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Articles 2311 - 2340 of 11068
Full-Text Articles in Medicine and Health Sciences
Economic Equity And People With Disabilities: Development And Characterization Of A Novel Index, Bhavneet Walia, Katherine Mcdonald, Joy Hammel, Lex Frieden, Michael Morris, Barry Whaley, Vinh Nguyen
Economic Equity And People With Disabilities: Development And Characterization Of A Novel Index, Bhavneet Walia, Katherine Mcdonald, Joy Hammel, Lex Frieden, Michael Morris, Barry Whaley, Vinh Nguyen
Faculty, Staff and Student Publications
Here we develop two new social indices: The ADA PARC Absolute Economic Opportunity Index and the ADA PARC Relative Economic Opportunity Index. These indices allow us novel examinations of economic equity between people with and without disabilities within a U.S. State and between people with disabilities in different states using aggregations of multiple component economic indicators. These represent the first efforts to offer U.S. indices of this focus, an important development given the distinct economic needs of people with disabilities and the value in accounting for distinct national policies. The indices rely on U.S. Census and other data on economic …
Ensuring Trust In Genomics Research, Erman Ayday, Jaideep Vaidya, Xiaoqian Jiang, Amalio Telenti
Ensuring Trust In Genomics Research, Erman Ayday, Jaideep Vaidya, Xiaoqian Jiang, Amalio Telenti
Faculty, Staff and Student Publications
Reproducibility, transparency, representation, and privacy underpin the trust on genomics research in general and genome-wide association studies (GWAS) in particular. Concerns about these issues can be mitigated by technologies that address privacy protection, quality control, and verifiability of GWAS. However, many of the existing technological solutions have been developed in isolation and may address one aspect of reproducibility, transparency, representation, and privacy of GWAS while unknowingly impacting other aspects. As a consequence, the current patchwork of technological tools only partially and in an overlapping manner address issues with GWAS, sometimes even creating more problems. This paper addresses the progress in …
Effect Of Ultrasound On The Stability Of Partial Nitrification: Under The Interference Of Aeration Rate, Ying Xie, Yichun Zhu, Jieyuan Yang, Guangming Zhang, Shuai Tian, Junfeng Lian, Shanyan Dong
Effect Of Ultrasound On The Stability Of Partial Nitrification: Under The Interference Of Aeration Rate, Ying Xie, Yichun Zhu, Jieyuan Yang, Guangming Zhang, Shuai Tian, Junfeng Lian, Shanyan Dong
Faculty, Staff and Student Publications
The fluctuation of dissolved oxygen is one of the primary cause of disruptions to the consistent operation of partial nitrification, and the level of dissolved oxygen is mainly controlled by the aeration rate. This study investigated the influence of ultrasonic treatment on the stability of partial nitrification of activated sludge under different aeration conditions. After being treated with ultrasound (energy density = 0.20 W·mL−1, treatment time = 10 min), partial nitrification process operated stably for 67 days, with the nitrite accumulation rate above 83.89 %. The effluent contained 42.50 mg·L−1 of nitrite, much higher than the control reactor (0.30 mg·L−1). …
Gene Variants In Bola-Dmb, Decr1, Fasn And Srebf1 Associated With Conceptus Death On Day 16 Of Pregnancy In Holstein Cows [Abstract], Carolina L. Gonzalez-Berrios, Courtney Bowden, Pablo J. Pinedo, Jeanette V. Bishop, Hana Van Campen, Thomas R. R. Hansen, Milton G. Thomas
Gene Variants In Bola-Dmb, Decr1, Fasn And Srebf1 Associated With Conceptus Death On Day 16 Of Pregnancy In Holstein Cows [Abstract], Carolina L. Gonzalez-Berrios, Courtney Bowden, Pablo J. Pinedo, Jeanette V. Bishop, Hana Van Campen, Thomas R. R. Hansen, Milton G. Thomas
United States Department of Agriculture Wildlife Services: Staff Publications
Investigating the influences of single nucleotide polymorphisms (SNP) associated with conceptus death (CD) on day 16 of pregnancy could distinguish cows who have inferior value for fertility traits. We hypothesized that CD is associated with SNP genotypes that disrupt maternal recognition and lead to early pregnancy loss. RNA sequences from Holstein cow pregnancies (n = 15) with normal conceptuses (Norm) or CD were subjected to SNP discovery via Qiagen CLC Genomics Workbench. Selected SNP were based on previous fertility studies, differentially expressed genes within pregnancy development analyses and proximity to SNP associated with fertility traits in the Cattle QTL …
Delivering Healthcare To The Underserved, Edward Booty
Delivering Healthcare To The Underserved, Edward Booty
Asian Management Insights
Non-profits, governments, and businesses need to come together and use a data-driven approach to improve local basic healthcare access.
The Santa Clara, 2023-10-31, Santa Clara University
The Santa Clara, 2023-10-31, Santa Clara University
The Santa Clara
No abstract provided.
Depaul Digest
DePaul Magazine
College of Education Professor Jason Goulah fosters hope, happiness and global citizenship through DePaul’s Institute for Daisaku Ikeda Studies in Education. Associate Journalism Professor Jill Hopke shares how to talk about climate change. News briefs from DePaul’s 10 colleges and schools: Occupational Therapy Standardized Patient Program, Financial Planning Certificate program, Business Education in Technology and Analytics Hub, Racial Justice Initiative, Teacher Quality Partnership grant, Intimate Partner Violence and Brain Injury collaboration, School of Music Career Closet, Sports Photojournalism course, DePaul Migration Collaborative’s Solutions Lab, Inclusive Screenwriting courses. New appointments: School of Music Dean John Milbauer, College of Education Dean Jennifer …
Skin Lipids Alone Enable Conspecific Tracking In An Invasive Reptile, The Argentine Black And White Tegu Lizard (Salvator Merianae), M. Rockwell Parker, Eric A. Tillman, Lauren A. Nazarian, Megan L. Barlowe, Julianna M. Lincoln, Bryan M. Kluever
Skin Lipids Alone Enable Conspecific Tracking In An Invasive Reptile, The Argentine Black And White Tegu Lizard (Salvator Merianae), M. Rockwell Parker, Eric A. Tillman, Lauren A. Nazarian, Megan L. Barlowe, Julianna M. Lincoln, Bryan M. Kluever
United States Department of Agriculture Wildlife Services: Staff Publications
Locating potential mates in non-native habitats is one of the most important challenges faced by invasive vertebrate species. The Argentine black and white tegu lizard (Salvator merianae) is a major invasive reptile species in the contiguous United States and is rapidly expanding its range across Florida and the Southeast, in part due to inadequate management strategies and tools. Because a wide array of reptiles, especially squamates (snakes and lizards), have been well-studied for their reliance on chemical cues to locate conspecifics, our project aimed to isolate chemical cues from tegus and assess the ability of adult males and …
Surface Premelting Of Ice Far Below The Triple Point, Yulin Lin, Tao Zhou, Nathan D Rosenmann, Lei Yu, Thomas E Gage, Suvo Banik, Arnab Neogi, Henry Chan, Aiwen Lei, Xiao-Min Lin, Martin Holt, Ilke Arslan, Jianguo Wen
Surface Premelting Of Ice Far Below The Triple Point, Yulin Lin, Tao Zhou, Nathan D Rosenmann, Lei Yu, Thomas E Gage, Suvo Banik, Arnab Neogi, Henry Chan, Aiwen Lei, Xiao-Min Lin, Martin Holt, Ilke Arslan, Jianguo Wen
Faculty, Staff and Student Publications
Premelting of ice, a quasi-liquid layer (QLL) at the surface below the melting temperature, was first postulated by Michael Faraday 160 y ago. Since then, it has been extensively studied theoretically and experimentally through many techniques. Existing work has been performed predominantly on hexagonal ice, at conditions close to the triple point. Whether the same phenomenon can persist at much lower pressure and temperature, where stacking disordered ice sublimates directly into water vapor, remains unclear. Herein, we report direct observations of surface premelting on ice nanocrystals below the sublimation temperature using transmission electron microscopy (TEM). Similar to what has been …
Braf Inhibitors In Metastatic Colorectal Cancer And Mechanisms Of Resistance: A Review Of The Literature, Patricia Guerrero, Víctor Albarrán, María San Román, Carlos González-Merino, Coral García De Quevedo, Jaime Moreno, Juan Carlos Calvo, Guillermo González, Inmaculada Orejana, Jesús Chamorro, Íñigo Martínez-Delfrade, Blanca Morón, Belén De Frutos, María Reyes Ferreiro
Braf Inhibitors In Metastatic Colorectal Cancer And Mechanisms Of Resistance: A Review Of The Literature, Patricia Guerrero, Víctor Albarrán, María San Román, Carlos González-Merino, Coral García De Quevedo, Jaime Moreno, Juan Carlos Calvo, Guillermo González, Inmaculada Orejana, Jesús Chamorro, Íñigo Martínez-Delfrade, Blanca Morón, Belén De Frutos, María Reyes Ferreiro
Faculty, Staff and Students Publications
Metastatic colorectal cancer (mCRC) with mutated BRAF exhibits distinct biological and molecular features that set it apart from other subtypes of CRC. Current standard treatment for these tumors involves a combination of chemotherapy (CT) and VEGF inhibitors. Recently, targeted therapy against BRAF and immunotherapy (IT) for cases with microsatellite instability (MSI) have been integrated into clinical practice. While targeted therapy has shown promising results, resistance to treatment eventually develops in a significant portion of responsive patients. This article aims to review the available literature on mechanisms of resistance to BRAF inhibitors (BRAFis) and potential therapeutic strategies to overcome them.
10.30.2023 Orsp Connect, Liz Williamson
12th International Conference On Business, Technology And Innovation 2023, University For Business And Technology - Ubt
12th International Conference On Business, Technology And Innovation 2023, University For Business And Technology - Ubt
UBT International Conference
Welcome to IC – UBT 2023
UBT Annual International Conference is the 12th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make …
A Dynamic Online Dashboard For Tracking The Performance Of Division 1 Basketball Athletic Performance, Erica Juliano, Chelsea Thakkar, Christopher B. Taber, Mehul S. Raval, Kaya Tolga, Samah Senbel
A Dynamic Online Dashboard For Tracking The Performance Of Division 1 Basketball Athletic Performance, Erica Juliano, Chelsea Thakkar, Christopher B. Taber, Mehul S. Raval, Kaya Tolga, Samah Senbel
School of Computer Science & Engineering Undergraduate Publications
Using Data Analytics is a vital part of sport performance enhancement. We collect data from the Division 1 'Women's basketball athletes and coaches at our university, for use in analysis and prediction. Several data sources are used daily and weekly: WHOOP straps, weekly surveys, polar straps, jump analysis, and training session information. In this paper, we present an online dashboard to visually present the data to the athletes and coaches. R shiny was used to develop the platform, with the data stored on the cloud for instant updates of the dashboard as the data becomes available. The performance of athletes …
Modelling And Forecasting Claim Payments Of Tanzania National Health Insurance Fund, Imani Kapungu, Emmanuel Evarest, Nyimvua Shaban, Andongwisye J. Mwakisisile
Modelling And Forecasting Claim Payments Of Tanzania National Health Insurance Fund, Imani Kapungu, Emmanuel Evarest, Nyimvua Shaban, Andongwisye J. Mwakisisile
Tanzania Journal of Science
The expenses of medical services are increasing across the globe. As a result, pressure is placed on government and insurance companies’ budgets. The amounts of money collected are not enough to cover the claim payments. Therefore, it threatens the sustainability of the health insurance companies due to the mismatch of income and expenditures. This study aimed to model and forecast claim payments for the national health insurance fund (NHIF) in Tanzania. The claim payment data for the period of 2001–2021 from NHIF were used in building the ARIMA model. It was proven that ARIMA (0, 2, 2) is the most …
2023 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Diane Highland
2023 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Diane Highland
Programs
Annually, Eastern Illinois University honors faculty achievements in the areas of research, creativity, and engagement. This year, the list of faculty accomplishments is again truly impressive, reflective of an engaged faculty committed to excellence and the ongoing pursuit and creation of knowledge. A number of these accomplishments occurred in collaboration with our students, who serve as co-authors, research assistants and partners in bringing these activities to fruition. Indeed, in some cases these professional ambitions transpired over the course of many years, and are a testament to persistence and tenacity--ensuring that these works extend to a broader community of scholars that …
Statistical And Machine Learning Approaches To Describe Factors Affecting Preweaning Mortality Of Piglets, Md Towfiqur Rahman, Tami M. Brown-Brandl, Gary A. Rohrer, Sudhendu R. Sharma, Vamsi Manthena, Yeyin Shi
Statistical And Machine Learning Approaches To Describe Factors Affecting Preweaning Mortality Of Piglets, Md Towfiqur Rahman, Tami M. Brown-Brandl, Gary A. Rohrer, Sudhendu R. Sharma, Vamsi Manthena, Yeyin Shi
Department of Agricultural and Biological Systems Engineering: Faculty Publications
High preweaning mortality (PWM) rates for piglets are a significant concern for the worldwide pork industries, causing economic loss and well-being issues. This study focused on identifying the factors affecting PWM, overlays, and predicting PWM using historical production data with statistical and machine learning models. Data were collected from 1,982 litters from the United States Meat Animal Research Center, Nebraska, over the years 2016 to 2021. Sows were housed in a farrowing building with three rooms, each with 20 farrowing crates, and taken care of by well-trained animal caretakers. A generalized linear model was used to analyze the various sow, …
The Contractual Liability Arising From The Violation Of Negotiations Through Modern Means Of Communication In The Jordanian Legislation, Yassin Al Qudah Dr., Juhainah Al Momani
The Contractual Liability Arising From The Violation Of Negotiations Through Modern Means Of Communication In The Jordanian Legislation, Yassin Al Qudah Dr., Juhainah Al Momani
Middle East Journal of Communication Studies
This study aims to show the effects of contractual liability for breach of negotiation via electronic means of communication in Jordanian legislation. Where it became clear that preliminary electronic negotiations are a previous basic stage in the electronic contracting process, in terms of organizing the conduct of negotiations by putting forward ideas and offers between the negotiating parties, and discussing among them to reach mutual agreement until the negotiated contract is concluded. As a result, at this stage, a set of obligations is created by each of the parties, otherwise civil liability may arise on the breaching party. This study …
The Effectiveness Of Field Training In Qualifying Students Of Media Faculties For The Labor Market: Yarmouk And Middle East Universities As A Model, Saddam Al-Masshaqbah Dr., Ramez Abuhasirah Dr.
The Effectiveness Of Field Training In Qualifying Students Of Media Faculties For The Labor Market: Yarmouk And Middle East Universities As A Model, Saddam Al-Masshaqbah Dr., Ramez Abuhasirah Dr.
Middle East Journal of Communication Studies
The study aimed to identify the effectiveness of the field training course in raising the capabilities of students of media faculties in public and private Jordanian universities and qualifying them for the labor market. The results showed that the degree of students' commitment to attendance during the field training period in media institutions came to a "huge" degree, at a rate of (39.8%), while the degree of their benefit from field training came to a "medium" degree, at a rate of (29.2%). In: "Journalism Editing," Preparation of Radio and Television Programs," and "The Art of Speaking and Presentation." training" with …
Palestinian Journalists' Trends Towards Freelance Platforms As An Alternative Of Traditional Work In Journalistic Work And The Gratifications Achieved "A Field Study", Amin Wafi Prof.
Middle East Journal of Communication Studies
This study aims to identify the trends of media students towards the use of digital freelancer platforms in media work as an alternative to traditional journalism by knowing the degree of interest of students in digital freelancer platforms. The degree to which they are exposed، the reasons for exposure، the most important subjects to which they are exposed، the most important platforms they pursue، the most important skill needs، motivations، and stimuli that drive them to deal with freelancer platforms as an alternative to traditional journalism. It is a descriptive study and applied the survey curriculum in the framework of …
Use Of Silica Dust And Lunar Simulants For Assessing Lunar Regolith Exposure, Layzamarie Irizarry-Colon
Use Of Silica Dust And Lunar Simulants For Assessing Lunar Regolith Exposure, Layzamarie Irizarry-Colon
USF Tampa Graduate Theses and Dissertations
The utilization of the lunar regolith holds immense potential for future space exploration, but the potential health risks associated with lunar regolith are a significant concern. This literature review seeks to critically assess the use of silica and lunar simulants standards and permissible exposure limits (PELs) to evaluate the adverse health effects of lunar regolith. The literature review covers an extensive analysis of existing research, health risks, toxicological properties, and physical and chemical composition associated with silica, lunar simulants, and lunar regolith by using three main sources: regulations, scholarly articles, and Kennedy Space Center (KSC) discussion. This comprehensive analysis forms …
A Framework To Validate Fluorescently Labeled Dna-Binding Proteins For Single-Molecule Experiments, Miranda Molina, Lindsey E. Way, Zhongqing Ren, Qin Liao, Bianca Guerra, Brandon Shields, Xindan Wang, Hyeongjun Kim
A Framework To Validate Fluorescently Labeled Dna-Binding Proteins For Single-Molecule Experiments, Miranda Molina, Lindsey E. Way, Zhongqing Ren, Qin Liao, Bianca Guerra, Brandon Shields, Xindan Wang, Hyeongjun Kim
Physics & Astronomy Faculty Publications
Highlights
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KCK tag can alter protein properties both quantitatively and qualitatively
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Electrostatic interactions between the KCK tag and DNA contribute to the artifacts
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Adding a short peptide tag to ParB protein does not lead to its in vivo changes
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Single-molecule DNA flow-stretching assay can detect protein property changes
Motivation
Single-molecule fluorescence microscopy has been extensively used in modern biology to define the molecular action of proteins. Appending short peptide tags is a common strategy to enhance fluorescence labeling. Here, we evaluate the impact of a commonly used tag, the lysine-cysteine-lysine (KCK) tag, on protein behavior in single-molecule DNA flow-stretching assay, …
Entanglements Of Teenage Food Security Within High School Pantries In Pinellas County, Florida, Karen T. Díaz Serrano
Entanglements Of Teenage Food Security Within High School Pantries In Pinellas County, Florida, Karen T. Díaz Serrano
USF Tampa Graduate Theses and Dissertations
Food insecurity has the ability to shape an individual’s or a family’s everyday life and take emotional, psychological, and physical tolls. Among adolescents, not having access to nutritious food could lead to physical effects during growth and development. Moreover, the stress and anxiety of not knowing where their next meal is coming from and the social stigma associated with being food insecure can have negative effects on mental health. A recent solution to these issues is locating food pantries in high schools. Purpose: This exploratory study examined how high school students in Pinellas County, Florida perceive the use of a …
Photocurable Ionized Vinylimidazole Liquid Salt For Antibacterial Application, Gina Park, Lisa Ahlberg, Robert Zdor
Photocurable Ionized Vinylimidazole Liquid Salt For Antibacterial Application, Gina Park, Lisa Ahlberg, Robert Zdor
Celebration of Research and Creative Scholarship
There has been an increasing demand for antibacterial dental composite as it can prevent the biofilm formation and the adhesion of bacteria after the treatment causing the consequential cavities. Previous study explored the antibacterial activity of the heterogenous mixture of heterocyclic polymer and resin. It showed limitations as the mixture did not show antibacterial activity since the mixture could only contain a small amount of heterocyclic polymer within the resin due to its inconvenience of shaping and low miscibility. To overcome this limitation, this research focused on synthesizing heterocyclic antibacterial monomer liquid salt and curing it with UV light to …
Evaluating The Impact Of An Mhealth Platform For Managing Acute Postoperative Dental Pain: Randomized Controlled Trial, Bunmi Tokede, Alfa Yansane, Ana Ibarra-Noriega, Joanna Mullins, Kristen Simmons, Nicholas Skourtes, Urvi Mehta, Sayali Tungare, David Holmes, Joel White, Muhammad Walji, Elsbeth Kalenderian
Evaluating The Impact Of An Mhealth Platform For Managing Acute Postoperative Dental Pain: Randomized Controlled Trial, Bunmi Tokede, Alfa Yansane, Ana Ibarra-Noriega, Joanna Mullins, Kristen Simmons, Nicholas Skourtes, Urvi Mehta, Sayali Tungare, David Holmes, Joel White, Muhammad Walji, Elsbeth Kalenderian
Faculty, Staff and Student Publications
BACKGROUND: Postoperative dental pain is pervasive and can affect a patient's quality of life. Adopting a patient-centric approach to pain management involves having contemporaneous information about the patient's experience of pain and using it to personalize care.
OBJECTIVE: In this study, we evaluated the use of a mobile health (mHealth) platform to collect pain-related patient-reported outcomes over 7 days after the patients underwent pain-inducing dental procedures; we then relayed the information to the dentist and determined its impact on the patient's pain experience.
METHODS: The study used a cluster-randomized experimental study design with an intervention arm where patients were prompted …
Determining The Ideal Concentrations Of Ethanol And Propylene Glycol In Ethosomes For Transdermal Delivery Of Vitamin D3, Rebecca Conner
Determining The Ideal Concentrations Of Ethanol And Propylene Glycol In Ethosomes For Transdermal Delivery Of Vitamin D3, Rebecca Conner
Harrisburg University Research Symposium: Highlighting Research, Innovation, & Creativity
Vitamin D3 is an important chemical in the human body, however, many Americans have low levels of this vitamin. There are plenty of oral supplementations for Vitamin D3 deficiency, but those of older age and busy schedules may struggle to meet the minimum requirement. A recently developed ethosomal transmembrane delivery system (Touitou, 2000), similar to liposomes but also containing ethanol, allows users to apply a gel dermally and have the desired drug or active ingredient reach the bloodstream faster. However, there is considerable variation in the concentration of ethanol and permeation enhancers used. Using an affordable method to …
Epidemiologic Understanding Of The Un Sustainable Development Goals, Zeinab Baba
Epidemiologic Understanding Of The Un Sustainable Development Goals, Zeinab Baba
Sustainability Research & Practice Seminar Presentations
A Sustainability Research & Practice Seminar entitled "Epidemiologic Understanding of the UN Sustainable Development Goals," presented by Professor Zeinab Baba, Department of Public Health Sciences, West Chester University of Pennsylvania.
Braf D594a Mutation Defines A Unique Biological And Immuno-Modulatory Subgroup Associated With Functional Cd8+ T Cell Infiltration In Colorectal Cancer, Wenjing Li, Chenyi Zhao, Wenhui Li, Yang Gong, Kaili Ma, Yujie Lu, Xiaowei Liu, Lianjun Zhang, Feng Guo
Braf D594a Mutation Defines A Unique Biological And Immuno-Modulatory Subgroup Associated With Functional Cd8+ T Cell Infiltration In Colorectal Cancer, Wenjing Li, Chenyi Zhao, Wenhui Li, Yang Gong, Kaili Ma, Yujie Lu, Xiaowei Liu, Lianjun Zhang, Feng Guo
Faculty, Staff and Student Publications
BACKGROUND: BRAF non-V600 mutation occupies a relatively small but critical subset in colorectal cancer (CRC). However, little is known about the biological functions and impacts of BRAF class III mutation in CRC. Here, we aim to explore how D594A mutation impacts on biological behaviors and immune related signatures in murine CRC cells.
METHODS: BRAF V600E (class I), G469V (class II) and D594A (class III) mutant cell lines were established based on MC38 cells. The biological behaviors of cells were evaluated in respect of cell growth, cell proliferation, cell apoptosis, cell migration and invasion by the methods of colony-forming assay, CCK-8 …
Helping Frontline Workers In Texas-A Framework For Resource Development, Karima Lalani, Meredith O'Neal, Simone Lee Joannou, Bhanumathi Gopal, Tiffany Champagne-Langabeer
Helping Frontline Workers In Texas-A Framework For Resource Development, Karima Lalani, Meredith O'Neal, Simone Lee Joannou, Bhanumathi Gopal, Tiffany Champagne-Langabeer
Faculty, Staff and Student Publications
First responders disproportionately experience occupational stress when compared to the general population, and COVID-19 has exacerbated this stress. The nature of their duties as law enforcement officers, firefighters, and medics exposes them to repeated trauma, increasing their risk of developing a broad array of mental health issues, including post-traumatic stress disorder (PTSD), substance use disorder (SUD), and compassion fatigue. This paper describes the need for resources for frontline workers and provides a framework for creating and implementing resources. A team of interdisciplinary subject matter experts developed two major resources. The first resource was a 24/7 helpline to support first responders …
Repurposing The Fda-Approved Anthelmintic Pyrvinium Pamoate For Pancreatic Cancer Treatment: Study Protocol For A Phase I Clinical Trial In Early-Stage Pancreatic Ductal Adenocarcinoma, Francesca M. Ponzini, Christopher W. Schultz, Benjamin E. Leiby, Shawnna Cannaday, T. Yeo, James Posey, Wilbur B. Bowne, Charles Yeo, Jonathan R. Brody, Harish Lavu, Avinoam Nevler
Repurposing The Fda-Approved Anthelmintic Pyrvinium Pamoate For Pancreatic Cancer Treatment: Study Protocol For A Phase I Clinical Trial In Early-Stage Pancreatic Ductal Adenocarcinoma, Francesca M. Ponzini, Christopher W. Schultz, Benjamin E. Leiby, Shawnna Cannaday, T. Yeo, James Posey, Wilbur B. Bowne, Charles Yeo, Jonathan R. Brody, Harish Lavu, Avinoam Nevler
Department of Surgery Faculty Papers
BACKGROUND: Recent reports of the utilisation of pyrvinium pamoate (PP), an FDA-approved anti-helminth, have shown that it inhibits pancreatic ductal adenocarcinoma (PDAC) cell growth and proliferation in-vitro and in-vivo in preclinical models. Here, we report about an ongoing phase I open-label, single-arm, dose escalation clinical trial to determine the safety and tolerability of PP in PDAC surgical candidates.
METHODS AND ANALYSIS: In a 3+3 dose design, PP is initiated 3 days prior to surgery. The first three patients will be treated with the initial dose of PP at 5 mg/kg orally for 3 days prior to surgery. Dose doubling will …
10.16.2023 Orsp Connect, Liz Williamson