Medicine and Health Sciences Commons^™

Immunohistochemical Expression Of C-Erb-B2, Steroid Receptors And Cathepsin-D In Breast Carcinomas: A Clinicopathologic Trial, Hadi̇ce Eli̇f Peştereli̇, Okan Erdoğan, Bahar Kiliçarslan, Taner Çolak, Evren Tercan, Mustafa Akaydin, Şeyda Karaveli̇

Turkish Journal of Medical Sciences

Aim: We investigated the role of c-erb-B2, hormone receptors and cathepsin D in breast carcinoma progression and their correlation with each other. Methods: Forty-six breast carcinoma patients, operated on in the deparment of surgery and diagnosed in the pathology department, were classified according to their histopathological characteristics; the results of immunostaining with estrogen and progesterone receptors, c-erb-B2 and cathepsin-D were correlated with the stage and the disease-free survival of the patients. Results: Nuclear positivity was observed in 23 (50 %) cases for estrogen receptor and in 16 (34.8 %) cases for progesterone receptor. There was membranous staining with c-erb-B2 in …

The Short-Term Results Of Intensive Insulin Therapy In Preadolescent Children With Type-1 Diabetes, Ayşenur Ökten, Gülay Kaya, Mukaddes Doğan Kalyoncu, Gamze Çan

Turkish Journal of Medical Sciences

Purpose: The aim of this study was to observe the effects of and compliance with an intensive insulin regimen in preadolescent children with type-1 diabetes. Patients and methods: Eleven insulin-dependent diabetic patients, five girls and six boys aged 8 - 11 years (mean 9 years 3 months) with a mean±SD diabetes duration of 2±1.07 years, participated in this study. The results of the intensive insulin regimen were evaluated after one-year follow-up in 11 patients, and in 8 patients at 18 months. In the first year of this study we aimed to bring about higher blood glucose than is generally advised, …

Lung Functions In Workers Exposed To Tobacco Dust, Ahmet Tevfi̇k Sünter, Faruk Bağirici, Ci̇had Dündar, Abdullah Marangoz, Yildiz Pekşen

Turkish Journal of Medical Sciences

Workers in the tobacco industry are exposed to tobacco dust, which has allergenic and irritative effects on airways. In this study, our aim was to determine whether tobacco dust has any effect on lung functions and volumes. A questionnaire about working conditions was applied to 448 workers, some of which had been exposed to tobacco dust while others had not, and all workers underwent measurements of spirometric flow and volume. Of the study group, 126 workers were exposed to tobacco dust for more than 10 years and 55 were not. All of these 181 workers were also nonsmokers. There were …

Distribution Of Some Extracellular Matrix Proteins And Ultrastructural Findings In Sural Nerve Biopsy In Demyelinating Disease, Egemen İdi̇man, Göksemi̇n Demi̇r, Ü. Ali̇ Kayişli, İ. Ş. Şengün, Necdet Demi̇r, Ramazan Demi̇r

Turkish Journal of Medical Sciences

The involvement of both the peripheral nervous system (PNS) and central nervous system (CNS) in multiple sclerosis is a seldom encountered combination in neurology clinics. In this report, immunohistochemical and ultrastructural techniques were used to analyse the disease course of a patient exhibiting involvement of both systems. In 1980, a 44-year-old man was admitted to our clinic with progressive weakness and decreased sensation of the right lower extremity, and sensory abnormality exhibiting stocking distribution. In electromyolography (EMG), demyelinating sensory motor polyneuropathy was determined. Ten years later, he was admitted again due to progression of weakness in the four extremities. Pyramidal …

Fetal 45,X/46,Xy Mosaicism, Cytogenetic And Morphologic Findings In Pregnancy, Murat Derbent, Banu Bi̇lezi̇kçi̇, İdi̇l Alpas, Volkan Baltaci

Turkish Journal of Medical Sciences

No abstract provided.

Irreversible Blindness: An Unusual Complication Of The Caldwell-Luc Operation, Gülhanim Haciyakupoğlu, Müsli̇me Yalaz, Altan Atakan Özcan, Erol Aksungur

Turkish Journal of Medical Sciences

No abstract provided.

A Case Of Malignant Hyperthermia During Sevoflurane Anesthesia, Si̇bel Bariş, Deni̇z Karakaya, Fuat Güldoğuş, Bi̇nnur Sarihasan, Ati̇lla Tekat

Turkish Journal of Medical Sciences

No abstract provided.

Hibernoma: A Case Report And Discussion Of A Rare Tumor, Mustafa Kösem, Meti̇n Karakök

Turkish Journal of Medical Sciences

No abstract provided.

Sialolithiasis (Salivary Stone), Mehmet Dalkiz, Necdet Doğan, Bedri̇ Beydemi̇r

Turkish Journal of Medical Sciences

No abstract provided.

Central Chemosensitivity, Sleep, And Wakefulness, E. E. Nattie, A Li

Dartmouth Scholarship

No abstract provided.

Effects Of The Use Of Hypochlorite As A Cleaning Substance On Pulmonary Functions, Rezan Demi̇ralay

Turkish Journal of Medical Sciences

This study was carried out to investigate the effects of a low hypochlorite concentration as a cleaning substance on pulmonary functions. For this purpose, 23 cleaning workers from the Faculty of Medicine of Suleyman Demirel University were selected as the study group and 14 people from technical personnel as the control group. The study group consisted of 17 females and 6 males with a mean age of 26.4±5.6 years and the mean duration of exposure to the substance in question was 10.3±10.7 months without any atopy history. The control group consisted of 12 females and 2 males with a mean …

Nasal Glioma: Report Of Two Cases, Ali̇ Kemal Uzunlar, Üstün Osma, Fahri̇ Yilmaz, İsmai̇l Topcu

Turkish Journal of Medical Sciences

No abstract provided.

Is Eradication Of Helicobacter Pylori An Alternative Treatment For Rosacea?, Pinar Yüksel Başak, Buket Ci̇ci̇oğlu Aridoğan

Turkish Journal of Medical Sciences

Several reports have focused on either the increased prevalence of Helicobacter pylori infection or lack of association in patients with rosacea. In this study, 19 patients with rosacea and 38 healthy controls were investigated for seropositivity to Helicobacter pylori by ELISA and the effects of eradication treatment on clinical improvement were monitored. Statistical analysis was performed using Student's t test, Mann-Whitney U test, Wilcoxon signed ranks test, McNemar's test, and chi-squared and correlation tests. No correlation was detected between the degree of severity of disease and Helicobacter pylori positivity. Our results suggest that Helicobacter pylori may be an aggravating factor, …

Susceptibility Of Mycobacterium Tuberculosis Strains To First-Line And Second-Line Antituberculosis Drugs In Ege University Hospital, Candan Çi̇çek Saydam, Cengi̇z Çavuşoğlu, Di̇lek Burhanoğlu, Ni̇sel Özkalay, F. Zühre Badak, Altinay Bi̇lgi̇ç

Turkish Journal of Medical Sciences

Recently tuberculosis has shown a speedy worldwide spread. The incidence of drug-resistant Mycobacterium tuberculosis is increasing in almost all industrialized and developing countries. The epidemiology of multiple drug resistance varies in different regions and countries. The aim of this study was to determine the activities of first-line (isoniazid, rifampin, ethambutol and streptomycin) and second-line (kanamycin, para-aminosalicylic acid, ethionamide and capreomycin) antituberculosis drugs on 100 various clinical isolates of M. tuberculosis. Mycobacterium tuberculosis ATCC 27294, ATCC 35838, ATCC 35825 and ATCC 35837 were used for internal quality control. First-line drug resistant strains were isolated from 10 clinical specimens. Six of them …

Bcl - 2 Expression In Carcinoma Of The Uterine Cervix And Its Relationship With Prognostic Variables, Sema Zergeroğlu, Tayfun Güngör, Orhan S. Aksakal, Emel Ebru Parlakyi̇ği̇t, Oya Gökmen

Turkish Journal of Medical Sciences

Objective: The aim of this study was to evaluate the importance of the apoptotic activity of squamous cell carcinoma of the cervix and Bcl-2 expression. Materials and Methods: Twenty-seven women with cervical squamous cell carcinoma, admitted to our unit between 1996 and 1998, were reviewed. Patients were classified according to staging and grading systems. Bcl-2 protein material was investigated by immunohistochemistry (streptoavidin, biotine, alkaline phosphatase technique). Results: After immunohistochemical staining, 12 of the 27 cases stained positively (44%). There was a correlation between the grade and staining percentage. We found no significant relationship with stage and staining intensity. Conclusions: Bcl-2 …

Homocysteine Levels And Other Risk Factors In Coronary Heart Disease, Gi̇ray Bozkaya, Aydan Çavuşoğlu, Si̇bel Bi̇lgi̇li̇, Baysal Karaca, Ercüment Cengi̇z, Oktay Bi̇lgi̇r

Turkish Journal of Medical Sciences

Many risk factors for coronary heart disease (CHD) have been reported to date. Recently, it has been shown that elevations in homocysteine (Hcy) levels may contribute to the development of coronary heart diseases. In this study, our aim was to determine the relation of Hcy levels and other risk factors in CHD. Serum Hcy, lipoprotein(a) [Lp(a)], C-reactive protein (CRP), fibrinogen, cholesterol, triglyceride, HDL and LDL levels were measured in 51 male patients, diagnosed with CHD with negative T elevations in electrocardiograms, and in 20 healthy males. Hcy was determined in serum samples with Fluorescence Polarization Immunoassay (FPIA) on Abbott IMx. …

Faculty Publications 2000, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 824 publications.

Ups And Downs Of Mucosal Cellular Immunity Against Protozoan Parasites, Lloyd H. Kasper, Dominique Buzoni-Gatel

Dartmouth Scholarship

No abstract provided.

A Noninvasive Test For Vesico-Ureteric Reflux In Children, R. A. Mevorach, B. Cilento, S. Zahorian, C. Badgett, R. Walker, A. Atala, S. Iannello, M. Meyer

Electrical & Computer Engineering Faculty Publications

Objective To report the development and testing of a device for the noninvasive diagnosis of vesico‐ureteric reflux (VUR) which avoids the need for urethral catheterization (currently required to reliably determine the presence of VUR), and which thus avoids the anxiety of parents and patients that causes many families to refuse such evaluation.

Patients and methods Fifty‐four children (49 girls and five boys, mean age 7.2 years, range 4–14) previously evaluated as having VUR volunteered to participate; no child was symptomatic at the time of the study. Refluxing units were known to be present by voiding cysto‐urethrography (within 1 year, mean …

Titrating And Evaluating Multiple Drug Regimens Within Subjects, Margaret Shih

Theses and Dissertations

The dosing of combination therapies is commonly undertaken empirically by practicing physicians, and there is a lack of a coherent algorithm to approach the problem of combination dosing. Current methods of evaluating multiple drug combinations in clinical trials generally do not provide information regarding the location of more effective dosages when the combination is not found to differ from the standard, even though the absence of a difference does not necessarily mean the new combination is ineffective. Additionally, if a new combination is found to be more effective, often a large proportion of the subjects has not benefited from the …

Molecular Genetic Investigation Of Autosomal Dominant Muscular Dystrophy, Christopher Meredith

Theses: Doctorates and Masters

This thesis contributes to the Human Genome Project by adding detail to the physical and genetic maps of the human genome, and by identifying a strong candidate gene for a form of distal myopathy. Genomic clones for the human skeletal muscle genes slow troponin (TNN/1), alpha actin (ACTA1), and (3-tropomyosin (TPM2) were isolated for use in the fluorescent in situ hybridisation localisation of these genes on the cytogenetic map of the human genome. The localisation of these genes made them potential candidates for inherited skeletal muscle diseases, including the muscular dystrophies investigated here. Microsatellite, VNTR and RFLP markers were used …

Genetic Variation And Disease In The Roma (Gypsies), David J. Gresham

Theses: Doctorates and Masters

The Roma (Gypsies) are a European people composed of a mosaic of culturally heterogeneous populations. Linguistic analyses point to their origins in the Indian subcontinent. Cultural diversity in extant Romani populations suggests that they are descended from a mixture of Indian populations. Previous population genetic studies of the Roma have supported this claim by demonstrating the genetic heterogeneity of Romani populations. More recently, medical genetic research has detected identical founder mutations in separated Romani populations, which provides evidence of their relatedness. In this thesis, the genetic heritage of the Roma and its significance for genetic disease and research is investigated. …

Epstein-Barr Virus Serology In The Diagnosis Of Nasopharyngeal Carcinoma From Sarawak, Madeline Wong Mei Fong

Student Works (2000-2009)

The Epstein-Barr virus (EBV) is closely associated with nasopharyngcal carcinoma (NPC). The role(s) of EBV in NPC remains unclear but antibodies to two EBV proteins namely the viral capsid antigen (VCA) and early antigen (EA), are clinically useful diagnostic markers of NPC. The NPC scenario in Malaysia has been based on studies done on West Malaysian patients but not much has been described for NPC in Sarawak, East Malaysia. In this study, 164 NPC sera from newly histologically confirmed NPC patients were collected from the Radiotherapy Unit of Kuching General Hospital, Sarawak prior to radiotherapy. One hundred and forty seven …

Biochemical Bone Markers In Prostate Cancer Patients With Local And Advanced Bone Metastates, Hülya Aksoy, Yilmaz Aksoy, Fati̇h Akçay, İsa Özbey

Turkish Journal of Medical Sciences

In the present study involving patients with bone metastases arising from prostate cancer, we measured urinary deoxypyridinoline (DPD) as a marker of collagen breakdown activity, serum total and bone-specific alkaline phosphatase activities and serum prostate specific antigen (PSA). This study included 20 patients with benign prostate hyperplasia (BPH) and 23 patients with carcinoma, 11 of had with bone metastases. DPD excretion in urine was significantly greater in prostate cancer patients with bone metastasis than in those with localised prostate cancer or BPH (p0.05). The serum markers of bone formation [total alkaline phosphatase (T-ALP) and bone ALP (B-ALP)] displayed higher mean …

Unusual Presentation Of A Chondromyxoid Fibroma Of The Temporal Bone, Asuman Ni̇han Haberal, Banu Bi̇lezi̇kçi̇, Mehmet Coşkun, Nur Altinörs, Beyhan Demi̇rhan

Turkish Journal of Medical Sciences

No abstract provided.

A Cadaveric Study Of The Anatomic Variations Of The Brachial Plexus Nerves In The Axillar Region And Arm, Z. Asli Aktan, Lokman Öztürk, Okan Bi̇lge, Mehmet Asim Özer, Yelda Atamaz Pinar

Turkish Journal of Medical Sciences

Forty-eight upper limbs were dissected in order to study the courses and relations of the brachial plexus nerves in the axilla. Connections between the musculocutaneous and median nerves were found in five arms. There was a suprascapular nerve arising from the union of C4 and C5 directly in one cadaver. A branch from the median nerve extending to the brachial artery was determined. In one of the cadavers the radial nerve arose only from the union of posterior divisions of the inferior and middle trunks.

Comparison By Magnetic Magnetic Resonance Imaging Of The Effects Of Two Different Non-Steroidal Anti-Inflammatory Drugs On Edema Following The Surgical Extraction Of Impacted Third Molars, Mehmet Yaltirik, C. Korhan Oral, Okhan Oral, Çeti̇n Kasapoğlu, Vedat Çebi̇

Turkish Journal of Medical Sciences

Non-steroidal anti-inflammatory drugs are continuously being developed for use as therapeutic agents for inflammatory diseases. The NSAI agents are commonly used in the control of pain by their effects on suppressing the inflammatory reaction. Pain and edema are universal complications following the surgical extraction of impacted third molars. Felden (piroxicam) and Tilcotil (felden) were used in this study for comparing the antiinflammatory effects of two different chemical agents on the control of pain and inflammation following the surgical extraction of bilaterally impacted mesio-angullary positioned lower third molars. A total of 10 patients aged from 20 to 24 attending our clinic …

The Effects Of Benzo(A) Pyrene Doxorubicin And Paclitaxel On P170 Glycoprotein, Di̇dem Turgut Coşan, Ayşe Başaran

Turkish Journal of Medical Sciences

B(a)P is a mutagenic, carcinogenic and teratogenic substance. Paclitaxel and doxorubicin are antineoplastic drugs widely used in cancer treatment. The purpose of this study is to observe the effects of doxorubicin and paclitaxel on p170 glycoprotein in rat liver and kidney tissue after administration of B(a)P. As is well known, p170 glycoprotein is an indicator of drug resistance. We hypothesized that a combination of these antineoplastic drugs would cause lower p170 levels and thus would have a stronger effect than single drug administration. For confirmation, a combination of drugs was used to prevent the development of drug resistance. In this …

Protective Effects Of Vitamin E Selenium And Allopurinol Against Stress-Induced Ulcer Formation In Rats, Nai̇me Canoruç, Ramazan Çi̇çek, Aytaç Atamer, Mehmet Dursun, Cengi̇z Turgut, Ensari̇ Güneli̇, Fi̇kri̇ Canoruç

Turkish Journal of Medical Sciences

This study was carried out in the Health Research Center (DÜSAM) laboratory of Dicle University. Vitamin E, Selenium and Allopurinol were given to counteract gastric damage caused by stress in rats. In the study 64 male Sprague dawley rats were used. They were divided into 8 groups, and protective agents were applied at different doses for 8 weeks. Then, performing cold-restraint stress stomach tissues were taken out and investigated macroscopically to determine mucosal damage. Lipid peroxidation levels in the stomach specimens were determined by identifying Malondialdehyde (MDA) levels by the thiobarbituric acid method. These agents have shown protective effects against …

Apolipoprotein-E Genotyping In Patients With Coronary Heart Disease, İbrahi̇m Pi̇ri̇m, Muhammet Fevzi̇ Polat, Ersi̇n Akarsu, Yaşar Nuri̇ Şahi̇n, Engi̇n Bozkurt

Turkish Journal of Medical Sciences

The aim of the study was to establish apolipoprotein E genotype in the patients with coronary heart disease (CHD) who are inhabitants of the north-east of Turkey. The study involved 106 patients (70 male, 36 female; ages ranging from 37 to 69 years) who are local people and were angiocardiographically diagnosed for CHD. The risk factors such as smoking, alcohol and obesity were determined and serum triglyceride, total cholesterol, LDL and HDL were measured in the subjects. Each patient sample was apolipoprotein E genotyped, which was achieved by PCR amplification of the 227 bp region followed by Cfo I digestion …