Medicine and Health Sciences Commons^™

A Database And Tool, Im Browser, For Exploring And Integrating Emerging Gene And Protein Interaction Data For Drosophila, Svetlana Pacifico, Guozhen Liu, Stephen Guest, Jodi R. Parrish, Farshad Fotouhi, Russell L. Finley Jr

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Biological processes are mediated by networks of interacting genes and proteins. Efforts to map and understand these networks are resulting in the proliferation of interaction data derived from both experimental and computational techniques for a number of organisms. The volume of this data combined with the variety of specific forms it can take has created a need for comprehensive databases that include all of the available data sets, and for exploration tools to facilitate data integration and analysis. One powerful paradigm for the navigation and analysis of interaction data is an interaction graph or map that represents proteins …

Meaningful Labeling Of Integrated Query Interfaces, Eduard Dragut, Clement Yu, Weiyi Meng

Cyber Center Publications

The contents of Web databases are accessed through queries formulated on complex user interfaces. In many domains of interest (e.g. Auto) users are interested in obtaining information from alternative sources. Thus, they have to access many individual Web databases via query interfaces. We aim to construct automatically a well-designed query interface that integrates a set of interfaces in the same domain. This will permit users to access information uniformly from multiple sources. Earlier research in this area includes matching attributes across multiple query interfaces in the same domain and grouping related attributes. In this paper, we investigate the naming of …

Interdependency Of Pharmacokinetic Parameters: A Chicken-And-Egg Problem? Not!, Reza Mehvar

Pharmacy Faculty Articles and Research

Pharmacokinetic (PK) software packages are widely used by scientists in different disciplines to estimate PK parameters. However, their use without a clear understanding of physiological parameters affecting the PK parameters and how different PK parameters are related to each other may result in erroneous interpretation of data. Often, mathematical relationships used for the estimation of PK parameters obscure the true physiological relationships among these parameters, prompting a discussion of which parameter came first and giving the appearance of the-chicken-and-the-egg dilemma. In this article, the author attempts to show how different PK parameters are related to physiological parameters and each other …

Optimal Therapy Regimens For Treatment-Resistant Mutations Of Hiv, Weiqing Gu, Helen Moore

All HMC Faculty Publications and Research

In this paper, we use control theory to determine optimal treatment regimens for HIV patients, taking into account treatment-resistant mutations of the virus. We perform optimal control analysis on a model developed previously for the dynamics of HIV with strains of various resistance to treatment (Moore and Gu, 2005). This model incorporates three types of resistance to treatments: strains that are not responsive to protease inhibitors, strains not responsive to reverse transcriptase inhibitors, and strains not responsive to either of these treatments. We solve for the optimal treatment regimens analytically and numerically. We find parameter regimes for which optimal dosing …

Importing Extended Producer Responsibility For Electronic Equipment Into The United States, Chad Raphael, Ted Smith

Communication

Extended Producer Responsibility (EPR) is a policy approach that holds manufacturers accountable for the full costs of their products at every stage in their life cycle. EPR typically involves requiring that producers take back their products at the end of their useful lives, or pay a recycling contractor to do so, thereby internalizing the costs of recycling or disposal in a manufacturer’s bottom line. When companies know that they will bear the costs of product return and recycling, they are more likely to redesign their products for easier and safer handling at each step in the life cycle. This approach …

Combining Linear Regression With Reconstructability Analysis: A Study Of Differences In Health Status, Renato Carletti, Martin Zwick

Complex Systems Faculty Publications and Presentations

A linear regression model was used to predict variations in health status with the hypothesis that literacy level as a proximal measure for educational attainment would show a strong correlation with health status. Groups of other independent variables have also been introduced in the model to test whether the effect of literacy on health would have been mediated by other factors, or increased by them. The linear regression model did not show any strong relation between literacy and health, but pointed to other factors as predictors of health status.

Methods of data mining have been used for exploring throughout all …

Potential Of Vibrational Spectroscopy In The Diagnosis Of Human Tumours., Eoghan O'Faolain

Doctoral

Just fewer than 20,000 people are annually diagnosed with some form of cancer in Ireland and one in three people are likely to contract some form of cancer by age 74. With the number of cases increasing at an annual rate of 2%, the early detection and treatment of cancer is becoming increasingly important. Both IR and Raman spectroscopy offer the potential for real time, quantitative detection of cancer and even precancer. This study investigates the potential of Raman and Fourier transform infrared, both benchtop and synchrotron spectroscopies for the detection of cervical cancer. The tissue was classified and its …

K-Spmm: A Database Of Murine Spermatogenic Promoters Modules & Motifs, Yi Lu, Adrian E. Platts, G Charles Ostermeier, Stephen A. Krawetz

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Understanding the regulatory processes that coordinate the cascade of gene expression leading to male gamete development has proven challenging. Research has been hindered in part by an incomplete picture of the regulatory elements that are both characteristic of and distinctive to the broad population of spermatogenically expressed genes.

Description

K-SPMM, a database of murine Spermatogenic Promoters Modules and Motifs, has been developed as a web-based resource for the comparative analysis of promoter regions and their constituent elements in developing male germ cells. The system contains data on 7,551 genes and 11,715 putative promoter regions …

University Of Texas At Tyler Catalog, 2006 - 2008, University Of Texas At Tyler

Catalogs

No abstract provided.

Horizontal Subsurface Flow Constructed Wetlands For On-Site Wastewater Treatment, Boyd C. Hoddinott

Master of Public Health Program Student Publications

Horizontal subsurface flow constructed wetlands (SSFCWs) are being used worldwide to treat wastewater from a variety of sources. An extensive literature review was conducted to update the current state of scientific knowledge on the performance of SSFCWs for domestic wastewater treatment. This review documented good treatment efficiency for the five commonly measured parameters (TSS, BOD, nitrogen, phosphorus, and fecal coliforms).

An attempt at a Meta analysis turned up a myriad of problems preventing a proper statistical review. These include lack of adherence to standard methods for effluent analysis, varying metrics for reporting treatment efficiency, variability in the nitrogen species which …

Information Systems And Health Care Xiii: Examining The Critical Requirements, Design Approaches And Evaluation Methods For A Public Health Emergency Response System, Ann L. Fruhling

Information Systems and Quantitative Analysis Faculty Publications

Research pertaining to emergency response systems has accelerated over the past few years, particularly since 9/11 events, and more recently due to Hurricane Katrina and concern over a potential of an avian flu pandemic. This study examines the requirements that are the most demanding with respect to software and hardware, and the associated design strategies for a public health emergency response system (ERS) for electronic laboratory diagnostics consultation. In addition, this study illustrates ways to evaluate the design decisions.

An important goal of a public health ERS is to improve the communication and notification of life-threatening diseases and harmful agents. …

Preparation Of Some Substituted Terephthalic Acids, Susanna Branion, Vladimir Benin

Chemistry Faculty Publications

We report in detail the preparation of two substituted terephthalic acids: 2‐sulfomethylterephthalic acid (1) and 2‐phosphonoterephthalic acid (2). Efficient, short syntheses have been developed for both compounds. They are potentially useful monomers for construction of acid‐pendant polymer chains.

Preparation, Characterization And Dft Studies Of Some New N-Nitrosocarbamates And N-Nitrosoureas, Ragavan Narayanan, Helene Hedian, Eric Shamo, Vladimir Benin

Chemistry Faculty Publications

We are presenting the preparation, characterization and density functional theory (DFT) studies {B3LYP/6-31+G(d)) of several reiated classes of N-nitrosocarbamates and N-nitrosoureas. The iong-range goal is the design and preparation of compounds, which would undergo photochemical or hydrolytic decomposition, to yield stabilized cyclic cations that can serve as alkylating agents at various nucleophilic centers, including DNA bases.

Temporal Processing In The Exponential Integrate-And-Fire Model Is Nonlinear, Joanna R. Wares, Todd W. Troyer

Department of Math & Statistics Faculty Publications

The exponential integrate-and-fire (EIF) model was introduced by Fourcaud-Trocme et al. (2003) as an extension of the standard leaky integrate-and-fire model (LIF). Here, the nonlinearity in the EIF model’s temporal response to square-wave inputs is investigated. Comparing the time course of onset and offset responses revealed that offset responses have a steeper initial slope, but a slower approach to equilibrium. A linear systems analysis performed for these square-wave inputs indicates that at frequencies above ~40 Hz, gain was slightly smaller for square-wave inputs, but phase did not change significantly relative to simulations in which the corresponding sinusoids were presented in …

Advances And Applications Of Dezert-Smarandache Theory (Dsmt) For Information Fusion (Collected Works), Vol. 2, Florentin Smarandache, Jean Dezert

Branch Mathematics and Statistics Faculty and Staff Publications

This second volume dedicated to Dezert-Smarandache Theory (DSmT) in Information Fusion brings in new fusion quantitative rules (such as the PCR1-6, where PCR5 for two sources does the most mathematically exact redistribution of conflicting masses to the non-empty sets in the fusion literature), qualitative fusion rules, and the Belief Conditioning Rule (BCR) which is different from the classical conditioning rule used by the fusion community working with the Mathematical Theory of Evidence.

Other fusion rules are constructed based on T-norm and T-conorm (hence using fuzzy logic and fuzzy set in information fusion), or more general fusion rules based on N-norm …

Introduction To N-Adaptive Fuzzy Models To Analyze Public Opinion On Aids, Florentin Smarandache, W.B. Vasantha Kandasamy

Branch Mathematics and Statistics Faculty and Staff Publications

“AIDS is not simply a physical malady, it is also an artifact of social and sexual transgression, violated taboo, fractured identity—political and personal projections. Its key words are primarily the property of the powerful. AIDS: Keywords – is my attempt to identify and contest some of the assumptions underlying our current ‘knowledge’. In this effort I am joined by many AIDS activists including people living with AIDS— Acquired Immuno Deficiency Syndrome. “A syndrome is a pattern of symptoms pointing to a “morbid state” which may or may not be caused by infectious agents; a disease, on the other hand is, …

Application Of Cognitive Engineering Principles To The Redesign Of A Dichotomous Identification Key For Parasitology, Kimberly A. Smith-Akins, Sharon Mclane, Thomas M. Craig, Todd R. Johnson

Faculty, Staff and Student Publications

Dichotomous identification keys are used throughout biology for identification of plants, insects, and parasites. However, correct use of identification keys can be difficult as they are not usually intended for novice users who may not be familiar with the terminology used or with the morphology of the organism being identified. Therefore, we applied cognitive engineering principles to redesign a parasitology identification key for the Internet. We addressed issues of visual clutter and spatial distance by displaying a single question couplet at a time and by switching to the appropriate next couplet after the user made a choice. Our analysis of …

A Time-Motion Study Of Registered Nurses’ Workflow In Intensive Care Unit Remote Monitoring, Zhihua Tang, Janine Mazabob, Liza Weavind, Eric Thomas, Todd R. Johnson

Faculty, Staff and Student Publications

Utilizing advanced information technology, Intensive Care Unit (ICU) remote monitoring allows highly trained specialists to oversee a large number of patients at multiple sites on a continuous basis. In the current research, we conducted a time-motion study of registered nurses’ work in an ICU remote monitoring facility. Data were collected on seven nurses through 40 hours of observation. The results showed that nurses’ essential tasks were centered on three themes: monitoring patients, maintaining patients’ health records, and managing technology use. In monitoring patients, nurses spent 52% of the time assimilating information embedded in a clinical information system and 15% on …

Development Of Dose Coefficients For Radionuclides Produced In Spallation Targets, Phillip W. Patton, Mark Rudin

Transmutation Sciences Physics (TRP)

Dose coefficients permit simple determination of radiation dose associated with various exposure scenarios, and ultimately permit radiation safety personnel to assess the health risks to workers in a nuclear facility. Specifically, radiation safety personnel use dose coefficients to determine the radiation dose incurred to a tissue or organ system from a given exposure. These parameters are often expressed in terms of Annual Limits on Intake (ALIs) and Derived Air Concentrations (DACs).

The research consortium comprised of representatives from several universities and national laboratories has successfully generated internal and external dose conversion coefficients for twenty radionuclides produced in spallation neutron sources. …

Lsuhsc Facilities Biweekly Update: January 2006, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2006

LSUHSC Facilities Biweekly Updates from January 13 and 27, 2006.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Lsuhsc Facilities Daily Update: January 2006, Lsuhsc Property And Facilities Management

LSUHSC Facilities Daily Updates: 2006

LSUHSC Dailly Facilities Updates from January 2006. These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Using Citation Data To Improve Retrieval From Medline, Elmer V Bernstam, Jorge R Herskovic, Yindalon Aphinyanaphongs, Constantin F Aliferis, Madurai G Sriram, William R Hersh

Faculty, Staff and Student Publications

OBJECTIVE: To determine whether algorithms developed for the World Wide Web can be applied to the biomedical literature in order to identify articles that are important as well as relevant. DESIGN AND MEASUREMENTS A direct comparison of eight algorithms: simple PubMed queries, clinical queries (sensitive and specific versions), vector cosine comparison, citation count, journal impact factor, PageRank, and machine learning based on polynomial support vector machines. The objective was to prioritize important articles, defined as being included in a pre-existing bibliography of important literature in surgical oncology. RESULTS Citation-based algorithms were more effective than noncitation-based algorithms at identifying important articles. …

Hybrid Committee Classifier For A Computerized Colonic Polyp Detection System, Jiang Li, Jianhua Yao, Nicholas Petrick, Ronald M. Summers, Amy K. Hara, Joseph M. Reinhardt (Ed.), Josien P.W. Pluim (Ed.)

Electrical & Computer Engineering Faculty Publications

We present a hybrid committee classifier for computer-aided detection (CAD) of colonic polyps in CT colonography (CTC). The classifier involved an ensemble of support vector machines (SVM) and neural networks (NN) for classification, a progressive search algorithm for selecting a set of features used by the SVMs and a floating search algorithm for selecting features used by the NNs. A total of 102 quantitative features were calculated for each polyp candidate found by a prototype CAD system. 3 features were selected for each of 7 SVM classifiers which were then combined to form a committee of SVMs classifier. Similarly, features …

Mapping Concepts In Medical Error Taxonomies, Min Zhu, Yong Huang, Yang Gong, Juliana J. Brixey, Jiajie Zhang, James P. Turley

Faculty, Staff and Student Publications

No abstract provided.

Model Checking For Roc Regression Analysis, Tianxi Cai, Yingye Zheng

Harvard University Biostatistics Working Paper Series

The Receiver Operating Characteristic (ROC) curve is a prominent tool for characterizing the accuracy of continuous diagnostic test. To account for factors that might invluence the test accuracy, various ROC regression methods have been proposed. However, as in any regression analysis, when the assumed models do not fit the data well, these methods may render invalid and misleading results. To date practical model checking techniques suitable for validating existing ROC regression models are not yet available. In this paper, we develop cumulative residual based procedures to graphically and numerically assess the goodness-of-fit for some commonly used ROC regression models, and …

Spatial Autocorrelation Of Deer-Vehicle Accidents In Vigo County, J. Scott Horn

All-Inclusive List of Electronic Theses and Dissertations

Deer-vehicle accidents (DV As) are a problem in many areas. They cause millions of dollars in property damage, personal injury, and loss of life each year. This thesis examines whether DVAs in Vigo County, Indiana during the year 2000 were spatially autocorrelated; and whether DV As selected by deer habitat were spatially autocorrelated. Specifically using Moran's I to test for spatial autocorrelation this study determined if and to what degree spatial autocorrelation existed among these DVAs. A Moran's I value of .0023 shows that the accidents occurred randomly. These DV A data were then used to plot a map which …

Message From The Provost, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Mcnair Scholars Program, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Full Issue, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Notes From The Director, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.