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Articles 1951 - 1980 of 11064

Full-Text Articles in Medicine and Health Sciences

History And Distribution Of The Wood Stork (Mycteria Americana) In Arkansas, R. Tumlison, L. Serviss Jan 2024

History And Distribution Of The Wood Stork (Mycteria Americana) In Arkansas, R. Tumlison, L. Serviss

Journal of the Arkansas Academy of Science

Wood Storks (Mycteria americana) were thought to be common visitors to Arkansas in the early 1900s, but observations declined mid-century. Surveys of citizen science data and other online sources indicate that numbers of unique observations and total counts of birds have increased since 2000. Storks do not breed here, but have been reported in 34 of 75 counties, and appear mostly in August and September. Birds apparently originate from Mexico. Number of observations have increased since 2016, but many of those observations include only a few birds rather than larger flocks.


Geographical Variation In Songs Of Bachman’S Sparrow (Peucaea Aestivalis), L. Nguyen, K. Doñas, J. Jackson, R. Kannan Jan 2024

Geographical Variation In Songs Of Bachman’S Sparrow (Peucaea Aestivalis), L. Nguyen, K. Doñas, J. Jackson, R. Kannan

Journal of the Arkansas Academy of Science

We present an analysis of geographic variation in primary song components of the Near Threatened North American endemic, Bachman’s Sparrow (Peucaea aestivalis). These songs have 2 distinct portions: an introductory tweet we call the "whistle" and a more complex second portion that we call the "trill". We analyzed 327 songs from 111 recordings downloaded from eBird.org from the entire current range of the species. We grouped the recordings into 3 distinct geographic clusters, East, Central, and West. The data measured from spectrograms suggest a significant statistical difference among groups for 3 measured characteristics: frequency range of trill, number of horizontal …


An Annotated Checklist Of The Camel Crickets (Insecta: Orthoptera: Rhaphidophoridae) Of Arkansas, H.W. Robison, C.T. Mcallister Jan 2024

An Annotated Checklist Of The Camel Crickets (Insecta: Orthoptera: Rhaphidophoridae) Of Arkansas, H.W. Robison, C.T. Mcallister

Journal of the Arkansas Academy of Science

A total of 14 native species of camel crickets and one introduced taxon representing three genera (Ceuthophilus, Phrixocnemis, and Diestrammena) of the orthopteran family Rhaphidophoridae, are herein reported from Arkansas. The most diverse genus was Ceuthophilus, with 13 native species, while Phrixocnemis had one native species, and Diestrammena, formerly Tachycines, was represented by one introduced species. This updated checklist is intended to be of use to entomologists, naturalists, professional biologists, and resource managers in evaluating the biodiversity of Arkansas. State distributional maps are provided for each species listed by county, and habitats are discussed in which each species was taken …


Fish Leeches Of Arkansas, D.J. Richardson, W.E. Moser, C.T. Mcallister, S.P. Lawson, H.W. Robison Jan 2024

Fish Leeches Of Arkansas, D.J. Richardson, W.E. Moser, C.T. Mcallister, S.P. Lawson, H.W. Robison

Journal of the Arkansas Academy of Science

Recent collection within Arkansas greatly enlarges the knowledge concerning hosts and distributions of fish leeches within the state. The natural history of the 6 species of fish leeches known from Arkansas (Placobdella montifera, Placobdella pediculata, Cystobranchus klemmi, Cystobranchus verrilli, Myzobdella lugubris, and Myzobdella reducta) is reviewed and updated and molecular data are provided.


Development Of A Positive Urinalysis Criteria Using A Machine Learning Approach, Kari Flicker, Jessica Parrott, Tammy Speerhas, Turaj Vazifedan, Theresa Guins, Jeffrey Bobrowtiz, Anne Mcevoy, Jade Eves, Debra Conrad, Benjamin Klick Jan 2024

Development Of A Positive Urinalysis Criteria Using A Machine Learning Approach, Kari Flicker, Jessica Parrott, Tammy Speerhas, Turaj Vazifedan, Theresa Guins, Jeffrey Bobrowtiz, Anne Mcevoy, Jade Eves, Debra Conrad, Benjamin Klick

Ellmer School of Nursing Faculty Publications

Background: Urinary tract infections (UTIs) are a commonly encountered diagnosis at pediatric urgent care (UC) centers. The urinalysis (UA) is usually the initial study in UC settings used to guide decisions regarding initiating empiric antibiotics and/or pursuing urine culture. However, studies in pediatric UC settings examining the ideal threshold for a positive result are lacking.

Methods: UA result data were extracted from the records of 6,327 pediatric patients, which were collected as part of a previous QI project. Logistic regression was used to determine the predictors of positive urine cultures. Decision trees for a positive UA result for both clean …


Body-Oriented Gesture Generation System For Medical Interpreter Robots Based On Reinforcement Learning From Human Feedback, Tung Ngo, Emma Murphy, Conor Mcginn, Robert Ross Jan 2024

Body-Oriented Gesture Generation System For Medical Interpreter Robots Based On Reinforcement Learning From Human Feedback, Tung Ngo, Emma Murphy, Conor Mcginn, Robert Ross

Conference papers

Medical interpreters are crucial in facilitating communication between healthcare stakeholders who speak different languages. Body-oriented gestures convey critical information essential for accurate and high-quality interpretation in healthcare settings. This study introduces a body-oriented gesture generation system designed for medical interpreter robots based on reinforcement learning from human feedback (RLHF). The system allows robots to interpret more naturally and improve over time through interactions with humans. By adopting a human-centered development approach, we tailor our system to address the actual needs of healthcare stakeholders.


Landscape-Scale Epidemiological Dynamics Of Sars-Cov-2 In White-Tailed Deer, Joshua Hewitt, Grete Wilson-Henjum, Derek T. Collins, Timothy J. Linder, Julianna B. Lenoch, Jonathan D. Heale, Christopher A. Quintanal, Robert Pleszewski, Dillon S. Mcbride, Andrew S. Bowman, Jeffrey C. Chandler, Susan A. Shriner, Sarah N. Bevins, Dennis J. Kohler, Richard B. Chipman, Allen L. Gosser, David L. Bergman, Thomas J. Deliberto, Kim M. Pepin Jan 2024

Landscape-Scale Epidemiological Dynamics Of Sars-Cov-2 In White-Tailed Deer, Joshua Hewitt, Grete Wilson-Henjum, Derek T. Collins, Timothy J. Linder, Julianna B. Lenoch, Jonathan D. Heale, Christopher A. Quintanal, Robert Pleszewski, Dillon S. Mcbride, Andrew S. Bowman, Jeffrey C. Chandler, Susan A. Shriner, Sarah N. Bevins, Dennis J. Kohler, Richard B. Chipman, Allen L. Gosser, David L. Bergman, Thomas J. Deliberto, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

Understanding pathogen emergence in new host species is fundamental for developing prevention and response plans for human and animal health. We leveraged a large-scale surveillance dataset coordinated by United States Department of Agriculture, Animal and Plant Health Inspection Service and State Natural Resources Agencies to quantify the outbreak dynamics of SARS-CoV-2 in North American white-tailed deer (Odocoileus virginianus; WTD) throughout its range in the United States. Local epidemics in WTD were well approximated by a single-outbreak peak followed by fade out. Outbreaks peaked early in the northeast and mid- Atlantic. Local effective reproduction ratios of SARS-CoV-2 were between …


What Is Known, Unknown, And Needed To Be Known About Damage Caused By Wild Pigs, Kurt C. Vercauteren, Kim M. Pepin, Seth M. Cook, Sophie Mckee, Abigail Pagels, Keely J. Kohen, Ingrid A. Messner, Michael P. Glow, Nathan P. Snow Jan 2024

What Is Known, Unknown, And Needed To Be Known About Damage Caused By Wild Pigs, Kurt C. Vercauteren, Kim M. Pepin, Seth M. Cook, Sophie Mckee, Abigail Pagels, Keely J. Kohen, Ingrid A. Messner, Michael P. Glow, Nathan P. Snow

United States Department of Agriculture Wildlife Services: Staff Publications

Damage assessments provide evidence for initiating and evaluating management programs that protect natural resources and human livelihoods against invasive species. Wild pigs (Sus scrofa) cause extensive damage in their native and non-native ranges, but the extent of current damage and efficacy of management of the damage (i.e., population control of wild pigs, exclusion fencing, etc.) remains poorly described. We conducted a systematic review of physical damage caused by wild pigs to summarize what is known and identify knowledge gaps for damage assessment. Wild pig damage assessments have been overwhelmingly qualitative (84% of studies) and measured differently across studies, …


Tracking Sero-Molecular Trends Of Swine Brucellosis In Hawai'i And The Central Pacific, Thi Hai Au La, Ian A. Mcmillan, Prashant Dahal, Andrew H. Burger, Mahdi Belcaid, Darrin M. Phelps, Samuel M. Goldstein, Vienna R. Brown, Michael H. Norris Jan 2024

Tracking Sero-Molecular Trends Of Swine Brucellosis In Hawai'i And The Central Pacific, Thi Hai Au La, Ian A. Mcmillan, Prashant Dahal, Andrew H. Burger, Mahdi Belcaid, Darrin M. Phelps, Samuel M. Goldstein, Vienna R. Brown, Michael H. Norris

United States Department of Agriculture Wildlife Services: Staff Publications

Introduction

Brucellosis is a zoonotic disease of mammals caused by bacterial species of the Brucella genus. The reservoir for disease is typically mammals, with species of Brucella found infecting amphibians, bats, and marine mammals. Brucella spp. can pass directly to humans through contact with infected animals or their products. Brucella spp. can cause chronic debilitating infections in mammals, including humans, and is associated with spontaneous abortions in infected animals, causing reduced fecundity. In Hawai‘i, terrestrial species that could harbor Brucella spp. include swine, cattle, horses, and axis deer among others. The numerous feral swine in Hawai‘i are known to carry …


The Impact Of Dissolved Organic Matter On Photodegradation Rates, Byproduct Formations, And Degradation Pathways For Two Neonicotinoid Insecticides In Simulated River Waters, Josephus F. Borsuah, Tiffany L. Messer, Daniel D. Snow, Steven D. Comfort, Shannon Bartelt-Hunt Jan 2024

The Impact Of Dissolved Organic Matter On Photodegradation Rates, Byproduct Formations, And Degradation Pathways For Two Neonicotinoid Insecticides In Simulated River Waters, Josephus F. Borsuah, Tiffany L. Messer, Daniel D. Snow, Steven D. Comfort, Shannon Bartelt-Hunt

UK CARES Faculty Publications

The influences of dissolved organic matter (DOM) on neonicotinoid photochemical degradation and product formation in natural waters remain unclear, potentially impacting the sustainability of river systems. Therefore, our overall objective was to investigate the photodegradation mechanisms and phototransformation byproducts of two neonicotinoid pesticides, imidacloprid and thiamethoxam, under simulated sunlight at the microcosm scale, to assess the implications of DOM for insecticide degradation in rivers. Direct and indirect photolysis were investigated using twelve water matrices to identify possible reaction pathways with two DOM sources and three quenching agents. Imidacloprid, thiamethoxam, and potential degradants were measured, and reaction pathways identified. The photodegradation …


Flexible Attenuation Fields: Tomographic Reconstruction From Heterogeneous Datasets, Clifford S. Parker Jan 2024

Flexible Attenuation Fields: Tomographic Reconstruction From Heterogeneous Datasets, Clifford S. Parker

Theses and Dissertations--Computer Science

Traditional reconstruction methods for X-ray computed tomography (CT) are highly constrained in the variety of input datasets they admit. Many of the imaging settings -- the incident energy, field-of-view, effective resolution -- remain fixed across projection images, and the only real variance is in the detector's position and orientation with respect to the scene. In contrast, methods for 3D reconstruction of natural scenes are extremely flexible to the geometric and photometric properties of the input datasets, readily accepting and benefiting from images captured under varying lighting conditions, with different cameras, and at disparate points in time and space. Extending CT …


When Brain Meets Artificial Intelligence, Lu Zhang Jan 2024

When Brain Meets Artificial Intelligence, Lu Zhang

Computer Science and Engineering Dissertations - Archive

When we review the history of development of artificial intelligence (AI), we will find that brain science plays a pivotal role in fostering breakthroughs in AI, such as artificial neural networks (ANNs). Today, AI has made remarkable strides, particularly with the emergence of large language models (LLMs), surpassing expectations and achieving human-level performance in certain tasks. Nonetheless, an insurmountable gap remains between AI and human intelligence. It is urgent to establish a bridge between brain science and AI, promoting their mutual enhancement and collaborations. This involve establishing connections from brain science to AI (brain-inspired AI), and reversely, from AI to …


Outpatient Fall Prevention In Ambulatory Adults 65 Years Old And Over, Dorothy L. Osborne-White Jan 2024

Outpatient Fall Prevention In Ambulatory Adults 65 Years Old And Over, Dorothy L. Osborne-White

Doctor of Nursing Practice (DNP) Scholarly Projects - Archive

Background: In the United States (U.S.), falls are the leading cause of injury among adults 65 and over, resulting in 36 million falls yearly (Moreland et al., 2020). According to the Centers for Disease Control and Prevention (CDC, 2023), one in four older adults experiences a fall each year. Falls are the world's second most prominent cause of accidental deaths (World Health Organization [WHO], 2021). Falls are the leading cause of both fatal and non-fatal injuries among older adults (Moreland et al., 2020).

Methods: A quality improvement project that included a fall bundle was implemented in a primary clinic. A …


Quantifying Non-Primary Dna Formations Through Mechanical And Geometric Models, Sonia E. Teodorescu Jan 2024

Quantifying Non-Primary Dna Formations Through Mechanical And Geometric Models, Sonia E. Teodorescu

Undergraduate Journal of Mathematical Modeling: One + Two

In this article, mechanical and geometric models for DNA strains (regarded as a helical structure in 3 dimensions, embedded into surfaces of various shapes (straight or curved cylinders, spheres, or projected into planes), are analyzed in order to obtain parameter estimates for DNA characteristics which can be used to detect the formation of secondary and tertiary formations in the presence of disorder. The models allow for the explicit representation of the DNA shape on constrained geometries and can therefore be implemented directly into {\it{ab initio}} or synthetic simulation studies.


Predicting The Need For Cardiovascular Surgery: A Comparative Study Of Machine Learning Models, Arman Ghavidel, Pilar Pazos, Rolando Del Aguila Suarez, Alireza Atashi Jan 2024

Predicting The Need For Cardiovascular Surgery: A Comparative Study Of Machine Learning Models, Arman Ghavidel, Pilar Pazos, Rolando Del Aguila Suarez, Alireza Atashi

Engineering Management & Systems Engineering Faculty Publications

This research examines the efficacy of ensemble Machine Learning (ML) models, mainly focusing on Deep Neural Networks (DNNs), in predicting the need for cardiovascular surgery, a critical aspect of clinical decision-making. It addresses key challenges such as class imbalance, which is pivotal in healthcare settings. The research involved a comprehensive comparison and evaluation of the performance of previously published ML methods against a new Deep Learning (DL) model. This comparison utilized a dataset encompassing 50,000 patient records from a large hospital between 2015-2022. The study proposes enhancing the efficacy of these models through feature selection and hyperparameter optimization, employing techniques …


Genetic Tracking Of A Rabid Coyote (Canis Latrans) Detected Beyond A Rabies Enzootic Area In West Virginia, Usa, Matthew W. Hopken, Crystal Gigante, Amy T. Gilbert, Richard B. Chipman, Jordana D. Kirby, Rene Edgar Condori, Samuel Mills, Chelsea Hartley, John Forbes, Lisa Dettinger, Dongxiang Xia, Yu Li, Bridgett Vonholdt Jan 2024

Genetic Tracking Of A Rabid Coyote (Canis Latrans) Detected Beyond A Rabies Enzootic Area In West Virginia, Usa, Matthew W. Hopken, Crystal Gigante, Amy T. Gilbert, Richard B. Chipman, Jordana D. Kirby, Rene Edgar Condori, Samuel Mills, Chelsea Hartley, John Forbes, Lisa Dettinger, Dongxiang Xia, Yu Li, Bridgett Vonholdt

United States Department of Agriculture Wildlife Services: Staff Publications

Wildlife translocation and cross-species transmission can impede control and elimination of emerging zoonotic diseases. Tracking the geographic origin of both host and virus (i.e., translocation versus local infection) may help determine the most effective response when high-risk cases of emerging pathogens are identified in wildlife. In May 2022, a coyote (Canis latrans) infected with the raccoon (Procyon lotor) rabies virus variant (RRV) was collected in Lewis County, West Virginia, USA, an area free from RRV. We applied host population genomics and RRV phylogenetic analyses to determine the most likely geographic origin of the rabid coyote. Coyote …


Swosu Research And Scholarly Activity Fair 2024, Swosu Office Of Sponsored Programs Jan 2024

Swosu Research And Scholarly Activity Fair 2024, Swosu Office Of Sponsored Programs

SWOSU Research and Scholarly Activity Fair Programs

On behalf of the members of the University Research and Scholarly Activity Committee (USRAC) and the Office of Sponsored Programs (OSP) at Southwestern Oklahoma State University (SWOSU) - Welcome to the Thirty-Second SWOSU Research and Scholarly Activity Fair! There are 61 poster presentations and 10 oral presentations involving over 100 student and faculty researchers, writers, presenters, artists, collaborators, and faculty sponsors encompassing activities from the SWOSU Departments of Biological Sciences, Chemistry & Physics, Engineering Technology, Kinesiology, Language & Literature, Mathematics, Music, Parks and Recreation Management, Pharmacy, Psychology, and Social Sciences.


Pupillometry As A Viable Augmentative And Alternative Communication Pathway: A Machine Learning Application, Kouadio Marc-Antoine Niamba Jan 2024

Pupillometry As A Viable Augmentative And Alternative Communication Pathway: A Machine Learning Application, Kouadio Marc-Antoine Niamba

Dissertations and Theses

Every year, clinicians diagnose 5000 new Amyotrophic Lateral Sclerosis (ALS) cases in the United States (Mehta et al., 2018). ALS is a degenerative neuromuscular disease that prevents neurons from sending impulses to the muscles, thus resulting in paralysis and death. People with ALS (PALS) not only experience limited mobility but also lose their ability to communicate. Although the disease currently remains incurable, efforts to improve the patients’ communication are increasingly leading toward Augmentative and Alternative Communication (AAC) systems (Beukelman and Mirenda, 2013). AAC systems are assistive technologies that propose to counteract the defects resulting from ALS through non-verbal communication channels. …


Examining Stigma In Rural Mental Health Care Settings: A Mixed Methods Approach, Lainie Krumenacker Jan 2024

Examining Stigma In Rural Mental Health Care Settings: A Mixed Methods Approach, Lainie Krumenacker

Murray State Theses and Dissertations

More than half of Americans will be diagnosed with a mental illness in their lifetime (CDC, 2021), yet stigma towards mental health affects both patients and providers. Although programs exist to address stigma, improve cultural competency among providers, and educate families on the importance of support, facilities are often limited on programs they provide due to allocation of resources and funds. Without a shift in treatment and programing, stigma will continue to impact patient care and outcome.

This study explored stigma among mental health providers in rural communities, while exploring potential differences in treatment among patients due to race. Mental …


Relative Altitude Estimation Of Infrared Thermal Uav Images Using Sift Features, Shirin Nasr Esfahani, Jagannathan Sarangapani Jan 2024

Relative Altitude Estimation Of Infrared Thermal Uav Images Using Sift Features, Shirin Nasr Esfahani, Jagannathan Sarangapani

Electrical and Computer Engineering Faculty Research & Creative Works

Unmanned Aerial Vehicles (UAVs) have become indispensable in various applications, including surveillance, urban scene analysis, and agricultural monitoring. Accurate altitude estimation is critical for UAV operations, especially in environments where traditional sensors like GPS, pressure altimeters, and radar may fail. This paper explores the use of infrared and thermal imaging for relative altitude estimation of UAVs, highlighting their significant advantages over traditional RGB images. Infrared and thermal imaging offer superior performance in low-light and adverse weather conditions, providing clearer visibility and more reliable feature detection. By leveraging the Scale-Invariant Feature Transform (SIFT) features, this approach utilizes the inherent benefits of …


Pleated Plasma Membrane Complex In Spermatids Of The Western Siren, Siren Nettingi (Caudata: Sirenidae), S.E. Trauth Jan 2024

Pleated Plasma Membrane Complex In Spermatids Of The Western Siren, Siren Nettingi (Caudata: Sirenidae), S.E. Trauth

Journal of the Arkansas Academy of Science

I investigated the pleated plasma membrane complex of linear folds and biflagellar entities in developing spermatids of the Western Siren, Siren nettingi. My primary goal was to reveal the ultrastructural morphology of these distinctive cellular folds (usually 8 in number) as they support the flagellar formation of biflagellated sperm found in this salamander and in other members in the family Sirenidae. My results reveal that the biflagellar components (2 sets of axonemes, undulating membranes, and axial fibers), termed biflagellar complex, develop between folds or are attached onto these folds. The folds themselves are transitory and do not directly contribute to …


Selecting And Evaluating Key Mds-Updrs Activities Using Wearable Devices For Parkinson's Disease Self-Assessment, Yuting Zhao, Xulong Wang, Xiyang Peng, Ziheng Li, Fengtao Nan, Menghui Zhuo, Jun Qi, Yun Yang, Zhong Zhao, Lida Xu, Po Yang Jan 2024

Selecting And Evaluating Key Mds-Updrs Activities Using Wearable Devices For Parkinson's Disease Self-Assessment, Yuting Zhao, Xulong Wang, Xiyang Peng, Ziheng Li, Fengtao Nan, Menghui Zhuo, Jun Qi, Yun Yang, Zhong Zhao, Lida Xu, Po Yang

Information Technology & Decision Sciences Faculty Publications

Parkinson's disease (PD) is a complex neurodegenerative disease in the elderly. This disease has no cure, but assessing these motor symptoms will help slow down that progression. Inertial sensing-based wearable devices (ISWDs) such as mobile phones and smartwatches have been widely employed to analyse the condition of PD patients. However, most studies purely focused on a single activity or symptom, which may ignore the correlation between activities and complementary characteristics. In this paper, a novel technical pipeline is proposed for fine-grained classification of PD severity grades, which identify the most representative activities. We also propose a multi-activities combination scheme based …


Diel Vertical Migration Rates Of The Dinoflagellate Species Margalefidinium Polykrikoides In A Lower Chesapeake Bay Tributary, S. Clayton, Jacqueline B. Chrabot, Michael Echevarria, Leah Gibala-Smith, Kathryn Mogatas, Peter Bernhardt, Margaret R. Mulholland Jan 2024

Diel Vertical Migration Rates Of The Dinoflagellate Species Margalefidinium Polykrikoides In A Lower Chesapeake Bay Tributary, S. Clayton, Jacqueline B. Chrabot, Michael Echevarria, Leah Gibala-Smith, Kathryn Mogatas, Peter Bernhardt, Margaret R. Mulholland

OES Faculty Publications

Margalefidinium polykrikoides is a mixotrophic dinoflagellate harmful algal bloom (HAB) species that blooms annually in the lower Chesapeake Bay. M. polykrikoides undertakes a diel vertical migration (DVM) which may give it a competitive advantage over purely phototrophic organisms who cannot access deeper nutrient pools and allow it to form large toxic blooms. Laboratory-based estimates of M. polykrikoides’ DVM rates suggest that it is one of the fastest known dinoflagellate swimmers and understanding this behavior is likely important for modeling and predicting M. polykrikoides blooms. However, to date, no field-derived estimates of M. polykrikoides’ DVM rates have been made in the …


Quantification Of Antiviral Drug Tenofovir (Tfv) By Surface-Enhanced Raman Spectroscopy (Sers) Using Cumulative Distribution Functions (Cdfs), Marguerite R. Butler, Jana Hrncirova, Meredith Clark, Sucharita Dutta, John B. Cooper Jan 2024

Quantification Of Antiviral Drug Tenofovir (Tfv) By Surface-Enhanced Raman Spectroscopy (Sers) Using Cumulative Distribution Functions (Cdfs), Marguerite R. Butler, Jana Hrncirova, Meredith Clark, Sucharita Dutta, John B. Cooper

Chemistry & Biochemistry Faculty Publications

Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive spectroscopic technique that generates signal-enhanced fingerprint vibrational spectra of small molecules. However, without rigorous control of SERS substrate active sites, geometry, surface area, or surface functionality, SERS is notoriously irreproducible, complicating the consistent quantitative analysis of small molecules. While evaporatively prepared samples yield significant SERS enhancement resulting in lower detection limits, the distribution of these enhancements along the SERS surface is inherently stochastic. Acquiring spatially resolved SERS spectra of these dried surfaces, we have shown that this enhancement is governed by a power law as a function of analyte concentration. Consequently, by definition, …


Reiq-Mediated Alarmone Signalling Regulates Growth, Stress-Induced Biofilm Formation And Spore Accumulation In Clostridioides Difficile, Areej Malik, Adenrele Oludiran, Asia Poudel, Orlando Berumen Alvarez, Charles Woodward, Erin B. Purcell Jan 2024

Reiq-Mediated Alarmone Signalling Regulates Growth, Stress-Induced Biofilm Formation And Spore Accumulation In Clostridioides Difficile, Areej Malik, Adenrele Oludiran, Asia Poudel, Orlando Berumen Alvarez, Charles Woodward, Erin B. Purcell

Chemistry & Biochemistry Faculty Publications

The bacterial stringent response (SR) is a conserved transcriptional reprogramming pathway mediated by the nucleotide signalling alarmones, (pp)pGpp. The SR has been implicated in antibiotic survival in Clostridioides difficile, a biofilm- and spore-forming pathogen that causes resilient, highly recurrent C. difficile infections. The role of the SR in other processes and the effectors by which it regulates C. difficile physiology are unknown. C. difficile RelQ is a clostridial alarmone synthetase. Deletion of relQ dysregulates C. difficile growth in unstressed conditions, affects susceptibility to antibiotic and oxidative stressors and drastically reduces biofilm formation. While wild-type C. difficile displays increased biofilm …


Lead Bioaccessibility And Commonly Measured Soil Characteristics (Detroit, Mi, Usa) – Phase 1, Sabrina R. Good, Allison R. Harris, Patrick Crouch, Conor T. Gowan, William D. Shuster, Shawn P. Mcelmurry Jan 2024

Lead Bioaccessibility And Commonly Measured Soil Characteristics (Detroit, Mi, Usa) – Phase 1, Sabrina R. Good, Allison R. Harris, Patrick Crouch, Conor T. Gowan, William D. Shuster, Shawn P. Mcelmurry

Open Data at Wayne State

Contaminated urban soil is one of the major contributors to child Pb exposure. To gain a better understanding of Pb risk in urban areas, composite samples were collected from 142 residential, privately owned, parcels in Detroit, Hamtramck, and Highland Park, Michigan, with approval from the property owners. The proximity of soil sampling and former smelter locations were also reported. Sample were collected from areas covered with turf grass. Four samples were collected, one from each cardinal direction (north, south, east, and west), 20 cm from an aluminum tent stake driven into the center of the sampling site. Soils were collected …


Spectroscopic Serology For The Quantitative Screening Of Carotenoid Compounds In Human Blood – Correlation With Clinical Macular Pigment Factors, Joy Udensi Jan 2024

Spectroscopic Serology For The Quantitative Screening Of Carotenoid Compounds In Human Blood – Correlation With Clinical Macular Pigment Factors, Joy Udensi

Doctoral

Carotenoids represent a wide range of naturally occurring pigmented compounds with an obvious presence in many plants and some animals. They constitute an important component of the human diet and have been widely recognised for their antioxidant and vision protection advantages.


Enhancing 21 U.S.C. §§ 355, 356, And 360 To Encompass Artificial Intelligence-Based Drug Design And Manufacturing Methods, Aj Tsang Jan 2024

Enhancing 21 U.S.C. §§ 355, 356, And 360 To Encompass Artificial Intelligence-Based Drug Design And Manufacturing Methods, Aj Tsang

Michigan Technology Law Review

Despite newfound attention to how artificial intelligence (AI) may accelerate pharmaceutical development, federal regulators may find that current statutes are ambiguous or silent about their applicability to AI-based drug design and manufacturing methods. This poses a serious problem in the era of Loper Bright and the Major Questions Doctrine. As federal agencies struggle to adjust to courts’ growing demand for Congress to craft clear, explicit, and express delegations of authority, this note develops a statutory framework in which the Food and Drug Administration (FDA) would have more flexibility to regulate the use of AI in advanced drug manufacturing. Guided by …


The Hazard Prediction Problem, Mary E. Helander, Brendan Smith, Sylvia Charchut, Erika Swiatowy, Calvin Nau, Gregory Cavaretta, Timothy Schuler, Adam Schunk, Héctor Ortiz-Peña Jan 2024

The Hazard Prediction Problem, Mary E. Helander, Brendan Smith, Sylvia Charchut, Erika Swiatowy, Calvin Nau, Gregory Cavaretta, Timothy Schuler, Adam Schunk, Héctor Ortiz-Peña

Social Science - All Scholarship

This work formulates the hazard prediction problem while addressing the research question: Can machine learning create a model to automatically recognize patterns that correspond to hazard state conditions during a mission-critical operation? Supervised learning models were trained and tested on data observed from mission simulators, which allowed for safe observation of dynamic system states and undesirable casualty events. The prediction task was formulated as a binary classification problem, producing the probability of being in a hazard state at time t and providing situational awareness of a possible imminent loss. Several modeling architectures were investigated: neural networks, logistic regression, a support …


A Systematic Study Of Freezing Behavior In Earthworms In Response To Auditory And Vibratory Stimuli, Navjot Singh, A. Burton, Dragana Ivkovich Claflin Jan 2024

A Systematic Study Of Freezing Behavior In Earthworms In Response To Auditory And Vibratory Stimuli, Navjot Singh, A. Burton, Dragana Ivkovich Claflin

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

This study examined the parameters needed to reliably induce a freezing fear response to a predator-like auditory stimulus in the earthworm species Eisenia Fetida. Previous work from our lab found that a grunting noise was more reliable in causing freezing compared to a mole sound, i.e. artificial versus natural predators of E. Fetida (Worthen et al., 2024). In the present study, 8 amplitude levels of grunting sound were presented in either serial or random order. The speaker location was varied so that it either did or did not touch the apparatus, thus producing a mechanical vibration in addition to the …