Medicine and Health Sciences Commons^™

Prevalence And Level Of Enterohemorrhagic Escherichia Coli In Culled Dairy Cows At Harvest, Zachary R. Stromberg, Gentry L. Lewis, Sharif S. Aly, Terry W. Lehenbauer, Joseph M. Bosilevac, Natalia Cernicchiaro, Rodney A. Moxley

School of Veterinary and Biomedical Sciences: Faculty Publications

The primary objective of this study was to determine the prevalence and level of enterohemorrhagic Escherichia coli (EHEC) O26, O45, O103, O111, O121, and O145 (collectively EHEC-6) plus EHEC O157 in fecal, hide, and preintervention carcass surface samples from culled dairy cows. Matched samples (n=300) were collected from 100 cows at harvest and tested by a culture-based method and two molecular methods: NeoSEEK STEC (NS) and Atlas STEC EG2 Combo. Both the culture and NS methods can be used to discriminate among the seven EHEC types (EHEC-7), from which the cumulative prevalence was inferred, whereas the Atlas method can discriminate …

Recapitulating Cross-Species Transmission Of Sivcpz To Humans Using Humanized-Blt Mice, Zhe Yuan, Guobin Kang, Fangrui Ma, Wuxun Lu, Wenjin Fan, Christine M. Fennessey, Brandon F. Keele, Qingsheng Li

Nebraska Center for Virology: Faculty Publications

The origins of HIV-1 have been widely accepted to be the consequence of simian immunodeficiency viruses from wild chimpanzees (SIVcpz) crossing over to humans. However, there has not been any in vivo study of SIVcpz infection of humans. Also, it remains largely unknown why only specific SIVcpz strains have achieved cross-species transmission and what transmission risk might exist for those SIVcpz strains that have not been found to infect humans. Closing this knowledge gap is essential for better understanding cross-species transmission and predicting the likelihood of additional cross-species transmissions of SIV into humans. Here we show hu-BLT mice are susceptible …

High Glucose Induces Reactivation Of Latent Kaposi’S Sarcoma-Associated Herpesvirus, Fengchun Ye, Yan Zeng, Jingfeng Sha, Tiffany Jones, Kurt Kuhne, Charles Wood, Shou-Jiang Gao

Nebraska Center for Virology: Faculty Publications

High prevalence of Kaposi’s sarcoma (KS) is seen in diabetic patients. It is unknown if the physiological condition of diabetes contributes to KS development. We found elevated levels of viral lytic gene expression when Kaposi’s sarcoma-associated herpesvirus (KSHV) infected cells were cultured in high glucose medium. To demonstrate the association between high glucose and KSHV replication, we xeno29

grafted telomerase-immortalized human umbilical vein endothelial cells that are infected with KSHV (TIVE-KSHV) into hyperglycemic and normal nude mice. The injected cells expressed significantly higher levels of KSHV lytic genes in hyperglycemic mice than in normal mice. We further demonstrated that high …

Persistent Low-Level Replication Of Sivδnef Drives Maturation Of Antibody And Cd8 T Cell Responses To Induce Protective Immunity Against Vaginal Siv Infection, Sama Adnan, R. Keith Reeves, Jacqueline Gillis, Fay E. Wong, Yi Yu, Jeremy V. Camp, Qingsheng Li, Michelle Connole, Yuan Li, Michael Piatak Jr., Jeffrey D. Lifson, Wenjun Li, Brandon F. Keele, Pamela A. Kozlowski, Ronald C. Desrosiers, Ashley T. Haase, R. Paul Johnson

Nebraska Center for Virology: Faculty Publications

Defining the correlates of immune protection conferred by SIVΔnef, the most effective vaccine against SIV challenge, could enable the design of a protective vaccine against HIV infection. Here we provide a comprehensive assessment of immune responses that protect against SIV infection through detailed analyses of cellular and humoral immune responses in the blood and tissues of rhesus macaques vaccinated with SIVΔnef and then vaginally challenged with wild-type SIV. Despite the presence of robust cellular immune responses, animals at 5 weeks after vaccination displayed only transient viral suppression of challenge virus, whereas all macaques challenged at weeks 20 and 40 post-SIVΔnef …

Crp, Hba1c, Lipid, And Biochemical Parameters And Their Relation With Maternal Visceral Adipose Tissue And Subcutaneous Fat Tissue Thickness, Müzeyyen Duran, Aydin Köşüş, Nermi̇n Köşüş, Ni̇lgün Turhan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to find whether maternal visceral tissue (VAT) or subcutaneous fat tissue (SCFT) thicknesses are associated with CRP, HbA1c, lipid, and biochemical parameters in the first trimester of pregnancy. Materials and methods: Ninety pregnant women were enrolled. Body mass index (BMI), VAT, and SCFT were measured. The best cut-off points for grouping subjects were found to be 4 cm for VAT and 2 cm for SCFT. Venous blood samples were collected. Results: VAT was higher than 4 cm in all cases with high BMIs. High CRP and HbA1c were found in 45.5% and 18.2% …

Host Immune Responses And Peritumoral Stromal Reactions In Different Basal Cell Carcinoma Subtypes: Histopathological Comparison Of Basosquamous Carcinoma And High-Risk And Low-Risk Basal Cell Carcinoma Subtypes, Ni̇lay Duman, Ni̇lay Şen Korkmaz, Zafer Erol

Turkish Journal of Medical Sciences

Background/aim: The literature does not include sufficient data on the associations between host immune responses and stromal reactions in different basal cell carcinoma (BCC) subtypes. The aim of the study was to compare host immune responses and stromal reactions between basosquamous carcinoma (BSC) and high-risk (HR) and low-risk (LR) BCC subtypes. Materials and methods: The study included 35 BSC, 40 HR-BCC, and 40 LR-BCC patients. Age, sex, lesion location, density of peritumoral/adjacent perivascular inflammation, presence of lymphoid follicle formation, and stromal reaction type were compared between groups. Results: In all 3 groups, age, sex distribution, and lesion location were similar. …

Analysis Of The Hip Fracture Records Of A Central Training And Research Hospital By Selected Characteristics, Deni̇z Çankaya, Burak Yoldaş, Eli̇f Çankaya, Yalçin Çakir, Cemal Aydin, Abdullah Yalçin Tabak

Turkish Journal of Medical Sciences

Background/aim: Despite the importance of hip fractures, very few studies have assessed their epidemiological characteristics in Turkey. The aim of this study was to evaluate the frequency and demography of hip fractures from the recent data of a central training and research hospital. Materials and methods: In this descriptive study, we identified hip fracture cases between 2009 and 2013. The age, sex, region, injury pattern, and calendar year for all patients were evaluated. Results: Among the 687 patients (488 women, 199 men) described in our clinic's records, 122, 131, 144, 138, and 154 patients applied with hip fractures from the …

Clinical Features Of Infants Treated For Severe Retinopathy Of Prematurity: 8-Yearstudy From A Large Tertiary Neonatal Intensive Care Unit In Turkey, Zühal Özen Tunay, Özdemi̇r Özdemi̇r, Damla Ergi̇ntürk Acar, İkbal Seza Petri̇çli̇, Şeri̇fe Suna Oğuz

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to report the gestational age (GA) and birth weight (BW) distribution of premature babies who needed treatment for retinopathy of prematurity (ROP) and to assess the timing of the treatment. Materials and methods: The records of 9008 infants who were screened for ROP were examined and 556 infants who underwent laser therapy for ROP were reviewed. Sex, GA, BW, postnatal age, and postmenstrual (PM) age at the time of laser therapy were recorded. The babies were classified as in-born (Group 1) and out-born infants (Group 2). Results: The mean GA was 27.3 weeks …

Minor Salivary Gland Evaluation: Sjögren?S Syndrome, Sülen Sarioğlu, Ülkü Küçük, Pinar Çeti̇n, İsmai̇l Sari, Ahmet Meri̇h Bi̇rli̇k

Turkish Journal of Medical Sciences

Background/aim:1397645907We aimed to analyze the value of 3 serial sections, spaced 2001397645907μm1397645907apart,1397645907for quantification of lymphocyte and plasma cell foci in1397645907minor salivary gland biopsy (MSGB).1397645907 Materials and methods:1397645907Labial MSGBs from 69 patients with Sjögren's syndrome (SS) and scleroderma were used for this study. Each sample was prepared as 3 serial sections spaced 2001397645907μm apart.1397645907Lymphocytic and plasma cell focus score (LFS, PFS) were determined for each section, and the diagnostic results were compared to those obtained from a single section. Results: For 22 of the 69 patients, all 3 sections1397645907were scored at1397645907

Seasonal Vitamin D Status And Endothelial Function In Healthcare Workers, Özlem Hali̇loğlu, Tolga Kasaci, Di̇lek Yavuz

Turkish Journal of Medical Sciences

Background/aim: Healthcare workers have long working hours indoors and are at risk of vitamin D deficiency. The aim of this study was to determine seasonal vitamin D status and its relationship with early atherosclerotic markers, endothelial function, and carotid intima-media thickness (CIMT) in healthcare workers of Marmara University Hospital, İstanbul. Materials and methods: One hundred and ninety healthy volunteer healthcare workers and 66 nonmedical volunteers of Marmara University Hospital were included in the study and 25-hydroxyvitamin D (25(OH)D), calcium, intact parathyroid hormone (PTH), endothelial function, and CIMT were measured twice during winter and summer seasons. Results: Mean vitamin D levels …

An Experimental Comparative Study On Classic Tube Thoracostomy And Thoracostomy With A Newly Designed Thorax Drainage Catheter*, Mahmut Tokur, Mehmet Ergi̇n, Mehmet Okumuş, Zerri̇n Defne Dündar

Turkish Journal of Medical Sciences

Background/aim: The collection of fluids, blood, pus, or air in the pleural cavity is a pathological condition requiring pleural drainage. A newly designed thorax drainage catheter in the prototype phase was used in this experimental study to test its efficacy. Materials and methods: A hemopneumothorax was first caused by a penetrating injury on the frontal axis of the sixth intercostal space on the right hemithorax with a scalpel on 6 female Sus domesticus swine subjects. After resting for 5 min, a tube or catheter was inserted. The same procedure with a tube thoracostomy or thorax drainage catheter was repeated on …

The Effect Of Transtheoretical Model-Based Individual Counseling, Training, And A 6-Month Follow-Up On Smoking Cessation In Adult Women: A Randomized Controlled Trial*, Ayşe Koyun, Kafi̇ye Eroğlu

Turkish Journal of Medical Sciences

Background/aim: This study was conducted to determine the effect of transtheoretical model (TTM)-based individual counseling, training, and a 6-month follow-up on smoking cessation in adult women. Materials and methods: We carried out this randomized controlled trial in Konya, Turkey. Female subjects were randomly assigned into groups in a 1:1 ratio using block randomization, block size 3 × 3, divided by stages (precontemplation, contemplation, and preparation) and age (20-29, 30-39, and 40-49 years). The study was completed with 77 women (an intervention group containing 38 participants and a control group of 39 participants). The intervention group was interviewed 5 times (baseline …

The Utility Of Ebus-Tbna In Mediastinal Or Hilar Lymph Node Evaluation In Extrapulmonary Malignancy, Onur Fevzi̇ Erer, Ceyda Anar, Serhat Erol, Seri̇r Özkan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to determine the diagnostic performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of mediastinal and hilar lymph nodes (LNs) in patients with known extrapulmonary malignancy. Materials and methods: Between March 2011 and August 2013, 378 EBUS-TBNA procedures were performed. Sixty-three (16.6%) of these were performed on known extrapulmonary malignancy patients. Results: There were 28 male and 35 female patients, with median ages of 65 years (min-max: 53-87) and 57 years (min-max: 39-76), respectively. From the 63 cases, 138 lymph nodes (LNs) were sampled with EBUS-TBNA (median: 2 LNs/patient; min-max: 1-4). …

Effects Of Immunosuppressive Drugs On Oral Mucosa In Patients With Behçet?S Disease: Cytomorphological And Cytopathological Assessment, Eda Di̇yarbakir, Adem Kara, Sadullah Keleş, Jale Selli̇, Handan Bi̇len, Ni̇lnur Eyerci̇, Necmetti̇n Akdeni̇z, Orhan Ateş, Hasan Doğan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate cytomorphological and cytopathological changes in oral exfoliated smears collected from immunosuppressed patients with Behçet's disease (BD) using stereological methods. Materials and methods: For cytomorphometric analysis, mucosal cell smears were obtained from the buccal mucosa and the floor of the mouths of BD patients treated with immunosuppressive drugs and from healthy volunteers. All mucosal smears from the patients and the healthy volunteers were stained using the Papanicolaou method and examined cytopathologically under light microscopy and cytomorphologically via the stereological nucleator method. Results: The cytomorphological analysis revealed 3 types of mucosal cells, with …

Intrabone Marrow Injection Enhances Placental Mesenchymal Stem Cellmediated Support Of Hematopoiesis In Mice, Ya Hong Yuan, Chun Fang Zhou, Zhi Yong Lu, Xiao Li Wang, Yan Ding, Dongsheng Li

Turkish Journal of Medical Sciences

Background/aim: In order to determine the synergistic effects of human placental mesenchymal stem cells (PMSCs) on hematopoiesis in vivo, we compared the intrabone marrow injection (IBMI) with the conventional intravenous injection (IVI). Materials and methods: C57BL/6 recipient mice conditioned with lethal doses of irradiation were transplanted with bone marrow mononuclear cells (MNCs) and bone marrow-derived mesenchymal stem cells (BMSCs) from BALB/c mice by IBMI or IVI. NOD/SCID recipient mice conditioned with sublethal doses of irradiation were transplanted with human umbilical cord blood MNCs (UCB-MNCs) and PMSCs by IBMI or IVI. Results: The number of hematopoietic cells was significantly higher in …

The Effect Of Proanthocyanidin On Formaldehyde-Induced Toxicity In Rat Testes, Eni̇s Uluçam, Elvan Bakar

Turkish Journal of Medical Sciences

Background/aim: This study investigated the effect of proanthocyanidin (PA) against formaldehyde (FA)-induced lipid peroxidation damage and morphological changes in rat testes. Materials and methods: Twenty-one Wistar albino rats were randomized into 3 groups: control, FA, and FA + PA groups. Plasma and tissue malondialdehyde (MDA) and total sialic acid (TSA) levels were measured. Testes tissues were observed by light and electron microscopy. Results: TSA (plasma and tissue) levels decreased and MDA (plasma) significantly increased (P < 0.05) in rats treated with FA compared to the controls. Tissue MDA levels were not significantly different. Several necrotic changes were observed in testes tissues by light and electron microscopy. Disordering in epithelia of seminiferous tubules, vacuolization between germinal epithelium cells, and separated basement membranes were observed by light microscope. Immunopositivity in Leydig cells decreased in the FA group (P < 0.05). In the FA + PA group there were more immune Leydig cells reacting immune-positively than in the FA group (P < 0.05). Ultrastructurally, FA also caused disorganization and loss of mitochondrial cristae, and dilatation in endoplasmic reticulum in testes. Conclusion: The results suggest that PA has a protective effect on FA toxicity in testes.

Apitherapy Products Enhance The Recovery Of Ccl4-Induced Hepatic Damages In Rats, Özlem Saral, Oktay Yildiz, Rezzan Ali̇yazicioğlu, Esi̇n Yuluğ, Si̇nan Canpolat, Ferhat Öztürk, Sevgi̇ Kolayli

Turkish Journal of Medical Sciences

Background/aim: Our objective was to identify the antioxidant properties of honeybee products from Turkey, chestnut honey, pollen, propolis, and royal jelly, and their hepatoprotective activity against CCl4-induced hepatic damage in rats. Materials and methods: Animals were fed with honeybee products for 7 days following CCl4 injection. Development of liver damage and oxidative stress were monitored by measuring the activities of the enzymes alanine transaminase, aspartate transaminase, malondialdehyde, superoxide dismutase, and catalase. Antioxidant capacities of the bee products were identified using FRAP and DPPH assays, as well as by measuring total phenolic and flavonoid contents. Results: The antioxidant activities of the …

Comparison Of A Real-Time Polymerase Chain Reaction-Based System And Erlich-Ziehl-Neelsen Method With Culture In The Identification Of Mycobacterium Tuberculosis, Kemal Bi̇lgi̇n, Kerametti̇n Yanik, Adi̇l Karadağ, Hakan Odabaşi, Hakan Taş, Murat Günaydin

Turkish Journal of Medical Sciences

Background/aims: Ankaferd blood stopper (ABS) is a mixture of certain ratios of 5 different plant roots (Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica). The aim of this study is to evaluate the histopathological effects of ABS on articular cartilage in vitro. Materials and methods: Twenty-one albino Sprague Dawley rats were randomly allocated to 3 groups: 0.1 mL of saline was injected in the first group, 0.1 mL of ABS was injected in the second group, and 0.1 mL of blood and 0.1 mL of ABS were injected in the third group. One month later all rats …

Evaluation Of New Multiplex Pcr Primers For The Identification Ofplasmodium Species Found In Sabah, Malaysia, Cheronie Shely Stanis, Beng Kah Song, Tock Hing Chua, Yee Ling Lau, Jenarun Jelip

Turkish Journal of Medical Sciences

Background/aim: Malaria is a major public health problem, especially in the Southeast Asia region, caused by 5 species of Plasmodium (P. falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi). The aim of this study was to compare parasite species identification methods using the new multiplex polymerase chain reaction (PCR) against nested PCR and microscopy. Materials and methods: Blood samples on filter papers were subject to conventional PCR methods using primers designed by us in multiplex PCR and previously designed primers of nested PCR. Both sets of results were compared with microscopic identification. Results: Of the 129 samples identified …

Quantitative Comparison Of Immunohistochemical And Pcr Analysis Of Midkine Expression In Breast Cancer Types And Serum Midkine Level, Hülya Çeti̇n Sorkun, Meti̇n Akbulut, Yaşar Enli̇, Emre Tepeli̇, Sevgi̇ Özkan, Ergün Erdem

Turkish Journal of Medical Sciences

Background/aim: Midkine (MK), a heparin-binding growth factor, has an important role in cancer progression. The aim of this study was to determine MK expression in breast tissue and the preoperative and postoperative serum levels of patients with breast cancer. Materials and methods: Sixty-one patients with breast cancer participated in our study. The MK serum levels were measured pre- and postoperatively for these patients. We also analyzed breast tissues of the 61 patients immunohistochemically. We examined serum midkine levels in 49 healthy volunteers. Results: MK expression was observed in 44 (72.1%) of 61 breast cancer patients. In breast cancer patients the …

Intraarticular Ankaferd Blood Stopper Application Increases Cartilage Degeneration: An Experimental Study, İbrahi̇m Kaya, Deni̇z Gülabi̇, Murat Yilmaz, Ali̇ Baş, Gülteki̇n Sitki Çeçen, Nurullah Şener

Turkish Journal of Medical Sciences

Background/aim: Ankaferd blood stopper (ABS) is a mixture of certain ratios of 5 different plant roots (Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica). The aim of this study is to evaluate the histopathological effects of ABS on articular cartilage in vitro. Materials and methods: Twenty-one albino Sprague Dawley rats were randomly allocated to 3 groups: 0.1 mL of saline was injected in the first group, 0.1 mL of ABS was injected in the second group, and 0.1 mL of blood and 0.1 mL of ABS were injected in the third group. One month later all rats …

Evaluation Of Brainstem Auditory Evoked Potentials And Their Relationshipwith Levels Of Thyroid Autoantibodies In Patients With Vitiligo, İlhan Çeçen, Ayşe Serap Karadağ, Temel Tombul, Serap Güneş Bi̇lgi̇li̇, Ömer Çalka, Ahmet Zübeyi̇r Burakgazi̇

Turkish Journal of Medical Sciences

Background/aim: Vitiligo is a common depigmenting disorder. The damage can also occur in similar ways to melanocytes within other organs. We evaluated the brainstem and auditory pathway functions by evaluating brainstem auditory evoked potentials (BAEPs) and whether there is any relationship between auditory functions and autoimmunity. Materials and methods: Forty patients with vitiligo and 20 healthy volunteers were enrolled. Thyroid functions and autoantibodies were examined and BAEP tests were assessed by a neurologist. Results: Antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-TGA) antibody positivity was higher in the patient group (P < 0.05). A negative correlation was detected between anti-TPO and lead III, IV, and V latency and I?III interpeak latency (IPL) of the right ear together with lead IV latency and I?V IPL of the left ear in the patient group. When each BAEP parameter was compared between the two groups, more abnormalities were detected in the V latency and III?V IPL of the left ear together with IV and V latency of the right ear. Conclusion: In this study the presence of a correlation between increased anti-TGA and anti-TPO levels and BAEP parameters may be related to an autoimmune-mediated mechanism. However, further studies are needed to be performed in a large patient series.

Health-Related Behaviors And Nutritional Status Of Adolescents Who Study Asboarders And Day-Students, Emi̇ne Ela Küçük, Osman Günay

Turkish Journal of Medical Sciences

Background/aim: Boarders and day-students study together in regional boarding schools. This study was carried out to compare the health and nutritional status of boarders and day-students who study at regional boarding schools in Turkey. Materials and methods: A total 634 boarders and 492 day-students in the 4th?8th years of nine boarding schools in Giresun Province of Turkey were included. A questionnaire including 49 questions about sociodemographic characteristics and health and nutritional status was completed by the students. Height and weight measurements of the students were also taken. The chi-square test was used for statistical analyses. Results: The boarders evaluated their …

The Effects Of Conscious Sedation With Nitrous Oxide/Oxygen On Cognitive Functions, Sara Samur Ergüven, Ertan Ali̇ Deli̇lbaşi, Berri̇n Işik, Ferhunde Öktem

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the effects of conscious sedation with 40% nitrous oxide/oxygen (N2O/O2) on cognitive functions. Materials and methods: Forty dental patients referred to the sedation unit at Gazi University Faculty of Dentistry Department of Oral and Maxillofacial Surgery received a combination of 40% N2O/O2 inhalation for conscious sedation. Psychometric tests were applied three times: before sedation, during sedation, and at the end of the recovery, for assessing cognitive functions. Results: The results of this study showed that the 40% N2O/O2 combination impaired cognitive functions during the conscious sedation. Recovery of most of the …

The High Prevalence Of Encephalitozoon Intestinalis In Patients Receiving Chemotherapy And Children With Growth Retardation And The Validity Of Real-Time Pcr In Its Diagnosis, Ülfet Çeti̇nkaya, Süleyman Yazar, Sali̇h Kuk, Eda Si̇vcan, Leylagül Kaynar, Duran Arslan, İzzet Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the presence of Encephalitozoon intestinalis in different patient groups consisting of immunocompromised and immunocompetent individuals. Materials and methods: The stool samples of 100 patients consisting of 25 patients receiving chemotherapy and with acute gastrointestinal complaints, 25 with bone marrow transplant and acute gastrointestinal complaints, 25 with urticaria, and 25 with growth retardation were included in the study. As control groups, 25 subjects without any chronic disease but with acute gastrointestinal complaints and 25 healthy volunteers, making a total of 50 subjects, were included in the study. E. intestinalis was investigated by …

Comparison Of The Effects Of Peep Levels On Respiratory Mechanics And Elimination Of Volatile Anesthetic Agents In Patients Undergoing Laparoscopic Cholecystectomy; A Prospective, Randomized, Clinical Trial, Hüsnü Mert Arinalp, Nurten Bakan, Gülşah Karaören, Ömer Torun Şahi̇n, Emre Çeli̇ksoy

Turkish Journal of Medical Sciences

Background/aim: In laparoscopic procedures, intraabdominal carbon dioxide (CO2) insufflation can cause decreased compliance, increased airway resistance, and impaired ventilation-perfusion ratios. We aimed to investigate the effects of intraoperative positive end-expiratory pressure (PEEP) treatment on respiratory dynamics and elimination time of volatile anesthetic agents. Materials and methods: In the present study, 75 ASA I-II patients were randomized into 3 groups to receive 0 cmH2O PEEP (group I), 5 cmH2O PEEP (group II), or 8 cmH2O PEEP (group III). Hemodynamic parameters, peak and plateau inspiratory airway pressures (Ppeak, Pplateau), compliance values, the ratio of the fractions of inspired and expired concentration of …

Coexistence Of Preeclampsia And Inherited Thrombophilia In Turkish Pregnant Women, Mehtap Polat, Ebru Hacer Bi̇beroğlu, İsmai̇l Güler, Ömer Kutay Bi̇beroğlu

Turkish Journal of Medical Sciences

Background/aim: To examine the relationship of inherited thrombophilia and other thrombotic risk factors with preeclampsia (PE) in a population of pregnant Turkish women. Materials and methods: This was a case cross-sectional study in which 70 women with PE and 60 normal pregnant women were studied to find out the frequency of women with risk factors including inherited thrombophilia among preeclamptic cases. Results: Hemoglobin, platelet count, uric acid, vitamin B12, folic acid, copper, homocysteine, plasminogen activator inhibitor-1, fibrinogen, protein S, protein C, activated protein C resistance values show significant differences in women with PE in comparison to women with normal pregnancy. …

An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l

Turkish Journal of Medical Sciences

Background/aim: The aims of this study were to evaluate measles incidence and the effect of elimination strategy interventions on the disease from 1960 to 2014 in Turkey. The administration of measles vaccine started in the rural regions in 1970; it was carried out as a campaign along with the National Vaccine Campaign in 1985, and it has been employed as combined measles, mumps, and rubella under the scope of the Measles Elimination Program (MEP) since 2006 in Turkey. While a dramatic decrease in the reporting of measles was observed between 2000 and 2010, the number of the cases has increased …

Reliability And Validity Of The Turkish Version Of Myastheniagravis-Quality Of Life Questionnaire-15 Item, Ni̇da Fatma Taşcilar, Özge Saraçli, Mehmet Ali̇ Kurçer, Handan Ankarali, Ufuk Emre

Turkish Journal of Medical Sciences

Background/aim: The myasthenia gravis-quality of life questionnaire 15 item (MG-QOL15) is a validated, short, and easy to use disease-specific quality of life (QOL) tool in myasthenia gravis. Other than Turkish, a lot of versions of the MG-QOL15 have been used in different languages in different cultures. Therefore, the aim of this study was to translate and construct a validated and adapted Turkish version of the MG-QOL15 [MG-QOL15(T)]. Materials and methods: After translation, back-translation, and comparison of the 2 English versions of the MG-QOL15, it was tested by 22 monolingual healthy individuals and then 23 patients with clinically stable MG. Afterwards, …

The Effectiveness Of A Back School Program In Lowerlimb Amputees: A Randomized Controlled Study, Bahar Anaforoğlu, Fati̇h Erbahçeci̇, Mehmet Atif Erol Akseki̇li̇

Turkish Journal of Medical Sciences

Background/aim: A few studies have been carried out in lower limb amputees (LLAs) and they examined the incidence of and reasons for low back pain. The aim of this study was to assess the effectiveness of a back school program in LLAs with mechanical low back pain (MLBP). Materials and methods: Forty male unilateral transfemoral amputees with MLBP were randomly allocated into two groups. A back school program was applied to Group 1 over 2 weeks. A booklet for home use was given to each participant in Group 2. Pain was assessed using a visual analogue scale. Spinal flexibility measurements …