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Articles 35611 - 35640 of 46077
Full-Text Articles in Medicine and Health Sciences
The Role Of Apelin In The Assessment Of Response To Chemotherapyand Prognosis In Stage 4 Nonsmall Cell Lung Cancer, Si̇nem Özsari, Gürsel Çok, Ali̇ Veral, Ti̇mur Köse
The Role Of Apelin In The Assessment Of Response To Chemotherapyand Prognosis In Stage 4 Nonsmall Cell Lung Cancer, Si̇nem Özsari, Gürsel Çok, Ali̇ Veral, Ti̇mur Köse
Turkish Journal of Medical Sciences
Background/aim: Prediction of response to chemotherapy and prognosis bears clinical significance in patients with lung cancer. The aim of the study was to examine the association between apelin expression in tumor tissues and overall survival, progression-free survival, chemoresistance, and treatment response in stage 4 nonsmall cell lung cancer (NSCLC) patients undergoing chemotherapy. Materials and methods: A total of 81 patients who received chemotherapy due to a biopsy-documented diagnosis of NSCLC between 2004 and 2011 were retrospectively studied. Bronchoscopic biopsy samples were examined immunohistochemically. Results: Of the overall study population (n = 81), the mean age was 59.0 ± 9.2 years; …
Cognitive Impairment One Year After Ischemic Stroke: Predictorsand Dynamics Of Significant Determinants, Margarita Lubomirova Alexandrova, Maya Penkova Danovska
Cognitive Impairment One Year After Ischemic Stroke: Predictorsand Dynamics Of Significant Determinants, Margarita Lubomirova Alexandrova, Maya Penkova Danovska
Turkish Journal of Medical Sciences
Background/aim: Evidence suggests that the risk for dementia increases after stroke. This study investigated the dynamics of the neurological and cognitive status of patients with no baseline dementia over a 1-year period after ischemic stroke. Materials and methods: We examined 47 ischemic stroke patients admitted within 48 h of ictus. Their neurological and cognitive statuses, blood biochemical parameters, and microalbuminuria levels were prospectively evaluated over a 1-year period post-stroke. Results: A more severe neurological deficit was found in the cognitively impaired patients (P = 0.003). The NIHSS score over a 1-year follow-up period improved only in patients with normal cognition …
Relationship Between Gestational Transient Thyrotoxicosis And Vitamin D, Feri̇t Keri̇m Küçükler, Yasi̇n Şi̇mşek, Ümi̇t Görkem, Berçem Ayçi̇çek Doğan, Serdar Güler
Relationship Between Gestational Transient Thyrotoxicosis And Vitamin D, Feri̇t Keri̇m Küçükler, Yasi̇n Şi̇mşek, Ümi̇t Görkem, Berçem Ayçi̇çek Doğan, Serdar Güler
Turkish Journal of Medical Sciences
Background/aim: Gestational transient thyrotoxicosis (GTT) is a transient, mild hyperthyroidism that occurs early in pregnancy and is due to human chorionic gonadotropin. There is no clear information about why only some pregnant women develop GTT. Previous papers stated that vitamin D plays a role in thyroid functions. We aimed to evaluate the relationship between vitamin D and GTT. Materials and methods: Fifty-three patients diagnosed with GTT at the 6th to 10th weeks of gestation were included in the study (GTT group). Thirty-five pregnant women with normal thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) levels served as a …
Health-Related Quality Of Life Of Pediatric Renal Transplant Recipientsand Their Parents: The Role Of Associated Factors And Clinical Counseling, Bahar Büyükkaragöz, Necla Buyan, Nahi̇de Doğrucan, Bülent Çeli̇k
Health-Related Quality Of Life Of Pediatric Renal Transplant Recipientsand Their Parents: The Role Of Associated Factors And Clinical Counseling, Bahar Büyükkaragöz, Necla Buyan, Nahi̇de Doğrucan, Bülent Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: This study evaluates the health-related quality of life (HRQoL) of pediatric renal transplant recipients and their parents and investigates the effects of clinical, socioeconomic, and psychological factors as well as continuous counseling on the HRQoL. Materials and methods: Patients aged 8-17 years (mean: 14.9 ± 2.9) were enrolled. Clinical and demographic data were noted. The Beck Depression Inventory (BDI), Rosenberg Self-Esteem Scale (RSES), and Turkish version of the Kinder Lebensqualität Fragebogen (KINDL) questionnaire for children and the BDI, RSES, parent-proxy version of KINDL, and Short-Form 36 (SF-36) for parents were applied (step 1). Following a 1-year counseling program, the …
Should Antibiotics Be Administered After Endoscopic Mucosalresection In Patients With Colon Polyps?, Zhimeng Shi, Hui Qiu, Huangang Liu, Honggang Yu
Should Antibiotics Be Administered After Endoscopic Mucosalresection In Patients With Colon Polyps?, Zhimeng Shi, Hui Qiu, Huangang Liu, Honggang Yu
Turkish Journal of Medical Sciences
Background/aim: Endoscopic mucosal resection (EMR) is widely used for treating gastrointestinal polypoid lesions. However, it is currently unclear whether antibiotic administration is necessary after EMR of colon polyps to prevent infection. We aimed to assess whether antibiotic administration is essential in such conditions. Materials and methods: In total, 115 patients with colon polyps were randomly assigned to 3 groups based on the treatment given after EMR: Group A, no antibiotics treatment after EMR (n = 38); Group B, administration of levofloxacin after EMR (n = 38); and Group C, administration of ceftazidime after EMR (n = 39). Results: The colon …
The Frequency Of Buccopalpebral Reflex In Parkinson Disease, Hülya Eser, Yasemi̇n Ünal, Gülni̇hal Kutlu, Ruhsen Öcal, Levent Ertuğrul İnan
The Frequency Of Buccopalpebral Reflex In Parkinson Disease, Hülya Eser, Yasemi̇n Ünal, Gülni̇hal Kutlu, Ruhsen Öcal, Levent Ertuğrul İnan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to define the frequency of a primitive reflex, the buccopalpebral reflex (BPR), and its association with the clinical situation in patients with Parkinson disease. Materials and methods: Between May 2010 and May 2011, 222 patients, 115 with Parkinson disease and 107 patients without any sign of neurodegenerative disease, were included in the study. All included patients were examined for BPR and snout reflex and were also evaluated with the Mini Mental State Examination. All patients with Parkinson disease were classified with the Unified Parkinson's Disease Rating Scale (UPDRS) and the Hoehn and Yahr Score to determine …
Prevalence Of Infectious Agents In Patients With Systemic Sclerosis:Defining The Control Group, Davide Giuseppe Ribaldone, Rinaldo Pellicano
Prevalence Of Infectious Agents In Patients With Systemic Sclerosis:Defining The Control Group, Davide Giuseppe Ribaldone, Rinaldo Pellicano
Turkish Journal of Medical Sciences
No abstract provided.
The Effect Of Systemic Isotretinoin Treatment On Skin Biophysicalparameters Among Patients With Acne Vulgaris, Emi̇ne Çölgeçen, Kemal Özyurt, Ayten Ferahbaş Kesi̇koğlu
The Effect Of Systemic Isotretinoin Treatment On Skin Biophysicalparameters Among Patients With Acne Vulgaris, Emi̇ne Çölgeçen, Kemal Özyurt, Ayten Ferahbaş Kesi̇koğlu
Turkish Journal of Medical Sciences
Background/aim: Systemic isotretinoin has been widely considered an effective and safe medical treatment for severe and refractory acne for nearly 3 decades. However, it also appears to cause undesirable cutaneous side effects. The aim of this study was to prospectively measure biophysical parameters of skin function among patients with acne vulgaris before and after 3 months of isotretinoin therapy, including pH, temperature, sebum content, skin hydration, and transepidermal water loss. Materials and methods: The study cohort consisted of 19 patients with acne vulgaris. Noninvasive methods were used to measure the biophysical characteristics of forehead skin. All measurements were repeated following …
The Effect Of Methylprednisolone Treatment On Fibrinolysis, Thecoagulation System, And Blood Loss In Cardiac Surgery, Leila Ebrahimi, Maryam Kheirandish, Mahnoush Foroughi
The Effect Of Methylprednisolone Treatment On Fibrinolysis, Thecoagulation System, And Blood Loss In Cardiac Surgery, Leila Ebrahimi, Maryam Kheirandish, Mahnoush Foroughi
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to examine steroid pretreatment in order to decrease postoperative coagulopathy disorders and bleeding. Materials and methods: In this randomized double-blinded study, the efficacy of low versus high doses of methylprednisolone on the coagulation system and postoperative bleeding was compared in patients who were undergoing cardiac surgery with cardiopulmonary bypass (CPB). The platelet response to agonists, D-dimer concentration, tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI-1) antigens, and platelet receptors CD42b, CD62P, and CD41a were evaluated. Results: The platelet response to agonists was reduced. The mean concentrations of D-dimer and tPA antigen increased although …
Removing The Specimen With Traction During Robotic Radical Prostatectomy Does Not Cause A Positive Surgical Margin, Serkan Altinova, Abi̇di̇n Egemen İşgören, Zi̇ya Akbulut, Muhammet Fuat Özcan, Abdullah Erdem Canda, Ali̇ Fuat Atmaca, Mevlana Derya Balbay
Removing The Specimen With Traction During Robotic Radical Prostatectomy Does Not Cause A Positive Surgical Margin, Serkan Altinova, Abi̇di̇n Egemen İşgören, Zi̇ya Akbulut, Muhammet Fuat Özcan, Abdullah Erdem Canda, Ali̇ Fuat Atmaca, Mevlana Derya Balbay
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to gauge whether removal of a specimen with traction during robot-assisted laparoscopic radical prostatectomy causes a positive surgical margin or not. Materials and methods: One hundred and sixty-nine patients with localized prostate cancer who underwent robot-assisted laparoscopic radical prostatectomy from 2009 to 2011 were included in the study. After dividing the patients into two groups, we recorded their characteristics and pre-op/post-op evaluations. Results: There were 111 and 58 patients in groups 1 (with traction) and 2 (without traction), respectively. We evaluated the patients' ages, follow-up time, body mass index (BMI), prostate-specific antigen (PSA) …
Clinical Correlation Between The 6-Min Walk Test Andcardiopulmonary Exercise Testing In Patients With Pulmonary Arterial Hypertension, Serap Acar, Sema Savci, Di̇dem Karadi̇bak, Buse Özcan Kahraman, Bahri̇ Akdeni̇z, Ebru Özpeli̇t, Can Sevi̇nç
Clinical Correlation Between The 6-Min Walk Test Andcardiopulmonary Exercise Testing In Patients With Pulmonary Arterial Hypertension, Serap Acar, Sema Savci, Di̇dem Karadi̇bak, Buse Özcan Kahraman, Bahri̇ Akdeni̇z, Ebru Özpeli̇t, Can Sevi̇nç
Turkish Journal of Medical Sciences
Background/aim: The aims of the present study were to assess the relationship between the distance walked during the 6-min walk test (6MWT) and exercise capacity as determined by cardiopulmonary exercise testing (CPET) in patients with pulmonary arterial hypertension (PAH) and to investigate the prognostic value of the 6MWT in comparison to clinical parameters of CPET and echocardiography findings. Materials and methods: Thirty PAH patients participated in the study. Subject characteristics and New York Heart Association (NYHA) classifications were recorded. All subjects completed the 6MWT and CPET. Relationships among the variables were analyzed by the Pearson correlation test. Correlation coefficients between …
The Demographics And Histopathological Features Of Oral Cavity Cancers In Turkey, Mehmet Düzlü, Recep Karamert, Faruk Kadri̇ Bakkal, Raşi̇t Cevi̇zci̇, Hakan Tutar, Mehmet Ekrem Zorlu, Alper Di̇lci̇, Faki̇h Ci̇hat Eravci
The Demographics And Histopathological Features Of Oral Cavity Cancers In Turkey, Mehmet Düzlü, Recep Karamert, Faruk Kadri̇ Bakkal, Raşi̇t Cevi̇zci̇, Hakan Tutar, Mehmet Ekrem Zorlu, Alper Di̇lci̇, Faki̇h Ci̇hat Eravci
Turkish Journal of Medical Sciences
Background/aim: This study aimed to examine the demographics and histopathological features of oral cavity cancers (OCCs) managed in our clinic. Materials and methods: Patients who were diagnosed with OCCs in the Gazi University Otorhinolaryngology Department between the years 1993 and 2013 were retrospectively enrolled in the study. Surgical archive charts and pathology records were reviewed in detail regarding the anatomical and histopathological profiles of the tumors, as well as the demographic data of the patients. Results: Out of 230 patients with OCCs, the most common anatomic location and histopathological diagnosis were found to be the oral tongue (41.4%) and squamous …
The Effects Of Balneotherapy On Acute, Process-Related, And Cumulative Peripheral Cardiac Responses And Pulmonary Functions In Patients With Musculoskeletal Disorders, Senem Şaş, Şeyda Toprak Çelenay, Derya Özer Kaya
The Effects Of Balneotherapy On Acute, Process-Related, And Cumulative Peripheral Cardiac Responses And Pulmonary Functions In Patients With Musculoskeletal Disorders, Senem Şaş, Şeyda Toprak Çelenay, Derya Özer Kaya
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the effects of balneotherapy on acute, process-related, and cumulative peripheral cardiac responses and pulmonary functions in patients with musculoskeletal disorders. Materials and methods: Ninety-eight patients with musculoskeletal disorders referred to physiotherapy with balneotherapy were recruited. The patients received balneotherapy for 20 min 5 times per week for 2 weeks. Blood pressure and pulse were measured at the 0th, 5th, 10th, 20th, and 30th minutes during the 1st and 10th sessions. All patients were subjected to pulmonary function testing before balneotherapy and after the 10th session. Results: It was found that systolic blood pressure decreased …
Cryptogenic Organizing Pneumonia: Clinical And Radiological Features, Treatment Outcomes Of 17 Patients, And Review Of The Literature, Eli̇f Yelda Ni̇ksarlioğlu, Gülci̇han Zehra Özkan, Nur Di̇lek Bakan, Si̇bel Yurt, Lütfi̇ye Kiliç, Güngör Çamsari
Cryptogenic Organizing Pneumonia: Clinical And Radiological Features, Treatment Outcomes Of 17 Patients, And Review Of The Literature, Eli̇f Yelda Ni̇ksarlioğlu, Gülci̇han Zehra Özkan, Nur Di̇lek Bakan, Si̇bel Yurt, Lütfi̇ye Kiliç, Güngör Çamsari
Turkish Journal of Medical Sciences
Background/aim: We evaluated patients with cryptogenic organizing pneumonia (COP) who attended our clinic. Materials and methods: We retrospectively investigated the clinical and radiological findings, diagnostic methods, treatment, and follow-up outcomes of 17 patients who had been histopathologically diagnosed with COP. Results: The mean age of the patients was 49.8 ± 10.4 years. The most common symptom was cough (n = 15; 88.2%) and the most common radiological finding (n = 10) was consolidation in the inferior lobes on thoracic computed tomography. The diagnosis of COP was made by open lung biopsy in 11 (64.7%) patients, transbronchial biopsy in 5 (29.4%), …
The Association Of Papillary Thyroid Cancer With Microcalcification In Thyroidnodules With Indeterminate Cytology Based On Fine-Needle Aspiration Biopsy, İbrahim Ali̇ Özemi̇r, Bariş Bayraktar, Ender Anilir, Kivilcim Orhun, Tunç Eren, Jüli̇de Sağiroğlu, Ayşe Bahar Ceyran, Rafet Yi̇ği̇tbaşi, Orhan Ali̇moğlu
The Association Of Papillary Thyroid Cancer With Microcalcification In Thyroidnodules With Indeterminate Cytology Based On Fine-Needle Aspiration Biopsy, İbrahim Ali̇ Özemi̇r, Bariş Bayraktar, Ender Anilir, Kivilcim Orhun, Tunç Eren, Jüli̇de Sağiroğlu, Ayşe Bahar Ceyran, Rafet Yi̇ği̇tbaşi, Orhan Ali̇moğlu
Turkish Journal of Medical Sciences
Background/aim: Microcalcifications are generally accepted as highly specific for thyroid malignancy, especially for papillary thyroid carcinoma (PTC). The aim of this study was to determine the significance of microcalcification within nodules that were classified as being of "indeterminate cytology" (IC) according to fine-needle aspiration biopsy. Materials and methods: Patients who underwent thyroidectomy between January 2010 and 2013 were included in the study. Nodules identified as "atypia/follicular lesion of undetermined significance", "follicular neoplasm/suspicious for follicular neoplasm", or "suspicious for malignancy" were categorized as IC. Patients were subcategorized depending on the presence of microcalcification (Group 1) or its absence (Group 2). The …
Pityriasis Rosea: A Natural History Of Pediatric Cases In Thecentral Anatolia Region Of Turkey, Emi̇ne Çölgeçen, Çi̇ğdem Kader, Yilmaz Ulaş, Pinar Öztürk, Öznur Küçük, Mehmet Balci
Pityriasis Rosea: A Natural History Of Pediatric Cases In Thecentral Anatolia Region Of Turkey, Emi̇ne Çölgeçen, Çi̇ğdem Kader, Yilmaz Ulaş, Pinar Öztürk, Öznur Küçük, Mehmet Balci
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey. Materials and methods: Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. Results: The average age of patients at time of diagnosis was 12 ± 3.9 years. Cases were most common in the winter (rainy, snowy months; n = 14, 31%). Fifteen …
Sleep Quality In Opioid-Naive And Opioid-Dependent Patientson Methadone Maintenance Therapy In Malaysia, Zalina Zahari, Muslih Abdulkarim Ibrahim, Soo Choon Tan, Nasir Mohamad, Rusli Ismail
Sleep Quality In Opioid-Naive And Opioid-Dependent Patientson Methadone Maintenance Therapy In Malaysia, Zalina Zahari, Muslih Abdulkarim Ibrahim, Soo Choon Tan, Nasir Mohamad, Rusli Ismail
Turkish Journal of Medical Sciences
Background/aim: Sleep disturbances may contribute to poor treatment outcomes in opioid-dependent patients. The extent to which the sleep profiles of opioid-dependent patients differ from those of the general Malaysian population is not documented. This study compared opioid-naive subjects and opioid-dependent patients on methadone maintenance therapy (MMT) in terms of their sleep quality. Materials and methods: Participants comprised Malay male opioid-naive subjects (n = 159) and opioid-dependent patients (n = 160) from MMT clinics in Kelantan, Malaysia, between March and October 2013. Sleep quality was evaluated using the translated and validated Malay version of the Pittsburgh Sleep Quality Index (PSQI). Results: …
Does Cpap Treatment Affect The Voice?, Güleser Saylam, Mustafa Şahi̇n, Di̇lek Demi̇ral, Ömer Bayir, Meli̇ke Bağnu Yüceege, Emel Çadalli Tatar, Mehmet Hakan Korkmaz
Does Cpap Treatment Affect The Voice?, Güleser Saylam, Mustafa Şahi̇n, Di̇lek Demi̇ral, Ömer Bayir, Meli̇ke Bağnu Yüceege, Emel Çadalli Tatar, Mehmet Hakan Korkmaz
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate alterations in voice parameters among patients using continuous positive airway pressure (CPAP) for the treatment of obstructive sleep apnea syndrome. Materials and methods: Patients with an indication for CPAP treatment without any voice problems and with normal laryngeal findings were included and voice parameters were evaluated before and 1 and 6 months after CPAP. Videolaryngostroboscopic findings, a self-rated scale (Voice Handicap Index-10, VHI-10), perceptual voice quality assessment (GRBAS: grade, roughness, breathiness, asthenia, strain), and acoustic parameters were compared. Results: Data from 70 subjects (48 men and 22 women) with a mean …
Acute Exudative Tonsillitis In Adults: The Use Of The Centor Scoreand Some Laboratory Tests, Yavuz Furuncuoğlu, Fi̇li̇z Sağlam, Ahmet Kutluhan
Acute Exudative Tonsillitis In Adults: The Use Of The Centor Scoreand Some Laboratory Tests, Yavuz Furuncuoğlu, Fi̇li̇z Sağlam, Ahmet Kutluhan
Turkish Journal of Medical Sciences
Background/aim: The aim of our study was to determine the usefulness of the Centor score and some basic laboratory tests (complete blood count and C-reactive protein) for the differential diagnosis of exudative tonsillitis due to Group A β-hemolytic streptococcus (GABHS) or due to non-GABHS agents. Materials and methods: The data of clinical and laboratory characteristics of the patients diagnosed with exudative tonsillitis were collected and statistically compared between those having positive GABHS throat culture result and those who were negative for any bacterial agent. Results: Totally 899 adult patients were included in our study; 56 (6.2%) of them were positive …
Plasma Levels Of Serotonin, Gastrointestinal Symptoms,And Sleep Problems In Children With Autism, Sorayya Khkheirouri, Parinaz Kalejahi, Seyyed Gholamreza Noorazar
Plasma Levels Of Serotonin, Gastrointestinal Symptoms,And Sleep Problems In Children With Autism, Sorayya Khkheirouri, Parinaz Kalejahi, Seyyed Gholamreza Noorazar
Turkish Journal of Medical Sciences
Background/aim: Autism is a neurodevelopmental disorder identified with higher frequency of serotonin abnormalities and gastrointestinal (GI) and sleep problems. This study aimed to evaluate the plasma levels of serotonin, GI symptoms, and sleep problems, and their relationship with autism severity in children with autism. Materials and methods: Thirty-five children with autism and 31 healthy subjects were studied. GI problems, sleep disorders, and severity of disorder were assessed. Plasma serotonin was determined using ELISA. Results: There was no significant association between GI problems and autism severity, but a significant positive correlation was seen between different indicators of sleep disorder and severity …
The Effect Of Deep Sclerectomy On Ocular Blood Flow: A 6-Month Clinical Trial, Arzu Özsoy, Murat Si̇nan Saricaoğlu, Mehtap Çavuşoğlu
The Effect Of Deep Sclerectomy On Ocular Blood Flow: A 6-Month Clinical Trial, Arzu Özsoy, Murat Si̇nan Saricaoğlu, Mehtap Çavuşoğlu
Turkish Journal of Medical Sciences
Background/aim: To investigate the effect of deep sclerectomy on retrobulbar blood flow. Materials and methods: This prospective study included 20 eyes of 20 patients with open angle glaucoma. Color Doppler imaging (CDI) examinations were performed before and 2, 12, and 24 weeks after deep sclerectomy. Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI) were measured for the ophthalmic artery (OA), central retinal artery (CRA), and temporal and nasal short posterior ciliary arteries (SPCAs) at each examination and the results were compared. Results: A significant decrease was determined in intraocular pressure (IOP) (P < 0.001) and a significant increase in ocular perfusion pressure (OPP) (P < 0.001) at all postoperative examinations. The EDV in OA increased significantly (P < 0.001), but the change in RI was not statistically significant (P = 0.67). EDV increased and RI decreased significantly in CRA and SPCA (P < 0.001). Conclusion: Deep sclerectomy decreases IOP and increases OPP significantly. Retrobulbar blood flow was seen to improve after deep sclerectomy.
Segmental Epidural Anesthesia For Percutaneous Kyphoplasty:Comparison With General Anesthesia, Alparslan Apan, Özgün Cuvaş Apan, Emi̇ne Arzu Köse
Segmental Epidural Anesthesia For Percutaneous Kyphoplasty:Comparison With General Anesthesia, Alparslan Apan, Özgün Cuvaş Apan, Emi̇ne Arzu Köse
Turkish Journal of Medical Sciences
Background/aim: This is a feasibility study evaluating whether segmental epidural anesthesia is an alternative anesthetic approach to general anesthesia for percutaneous kyphoplasty. Materials and methods: After ethics committee approval was obtained, 52 ASA class I-III patients scheduled for elective, single-level percutaneous kyphoplasty were recruited. The patients were divided into two equal groups. In Group E (Group Epidural) segmental epidural anesthesia was performed using the loss of resistance technique with saline. In Group G (Group Control) general anesthesia was performed. Hemodynamic parameters, intraoperative and postoperative analgesic requirements, visual analogue scale (VAS) scores, length of stay in the postanesthesia care unit (PACU), …
Bone Mineral Density And Growth In Children With Coeliac Disease On A Gluten Free-Diet, Ceyda Tuna Kirsaçlioğlu, Zari̇fe Kuloğlu, Aydan Tanca, Nuri̇ye Özlem Küçük, Zehra Aycan, Gönül Öçal, Arzu Ensari̇, Ayhan Gazi̇ Kalayci, Nurten Gi̇rgi̇n
Bone Mineral Density And Growth In Children With Coeliac Disease On A Gluten Free-Diet, Ceyda Tuna Kirsaçlioğlu, Zari̇fe Kuloğlu, Aydan Tanca, Nuri̇ye Özlem Küçük, Zehra Aycan, Gönül Öçal, Arzu Ensari̇, Ayhan Gazi̇ Kalayci, Nurten Gi̇rgi̇n
Turkish Journal of Medical Sciences
Background/aim: To evaluate changes in growth and bone metabolism during consumption of a gluten-free diet (GFD) in children with coeliac disease (CD). Materials and methods: Thirty-seven children with CD (mean age of 8.8 ± 4.6 years, 21 girls) were enrolled. Anthropometric measurements, bone mineral density (BMD) in lumbar 2-4 vertebrae, and serum alkaline phosphatase, calcium, and phosphorus levels at diagnosis and at follow-up were recorded. Results: The mean follow-up period was 3.5 ± 2.3 years. The BMD of patients was significantly lower than that of control subjects at the time of diagnosis but not after 1 year of the GFD. …
The Factors Affecting Survival In Patients With Bronchiectasis, Fatma Çi̇ftci̇, Eli̇f Şen, Sevgi̇ Behi̇ye Saryal, Zeynep Pinar Önen, Banu Gülbay, Öznur Yildiz, Turan Acican, Gülseren Karabiyikoğlu
The Factors Affecting Survival In Patients With Bronchiectasis, Fatma Çi̇ftci̇, Eli̇f Şen, Sevgi̇ Behi̇ye Saryal, Zeynep Pinar Önen, Banu Gülbay, Öznur Yildiz, Turan Acican, Gülseren Karabiyikoğlu
Turkish Journal of Medical Sciences
Background/aim: There is limited information about the rate and modifiers of mortality in noncystic fibrosis bronchiectasis. Materials and methods: This study enrolled a total of 56 bronchiectasis patients. Patients' body mass index, smoking habit, previous therapies, comorbid disorders, history of vaccination, bronchiectasis type and radiological extent, arterial blood gas analysis, respiratory function tests, and laboratory results were recorded. Results: After a follow-up of 65.38 ± 18.62 months the overall mortality rate was 35.7%. The mean survival duration was 46.42 ± 8.25 months. Advanced age significantly increased mortality (HR: 2.031; CI: 0.991?4.072, P = 0.035). A significant correlation was found between …
New Immunohistochemical Markers In The Differential Diagnosisof Nonsmall Cell Lung Carcinoma, Ferda Bi̇r, Duygu Çeli̇ker, Bi̇nnaz Fatma Evyapan, Arzu Yaren, Tamer Edi̇rne
New Immunohistochemical Markers In The Differential Diagnosisof Nonsmall Cell Lung Carcinoma, Ferda Bi̇r, Duygu Çeli̇ker, Bi̇nnaz Fatma Evyapan, Arzu Yaren, Tamer Edi̇rne
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in the differential diagnosis and prognosis of nonsmall cell lung cancer. Materials and methods: The expression of Napsin-A, NTRK-1, NTRK-2, and Desmoglein-3 was examined by immunohistochemistry in 50 squamous cell carcinomas and 50 adenocarcinomas. Desmocollin-3 was investigated in 29 squamous cell carcinoma and 29 adenocarcinoma cases. Associations between expression profiles of Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in lung cancers and clinicopathological variables were analyzed. Results: Napsin-A staining was statistically significant in detecting adenocarcinomas versus squamous cell carcinomas. The sensitivity of Napsin-A for adenocarcinomas was …
Association Of Neutrophil/Lymphocyte Ratio With The Degree Ofinterstitial Lung Disease In Systemic Sclerosis, Nurhan Ati̇lla, Gözde Yildirim Çeti̇n, Ayşe Balkarli
Association Of Neutrophil/Lymphocyte Ratio With The Degree Ofinterstitial Lung Disease In Systemic Sclerosis, Nurhan Ati̇lla, Gözde Yildirim Çeti̇n, Ayşe Balkarli
Turkish Journal of Medical Sciences
Background/aim: Determining the severity of systemic sclerosis related interstitial lung disease (SSc-ILD) is based on clinical and radiological findings, inflammation marker levels, and carbon monoxide diffusing capacity of the lung (DLCO). Recently studies are ongoing for objective and easy markers. Neutrophil/lymphocyte ratio (NLR) is shown to be a good marker for inflammation in recent clinical trials. In this study, we aimed to identify the possible relationship between NLR and carbon monoxide transfer coefficient (KCO) of SSc-ILD patients. Materials and methods: Fifty-nine patients with systemic sclerosis (SSc) were enrolled in the study. We used high-resolution computed tomography for diagnosis and used …
Exploring Cyp2b6 Activity By Measuring The Presence Ofnevirapine Hydroxy Metabolites In Plasma, Suzana Mustafa, Norul Badriah Hassan, Soo Choon Tan, Mahiran Mustafa, Ahmad Kashfi Ab Rahman, Lee Lee Low, Wan Nazirah Wan Yusuf
Exploring Cyp2b6 Activity By Measuring The Presence Ofnevirapine Hydroxy Metabolites In Plasma, Suzana Mustafa, Norul Badriah Hassan, Soo Choon Tan, Mahiran Mustafa, Ahmad Kashfi Ab Rahman, Lee Lee Low, Wan Nazirah Wan Yusuf
Turkish Journal of Medical Sciences
Background/aim: Nevirapine is a reverse-transcriptase inhibitor widely used in combination therapy to treat HIV infection. Nevirapine is extensively metabolized in the liver and CYP2B6 is mainly responsible for oxidation of 3-hydroxynevirapine (3-OH NVP). This study aims to explore CYP2B6 activity by measuring 2-hydroxynevirapine (2-OH NVP) and 3-OH NVP in plasma and to identify factors associated with nevirapine pharmacokinetic parameters. Materials and methods: A total of 112 patients were recruited and treated with nevirapine-based antiretroviral therapy. Plasma nevirapine and metabolite concentrations were assayed using high-performance liquid chromatography via liquid-liquid extraction. Results: Thirty-nine (34.8%) of the patients had no 3-OH NVP detected …
Growing Oxa-23 Type Strains Among Carbapenem-Resistant Acinetobacter Baumannii And Tigecycline As An Alternate Combination Therapy, Şeri̇fe Altun, Zeli̇ha Koçak Tufan, Belgi̇n Altun, Ufuk Önde, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz
Growing Oxa-23 Type Strains Among Carbapenem-Resistant Acinetobacter Baumannii And Tigecycline As An Alternate Combination Therapy, Şeri̇fe Altun, Zeli̇ha Koçak Tufan, Belgi̇n Altun, Ufuk Önde, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz
Turkish Journal of Medical Sciences
Background/aim: The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem. The aim of this study is to investigate the resistance patterns and tigecycline sensitivity of carbapenem-resistant A. baumannii strains. Materials and methods: Acinetobacter strains that were carbapenem-resistant and collected mainly from intensive care units were included into this study. The antibiotic sensitivity/resistance of the strains to other antibiotics and tigecycline were noted. Presence of blaOXA-23, blaOXA-48, blaOXA58, and NDM-1 was investigated by PCR. Results: In total, 44 carbapenem-resistant A. baumannii strains were detected. In addition, 57% (25/44) showed resistance to netilmicin and 2% …
Chrysin Prevents Brain Damage Caused By Global Cerebralischemia/Reperfusion In A C57bl/J6 Mouse Model, Mehmet Aki̇f Durak, Mustafa Namik Öztanir, Neşe Başak Türkmen, Osman Çi̇ftçi̇, Asli Taşlidere, Mehmet Tecelli̇oğlu, Ari̇f Önder
Chrysin Prevents Brain Damage Caused By Global Cerebralischemia/Reperfusion In A C57bl/J6 Mouse Model, Mehmet Aki̇f Durak, Mustafa Namik Öztanir, Neşe Başak Türkmen, Osman Çi̇ftçi̇, Asli Taşlidere, Mehmet Tecelli̇oğlu, Ari̇f Önder
Turkish Journal of Medical Sciences
Background/aim: The present study investigated the neuroprotective effects of chrysin (CRS) following global cerebral ischemia and reperfusion (I/R) in a C57BL/J6 mouse model. Materials and methods: A total of 40 mice were equally divided into four groups: (1) sham-operated (SH = control), (2) global cerebral I/R (I/R), (3) CRS, and (4) CRS + I/R. In the I/R group, the bilateral carotid arteries were clipped for 15 min and the mice were treated with vehicle (corn oil) for 10 days. In the CRS group, CRS (50 mg/kg) was given for 10 days without carotid occlusion. In the CRS + I/R group …
Presence Of Pathogenic Escherichia Coli Is Correlated With Bacterial Community Diversity And Composition On Pre-Harvest Cattle Hides, Jessica Chopyk, Ryan M. Moore, Zachary Dispirito, Zachary R. Stromberg, Gentry L. Lewis, David G. Renter, Natalia Cernicchiaro, Rodney A. Moxley, K. Eric Wommack
Presence Of Pathogenic Escherichia Coli Is Correlated With Bacterial Community Diversity And Composition On Pre-Harvest Cattle Hides, Jessica Chopyk, Ryan M. Moore, Zachary Dispirito, Zachary R. Stromberg, Gentry L. Lewis, David G. Renter, Natalia Cernicchiaro, Rodney A. Moxley, K. Eric Wommack
School of Veterinary and Biomedical Sciences: Faculty Publications
Background: Since 1982, specific serotypes of Shiga toxin-producing Escherichia coli (STEC) have been recognized as significant foodborne pathogens acquired from contaminated beef and, more recently, other food products. Cattle are the major reservoir hosts of these organisms, and while there have been advancements in food safety practices and industry standards, STEC still remains prevalent within beef cattle operations with cattle hides implicated as major sources of carcass contamination. To investigate whether the composition of hide-specific microbial communities are associated with STEC prevalence, 16S ribosomal RNA (rRNA) bacterial community profiles were obtained from hide and fecal samples collected from a large …