Medicine and Health Sciences Commons^™

Fall 1989, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Fall 1989

Effect Of Inhibitors Of Arachidonic Acid Metabolism On Corneal Neovascularization In The Rat, W. L. Haynes, A. D. Proia, G. K. Klintworth

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.

Porous Microspheres For Drug Delivery And Methods For Making Same, Patrick P. Deluca, Motoko Kanke, Toyomi Sato, Hans G. Schroeder

Pharmaceutical Sciences Faculty Patents

Controlled release drug delivery systems comprised of spherical microporous polymeric network of interconnecting channels containing pore incorporated drugs or other agents wherein the drugs or agents are confined within the pore channel are described. Also disclosed are processing parameters in connection with the novel method of the invention for obtaining drug delivery systems especially suited for parenteral as well as oral administration.

50 Years Of Excellence: A Commemorative History Honoring The 50th Anniversary Of The Southwestern Oklahoma State University School Of Pharmacy 1939-1989, Southwestern Oklahoma State University

Pharmacy

A Commemorative History Honoring the 50th Anniversary of the School of Pharmacy Southwestern Oklahoma State University 1939-1989

Pharmacokinetics Of Gentamicin In Neonates On Extracorporeal Membrane Oxygenation., W. Michael Southgate, Joseph T. Dipiro, Alex F. Robertson

Publications from the Office of the Dean

Extracorporeal membrane oxygenation (ECMO) has been used in more than 1,000 infants in 50 centers in the United States. The extracorporeal circuit contains approximately 400 ml of blood, an amount exceeding the blood volume of most full-term neonates. The effect of this additional blood volume on drug disposition is unknown. In this study, we determined the pharmacokinetic parameters of gentamicin in 10 infants on ECMO. Gentamicin concentrations were determined by a fluorescence polarization immunoassay. Pharmacokinetic parameters were determined from these concentrations by using a two-compartment model. Our study demonstrated a mean steady-state volume of distribution of 0.51 +/- 0.11 liters/kg, …

Southeastern University Of Health Sciences Catalog 1989-1991, Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Structure And Function Of Human Hemoglobin Covalently Labeled With Periodate-Oxidized Adenosine Triphosphate, Michael Kavanaugh, Max F. Perutz, Giulio Fermi, Daniel T. Shih, Richard T. Jones

Biomedical and Pharmaceutical Sciences Faculty Publications

Periodate-oxidized adenosine triphosphate (o-ATP), a ribose ring-opened dialdehyde derivative of ATP, reacts specifically with human deoxyhemoglobin to give a single major covalently modified product after reduction with sodium borohydride. This product, designated di-ATP Hb, was isolated using ion-exchange chromatography and shown to have incorporated two molecules of o-ATP/tetramer. Peptide mapping and x-ray crystallography at 2.8-A resolution indicate that a covalent adduct is formed between the ligand and residues Lys-82 EF6 of each beta chain in the organic phosphate-binding site of the molecule. di-ATP Hb exhibits a significantly decreased oxygen affinity (P50 = 20.8 mm Hg versus 5.8 mm Hg control; …

1989 Apothecary, Southwestern Oklahoma State University

Apothecary

The Apothecary staff would like to take this opportunity to congratulate the seniors who successfully completed their three years of professional training at Southwestern Oklahoma State University School of Pharmacy. We trust that they will strive for excellence in all of their endeavors and that they will use the knowledge that they have gained at Southwestern to make further advances in the Pharmacy profession.

Aldosterone Stimulates K Secretion Across Mammalian Colon Independent Of Na Absorption, Gerhard Rechkemmer, Dan R. Halm

Neuroscience, Cell Biology & Physiology Faculty Publications

K transport across guinea pig (Cavia porcellus) distal colon was measured in vitro using isotopically determined unidirectional fluxes. Aldosterone stimulated electrogenic Na absorption, as measured by amiloride-sensitive short-circuit current (I_sc), and reduced net K absorption from +2.5 ± 0.2 µEq/cm² per hr to +0.8 ± 0.3 µEq/cm² per hr (mean ± SEM). Amiloride addition to the mucosal solution did not enhance net K absorption, as expected if inhibiting active Na absorption would reduce active K secretion as in the distal nephron. The amiloride-insensitive I_sc was -1.0 ± 0.2 µEq/cm² per hr (mean ± SEM) …

Summer 1988, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Summer 1988

Hypothesis For Prediction Of Stimulant Drug Effectiveness Utilizing Sensory Integrative Diagnostic Methods, Judith Giencke Kimball

Occupational Therapy Faculty Publications

Despite extensive research, there has been no way to predict before drug administration which children with attention deficit hyperactivity disorder (ADHD) will respond to medication intended to calm them. A drug trial is the current method used. This paper discusses the action of stimulant medications and presents a hypothesis as to why they work on some children and not others. Sensory integration theory, particularly on vestibular system measures, that involves differential diagnosis of certain types of ADHD children, is used to explain why some children respond to stimulant medications.

Preparation Of Biodegradable Microspheres Useful As Carriers For Macromolecules, Patrick P. Deluca, Frantisek Rypacek

Pharmaceutical Sciences Faculty Patents

A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.

Identification Of The Binding Subunit Of The Sigma-Type Opiate Receptor By Photoaffinity Labeling With 1-(4-Azido-2-Methyl[6-3h]Phenyl)-3-(2-Methyl[4,6-3h]Phenyl)Guanidine, Michael Kavanaugh, Barbara C. Tester, Michael W. Scherz, John F. W. Keana, Eckard Weber

Biomedical and Pharmaceutical Sciences Faculty Publications

The sigma-type opiate receptor is a distinct binding site in the brain that may mediate some of the psychotomimetic effects caused by benzomorphan opiates and phencyclidine in humans. We have developed a synthetic, highly selective ligand for this receptor, 1,3-di-o-tolylguanidine (DTG). To identify the binding protein(s) of the sigma receptor, we have now synthesized a radiolabeled azide derivative of DTG, 1-(4-azido-2-methyl[6-3H]phenyl)-3-(2-methyl[4,6-3H]phenyl)-guanidine ([3H]N3DTG). In guinea pig brain membrane binding assays conducted in the dark, [3H]N3DTG bound reversibly, selectively, and with high affinity (Kd = 10 nM) to sigma receptors. The drug specificity profile of reversible [3H]-N3DTG binding was identical to that …

1988 Apothecary, Southwestern Oklahoma State University

Apothecary

The Apothecary staff would like to take this opportunity to congratulate the seniors who successfully completed their three years of professional training at Southwestern. We trust that they will strive for excellence in all of their endeavors and that they will use the knowledge they have gained at Southwestern to make further advances in the pharmacy profession.

We would like to extend a note of appreciation to the Southwestern Oklahoma State University School of Pharmacy alumni and friends, the individual stores, and the companies whose generous contributions have made the publication of the 1988 Apothecary possible.

Evaluating Cholesterol Screening In A Community Pharmacy, Osama Mohamed Ibrahim

University of the Pacific Theses and Dissertations

The purpose of this research project was to evaluate the role of the community pharmacist in screening, identifying, and referring ambulatory patients with high total blood cholesterol (TBC) in a community pharmacy. Fifty seven patients, out of 241 initially screened individuals, met the study inclusion criteria and were accepted into this study. Of these 57 patients, 51 patients completed the six month study period. The normal population group consisted of 164 participants with TBC < 200 mgjdL at the initial cholesterol testing (visit 1). The drop out group represented six patients who failed to continue attending the two follow up tests (visit 2 and 3). For screening purposes, a non-fasting whole blood sample was used to measure TBC using the Boehringer Mannheim Reflotron analyzer.

The project was evaluated based on mean TBC levels obtained during the initial screening and the two follow up tests, pre-test and post-test scores, behavior and …

Polyamine And Acetylpolyamine Levels During Phenylhydrazine-Induced Erythropoiesis In Mouse Spleen, Othman A. Alshabanah

University of the Pacific Theses and Dissertations

The phenylhydrazine-induced erythropoietic mouse spleen is used as a model system to demonstrate the relationship between tissue growth and polyamine metabolism. Phenylhydrazine produced significant changes in spleen weights, hematocrits and reticulocyte counts in Swiss-Webster mice. The average spleen weight went up from a control of 155 mg to 875 mg at 96 hours after phenylhydrazine administration, while a 49% reduction in the value of hematocrit was observed at 72 hours. Reticulocyte counts in peripheral blood went from 0.8 to 58% at 168 hours after treatment with phenylhydrazine. Phenylhydrazine at a dose of 40 mg/kg produced significant increases in the levels …

Triazoline Anticonvulsant Compounds And Compositions, Pankaja K. Kadaba

Pharmaceutical Sciences Faculty Patents

Anticonvulsant compositions comprise as the active ingredient a compound . . .

To see the remainder of this abstract, please download this patent.

Spring 1987, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Spring 1987

Peptide Elastase Inhibitors And Methods, George Digenis, Bushra J. Agha, Kiyoshi Tsuji

Pharmaceutical Sciences Faculty Patents

To read this abstract, please download this patent.

Effect Of Hemorrhagic Shock On Cefazolin And Gentamicin Pharmacokinetics In Dogs., Paul L. Dickson, Joseph T. Dipiro, Katherine A. Michael, Richard P. F. Cheung, Edward M. Hall

Publications from the Office of the Dean

The physiologic response to traumatic injury may alter the disposition of drugs and thereby affect their therapeutic or toxic potential. A study was conducted in 10 mongrel dogs to determine theeffect of experimental hemorrhagic shock with resuscitation on the pharmacokinetics of gentamicinand cefazolin. Single simultaneous intravenous doses of gentamicin (3 mg/kg) and cefazolin (25 mg/kg) were administered to each animal on an initial study day, after which serial blood and urine collections were performed. After 1 week, a standard hemorrhagic shock model was applied to each animal. Shock was continued for 1 h, after which the animal was resuscitated with …

1987 Apothecary, Southwestern Oklahoma State University

Apothecary

The Apothecary staff would like to take this opportunity to congratulate the seniors who successfully completed their three years of professional training at Southwestern. We trust that they will strive for excellence in all of their endeavors and that they will use the knowledge they have gained at Southwestern to make further advances in the pharmacy profession.

Asbestos And The Dalkon Shield: Corporate America On Trial, Joseph A. Page

Georgetown Law Faculty Publications and Other Works

Asbestos and the Dalkon Shield intrauterine device share a number of unhappy distinctions. Both products have exacted a terrible human toll. Damage suits seeking recovery for harm linked to both have put considerable strain on the judicial system. Corporate decisions made in the course of marketing both have been deemed reprehensible. Manufacturers of both have sought refuge in bankruptcy. And both have provided the grist for hard-hitting books by veteran investigative journalists.

Paul Brodeur's Outrageous Misconduct: The Asbestos Industry on Trial returns a harsh verdict against the Manville Corporation and others directly and indirectly involved in the production of what …

Investigation Of Physicochemical And Formulation Parameters For Transdermal Delivery Of Isoproterenol Hc1, Rajesh Arvindkumar Patel

University of the Pacific Theses and Dissertations

Effects of solubility, partition coefficient, pH and selected adjuvants (propylene glycol and Azone) on the percutaneous penetration of isoproterenol HC1 in vitro have been investigated using human cadaver skin. Preliminary stability studies demonstrated that isoproterenol HC1 was very stable (less than 1% decomposition) for 24 hours at 22(DEGREES) (+OR-) 0.5(DEGREES) in the pH range 1 to 7 in the following solvents: water, normal saline, propylene glycol and a series of propylene glycol-water mixtures (10,20,40 and 60% v/v). The rate of decomposition of the drug in aqueous solutions increased with pH beyond pH 8. In normal saline, the decomposition was significant …

Formulary Status Of Cephalosporins, Agnes J. Renault

University of the Pacific Theses and Dissertations

The primary purpose of this study is to analyze the formulary status of cephalosporins among a representative sample of hospitals in the United States. In addition, the research design attempts to determine the ranking of cephalsoporins in terms of acceptance to the hospitals' formulary and actual stocking of the cephaosoporin products. The study will attempt to ascertain the reasons for these rankings and the influence of DRG implementation, teaching status and hospital bed size on number of cephalosporins on formulary and in stock. This may yield insight into the strategies that hospitals are currently using to contain a significant proportion …

Design And Evaluation Of Theophylline Monitoring For Home Health Care Patients, May Naim Mikhail

University of the Pacific Theses and Dissertations

The purpose of this study was to design, evaluate, and determine the cost benefit of a pharmacokinetic service for home-based patients. Four randomly selected patient populations were used in evaluating the service for six months. The experimental group consisted of 17 patients who were under the care of family practice physicians in private practice and who received pharmacokinetic consultation and monitoring by a pharmacist as a home health care service. The retrospective control consisted of the same 17 patients of the experimental group whose past medical history for a period of six months was used. The concurrent control consisted of …

Opioid Receptor Effects Of Two Aminotetralin Derivatives In Guinea Pig Ileum Longitudinal Muscle And Mouse Vas Deferens Preparations, Francisca Fatima Matos

University of the Pacific Theses and Dissertations

Two substituted analogs of 3-amino-2,2-dimethyltetralin, namely 3-dimethylamino-7-hydroxy-2,2-dimethyl-1-tetralone HBr (J) and 3-dimethylamino-7-hydroxy-2,2-dimethyl-1-tetralol (MRSAL) were evaluated for opioid agonist and antagonist activity using the electrically-stimulated guinea pig ileum longitudinal muscle and mouse vas deferens preparations. The effects of these compounds in these tissues were compared to those induced by several opioid prototype agonists at mu, kappa and delta sites (normorphine, dihydromorphine, ethylketocyclazocine, U-50,488H, beta -endorphin, dynorphin 1-13, leu-enkephalin and DADLE) and one opioid antagonist (naloxone). The results of these experiments demonstrated that compound J inhibited contractions in a concentration-dependent manner as an opioid agonist and its effects were antagonized by naloxone in …

0458: Brad Dent Papers, 1987, Marshall University Special Collections

Guides to Manuscript Collections

` Marijuana cultivation: A comparison study of New Hanover and Brunswick Counties in coastal North Carolina and Cabell and Wayne Counties in the mountainous ranges of West Virginia,' a paper written for a psychology class at the University of North Carolina-Wilmington in the spring of 1987.

Alternative Pharmacokinetic Models In End Stage Renal Disease During Continuous Ambulatory Peritoneal Dialysis, Eugenio Cefali

Theses and Dissertations

An important principle of pharmacokinetic modeling is to use the least complicated model possible that adequately describes the process studied. Pharmacokinetic studies in peritoneal dialysis often attempt to describe the time course of drug concentration in the dialysate. Peritoneal dialysis patients are subjected to the inconvenience and risk of infection associated with sampling peritoneal fluid. Alternative pharmacokinetic models were used to study drug distribution during continuous ambulatory peritoneal dialysis (CAPD). Efficient pharmacokinetic models of distribution in the peritoneal cavity were described for three drugs and the classes they represent.

Procainamide pnarmacokinetics were determined in six CAPD patients. The time course …

Development Of The Analytical Methodology For Pyrimethamine And Its Application To Studies Of Partitioning And Binding In The Subcompartments Of Blood, Anita C. Rudy

Theses and Dissertations

An original HPLC assay was developed for pyrimethamine (PYR) in plasma, RBCs, and buffer for the purpose of studying its plasma protein binding and RBC partitioning.

Equilibrium dialysis (ED) was used to study protein binding. Isotonic phosphate buffer used in ED did not prevent small volume shifts. The pH of the plasma affected the protein binding of PYR although it was not significant for the comparison of binding at pH 7.4 vs. 8.0. PYR at 1000 ng/ml averaged 93.1% bound to plasma proteins. Binding to pure human albumin was 86.5% at lower levels of albumin and PYR (350 ng/ml). There …

Aryl Substituted 1h-4,5-Dihydro-1,2,3-Triazoles As Anticonvulsants, Pankaja K. Kadaba

Pharmaceutical Sciences Faculty Patents

Anticonvulsant compositions comprise as the active ingredient a compound . . .

To see the remainder of this abstract, please download this patent.