Medicine and Health Sciences Commons^™

1,2,3,-Triazole Anticonvulsant Drugs, Pankaja K. Kadaba

Pharmaceutical Sciences Faculty Patents

Anticonvulsant compositions comprise as the active ingredient a compound . . .

To see the remainder of this abstract, please download this patent.

Pesticidal Diphenylaziridines, Pankaja K. Kadaba, Douglas Lee Dahlman

Pharmaceutical Sciences Faculty Patents

Substituted 1,2-diphenylaziridines, particularly those which are substituted by halogen, are useful as pesticidal compositions. . . .

To read the remainder of this abstract, please download this patent.

Prediction Of Methylphenidate (Ritalin) Responsiveness Through Sensory Integrative Testing, Judith Giencke Kimball

Occupational Therapy Faculty Publications

Seventeen children previously judged to be good or poor responders to methylphenidate (Ritalin) were tested on sensory integrative measures while in the off-drug state. The tester was unaware of the children's drug response category. Results showed that children who were poor responders to Ritalin showed prolonged scores on and an adverse reaction to the Southern California Postrotary Nystagmus Test and had poorer equilibrium reactions and lower double tactile stimuli scores than the children judged good responders to Ritalin. These findings suggest that it might be possible to identify good and poor responders to Ritalin before the medication is given, something …

Spring 1986, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Spring 1986

1986 Apothecary, Southwestern Oklahoma State University

Apothecary

The Apothecary staff would like to take this opportunity to congratulate the seniors who have completed their three years of professional training. It is our hope that they will use the knowledge gained to further the profession of pharmacy and continue to display the high standard of excellence achieved at Southwestern Oklahoma State University School of Pharmacy.

The Partial Purification And Characterization Of A Soluble Activator For The Sodium Adenosinetriphosphatase From Rat Cerebral Cortex And The Effect Of Cholinergic Agents, Thibaldo Javier Manrique Blanco

University of the Pacific Theses and Dissertations

In order for organisms to co-exist with nonliving matter, envelop to protect their delicate internal functions must be present. There are other reasons for this boundary to exist, e.g. to limit the volume occupied by the organism and to compartmentalize the contents of the organism so that certain critical concentrations may be easily maintained. Such envelopes are, of course, the cellular membranes. Membranes differ greatly between species, as well as within species. Given the complexity to which organisms have evolved, membranes have developed with a myriad of functions and components. It is easy to see differences between plant cellular membranes …

Factors Associated With The Clinical Outcome And Nephrotoxicity In Patients Treated With Gentamicin, Wen-Hwei Chen

University of the Pacific Theses and Dissertations

This study is designed to investigate via discriminant analysis the factors that are associated with the clinical outcome and nephrotoxicity in patients receiving gentamicin.

Triazoline Anticonvulsant Drugs, Pankaja K. Kadaba

Pharmaceutical Sciences Faculty Patents

Anticonvulsant compositions comprise as the active ingredient a compound . . .

To see the remainder of this abstract, please download this patent.

Spring 1985, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Spring 1985

Intraoperative Ceforanide Pharmacokinetics And Protein Binding., Joseph T. Dipiro, Samir M. Bayoumi, Joseph J. Vallner, Robert R. Nesbit, Rajeev Gokhale, J. Peter Rissing

Publications from the Office of the Dean

The pharmacokinetics and protein binding of ceforanide were studied in 15 patients undergoing cholecystectomies. Each patient received ceforanide (20 mg/kg) intravenously on arrival in the operating room, after which serial blood samples were collected during the elimination phase for determination of total and free ceforanide concentrations in the serum. A high-pressure liquid chromatography assay was used, with a centrifugal filtration system for free-drug determinations. Serum concentration data for each individual were subjected to linear regression to determine the elimination rate constants (total and free drug), volumes of distribution, and systemic clearances. The mean elimination rate constants were 0.41 and 0.50 …

1985 Apothecary, Southwestern Oklahoma State University

Apothecary

The Apothecary staff would like to take this opportunity to congratulate the seniors who have completed their three years of professional training. It is our hope that they will use the vast knowledge gained to further the profession of pharmacy and continue to display the high standard of excellence achieved at Southwestern Oklahoma State University School of Pharmacy.

Evaluation Of Analytical, Pharmacokinetic And Pharmacodynamic Methods For The Study Of Digoxin, Santosh John Vetticaden

Theses and Dissertations

The primary objective of the research was to investigate the pharmacodynamics of digoxin in dogs. Initially an assay specific for digoxin in the presence of its major metabolites, viz., digoxigenin, digoxigenin mono-digitoxoside, digoxigenin bis-digitoxoside and dihydrodigoxin was developed using HPLC-RIA. Methodology for non-invasive measurement of left ventricular ejection time (LVET) and other systolic time intervals (STI) in beagle dogs were developed. This involved surgery for exteriorization of the carotid artery in the dogs and subsequent measurements of LVET and STI after recovery. STI, heart rate (HR) and digoxin levels were monitored in normal beagle dogs administered 0.05 mg/kg or 0.025 …

Method Of Administering Narcotic Antagonists And Analgesics And Novel Dosage Forms Containing Same, Anwar A. Hussain

Pharmaceutical Sciences Faculty Patents

The invention provides a novel method of administering narcotic antagonists, narcotic analgesics and related compounds, and novel dosage forms containing those compounds which are adapted for nasal administration. The nasal dosage forms disclosed include solutions, suspensions, gels and ointments. Especially preferred compounds which can be advantageously administered in accordance with the invention include naloxone, naltrexone, nalbuphine, levorphanol, buprenorphine, butorphanol, Δ⁹-tetrahydrocannabinol (THC), cannabidiol (CBD) and levonantradol.

Summer 1984, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Summer 1984

Alteration Of Gallium Biodistribution Using Indium Complexes For Enhanced Early Imaging, John W. Triplett

Pharmaceutical Sciences Faculty Patents

Radiopharmaceutical compositions and methods for tumor tomography in mammals are disclosed, wherein radioactive gallium and non-radioactive indium are injected into said mammals whereby the affinity of said radioactive gallium for non-tumor tissues is decreased, resulting in enhanced imaging characteristics.

Novel Method Of Administering Β-Blockers And Novel Dosage Forms Containing Same, Anwar A. Hussain

Pharmaceutical Sciences Faculty Patents

The invention provides a novel method of administering selected known adrenergic β-receptor blocking agents, such as dichloroisoproterenol, pronethalol, sotalol and alprenolol, which are of use in the treatment of angina pectoris, arrhythmias, hypertension and other cardiac conditions, and migraine. The invention further provides novel dosage forms of those β-blockers which are adapted for nasal administration and which include solutions, suspensions, gels and ointments.

1984 Apothecary, Southwestern Oklahoma State University

Apothecary

The Apothecary staff would like to take this opportunity to congratulate the seniors who have completed five rigorous years of education. It is our hope that you will use the vast knowledge gained to further the profession of pharmacy and continue to display the high standard of excellence achieved at SWOSU School of Pharmacy.

Computerized Formulation And Optimization Of Medicated Chewing Gum, Daniel J. Berky

University of the Pacific Theses and Dissertations

Sixty Four caffeinated chewing gum preparations were formulated by varying the amounts of (i) cinnamaldhyde, (0-0.75%), (ii) docusate (0-0.5%) and (iii) sucrose (40-60%). The gum base consisted of 33.33% yellow beeswax and 66.66% polyisobutylene MH, and was added, adjusting for a final weight of 2 grams per gum. The amount of caffeine was maintained at 100mg. The preparations were subjected to an in vivo release study as well as a hedonic survey with a panel of student volunteers.

Data were analyzed by using multiple linear regression on a mainframe computer. The resulting mathematical model was used to predict a theoretically …

Comparison Of Selected Radiopharmaceutical Chromatographic Quality Control Procedures, Lawrence Ray Andreatta

University of the Pacific Theses and Dissertations

The purpose of this study was to compare the accuracy and reproducibility of two commercially available chromatography kits with Instant Thin Layer Chromatography-Silica Gel (ITLC-SG) and Whatman Chromatography Paper. The two commercial kits evaluated were the- MAC Klt- produced-General Radioisotopes Products, and the TECH Kit by Ackerman Nuclear.

Pharmacognosy Of The Saururaceae : Microscopy Of Powdered Drugs, Prakash Vaman Mallya

University of the Pacific Theses and Dissertations

Plants of the family Sauruaceae are used in folk medicine in various parts of the world. Chemistry of some plants of this family and their chemotaxonomy has been investigated in our laboratory (12).

It is very difficult to establish identity and authenticity of commercially available crude drugs and powders of the Saururaceae because a detailed, collective study of microscopic features of these plants is not available. Original papers establishing plants of this family (see later) do not include microscopic features; they describe only gross morphologic and other classical features required for systematics. They are not useful for a pharmacologist in …

The Effect Of Selected Adjuvants On The In Vitro Percutaneous Penetration Of Benzocaine, See-Yan Lam

University of the Pacific Theses and Dissertations

This research project was designed to test whether the in vitro percutaneous penetration of benzocaine through human cadaver skin could be enhanced by dimethyl sulfoxide (DMSO), urea, polyoxyethylene (20) isohexadecyl ether and 1-dodecylazacycloheptan-2-one (Azone) in propylene glycol/water systems. Solubility and partitioning of benzocaine in propylene glycol/water systems was investigated. The adjuvant effects were studied in a 60/40 (V/V) propylene glycol/water co-solvent system. The well known drug penetration enhancer dimethyl sulfoxide did not enhance the penetration of benzocaine at any concentration level of DMSO under the conditions of the experiment. This lack of enhancement effect was probably due to increased solubility …

The Synthesis Of Various Substituted 3-Amino-7-Hydroxy-2,2-Dimethyltetralins And Their Opioid-Related Activities, David Alan Lippman

University of the Pacific Theses and Dissertations

A series of aminotetralones and aminotetralins were synthesized from the common intermediate F, 3-amino-2,2-dimethyl-7-methoxy- 1-tetralone. The final compounds derived from F were simple substituted and/or reduced analogues. The products would allow a progressive structure activity relationship to be drawn based on pharmacological testing.

The common intermediate F was synthesized utilizing a six step procedure starting with p-methoxyphenylacetic acid. The overall yield from the precursor to the F:HC1 was 25%. Compound F was either O-demethylated to form 3-amino-2,2-dimethyl-7-hydroxy-l-tetralone (I) or was dimethylated on the amine and subsequently O-demethylated to yield the 3-dimethylamino-7-hydroxy-2,2-dimethyl-l-tetralone (J). The last major modification was the reduction of …

Fatty Liver And Metabolism Of Xenobiotics In The Rat, Joyce D. Stone

Theses and Dissertations (ETD)

No abstract provided.

Nasal Dosage Forms Of Propranol, Anwar A. Hussain, Shinichiro Hirai, Rima Bawarshi

Pharmaceutical Sciences Faculty Patents

The invention relates to a novel method of administering propranolol, a known β-adrenergic blocking agent widely used in the treatment of angina pectoris, arrhythmias, hypertension and other cardiac conditions, and migraine. The invention further relates to novel dosage forms of propranolol which are adapted for nasal administration and which include solutions, suspensions, gels and ointments.

Nasal Dosage Forms Containing Natural Female Sex Horomones, Anwar A. Hussain, Shinichiro Hirai, Rima Bawarshi

Pharmaceutical Sciences Faculty Patents

The invention relates to a novel method of administering the natural female sex hormones, 17 β-estradiol and progesterone, to achieve enhanced bioavailability thereof. The invention further relates to novel dosage forms of 17 β-estradiol and/or progesterone which are adapted for nasal administration, such as solutions, suspensions, gels and ointments. The dosage forms containing a combination of 17 β-estradiol and progesterone are particularly useful as contraceptives, while the dosage forms containing only one of the hormonal components find utility in the treatment of conditions such as menopause, menstrual disorders, etc., which are known to respond to administration of a natural or …

Spring 1983, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Spring 1983

1983 Apothecary, Southwestern Oklahoma State University

Apothecary

The Apothecary staff would like to congratulate the seniors who have worked hard to complete five years of education. The graduating seniors have been more than well prepared for what lies ahead in this profession. This you owe to the administration, the faculty, and to yourselves. You have met, accepted, and mastered the challenges encountered and for this, you are to be commended.

Lack Of Influence Of Commonly Used Drugs On Bioassay Indicator Organisms., Joseph T. Dipiro, A. Thomas Taylor, John C. H. Steele Jr.

Publications from the Office of the Dean

Many commonly used pharmaceutical agents have been found to inhibit bacterial growth in vitro. Determinations of antimicrobial concentrations in sera of patients taking nonrecognized antibacterial agents could possibly be altered if bioassay systems are utilized for the determinations. We therefore attempted to determine the in vitro effect of commonly used drugs on bioassay indicator organisms. Fifty-one different agents (antihistamines, anticholinergics, central nervous system agents, cardiovascular agents, analgesics, steroids, muscle blockers, and other miscellaneous agents) were tested for inhibition or enhancement of the growth of Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, and Klebsiella pneumoniae. None of the agents tested exhibited any …

Pharmacology, James Boelkins

UND Departmental Histories

This departmental history was written on the occasion of the UND Centennial in 1983.

Synthesis Of Mesoionic Nucleosides As Potential Antineoplastic Agents, Shanaz Mohammedali Tejani

Theses and Dissertations

During the past few decades, analogs of purine nucleosides have been described that are modified either in the heterocyclic base, sugar moiety or both, and many of these modified nucleosides display antiviral and/or antineoplastic activity. The Class II mesoionic purinones are isosteric with their non~mesoionic purinone counterparts. It is conceivable that the mesoionic purinone nucleosides might constitute an entirely novel class of modified nucleosides with potential chemotherapeutic activity. That the mesoionic heterobases are bioisosteric as well as isosteric with non-mesoionic purinones was realized by demonstrating that certain mesoionic xanthine derivatives, such as Anhydro-8-ethylw-5-hydroxy-7-oxo-l,3,4-thiadiazolo[3,2-a]pyrimidinium hydroxide and Anhydro-6-p-chlorobenzyl-8-ethyl-5-hydroxy-7-oxo—l,3,4—thiadiazolo [3,2-a]pyrimidinium hydroxide were comparable …