Campaign For Public Fluoridation, Ryan Early, Xiao Gu, Yajing Huang, Lauren Meininger, Emma Phillips, Yao Su

School of Professional Studies

Water in Worcester: A Campaign for Public Fluoridation arose as a project from our sponsors, Chris Philbin, Vice President of Government Relations at UMass Memorial Health Care, and Joe O’Brien, former Worcester Mayor, Executive Director of the Environmental League of Massachusetts, and Clark University Adjunct Professor. Our goal has been to produce resources that will support the fight for fluoridation in the City of Worcester. Fluoridation has failed to pass in Worcester on four separate occasions, but Mr. Philbin and Mr. O’Brien believe that the time has come to try again.

In order to fluoridate Worcester’s water supply, the municipal …

Canine For Disabled Kids Awareness Campaign Research And Implementation Plan, Jiamin Gu, Kendall Harcourt, Chang Liu, Kiamu Liu, Jemmie Tejada

School of Professional Studies

According to the Americans with Disabilities Act (ADA) service animals are: “dogs that are individually trained to do work or perform tasks for people with disabilities” ( ADA, 2015). On the other hand, emotional support animals are: “dogs that provide comfort and support in forms of affection and companionship for an individual suffering from various mental and emotional conditions.” In addition, an emotional support animal is not required to perform any specific tasks for a disability like service dogs are (Ibid).

The ADA limits the number of questions that can be asked to protect the privacy of utilizers. In fact, …

Life Can Change In The Blink Of An Eye Capstone, Christopher Rutigliano, Jillian Elalaoui, Kristin Humphrey, Phillip Gates, Mohamed Ndjikam, Highness Meena, Adam Menard, Spencer Pickney

School of Professional Studies

Texting and driving is one of the most widespread and uncontrollable of epidemics that have arose to prominence in the 21st century. Texting and driving is now a global issue, that has left nations across the road scrambling to implement new laws and preventative measures to stunt the increasing rates of accidents and fatalities caused by texting and driving. The severity of the issue has lead to a multitude of different entities ranging from domestic and foreign governments, cell phone and car manufacturers, cell phone carriers, and insurance agencies to seek new methods to prevent texting and driving. Determining the …

A Social Media Plan For The Changemakers’ Playground, Meng Cong, Ciara Kilian, Xinling Wang, Sumanth Wilson, Chenyu Yan

School of Professional Studies

The purpose of this project was to create a social media plan for the Changemakers’ Playground campaign. The Changemakers’ Playground is a website thought up by our client, Sarah Lange, whereby ordinary individuals doing extraordinary things in their community can be celebrated for the work they are doing. Each person featured on the website, also known as a Changemaker, was interviewed by Sarah and that interview was split into three videos to be posted on the Changemakers’ Playground website throughout the week they are being featured. In short, our task was to create the Facebook, Twitter, and Instagram content to …

Oxidative Stress And Cardiovascular Risk In Type 1 Diabetes Mellitus: Insights From The Dcct/Edic Study, W. Wilson Tang, P. Mcgee, John M. Lachin, D. Li, B. Hoogwerf, S. Hazen, +Several Additional Authors

Epidemiology Faculty Publications

Background--Hyperglycemia leading to increased oxidative stress is implicated in the increased risk for the development of macrovascular and microvascular complications in patients with type 1 diabetes mellitus. Methods and Results--A random subcohort of 349 participants was selected from the DCCT/EDIC (Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications) cohort. This included 320 controls and 29 cardiovascular disease cases that were augmented with 98 additional known cases to yield a case cohort of 447 participants (320 controls, 127 cases). Biosamples from DCCT baseline, year 1, and closeout of DCCT, and 1 to 2 years post-DCCT (EDIC years 1 and …

Global Stability For A 2n + 1 Dimensional Hiv/Aids Epidemic Model With Treatments, Olusegun Michael Otunuga

Mathematics Faculty Research

In this work, we derive and analyze a 2n + 1-dimensional deterministic differential equation modeling the transmission and treatment of HIV (Human Immunodeficiency Virus) disease. The model is extended to a stochastic differential equation by introducing noise in the transmission rate of the disease. A theoretical treatment strategy of regular HIV testing and immediate treatment with Antiretroviral Therapy (ART) is investigated in the presence and absence of noise. By defining R0, n, Rt, n and Rt,n as the deterministic basic reproduction number in the absence of ART treatments, deterministic basic reproduction number in the presence of …

Analysis Of Episodes Of Care In Medicare Beneficiaries Newly Diagnosed With Alzheimer’S Disease, Rezaul K. Khandker, Christopher Black, Lin Xie, M. Furaha Kariburyo, Baishali M. Ambegaonkar, Onur Baser, Huseyin Yuce, Howard Fillit

Publications and Research

OBJECTIVES: To study transitions between healthcare settings and quantify the cost burdens associated with different combinations of transitions during a 6-month period before initial Alzheimer’s disease (AD) diagnosis so as to investigate how using an episode-of-care approach to payment for specific disease states might apply in AD.

DESIGN: A retrospective observational cohort study.

SETTING: United States.

PARTICIPANTS: A random sample of 8,995 individuals aged 65 to 100 with a diagnosis of AD (International Classification of Diseases, Ninth Revision, Clinical Modification code 331.0) were identified from the Medicare database between January 1, 2011, and June 30, 2014. This analysis identified individuals …

Breeding Season Ecology And Demography Of Lesser Scaup (Aythya Affinis) At Red Rock Lakes National Wildlife Refuge, Jeffrey M. Warren

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

It is hypothesized that individuals make reproductive decisions based on current assessments of their physiological condition and environmental conditions. For female lesser scaup (Aythya affinis), breeding occurs after an energetically costly spring migration. Increasing fat reserves (i.e., ‘body condition’) prior to breeding allows a female to produce a larger clutch of eggs, but time spent gaining body condition is costly in terms of time allowed to raise ducklings before freezing conditions in the fall. In Chapter 2 I explored rate of pre-breeding body condition gain in female lesser scaup, and how that rate influenced clutch size. Spring phenology, …

The Influence Of Parental Control And Parent-Child Relational Qualities On Adolescent Internet Addiction: A 3-Year Longitudinal Study In Hong Kong, Daniel T. L. Shek, Xiaoqin Zhu, Cecilia M. S. Ma

Pediatrics Faculty Publications

This study investigated how parental behavioral control, parental psychological control, and parent-child relational qualities predicted the initial level and rate of change in adolescent internet addiction (IA) across the junior high school years. The study also investigated the concurrent and longitudinal effects of different parenting factors on adolescent IA. Starting from the 2009/2010 academic year, 3,328 Grade 7 students (M_age = 12.59 ± 0.74 years) from 28 randomly selected secondary schools in Hong Kong responded on a yearly basis to a questionnaire measuring multiple constructs including socio-demographic characteristics, perceived parenting characteristics, and IA. Individual growth curve (IGC) analyses …

Development Of A ‘Smart’ Resistance Exercise Band To Assess Strength, Emily V. Wechsler, John A. Batsis, David F. Kotz, Ryan J. Halter

Wetterhahn Science Symposium Posters 2018

No abstract provided.

Assessing The Ordinality Of Response Bias With Item Response Models: A Case Study Using The Phq-9, Venessa N. Singhroy

Dissertations, Theses, and Capstone Projects

Improper scale usage in psychological and clinical assessment is an important problem. If respondents do not use the scales in a consistent manner, the reliability of a composite is likely to be attenuated. This is particularly problematic when particular items are singled out for special treatment or when subscales are of interest, not just a total score. This study used both non-parametric and parametric item response theory (IRT) methods to gain further insight into the validity of the PHQ-9, a dual purpose instrument that assesses the severity of depressive symptoms using nine Likert-scale items and allows the investigator to establish …

Evaluation Of The Biocompatibility And Micromechanical Properties Of Experimental Dental Adhesives, Hoda Moussa

Forensic Science Theses

The purpose of this study was to investigate the biocompatibility and micromechanical properties of newly synthesized antibacterial monomer and cross-linker functional surfactants into a commercially available dental adhesive (Single Bond, 3M ESPE, Saint Paul, MN, USA) at three concentrations (0.05, 0.1, 0.25 mg/mg). All groups were analyzed by evaluation of micro-tensile bond strength, ultimate tensile strength, cell viability, antibacterial properties, and surface micro-hardness. Scanning electron microscopy (SEM) was used for interfacial characterization.

Human extracted molars were used as a substrate for bonding adhesives for the micro-tensile bond strength (MTBS) and scanning electron microscopy (SEM) studies. Twenty resin-dentin beams (0.9 ± …