Medicine and Health Sciences Commons^™

Interaction Of Hypothalamic GabaA And Excitatory Amino Acid Receptors Controlling Heart Rate In Rats, Robert P. Soltis, Joseph A. Dimicco

Scholarship and Professional Work – COPHS

We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to stress. The purpose of this study was to examine the role of excitatory amino acid (EAA) receptors in the DMH in generating the cardiovascular changes caused by withdrawal of local GABAergic inhibition in urethan-anesthetized rats. Local treatment of the DMH with the nonselective EAA antagonist kynurenic acid blocked or reversed the increases in heart rate and blood pressure caused by microinjection of the GABAA antagonists bicuculline methiodide (BMI) …

3-Hydroxy-N-Methylpyrrolidone And Use As Transdermal Enhancer, George A. Digenis, Walter J. Doll, Amale Hawi

Pharmaceutical Sciences Faculty Patents

The novel compound, 3-hydroxy-N-methylpyrrolidone, is effective as a transdermal enhancer for the absorption of drugs through the skin of humans and animals. The 3-hydroxy-N-methylpyrrolidone is prepared from delta-butyrolactone which is converted to methyl 2,4-dibromobutyrate, this intermediate is reacted with methylamine to form N-methyl-2,4-dibromobutyramide, this intermediate is converted to 3-bromo-N-methyl-2-pyrrolidone by ring closure, and the 3-bromo-N-methyl-2-pyrrolidone is reacted with an alkaline earth metal carbonate or alkaline metal carbonate to form 3-hydroxy-N-methyl-2-pyrrolidone.

The Effect Of Total-Body Irradiation On Corneal Neovascularization In The Fischer 344 Rat After Chemical Cauterization, M. W. Scroggs, A. D. Proia, C. F. Smith, E. C. Halperin, G. K. Klintworth

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.

Biodegradable, Low Biological Toxicity Radiographic Contrast Medium And Method Of X-Ray Imaging, Michael J. Jay, Yun Ryo

Pharmaceutical Sciences Faculty Patents

A biodegradable, low biological toxicity, particulate radiographic contrast medium comprises biodegradable polymeric spheres of average molecular weight average diameter about 10-1,000 nm or about 0.01-1.0 micron carrying in at least radiographic contrasting amount of a radiographically opaque element.

A method of obtaining a tomographic image of the body portion of a subject comprises administering to the subject a radiographically-detectable amount of the biodegradable, low-toxicity radiographic medium of claim 1; allowing for the spheres to be taken-up by the body portion; and X-raying an area comprising the body portion.

A method of improving the contrast of a tomographic image of a …

1991 Apothecary, Southwestern Oklahoma State University

Apothecary

The Apothecary staff would like to take this opportunity to congratulate the seniors who successfully completed their three years of professional training at Southwestern Oklahoma State University School of Pharmacy. We trust that they will strive for excellence in all of their endeavors and that they will use the knowledge that they have gained at Southwestern to make further advances in the Pharmacy profession.

Novel Peptidyl Carbamate Inhibitors Of The Enzyme Elastase, George A. Digenis, Bushra J. Agha

Pharmaceutical Sciences Faculty Patents

To see the abstract, please download this patent.

Southeastern University Of The Health Sciences Catalog 1991-1993, Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Pharmacokinetics Of Ceftibuten-Cis And Its Trans Metabolite In Healthy Volunteers And In Patients With Chronic Renal Insufficiency, Judy Shepard Kelloway, Walid M. Awni, Chin C. Lin, Josephine Lim, Melton B. Affrime, William F. Keane, Gary R. Matzke, Charles E. Halstenson

Pharmacotherapy and Outcomes Science Publications

The impact of renal insufficiency on the dispositions of 300 mg of orally administered ceftibuten-cis, a new broad-spectrum oral cephalosporin, and its primary metabolite ceftibuten-trans was characterized in 30 adult subjects. Subjects were divided into five groups of six subjects each on the basis of their 24-h ambulatory creatinine clearances (CL_CR). The apparent total body clearance (CL_P/F; where F is absolute bioavailability) and renal clearance of ceftibuten-cis were significantly lower in subjects with end-stage renal disease (on maintenance hemodialysis; group V) and in those with severe (CL_CR, 5 …

Interaction Between Tetraethylammonium And Amino Acid Residues In The Pore Of Cloned Voltage-Dependent Potassium Channels, Michael Kavanaugh, Michael D. Varnum, Peregrine B. Osborne, Macdonald J. Christie, Andreas E. Busch, John P. Adelman, R. Alan North

Biomedical and Pharmaceutical Sciences Faculty Publications

Extracellular tetraethylammonium (TEA) inhibits currents in Xenopus oocytes that have been injected with mRNAs encoding voltage-dependent potassium channels. Concentration-response curves were used to measure the affinity of TEA; this differed up to 700-fold among channels RBK1 (KD 0.3 mM), RGK5 (KD 11 mM), and RBK2 (KD greater than 200 mM). Studies in which chimeric channels were expressed localized TEA binding to the putative extracellular loop between trans-membrane domains S5 and S6. Site-directed mutagenesis of residues in this region identified the residue Tyr379 of RBK1 as a crucial determinant of TEA sensitivity; substitution of Tyr in the equivalent positions of RBK2 …

GabaA And Excitatory Amino Acid Receptors In Dorsomedial Hypothalamus And Heart Rate In Rats, Robert P. Soltis, Joseph A. Dimicco

Scholarship and Professional Work – COPHS

We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in emotional stress. The purpose of this study was to determine whether excitatory amino acids (EAAs) can produce a cardiovascular response similar to that caused by the GABAA receptor antagonist bicuculline methiodide (BMI) when microinjected at the same hypothalamic site in urethan-anesthetized rats and to clarify the precise locus of action of these agents. N-methyl-D-aspartic acid (NMDA, 0.68-6.8 pmol/50 nl) and kainic acid (KA, 0.47-4.7 pmol/50 nl) produced dose-related …

Transdermal Drug Permeation Enhancement Using Low Molecular Weight Primary Aliphatic Thiols, Robert M. Bennett

MUSC Theses and Dissertations

Current transdermal drug delivery systems are limited to delivery, via passive diffusion, of a few substances exhibiting natural skin penetrability. These substances are low molecular weight, highly potent agents possessing a certain degree of hydrophilicity as well as lipophilicity. These limitations are dictated by the outermost layer of the skin, the stratum corneum, which acts as a barrier. The stratum corneum consists mostly of the protein keratin. The barrier strength of keratin is attributed to its extensive disulfide bond cross-linking. In order to expand the spectrum of transdermal drug candidates this keratin barrier must be overcome. Low molecular weight primary …

Pharmaceutical Risk And The Quality Of Life, Beat Hiltbrunner, Andreas Breitsprecher

RISK: Health, Safety & Environment (1990-2002)

Quality-of-life research is briefly described and said to be in its infancy. However, the authors observe that such studies may, e.g., make it possible to better match patients and therapies. They also predict that, as scientific difficulties are overcome, the pharmaceutical industry will become more active in planning, implementing and evaluating such research.

Calcium Diluents As Matrix Forming Agents In Sustained Release Dosage Forms, Jones W. Bryan Jr.

MUSC Theses and Dissertations

The purpose of this research was to evaluate the effect of the poorly soluble diluents; calcium sulfate dihydrate, dibasic calcium phosphate dihydrate, and tribasic calcium phosphate on medicament release from solid dosage forms. Initial findings led to an investigation of the use of these diluents as matrix forming agents in the formulation of sustained release solid dosage farms. An existing single station tablet press was instrumented with a transducer strain gauge apparatus to monitor compression force applied during tablet manufacture. An automated dissolution system was used to determine medicament release from the dosage forms under investigation. These three diluents when …

Pharmacutrical Marketing In India By Subba Rao, New Delhi :Asian Institute Of Pharmacutical Marketing Publiucation, 1990., R K Vijayasarathy

IIMB Management Review

No abstract provided.

A Procedure For Performance Assessment Of Drugs Hypothesized To Be Effective In Controlling Motion Sickness, Zainab N. Ahmed

Theses and Dissertations

The Air Force Institute of Technology (AFIT) is conducting research into the effectiveness of certain drugs for controlling motion sickness. If the drugs are found to be useful, they must still be proven to have no harmful effects on the operator's performance abilities. There are many methods for assessing performance effects of drugs but very little standardization exists. The Unified Tri-Services Cognitive Performance Assessment Battery (UTC-PAB) is a performance assessment method designed to be used by all military branches. This will encourage standardization of drug testing, exchange of data, and comparability of methods. Five tests were chosen from the UTC-PAB …

3-Hydroxy-N-Methylpyrrolidone And Preparation Thereof, George A. Digenis, Walter J. Doll, Amale Hawi

Pharmaceutical Sciences Faculty Patents

The novel compound, 3-hydroxy-N-methylpyrrolidone, is effective as a transdermal enhancer for the absorption of drugs through the skin of humans and animals. The 3-hydroxy-N-methylpyrrolidone is prepared from delta-butyrolactone which is converted to methyl 2,4-dibromobutyrate, this intermediate is reacted with methylamine to form N-methyl-2,4-dibromobutyramide, this intermediate is converted to 3-bromo-N-methyl-2-pyrrolidone by ring closure, and the 3-bromo-N-methyl-2-pyrrolidone is reacted with an alkaline earth metal carbonate or alkaline metal carbonate to form 3-hydroxy-N-methyl-2-pyrrolidone.

Fall 1990, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Fall 1990

The Effect Of Oxygen On Corneal Neovascularization, M. Culton, D. B. Chandler, A. D. Proia, D. Hickingbotham, G. K. Klintworth

Osteopathic Medicine, Jerry M. Wallace School of

No abstract provided.

Patient Perceptions Of Drug Risks And Benefits, Michael S. Brown, Linda J. Wastila, Carol I. Baras, Louis Lasagna

RISK: Health, Safety & Environment (1990-2002)

This is a report of a pilot study conducted to examine patients' perceptions of drug Risks and benefits. While all of the factors influencing such perceptions are important, the findings about the extent to which views are affected by patient understanding of and confidence in regulatory oversight should be of professional interest to an especially broad audience.

Effect Of Dietary Aluminum Sulfate On Calcium And Phosphorus Metabolism Of Broiler Chicks, Akmed S. Hussein, Austin H. Cantor, Thomas H. Johnson, Robert A. Yokel

Animal and Food Sciences Faculty Publications

The effect of dietary aluminum sulfate on Ca and P metabolism was studied using 1-day-oldmale broiler chicks. In Experiment 1, practical diets providing .90% Ca plus .45% available P (P_av), .90% Ca plus .78% P_av, 1.80% Ca plus .45% P_av, or 1.80% Ca plus .90% P_av were fed with 0 or .392% Al as aluminum sulfate for 21 days. The control diet (.90% Caplus .45% P_av) without added A1 was fed to all chicks during Days 22 to 49. In general, Al significantly (Pi), tibia breaking strength, tibia weight, percentage of …

Relationship Of Dietary Aluminum, Phosphorus, And Calcium To Phosphorus And Calcium Metabolism And Growth Performance Of Broiler Chicks, Akmed S. Hussein, Austin H. Cantor, Thomas H. Johnson, Robert A. Yokel

Animal and Food Sciences Faculty Publications

Dietary treatments providing three levels of added Al (0, .196, or .392%) as aluminum sulfate and of available phosphorus (P_av) (.45, .68, or .78%) in a factorial arrangement were administered to day-old chicks in Experiment 1. Plasma inorganic phosphorus (P_i) was significantly (P < .05) elevated by increasing P_av and was decreased by Al. Body weight gain, feed intake, and the gain:feed ratio at Day 21 were significantly decreased by increased concentrations of Al, but were unaffected by the P_av concentrations. Decreases of 39 and 73% in weight gain and of 34 and 66% in feed intake resulted from feeding …

Pharmacokinetics Of Cefepime In Patients With Respiratory Tract Infections, J. M. Kovarik, J. C. Ter Maaten, C. M. A. Rademaker, M. Deenstra, I. M. Hoepelman, H. C. Hart, Gary R. Matzke, J. Verhoef

Pharmacotherapy and Outcomes Science Publications

The steady-state pharmacokinetics of cefepime were evaluated in 10 middle-aged and elderly patients with acute lower respiratory tract infections who were receiving 1 g intravenously every 12 h. One preinfusion and 15 postinfusion serum samples and total urine output were collected over one dosing interval between days 3 and 8 of therapy. Cefepime concentrations in serum over time exhibited a multicompartmental profile. Peak and trough concentrations in serum determined by a validated high-performance liquid chromatography method were 71.2 +/- 17.2 (mean +/- standard deviation) and 6.0 +/- 4.9 mg/liter, respectively. The steady-state volume of distribution was 0.22 +/- 0.05 liter/kg. …

Apparent Biliary Pseudolithiasis During Ceftriaxone Therapy, Karen L. Heim-Duthoy, Erskine M. Caperton, Robert Pollock, Gary R. Matzke, Dirk Enthoven, Phillip K. Peterson

Pharmacotherapy and Outcomes Science Publications

Biliary pseudolithiasis has been reported in patients who received ceftriaxone therapy. To examine this phenomenon further, serial gallbladder sonograms were evaluated in 44 adult patients who received intravenous ceftriaxone at 2 g or a placebo daily for 14 days in a double-blind controlled study. Ultrasound examinations of gallbladders were performed on days 1 and 14 of therapy and 2 weeks posttherapy if abnormalities were observed on day 14. Eight patients were unevaluable because of abnormal base-line gallbladder sonograms. Thirty-six patients (ceftriaxone, n = 28; placebo, n = 8) demonstrated normal baseline gallbladder sonograms and were evaluated for the development of …

An Empirical Argument For Nontechnical Public Members On Advisory Committees: Fda As A Model, Joseph L. Lakshmanan

RISK: Health, Safety & Environment (1990-2002)

A discussion of the results of two surveys of present and past members of Food and Drug Administration Advisory Committees. The views and understanding of the issues before various categories of membership are compared and contrasted. It appears that technical members of advisory committees would generally welcome more participation by persons who lack special subject matter expertise.

Assessment Of Cefazolin And Cefuroxime Tissue Penetration By Using A Continuous Intravenous Infusion., John E. Connors, Joseph T. Dipiro, Ronald G. Hayter, K. Dale Hooker, Johnny A. Stanfield, Timothy R. Young

Publications from the Office of the Dean

A continuous intravenous infusion was used to assess the tissue penetration of cefazolin (14 subjects) and cefuroxime (15 subjects) in orthopedic surgery patients. Subjects were randomly assigned to receive a continuous intravenous infusion of cefazolin (mean, 178.6 mg/h) orcefuroxime (mean, 330.0 mg/h) at a rate estimated to achieve a target steady-state total concentration of 50 micrograms/ml in serum. The infusion was initiated 12 to 14 h before surgery, and blood and muscle tissue samples were collected intraoperatively at the times of incision and wound closure. Although there was a significant difference between the free concentrations ofcefazolin (at incision, 9.3 micrograms/ml; …

Effects Of Magnesium-Aluminum Hydroxide And Calcium Carbonate Antacids On Bioavailability Of Ofloxacin, Soledad Flor, David R. P. Guay, John A. Opsahl, Kenneth Tack, Gary R. Matzke

Pharmacotherapy and Outcomes Science Publications

The effects of 15- and 5-ml doses of magnesium-aluminum hydroxide (MAH) and calcium carbonate (CC) antacids, respectively, on the bioavailability of ofloxacin after single oral 400-mg doses of ofloxacin were investigated in a 32-subject, randomized, crossover, open-label study. On four separate occasions, subjects received ofloxacin alone or antacid 24 h before, 2 h before, or 2 h after ofloxacin administration (n = 16 for each antacid). CC administration had no significant effect on the rate and extent of ofloxacin absorption regardless of the timing of antacid administration. A small but significant negative effect of MAH administration 2 h before ofloxacin …

Pharmaceuticals And Intellectual Property: Meeting Needs Throughout The World, Thomas G. Field Jr.

Law Faculty Scholarship

To the extent that most people think about patents and other forms of intellectual property at all, they tend to be aware that the owners of such property may have the legal capacity to limit market entry--without fully appreciating the extent to which products or processes that can be easily copied might otherwise be unavailable. Focusing on their function in recouping risk capital, this article will survey the types and functions of intellectual property. Then it will attend to the situation in developing countries, particularly the role of intellectual property in meeting their needs for medical products.

Glucose Oxidase As A Pharmaceutical Antioxidant, Thomas F. Berg

MUSC Theses and Dissertations

Oxygen sensitive drugs in aqueous solutions are very susceptible to oxidative degradation. Antioxidants are frequently used to protect these drugs from oxidation. A 2-level resolution VI factorial was used to evaluate a glucose oxidase-catalase-glucose system and compare it to commonly used aqueous antioxidants. The drug models used to test the effectiveness of the enzyme system were ascorbic acid, morphine sulfate, and isoproterenol hydrochloride. The glucose oxidase system successfully protected the isoproterenol hydrochloride and was significantly better than the other systems tested. The glucose oxidase system was just as effective as the other antioxidants in protecting morphine sulfate. None of the …

1990 Apothecary, Southwestern Oklahoma State University

Apothecary

The Apothecary staff would like to take this opportunity to congratulate the seniors who successfully completed their three years of professional training at Southwestern Oklahoma State University School of Pharmacy. We trust that they will strive for excellence in all of their endeavors and that they will use the knowledge that they have gained at Southwestern to make further advances in the Pharmacy profession.

Novel Method Of Administering Aspirin And Dosage Forms Containing Same, Anwar A. Hussain, Lewis W. Dittert, Thomas S. Foster

Pharmaceutical Sciences Faculty Patents

The invention relates to a novel method of administering aspirin to achieve improved delivery thereof. The invention further relates to novel dosage forms of neutralized aspirin adapted for nasal administration, such as solutions, suspensions, gels and ointments. These dosage forms find utility in the treatment of conditions known to respond to the administration of aspirin, particularly in the treatment of migraine and in the mitigation of cardiovascular damage resulting from heart attack.