Medicine and Health Sciences Commons^™

Age Dependent Regulation Of Cardiac Sodium Channel Gain Of Function, Madison Nowak, David Ryan King, Steven Poelzing, Seth Weinberg

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Study Of Pair Formation Disease Models With A Two Phase Infection, Berlinda Rosa Batista

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Extracellular Hbv Dna Kinetics During Infection And Treatment In Primary Human Hepatocytes, Preeti Dubey

Biology and Medicine Through Mathematics Conference

No abstract provided.

Β Cell Network Dysfunction In Pancreatic Islets By Silencing Hub Cells, Janita Patwardhan, Bradford E. Peercy

Biology and Medicine Through Mathematics Conference

No abstract provided.

Coupled Influence Of Heart Rate Variability And Subcellular Calcium Heterogeneity On Cardiac Electromechanical Dynamics, Vrishti M. Phadumdeo, Seth H. Weinberg Ph.D

Biology and Medicine Through Mathematics Conference

No abstract provided.

Development Of A Mathematical Model For The Role Of Inflammation In Atherosclerosis, Marcella Torres, Jing Wang, Paul J. Yannie, Shobha Ghosh, Rebecca Segal, Angela Reynolds

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Pharmacokinetic Model Of Lead Absorption And Calcium Competitive Dynamics, Anca R. Radulescu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Robust Estimation For Factor Loadings With Application To Postpartum Depression, Kenneth Nieser

Biology and Medicine Through Mathematics Conference

No abstract provided.

Immunofluorescence Image Feature Analysis And Clustering Pipeline For Distinguishing Epithelial-Mesenchymal Transition, Shreyas Hirway, Nadiah Hassan, Dr. Christopher Lemmon, Dr. Seth Weinberg

Biology and Medicine Through Mathematics Conference

No abstract provided.

Understanding Toxin Production During Clostridioides Difficile Infection Using High Dimensional Data, Samantha Erwin, Joshua R. Fletcher, Casey M. Theriot, Cristina Lanzas

Biology and Medicine Through Mathematics Conference

No abstract provided.

Non-Mechanistic Learning Of Pdes From Discrete Spatial Data In Biology, Gary M. Lavigne Jr

Biology and Medicine Through Mathematics Conference

No abstract provided.

Decoys And Dilution: The Impact Of Incompetent Hosts On Prevalence Of Chagas Disease, Mondal H. Zahid

Biology and Medicine Through Mathematics Conference

No abstract provided.

Parameter Identifiability Of A Dynamical System Model Of Breathing In A Preterm Infant, Laura Ellwein Fix, Henry Rozycki

Biology and Medicine Through Mathematics Conference

No abstract provided.

Real-Time Interactive Simulation Of Human Atrial Electrical Activity On Realistic 3d Atrial Structures Using Webgl, Abouzar Kaboudian, Yanyan Ji, Elizabeth Cherry, Flavio H. Fenton

Biology and Medicine Through Mathematics Conference

No abstract provided.

Plenary Talk: Data Assimilation With Applications To Neuroscience, Tim Sauer

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Model Of Online Latent State Learning, Amy Cochran

Biology and Medicine Through Mathematics Conference

No abstract provided.

Machine Learning Methods To Forecast Temporal Pattern Of Aedes Mosquito Species Using Meteorological Variables In Ontario, Canada, Mohammad A. Al-Mamun, Ernest O. Asare

Biology and Medicine Through Mathematics Conference

No abstract provided.

Predictive Performance Of Existing Population Pharmacokinetic Models Of Tacrolimus In Pediatric Kidney Transplant Recipients, Alenka Chapron

Research Days

No abstract provided.

Modeling Malaria Dynamics With The Inclusion Of Long And Short Incubation Periods, Ana L. Vivas-Barber, Anne M. Fernando, Sunmi Lee

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Malaria-Hiv/Aids Co-Infection Model With Optimal Treatment And Insecticide-Treated Bednets, Eric Numfor

Biology and Medicine Through Mathematics Conference

No abstract provided.

Plenary Talk: Modeling The Folding Patterns Of The Human Brain In Development, Health, And Disease, Monica Hurdal

Biology and Medicine Through Mathematics Conference

No abstract provided.

Prospective Evaluation Of A Population Pharmacokinetic Model Of Pantoprazole For Obese Children, Alenka Chapron

Research Days

No abstract provided.

Epidemic Growth Rates And Host Movement Patterns Shape Management Performance For Pathogen Spillover At The Wildlife–Livestock Interface, Kezia R. Manlove, Laura M. Sampson, Benny Borremans, E. Frances Cassirer, Ryan S. Miller, Kim M. Pepin, Thomas E. Besser, Paul C. Cross

United States Department of Agriculture Wildlife Services: Staff Publications

Managing pathogen spillover at the wildlife–livestock interface is a key step towards improving global animal health, food security and wildlife conservation. However, predicting the effectiveness of management actions across host–pathogen systems with different life histories is an on-going challenge since data on intervention effectiveness are expensive to collect and results are system-specific.We developed a simulation model to explore how the efficacies of different management strategies vary according to host movement patterns and epidemic growth rates. The model suggested that fast-growing, fast-moving epidemics like avian influenza were best-managed with actions like biosecurity or containment, which limited and localized overall spillover risk. …

Disparities In Prostate Cancer Survival In Appalachian Kentucky: A Population-Based Study, Zin W. Myint, Richard O'Neal, Quan Chen, Bin Huang, Robin C. Vanderpool, Peng Wang

Internal Medicine Faculty Publications

Introduction: Prostate cancer (PC) is the most common male cancer in the USA. When comparing the incidence and mortality rates of PC, the Surveillance Epidemiology and End Results data of 2005–2014 show that Appalachian Kentucky had a lower incidence (113/100 000 v 137/100 000) but a higher mortality rate (23.8% v 21.8%) when compared to non-Appalachian Kentucky. The aim of this study was to further characterize the survival disparities of PC between Appalachian and non-Appalachian Kentucky.

Methods: All stages of PC patients diagnosed between 2007 and 2011 were collected through the Kentucky Cancer Registry. Baseline characteristics and survival outcomes were …

The Santa Clara, 2019-05-09, Santa Clara University

The Santa Clara

No abstract provided.

Differential Estimation Of Audiograms Using Gaussian Process Active Model Selection, Trevor Larsen

McKelvey School of Engineering Graduate Student Theses & Dissertations

Classical methods for psychometric function estimation either require excessive resources to perform, as in the method of constants, or produce only a low resolution approximation of the target psychometric function, as in adaptive staircase or up-down procedures. This thesis makes two primary contributions to the estimation of the audiogram, a clinically relevant psychometric function estimated by querying a patient’s for audibility of a collection of tones. First, it covers the implementation of a Gaussian process model for learning an audiogram using another audiogram as a prior belief to speed up the learning procedure. Second, it implements a use case of …

Predictive Validity Of A New Self-Report Measure Of Individual Skin Type Through Characterization Of Skin Melanin Using Reflectance Photospectroscopy, Mark Sanchez, Lisa Marriott, Teala Alvord, R. Samatham, S. Chang

Student Research Symposium

In the realm of research and dermatology, the Fitzpatrick Skin Type scale (FST) has been the gold standard of measurement to classify sun sensitivity for human’s skin. This scale is based on an individual’s dermal reaction to ultraviolet exposure (Parrish, et al., 1974; Fitzpatrick, 1975; Pathak, et al., 1976; Fitzpatrick, 1988). It was assumed in science as well as popular culture that individuals with darker skin were less susceptible to issues related to UV damage of their skin. More recent research (Eilers, et al., 2013) suggests that while melanin affords some skin protection, damage can still occur that may result …

Measurement Of Bystander Actions In Violence Intervention Evaluation: Opportunities And Challenges, Heather M. Bush, Samuel C. Bell, Ann L. Coker

Biostatistics Faculty Publications

Purpose of Review

This review discusses design and methodological challenges specific to measuring bystander actions in the evaluation of bystander-based violence prevention programming. “Bystanders” are defined as people who are present immediately before, during and/or after a violent event, but are not a perpetrator nor the intended victim. Bystander-based violence prevention programs seek to prevent or mitigate violent events by empowering bystanders to intervene on acts of violence and social norms that promulgate violence.

Recent Findings

Effective bystander-based violence prevention programs demonstrate increased bystander intentions, actions, and attitudes [Bringing in the Bystander: Banyard et al. J Community Psychol. 2007;35:463-481; iSCREAM: …

Investigations Of The Mechanism Of Action For Lung Cancer Cell Death By A 4-Trifluoromethoxy Substituted Chalcone, Trevor M. Stantliff

Undergraduate Theses

Chalcones are a diphenyl compound that serves as a natural precursor to flavonoids in plants. Chalcones have been shown to have anticancer and antimicrobial activities. Chemoprevention activity of chalcones are of high interest in medicinal chemistry because of the simple laboratory synthesis and modification via Claisen-Schmidt condensation. Previously this lab created and screened a library of synthetic chalcones against A549 lung adenocarcinoma cell line for antiproliferation properties. We identified a strong drug candidate (4-trifluoromethoxy substituted chalcone) for A549 growth inhibition. However, the cause of inhibition by the substituted chalcone remains to be identified We began to explore the mechanism of …

The Reproducibility Crisis In Scientific Research, Sarah Eline

Senior Honors Projects, 2010-2019

Following the push for evidence based practice, came a huge proliferation of research journals and journal articles. With this increase in quantity came an increased concern about the quality of these articles being published, which led to a multifield investigation regarding the reproducibility of scientific research. With studies in the fields of psychology and biomedicine only reaching approximately a 30% reproducibility rate, a conversation has been sparked that spans across every field of research. Upon further investigation, various causes for this reproducibility crisis have surfaced which include, lack of data sharing/ transparency, statistical errors, funding corruption, and the culture surrounding …