Medicine and Health Sciences Commons^™

Experiential Avoidance, Empathy, And Anger-Related Attitudesin Antisocial Personality Disorder, Kaasim Fati̇h Yavuz, Oktay Şahi̇n, Sevi̇nç Ulusoy, Okan Ufuk İpek, Erhan Kurt

Turkish Journal of Medical Sciences

Background/aim: In prevailing opinion, a strong relation exists between lack of empathy and antisocial personality disorder (ASPD). However, recent data fail to wholly clarify this relation, especially in consideration of empathy dimensions. In this study our aim was to address ASPD and social functionality from a contextual behavioral science viewpoint. Materials and methods: The present study was conducted with a sample of 34 individuals with ASPD and 32 healthy individuals as the control group. The participants were assessed with a sociodemographic form, Structured Clinical Interviews for DSM I and II (SCID-I and SCID-II), Social Functioning Scale (SFS), Acceptance and Action …

The Combined Effects Of Proteasome Inhibitor Bortezomib With Topoisomerase I And Ii Inhibitors On Topoisomerase Enzymes, Emi̇ne Öksüzoğlu, Çi̇ydem Tirinoğlu, Bariş Keri̇moğlu

Turkish Journal of Medical Sciences

Background/aim: DNA topoisomerases are ubiquitous enzymes that regulate conformational changes in DNA topology during essential cellular processes, and, for this reason, have been characterized as the cellular targets of a number of anticancer drugs. Bortezomib is a powerful proteasome inhibitor used in the treatment of hematological malignancies. In this study, we investigated the inhibitory effects of bortezomib on human topoisomerase I and II enzymes both alone and in combination modes with camptothecin and etoposide. Materials and methods: The interactions of these drugs with topoisomerase enzymes were evaluated by relaxation assay in cell-free systems. IC50 values of the drugs on topoisomerase …

Neuroprotective Effects Of Bone Marrow-Derived Mesenchymal Stem Cellsand Conditioned Medium In Mechanically Injured Neuroblastoma Cells, Mesut Mete, Işil Aydemi̇r, Ülkü Ünlü Ünsal, Yusuf Kurtuluş Duransoy, Mehmet İbrahi̇m Tuğlu, Mehmet Selçuki̇

Turkish Journal of Medical Sciences

Background/aim: Bone marrow-derived mesenchymal stem cells (BMSCs) possess self-renewal characteristics that distinguish them from other cell types. Recent studies have focused on the effects of conditioned medium (CM) that includes the extracellular matrix. Here we examined the neuroprotective effects of BMSCs and CM on damaged neuroblastoma cells. Materials and methods: The cells were divided into five groups: 1) healthy controls, 2) damaged cells alone, 3) damaged cells treated with BMSCs, 4) damaged cells treated with CM, and 5) damaged cells treated with both BMSCs and CM. Neuroprotective effects were then evaluated based upon the levels of oxidative stress, antitransforming growth …

Plasma Apolipoprotein J As A Potential Biomarker For Alzheimer's Disease: Australian Imaging, Biomarkers And Lifestyle Study Of Aging, Veer Gupta, James D. Doecke, Eugene Hone, Steve Pedrini, Simon M. Laws, Madhav Thambisetty, Ashley Bush,, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Stuart Lance Macaulay, Alan Rembach, Stephanie R. Rainey-Smith, Ralph N. Martins

Research outputs 2014 to 2021

Introduction:

For early detection of Alzheimer's disease (AD), the field needs biomarkers that can be used to detect disease status with high sensitivity and specificity. Apolipoprotein J (ApoJ, also known as clusterin) has long been associated with AD pathogenesis through various pathways. The aim of this study was to investigate the potential of plasma apoJ as a blood biomarker for AD.

Methods:

Using the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, the present study assayed plasma apoJ levels over baseline and 18 months in 833 individuals. Plasma ApoJ levels were analyzed with respect to clinical classification, age, gender, …

Comparing Biological Markers Of Alzheimer's Disease Across Blood Fraction And Platforms: Comparing Apples To Oranges, Sid E. O'Bryant, Simone Lista, Robert A. Rissman, Melissa Edwards, Fan Zhang, James Hall, Herik Zetterberg, Simon Lovestone, Veer Bular Gupta, Neill Graff-Radford, Ralph N. Martins, Andreas Jeromin, Stephen Waring, Esther Oh, Mitchel Kling, Laura D. Baker, Harald Hampel

Research outputs 2014 to 2021

Introduction:

This study investigated the comparability of potential Alzheimer's disease (AD) biomarkers across blood fractions and assay platforms.

Methods:

Nonfasting serum and plasma samples from 300 participants (150 AD patients and 150 controls) were analyzed. Proteomic markers were obtained via electrochemiluminescence or Luminex technology. Comparisons were conducted via Pearson correlations. The relative importance of proteins within an AD diagnostic profile was examined using random forest importance plots.

Results:

On the Meso Scale Discovery multiplex platform, 10 of the 21 markers shared > 50% of the variance across blood fractions (serum amyloid A R2 = 0.99, interleukin (IL)10 R2 = 0.95, fatty …

Finding Chemopreventatives To Reduce Amyloid Beta In Yeast, Ian Macreadie, Costa Arvanitis, Prashant Bharadwaj

Research outputs 2014 to 2021

Alzheimer's disease (AD) is the most common form of age-related dementia with the latest report (WorldAlzheimerReport, 2015) showing 46.8 million people are currently affected by dementia. That number is expected to double every 20 years unless there is effective therapeutic intervention.

China Suboptimal Health Cohort Study: Rationale, Design And Baseline Characteristics, Youxin Wang, Siqi Ge, Yuxiang Yan, Anxin Wang, Zhongyao Zhao, Xinwei Yu, Jing Qui, Mohamed Ali Alzain, Hao Wang, Honghong Fang, Qing Gao, Manshu Song, Jie Zhang, Yong Zhou, Wei Wang

Research outputs 2014 to 2021

Background:

Suboptimal health status (SHS) is a physical state between health and disease, characterized by the perception of health complaints, general weakness, chronic fatigue and low energy levels. SHS is proposed by the ancient concept of traditional Chinese medicine (TCM) from the perspective of preservative, predictive and personalized (precision) medicine. We previously created the suboptimal health status questionnaire 25 (SHSQ-25), a novel instrument to measure SHS, validated in various populations. SHSQ-25 thus affords a window of opportunity for early detection and intervention, contributing to the reduction of chronic disease burdens.

Methods/design:

To investigate the causative effect of SHS in non-communicable …

Neuroendocrine And Neurotrophic Signaling In Huntington's Disease: Implications For Pathogenic Mechanisms And Treatment Strategies, Danielle Bartlett, Travis M. Cruickshank, Anthony J. Hannan, Peter R. Eastwood, Alpár S. Lázár, Mel R. Ziman Dr

Research outputs 2014 to 2021

Huntington's disease (HD) is a fatal neurodegenerative disease caused by an extended polyglutamine tract in the huntingtin protein. Circadian, sleep and hypothalamic-pituitary-adrenal (HPA) axis disturbances are observed in HD as early as 15 years before clinical disease onset. Disturbances in these key processes result in increased cortisol and altered melatonin release which may negatively impact on brain-derived neurotrophic factor (BDNF) expression and contribute to documented neuropathological and clinical disease features. This review describes the normal interactions between neurotrophic factors, the HPA-axis and circadian rhythm, as indicated by levels of BDNF, cortisol and melatonin, and the alterations in these intricately balanced …

Appetite Control With Relevance To Mitochondrial Biogenesis And Activation Of Post-Prandial Lipid Metabolism In Obesity Linked Diabetes, Ian J. Martins

Research outputs 2014 to 2021

In various communities in the developing and developed world the understanding of the ingestion of a healthy diet [1] and hepatic fat metabolism has become of critical importance to the treatment of obesity linked Type 2 diabetes that is now linked to various organ diseases [2]. In the developing world transition to healthy diets has become urgent to prevent insulin resistance [3,4] and the obesity pandemic [5-8]. The liver is the major organ for the metabolism of dietary fat and after consumption of a meal in healthy individuals the fat is rapidly metabolized by the liver. In obesity linked Type …

A Persistently Low Hbv Dna Level Is A Predictor Of Spontaneous Hbsag Clearance In Patients With Chronic Hepatitis B, Alpay Ari, Şebnem Çalik, Selma Tosun, Si̇bel Özsu Caymaz

Turkish Journal of Medical Sciences

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Distribution Of Hepatitis C Virus Genotypes Among Intravenous Drug Users In The Çukurova Region Of Turkey, Enver Üçbi̇lek, Bahri̇ Abayli, Mahmut Bakir Koyuncu, Durdane Midikli, Süveyda Gözüküçük, Alper Akdağ, Osman Özdoğan, Engi̇n Altintaş, Orhan Sezgi̇n

Turkish Journal of Medical Sciences

Background/aim: The most common hepatitis C virus (HCV) genotype in Turkey is genotype 1. However, there has not been a study about the distribution of HCV genotypes among intravenous drug users (IVDUs) in the Çukurova region of Turkey. This study was planned to understand if there is a difference between IVDUs and the normal population. Materials and methods: Between May 2010 and May 2014, anti-HCV positive IVDUs who applied to the 6 hospitals in the Çukurova region of Turkey were included in this study. Their HCV genotypes were studied. Results: Ninety-seven anti-HCV positive IVDUs were screened in terms of HCV …

Significance Of Using A Nonlinear Analysis Technique, The Lyapunov Exponent, On The Understanding Of The Dynamics Of The Cardiorespiratory System In Rats, Tamer Zeren, Mustafa Özbek, Neci̇p Kutlu, Mahmut Akilli

Turkish Journal of Medical Sciences

Background/aim: Pneumocardiography (PNCG) is the recording method of cardiac-induced tracheal air flow and pressure pulsations in the respiratory airways. PNCG signals reflect both the lung and heart actions and could be accurately recorded in spontaneously breathing anesthetized rats. Nonlinear analysis methods, including the Lyapunov exponent, can be used to explain the biological dynamics of systems such as the cardiorespiratory system. Materials and methods: In this study, we recorded tracheal air flow signals, including PNCG signals, from 3 representative anesthetized rats and analyzed the nonlinear behavior of these complex signals using Lyapunov exponents. Results: Lyapunov exponents may also be used to …

Effects And Mechanisms Of Curcumin On The Hemodynamic Variablesof Isolated Perfused Rat Hearts, Erkan Kilinç, Zi̇ya Kaygisiz, Bedri̇ Seli̇m Benek, Kenan Gümüşteki̇n

Turkish Journal of Medical Sciences

Background/aim: There is no information on the dose-response relationship of curcumin on the hemodynamic variables of the heart at the organ level in isolated perfused rat hearts. We aimed to investigate the effects and mechanisms of curcumin on the hemodynamic variables of isolated perfused rat hearts. Materials and methods: Rats were randomly divided into 9 groups. The isolated rat heart was retrogradely perfused with modified Krebs-Henseleit solution. After the stabilization period, each group was administered one of the following treatments for 25 min: saline, dimethyl sulfoxide, and curcumin (0.2 μM, 1 μM, and 5 μM); atropine (1 μM); atropine (1 …

Fluctuations Of State Anxiety, Spinal Structure, And Postural Stabilityacross The Menstrual Cycle In Active Women, Derya Özer Kaya, Şeyda Toprak Çelenay

Turkish Journal of Medical Sciences

Background/aim: To investigate differences in state anxiety, spinal posture and mobility, postural competency, and stability across the menstrual cycle in active women. Materials and methods: Thirteen physically active women (18?25 years) with a regular menstrual cycle were recruited. Anxiety with the Spielberger State Trait Anxiety Inventory; spinal posture, mobility, and competency with a Spinal Mouse device (Idiag, Fehraltorf, Switzerland); and postural stability with a Biodex Balance System SD (Biodex Medical Systems, Inc., Shirley, NY, USA) were evaluated across phases of the menstrual cycle. Results: No significant differences were observed between phases of the menstrual cycle for state anxiety, spinal posture, …

An Unusual Pathology With An Undefined Etiology:Solitary Fibrous Tumors Of The Pleura, Kutsal Turhan, Ali̇ Özdi̇l, Ayşe Gül Ergönül, Deni̇z Nart, Alpaslan Çakan, Ufuk Çağirici

Turkish Journal of Medical Sciences

Background/aim: The aim of the present study was to evaluate the etiology and clinical and pathological behavior of solitary fibrous tumors of the pleura (SFTPs), as well as the most appropriate surgical approach and the results of long-term follow-up of this condition. Materials and methods: Clinical and long-term follow-up records of 14 patients who had surgery for SFTP between 2001 and 2014 were reviewed retrospectively. Etiological factors, diagnostic procedures, and clinical courses and outcomes for these patients were studied. Results: Of the 14 patients, 8 were male (57%) and 6 were female (43%) patients. The mean age was 54.14 ± …

Comparison Between The Use Of Saline And Seawater For Nasal Obstruction In Children Under 2 Years Of Age With Acute Upper Respiratory Infection, Tüli̇n Köksal, Mehmet Nevzat Çi̇zmeci̇, Davut Bozkaya, Mehmet Kenan Kanburoğlu, Şanliay Şahi̇n, Tuğba Taş, Çi̇ğdem Nükhet Yüksel, Mustafa Mansur Tatli

Turkish Journal of Medical Sciences

Background/aim: The effectiveness of isotonic and hypertonic saline solutions used to open the nasal passage and improve clinical symptoms was compared in children under 2 years of age admitted with the common cold. Materials and methods: The study was performed as a randomized, prospective, and double-blind study. The study included 109 children. The children using saline (0.9%) and seawater (2.3%) as nasal drops (the patient group) and the control group (in which nasal drops were not administered) were compared. Seventy-four patients received nasal drops from package A (seawater) in single days and from package B (physiological saline) in double days. …

Health Promotion Lifestyle Profile Scores Are Not Associatedwith Obesity In High School Students, Gi̇zem Li̇mni̇li̇, Ni̇lgün Özçakar, Mehtap Kartal

Turkish Journal of Medical Sciences

Background/aim: Obesity is a cause of preventable morbidity and mortality with an increasing prevalence. Health promoting lifestyle activities maintain or improve an individual?s health and in adolescence many habits are configured. The aim of this study was to determine the prevalence of overweight and obesity among adolescents and the relation between obesity and health promoting behaviors. Materials and methods: This is a cross-sectional study including 848 high school students aged 15?17. All students were administered a questionnaire including the Health Promotion Life-Style Profile Scale. Weight and height were measured and body mass index was calculated. Descriptive analysis, Pearson?s chi-square test, …

Plasma Lipoprotein(A) Levels Are Associated With The Severity Of Coronaryheart Disease In Han Chinese People, Li Zhu, Zhan Lu, Liren Zhu, Xiaoxiao Ouyang, Yang Yang, Yanping Feng, Ping Li, Wenjing Ye, Xiaoming Zhang, Xiuyun Zhang, Yongyan Song

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the association of lipoprotein(a) [Lp(a)] with the severity of coronary heart disease (CHD) in Han Chinese people. Materials and methods: Six hundred and seventy-nine patients with angiographically defined CHD were enrolled in this cross-sectional study. Fasting lipids were measured, and the severity of CHD was quantitatively assessed for each patient according to the number of stenotic coronary branches and the Gensini scoring system. Results: The levels of Lp(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and apolipoprotein (apo) B100 increased, while high-density lipoprotein cholesterol (HDL-C) and …

Kinesiotaping As An Alternative Treatment Method For Carpal Tunnel Syndrome, Duygu Geler Külcü, Canan Bursali, İlknur Aktaş, Seli̇n Bozkurt Alp, Feyza Ünlü Özkan, Pinar Akpinar

Turkish Journal of Medical Sciences

Background/aim: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy. Conservative treatment choices are not always satisfactory. The aim of this study was to investigate the effect of kinesiotaping (KT) on pain level, grip strength, and functional status compared with that of placebo KT and orthotic device (OD) in patients with CTS. Materials and methods: In this randomized, placebo-controlled study, participants were allocated into one of three groups: an experimental KT group (Group 1), a placebo KT group (Group 2), and an OD group (Group 3). Visual analogue scale (VAS) and Douleur Neuropathique 4 (DN4) scores, dynamometric grip strength …

N-Terminal-Pro Brain Natriuretic Peptide Levels In Children With Allergic Rhinitis, Hasi̇be Artaç, Hüsametti̇n Vatansev, Derya Çi̇men, Derya Arslan, Fatma Kaya, Seyi̇t Ali̇ Kayiş, Bülent Oran

Turkish Journal of Medical Sciences

Background/aim: Persistent upper airway obstruction may lead to increased pulmonary arterial pressure (PAP). The aim of this study was to evaluate N-terminal pro brain natriuretic peptide (NT-proBNP) concentrations and PAP values in children with allergic rhinitis. Materials and methods: Sixty-six patients with allergic rhinitis and 22 healthy children were prospectively enrolled in this study. Plasma NT-proBNP levels were measured at first admission and after treatment. Simultaneously, echocardiography was done to assess pulmonary arterial hypertension, and rhinitis symptom scores were recorded. Results: The median age of the study group was 9.0 (5.0?17.0) years; 26 were female. PAP was found to be …

Ilp-2 Modeling And Virtual Screening Of An Fda-Approved Library:A Possible Anticancer Therapy, Saeed Khalili, Hemn Mohammadpour, Mahideh Shokrollahi Barough, Parviz Kokhaei

Turkish Journal of Medical Sciences

Background/aim: The members of the inhibitors of apoptosis protein (IAP) family inhibit diverse components of the caspase signaling pathway, notably caspase 3, 7, and 9. ILP-2 (BIRC-8) is the most recently identified member of the IAPs, mainly interacting with caspase 9. This interaction would eventually lead to death resistance in the case of cancerous cells. Therefore, structural modeling of ILP-2 and finding applicable inhibitors of its interaction with caspase 9 are a compelling challenge. Materials and methods: Three main protein modeling approaches along with various model refinement measures were harnessed to achieve a reliable 3D model, using state-of-the-art software. Thereafter, …

Higher Neutrophil To Lymphocyte Ratio Is Related To A Lower Ejectionfraction In Bicuspid Aortic Valve Patients, Haci Ahmet Kasapkara, Abdullah Nabi̇ Aslan, Hüseyi̇n Ayhan, Murat Can Güney, Murat Akçay, Zeynep Şeyma Turi̇nay, Tahi̇r Durmaz, Telat Keleş, Engi̇n Bozkurt

Turkish Journal of Medical Sciences

Background/aim: Inflammation plays an important role in the pathophysiology of vascular disease. In this study, we aimed to evaluate the associations of neutrophil to lymphocyte ratio (NLR; an indicator of inflammation) with left ventricular ejection fraction and ascending aorta diameter in patients with a bicuspid aortic valve (BAV). Materials and methods: One hundred and thirty-nine consecutive patients with the diagnosis of BAV were enrolled in the study. Complete blood counts were analyzed for neutrophil and lymphocyte levels and NLR. The subjects were separated into two groups based on their ascending aorta diameter. The patients with ascending aorta diameter equal to …

Transesophageal Echocardiography Experience In Thepediatric Age Group In A Tertiary Cardiac Center, Peli̇n Ayyildiz, Alper Güzeltaş, İbrahi̇m Cansaran Tanidir, Taner Kasar, Erkut Öztürk, Yakup Ergül

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to evaluate the transesophageal echocardiography (TEE) findings of pediatric patients in a tertiary center where complex congenital heart surgery and interventional procedures have been performed. Materials and methods: All TEE studies performed between December 2009 and December 2014 were reviewed retrospectively. Patients were divided into 3 groups: perioperative, during interventional procedures, and due to other reasons. Demographic features, transthoracic echocardiography (TTE) reports, TEE reports, change in decision after TEE evaluation, and related complications were recorded. Results: A total of 703 patients who had TEE evaluation were included in the study; 51% were female …

The Effects Of Pulmonary Hypertension On Early Outcomes Inpatients Undergoing Coronary Artery Bypass Surgery, Bariş Akça, Köksal Dönmez, Olcay Murat Di̇şli̇, Feray Akgül Erdi̇l, Mehmet Cengi̇z Çolak, İlhan Koray Aydemi̇r, Bektaş Battaloğlu, Nevzat Erdi̇l

Turkish Journal of Medical Sciences

Background/aim: To investigate the effects of pulmonary hypertension on early clinical variables in patients undergoing coronary artery bypass grafting surgery. Materials and methods: The preoperative echocardiographic data of patients who underwent isolated coronary artery bypass surgery were evaluated retrospectively. A total of 1244 patients were included in the study. The patients were divided into two groups: one group consisted of patients with systolic pulmonary artery pressure (SPAP) values equal to or greater than 30 mmHg (Group 1, n = 184), while the other group consisted of patients with SPAP values below 30 mmHg (Group 2, n = 1060). Results: Early …

Correlation Of Ki-67 Proliferation Index And 18-Fluorodeoxyglucose Uptake In Colorectal Incidental Lesions Detected By Positron Emission Tomography-Computed Tomography, Servet Güreşci̇, Özlem Özmen, Meti̇n Uzman, Gülçi̇n Şi̇mşek, Ebru Tatci, Ati̇la Gökçek, Abdullah Özgür Yeni̇ova

Turkish Journal of Medical Sciences

Background/aim: To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region. Materials and methods: SUVmax values of 31 colorectal neoplasms that were incidentally detected during PET-CT examination were compared to dysplasia degree, histopathologic diagnosis, and immunohistochemical expression of the Ki-67 proliferation marker. Results: Statistically significant correlations were found between SUVmax and Ki-67 proliferation index, dysplasia degree, and histopathologic diagnosis. Median SUVmax value was found to be significantly higher in high-risk lesions than low-risk lesions. Conclusion: The Ki-67 proliferation index is …

Effects Of Resveratrol And Cigarette Smoking Onbone Healing: Histomorphometric Evaluation, Özge Kolkesen Şahi̇n, Müge Çina Aksoy, Mustafa Ci̇hat Avunduk

Turkish Journal of Medical Sciences

Background/aim: The aim of the present study is to investigate the effects of cigarette smoke (CS) and simultaneous application of resveratrol on bone healing histomorphometrically and to evaluate the effects of resveratrol on negative effects of CS. Materials and methods: For 4 weeks, Sprague Dawley rats were exposed to cigarette smoke at the equivalent of 6 cigarettes per day. After this period, monocortical defects were created in femurs by a trephine bur on day 28. Starting from the day of defect creation to the 28th postoperative day, rats were given 20 mg/kg body weight resveratrol. Histomorphometric examination of the number …

The Effect Of Low-Dose Methotrexate On Autologous Fat Graft Survival, Eli̇f Sari, Bülent Bakar, Bahram Sarkarati, Önder Bozdoğan, Tarik Çavuşoğlu

Turkish Journal of Medical Sciences

Background/aim: The survival of autologous fat graft tissue is dependent on various factors such as vascularization and inflammation. The aim of the present study was to evaluate the possible beneficial effects of low-dose methotrexate (LD-MTX) on fat graft volume and survival. Materials and methods: A total of 13 male Wistar albino rats were divided into two groups, a control group and an LD-MTX group. An autologous fat graft obtained from the inguinal region of each rat was transferred to its back. LD-MTX was administered intraperitoneally in the LD-MTX group once a week for 4 weeks after the surgical procedure. The …

Effects Of Cepae Extract, Allantoin, And Heparin Mixture On Developing Andalready Formed Epidural Fibrosis In A Rat Laminectomy Model, Rafet Özay, Osman Yüksel Yavuz, Abi̇t Aktaş, Funda Yi̇ği̇t, Nuri̇ Eralp Çeti̇nalp, Haci Mustafa Özdemi̇r, Zeki̇ Şekerci̇

Turkish Journal of Medical Sciences

Background/aim: The study was designed to investigate whether local administration of a mixture composed of cepae extract, allantoin, and heparin (CAH) decreased already formed epidural fibrosis (EF) at the laminectomy site. Materials and methods: Twenty-four adult male Sprague Dawley rats were equally divided into four groups. Laminectomy was performed at the L5 level in all rats. The group 2 and group 4 rats were treated with local drug administration. While the group 1 and 2 rats were sacrificed after 6 weeks, the remaining rats were reoperated and CAH mixture was applied in group 4. The vertebral columns of all rats …

The Consequences Of Aluminium Intake On Reproductive Function In Male Rats:A Three-Generation Study, Florin Muselin, Romeo Teodor Cristina, Violeta Igna, Eugenia Dumitrescu, Diana Brezovan, Alexandra Trif

Turkish Journal of Medical Sciences

Background/aim: The effects of aluminium exposure on reproductive biomarkers in male rats were followed in a three-generation study. Materials and methods: Forty Wistar male rats (F0) were divided into the following groups: control (C), receiving only tap water, and three experimental (E) groups, receiving aluminium sulphate (AS) (E1: 200 ppb, E2: 400 ppb, and E3: 1000 ppb) in drinking water for a 6-month exposure period. To obtain F1, three males from each group were mated with previously unexposed females (1:2 sex ratios) that during gestation and lactation were exposed to the same AS levels as males. The F1 generation male …

The Effects Of Novokinin, An At2 Agonist, On Blood Pressure, Vascular Responses, And Levels Of Adma, Nadph Oxidase, And Rho Kinase In Hypertension Induced By Nos Inhibition And Salt, Emre Mutlu, Selçuk İlhan, Eli̇f Onat, Murat Kara, Engi̇n Şahna

Turkish Journal of Medical Sciences

Background/aim: The effects of AT2 receptor agonist novokinin on blood pressure, eNOS, NADPH oxidase, protein arginine methyltransferases (PRMTs), and Rho kinase in hypertension were investigated. Furthermore, in isolated thoracic aorta rings, contractile and dilator responses were studied. Materials and methods: To develop hypertension, L-NAME was administered intraperitoneally and salt was given with tap water (1%) for 4 weeks. Novokinin was administered intraperitoneally for the last 2 weeks. Blood pressures were measured using the tail-cuff method and enzyme levels by real-time polymerase chain reaction in aortic tissues. Results: Blood pressure increased significantly in hypertensive rats. Novokinin reduced the blood pressure in …