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Articles 181 - 210 of 219
Full-Text Articles in Medicine and Health Sciences
The Risk Of Tumor Cell Dissemination In Mediastinoscopy: A Cytological Study, Yasemi̇n Bi̇lgi̇n Büyükkarabacak, Ayşen Taslak Şengül, Bi̇lge Can Meydan, Burçi̇n Çeli̇k, Mehmet Gökhan Pi̇rzi̇renli̇, Selçuk Gürz, Zeynep Peli̇n Sürücü, Ahmet Başoğlu
The Risk Of Tumor Cell Dissemination In Mediastinoscopy: A Cytological Study, Yasemi̇n Bi̇lgi̇n Büyükkarabacak, Ayşen Taslak Şengül, Bi̇lge Can Meydan, Burçi̇n Çeli̇k, Mehmet Gökhan Pi̇rzi̇renli̇, Selçuk Gürz, Zeynep Peli̇n Sürücü, Ahmet Başoğlu
Turkish Journal of Medical Sciences
Background/aim: Mediastinoscopy is an invasive procedure that is used in the diagnosis of mediastinal diseases and in staging lung cancer. Tumor cell seeding during mediastinoscopy along the mediastinum and the incision line is a very rare complication. This study aimed to test the safety of mediastinoscopy in terms of tumor seeding by cytological evaluation of mediastinal lavage samples taken before and after biopsy. Materials and methods: The patients who underwent mediastinoscopy in our hospital between 2011 and 2014 were studied prospectively. Seventy-three patients with a diagnosis of lung or mediastinal malignancy were included in the study. All patients underwent classical …
Determination Of Apoptosis And Cell Cycle Modulators (P16, P21, P27, P53, Bcl-2,Bax, Bcl-Xl, And Cyclin D1) In Thyroid Follicular Carcinoma, Follicular Adenoma,And Adenomatous Nodules Via A Tissue Microarray Method, Peyker Temi̇z, Gi̇zem Akkaş, Nalan Neşe, Fazi̇let Uğur Duman, Cansu Karakaş, Yamaç Erhan
Determination Of Apoptosis And Cell Cycle Modulators (P16, P21, P27, P53, Bcl-2,Bax, Bcl-Xl, And Cyclin D1) In Thyroid Follicular Carcinoma, Follicular Adenoma,And Adenomatous Nodules Via A Tissue Microarray Method, Peyker Temi̇z, Gi̇zem Akkaş, Nalan Neşe, Fazi̇let Uğur Duman, Cansu Karakaş, Yamaç Erhan
Turkish Journal of Medical Sciences
Background/aim: To identify the role of gene products associated with apoptosis and cell cycle in the pathogenesis of thyroid follicular neoplasm. Materials and methods: Thirty follicular adenomas (FAs), 16 follicular carcinomas (FCs), and 20 adenomatous nodules (ANs) were investigated with immunohistochemical staining of p16, p21, p27, p53, Bcl-2, Bax, Bcl-xL, and cyclin D1 via a tissue microarray method. Results: Bcl-2 showed a significant difference between the benign groups (AN and FA) and the malignant group (FC). Bax was significantly higher in the FC group. p53 was lowest in the AN group and highest in the FC group with significant differences …
Does Atraucan Cause More Postdural Puncture Backache?, Ruslan Abdullayev, Ömer Burak Küçükebe, Bülent Çeli̇k, Ni̇hal Ki̇rman, Hami̇t Si̇nan Hati̇poğlu, Fi̇li̇z Akaltun Hati̇poğlu
Does Atraucan Cause More Postdural Puncture Backache?, Ruslan Abdullayev, Ömer Burak Küçükebe, Bülent Çeli̇k, Ni̇hal Ki̇rman, Hami̇t Si̇nan Hati̇poğlu, Fi̇li̇z Akaltun Hati̇poğlu
Turkish Journal of Medical Sciences
Background/aim: Postdural puncture backache (PDPB) is the most frequent complaint after spinal anesthesia. In the literature its importance is generally overshadowed by postdural puncture headache. We studied two different kinds of spinal anesthesia needles to compare their technical handling capacities and incidences of PDPB. Materials and methods: Data of 256 pregnant female patients undergoing cesarean delivery under spinal anesthesia were collected for the study. Patients were divided into two groups as Group A (n = 109) and Group Q (n = 147) according to the spinal needle used for spinal anesthesia (i.e. 26-gauge atraumatic and 26-gauge Quincke needles, respectively). Backache …
Acute Tuberculosis In The Intensive Care Unit, Kazim Rollas, Ati̇la Kara, Nazmi̇ye Ebru Ortaç Ersoy, Kezban Özmen Süner, Mehmet Nezi̇r Güllü, Serpi̇l Öcal, Arzu Topeli̇
Acute Tuberculosis In The Intensive Care Unit, Kazim Rollas, Ati̇la Kara, Nazmi̇ye Ebru Ortaç Ersoy, Kezban Özmen Süner, Mehmet Nezi̇r Güllü, Serpi̇l Öcal, Arzu Topeli̇
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine mortality rates and to evaluate clinical features of patients with active tuberculosis (TB) requiring intensive care unit (ICU) admission. Materials and methods: The medical records of active TB patients requiring ICU admission were retrospectively reviewed over a 5-year period. Results: Sixteen patients with active TB admitted to the ICU were included in the study. Seven (43.8%) patients died in the ICU. The cause of mortality was septic shock in 5 patients and respiratory failure in 2 patients. The Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure …
Healthy Subjects' Knowledge Of Surgical Complications: A Hospital-Based Survey, Abdussamed Yalçin, Ersi̇n Gürkan Dumlu, Mehmet Tokaç, Ömer Parlak, Levent Öztürk, Mehmet Kiliç
Healthy Subjects' Knowledge Of Surgical Complications: A Hospital-Based Survey, Abdussamed Yalçin, Ersi̇n Gürkan Dumlu, Mehmet Tokaç, Ömer Parlak, Levent Öztürk, Mehmet Kiliç
Turkish Journal of Medical Sciences
Background/aim: There is an ongoing debate about how much a patient should know about serious or frequently occurring risks of their surgery. In this study, we evaluated healthy subjects' perspectives on knowledge of serious surgical complications. Materials and methods: Three hundred and thirty healthy subjects (151 women, 179 men; mean age: 43.6 ± 17.3 years) were surveyed with the study questionnaire. Social profile, surgical history of the healthy subjects, and presence of a relative while giving preoperative consent were assessed. Results: Only 23.5% (39/166) of the subjects were informed about all the potential complications of their previous surgical operation and …
Smoking Cessation And The Effect Of Nicotine Dependence Onrelapse Rate In İzmir, Turkey, Özlem Pekel, Gül Ergör, Türkan Günay, Hakan Baydur, Beri̇l Choussein, Refi̇k Budak, Si̇nem Doğanay
Smoking Cessation And The Effect Of Nicotine Dependence Onrelapse Rate In İzmir, Turkey, Özlem Pekel, Gül Ergör, Türkan Günay, Hakan Baydur, Beri̇l Choussein, Refi̇k Budak, Si̇nem Doğanay
Turkish Journal of Medical Sciences
Background/aim: Smoking is the leading preventable cause of death in the world. There is growing evidence of the need for community-based programs on smoking cessation. The main purpose of this study is to establish the rate of smoking cessation and restarting in 1 year at the Balçova Smoking Cessation Center. Materials and methods: This is a prospective study with a study group of 359 individuals who quit smoking at the Balçova Smoking Cessation Center for at least 4 weeks between October 2009 and April 2010. The outcomes of the study were 1-year cessation rate and relapse rate. Individuals who reported …
Epidemiological And Clinical Characteristics And Management Of Oropharyngeal Tularemia Outbreak, Mustafa Önder Uzun, Kerametti̇n Yanik, Müge Erdem, Uğur Kostakoğlu, Gürdal Yilmaz, Yeli̇z Tanriverdi̇ Çayci
Epidemiological And Clinical Characteristics And Management Of Oropharyngeal Tularemia Outbreak, Mustafa Önder Uzun, Kerametti̇n Yanik, Müge Erdem, Uğur Kostakoğlu, Gürdal Yilmaz, Yeli̇z Tanriverdi̇ Çayci
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to determine the epidemiological and clinical characteristics of patients diagnosed with tularemia and the effectiveness of the administered treatments. Materials and methods: Patients treated in our hospital between January 2009 and March 2011 and diagnosed with tularemia were evaluated retrospectively. Patients' epidemiological and clinical characteristics, administered treatments, and posttreatment findings were recorded on patient monitoring forms. Results: At anamnesis, 29% of patients used water from wells and 71% used water from the network supply; moreover, 48.4% had a history of contact with animals and 87.1% a history of lethargy. At physical examination, 96.8% …
Prevalence Of Hypertension And Its Association With Obesity Among Schoolchildren Aged 6-15 Living In Sakarya Province In Turkey, Fati̇h Muhammed Önsüz, Fi̇gen Demi̇r
Prevalence Of Hypertension And Its Association With Obesity Among Schoolchildren Aged 6-15 Living In Sakarya Province In Turkey, Fati̇h Muhammed Önsüz, Fi̇gen Demi̇r
Turkish Journal of Medical Sciences
Background/aim: Childhood hypertension and its association with obesity are becoming important issues worldwide. The prevalence of hypertension and obesity are growing in both developed and developing countries. This paper aimed to determine the prevalence of hypertension among school-aged children in Sakarya (western part of Turkey) and to determine whether or not obesity is associated with hypertension. Materials and methods: Twelve schools were randomly selected from an area in the center of the Sakarya. A total of 2166 students participated in the study. The students were visited at school, and their weights, heights, and blood pressures were measured. The World Health …
Vkorc1 And Cyp2c9 Genotypic Data-Based Dose Prediction Alone Does Not Accurately Predict Warfarin Dose Requirements In Some Malaysian Patients, Yung An Chua, Wan Zaidah Abdullah, Zurkurnai Yusof, Siew Hua Gan
Vkorc1 And Cyp2c9 Genotypic Data-Based Dose Prediction Alone Does Not Accurately Predict Warfarin Dose Requirements In Some Malaysian Patients, Yung An Chua, Wan Zaidah Abdullah, Zurkurnai Yusof, Siew Hua Gan
Turkish Journal of Medical Sciences
Background/aim: VKORC1 and CYP2C9 genetic polymorphisms may not accurately predict warfarin dose requirements. We evaluated an existing warfarin dosing algorithm developed for Malaysian patients that was based only on VKORC1 and CYP2C9 genes. Materials and methods: Five Malay patients receiving warfarin maintenance therapy were investigated for their CYP2C9*2, CYP2C9*3, and VKORC1-1639G>A genotypes and their vitamin K-dependent (VKD) clotting factor activities. The records of their daily warfarin doses and international normalized ratio (INR) 2 years prior to and after the measurement of VKD clotting factors activities were acquired. The mean warfarin doses were compared with predicted warfarin doses calculated from …
Antibiofilm Activity Of Trans-Cinnamaldehyde, P-Coumaric, And Ferulic Acids On Uropathogenic Escherichia Coli, Barbara Kot, Jolanta Wicha, Malgorzata Piechota, Katarzyna Wolska, Agata Gruzewska
Antibiofilm Activity Of Trans-Cinnamaldehyde, P-Coumaric, And Ferulic Acids On Uropathogenic Escherichia Coli, Barbara Kot, Jolanta Wicha, Malgorzata Piechota, Katarzyna Wolska, Agata Gruzewska
Turkish Journal of Medical Sciences
Background/aim: Biofilm on urinary catheters results in persistent infections that are resistant to antibiotics. In this study, phytochemicals were assessed as alternative antimicrobials in preventing and inactivating E. coli biofilm on urinary catheters. Materials and methods: Biofilm prevention was tested using catheter fragments inoculated with E. coli and treated with trans-cinnamaldehyde, p-coumaric, and ferulic acids (0%, 0.1%, 0.25%, and 0.5%) for 0, 1, 3, and 5 days. Inactivation of E. coli biofilm with the same agents at concentrations of 0%, 1%, 1.25%, or 1.5% used for 0, 1, 3, or 5 days was also evaluated. Results: All used concentrations of …
Periocular Changes In Topical Bimatoprost And Latanoprost Use, Meli̇sa Zi̇şan Karslioğlu, Melek Banu Hoşal, Oya Tekeli̇
Periocular Changes In Topical Bimatoprost And Latanoprost Use, Meli̇sa Zi̇şan Karslioğlu, Melek Banu Hoşal, Oya Tekeli̇
Turkish Journal of Medical Sciences
Background/aim: To evaluate the periocular changes due to topical bimatoprost and latanoprost use and to investigate their effects on the lacrimal drainage system. Materials and methods: All participants (69 eyes of 43 patients, 52 eyes of 26 controls) were classified into three groups: bimatoprost (0.03%) users, latanoprost (0.005%) users, and healthy controls. Each patient was examined before prostaglandin therapy, and then at the first, third, sixth, and twelfth month of therapy. Palpebral fissure height, upper eyelid crease, and levator function were measured, and lacrimal system drainage irrigation was performed. Periocular hyperpigmentation and upper eyelid sulcus were also examined. Results: No …
Urinary Incontinence Among Women Registered With A Family Health Center In The Southeastern Anatolia Region And The Factors Affecting Its Prevalence, Fatma Gözükara, İbrahi̇m Koruk, Burcu Kara
Urinary Incontinence Among Women Registered With A Family Health Center In The Southeastern Anatolia Region And The Factors Affecting Its Prevalence, Fatma Gözükara, İbrahi̇m Koruk, Burcu Kara
Turkish Journal of Medical Sciences
Background/aim: In regions such as Şanlıurfa, Turkey, where the fertility rate is high, suitable health policies to easily and successfully treat urinary incontinence (UI) are needed. This study was conducted to determine the prevalence and risk factors for UI among women in the region. Materials and methods: The participants in this cross-sectional study were selected by using 30 cluster sampling methods. A total of 300 women in the age group of 15-49 years were contacted to participate. Results: The prevalence of UI was 39.3% among women in this sample but only 8.0% actually received treatment. The logistic regression analysis showed …
Prevalence Of Helicobacter Pylori Caga, Baba2, And Dupa Genotypes Andcorrelation With Clinical Outcome In Malaysian Patients With Dyspepsia, Hussein Ali Osman, Habsah Hasan, Rapeah Suppian, Syed Hassan, Dzulkarnaen Zakaria Andee, Noorizan Abdul Majid, Bin Alwi Zilfalil
Prevalence Of Helicobacter Pylori Caga, Baba2, And Dupa Genotypes Andcorrelation With Clinical Outcome In Malaysian Patients With Dyspepsia, Hussein Ali Osman, Habsah Hasan, Rapeah Suppian, Syed Hassan, Dzulkarnaen Zakaria Andee, Noorizan Abdul Majid, Bin Alwi Zilfalil
Turkish Journal of Medical Sciences
Background/aim: The severity of disease outcome in dyspepsia has been attributed to Helicobacter pylori virulence genes. The aim of this study was to determine the distribution of H. pylori virulence genes (cagA, babA2, and dupA) and to determine whether or not there arises a significant correlation with clinical dyspepsia outcomes. Materials and methods: H. pylori genotypes cagA, babA2, and dupA were identified by polymerase chain reactions from gastric biopsy samples in 105 H. pylori-positive patients. Results: The positive rates for cagA, babA2, and dupA genes in H. pylori dyspeptic patients were 69.5%, 41.0%, and 22.9%, respectively. cagA was more prevalent …
Asymmetric Dimethylarginine Is Not A Good Predictor Of Ischemiausing Myocardial Perfusion Scintigraphy, Meli̇h Engi̇n Erkan, Muhammet Aşik, Taner Uçgun, Ni̇lgün Yildiz, Ayşe Yilmaz, Yusuf Aslantaş, Serkan Bulur, Huri̇ Ti̇lla İlçe, Mustafa Yildirim, Ramazan Memi̇şoğullari, Ahmet Semi̇h Doğan
Asymmetric Dimethylarginine Is Not A Good Predictor Of Ischemiausing Myocardial Perfusion Scintigraphy, Meli̇h Engi̇n Erkan, Muhammet Aşik, Taner Uçgun, Ni̇lgün Yildiz, Ayşe Yilmaz, Yusuf Aslantaş, Serkan Bulur, Huri̇ Ti̇lla İlçe, Mustafa Yildirim, Ramazan Memi̇şoğullari, Ahmet Semi̇h Doğan
Turkish Journal of Medical Sciences
Background/aim: Asymmetric dimethylarginine (ADMA) plays role in the pathogenesis of coronary artery disease and related mortality and morbidity through a number of mechanisms. We hypothesized that plasma ADMA levels would be increased in the presence of reversible ischemia as measured by GATED single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy (MPS). Materials and methods: Fasting i.v. blood samples were drawn before testing. All patients underwent 99mTc-sestamibi GATED SPECT MPS with a one-day stress-rest protocol; the images were visually analyzed. Post-stress GATED parameters, including ejection fraction, end systolic and end diastolic volumes, and automatic stress defect scores, were recorded. Results: …
The Relation Between Oxidative Stress Parameters, Ischemic Stroke,And Hemorrhagic Stroke, Ferhat İçme, Özcan Erel, Akkan Avci̇, Sali̇m Satar, Müge Gülen, Selen Acehan
The Relation Between Oxidative Stress Parameters, Ischemic Stroke,And Hemorrhagic Stroke, Ferhat İçme, Özcan Erel, Akkan Avci̇, Sali̇m Satar, Müge Gülen, Selen Acehan
Turkish Journal of Medical Sciences
Background/aim: The aims of this study were to investigate the significance of oxidative stress parameters in the pathogenesis of ischemic stroke and hemorrhagic stroke and to investigate their effects on stroke severity using the National Institutes of Health Stroke Scale (NIHSS). Materials and methods: A total of 92 patients, including 74 with ischemic stroke and 18 with hemorrhagic stroke, and 75 volunteers were enrolled in the study. Total oxidant status (TOS), total antioxidant status (TAS), paraoxonase, stimulating paraoxonase, arylesterase, and thiol levels were measured in both the patient and volunteer groups. NIHSS and oxidative stress index (OSI) scores were calculated. …
Effects Of Pretreatment With Esmolol And Lidocaine On Injection Pain Androcuronium-Induced Withdrawal Response, Jüli̇de Ergi̇l, Fatma Kavak Akelma, Derya Özkan, Gözde Bumi̇n Aydin, Ayşe Gürel, Meli̇h Akinci
Effects Of Pretreatment With Esmolol And Lidocaine On Injection Pain Androcuronium-Induced Withdrawal Response, Jüli̇de Ergi̇l, Fatma Kavak Akelma, Derya Özkan, Gözde Bumi̇n Aydin, Ayşe Gürel, Meli̇h Akinci
Turkish Journal of Medical Sciences
Background/aim: We aimed to compare the effectiveness of esmolol 1 mg/kg and lidocaine 1 mg/kg for injection pain and for the prevention of rocuronium-induced withdrawal response. Materials and methods: We enrolled a total of 81 patients in the study. Patients were randomly assigned to receive either 10 mL of 0.9% NaCl (Group P), esmolol 1 mg/kg (Group E), or lidocaine 1.0 mg/kg (Group L). A subparalyzing dose of rocuronium 0.05 mg/kg was administered to all patients and its effects were recorded. Anesthesia was induced with intravenous propofol and intravenous rocuronium 0.5 mg/kg in all groups. The withdrawal movements of the …
Herbal Self-Medication Use In Patients With Diabetes Mellitus Type 2, Ivana Damnjanovic, Dusanka Kitic, Nikola Stefanovic, Snezana Zlatkovic-Guberinic, Aleksandra Catic-Djordjevic, Radmila Velickovic-Radovanovic
Herbal Self-Medication Use In Patients With Diabetes Mellitus Type 2, Ivana Damnjanovic, Dusanka Kitic, Nikola Stefanovic, Snezana Zlatkovic-Guberinic, Aleksandra Catic-Djordjevic, Radmila Velickovic-Radovanovic
Turkish Journal of Medical Sciences
Background/aim: A considerable number of patients suffering from diabetes mellitus (DM) turn to self-medication using medicinal plants, preparations, and medicine. The aim of this study was to investigate self-medication using medicinal plants and the potential influence of health care professionals' advice or media information regarding the use of herbal dietary supplements with hypoglycemic effect in a population of patients with type 2 DM. Materials and methods: This research, in the form of an analytic cross-sectional study, was conducted in 6 pharmacies in the territory of Nis, Serbia, during October 2013. The criterion set for the study was to include patients …
Evaluation Of Patency Following Revision Technique Ofhigh-Velocity Arteriovenous Fistula, Ümi̇t Halici, Mehmet Ali̇ Kaygin, Özgür Dağ, Ahmet Aydin, Hüsnü Kami̇l Li̇mandal, Ümi̇t Arslan, Eyüp Serhat Çalik, Bi̇lgehan Erkut
Evaluation Of Patency Following Revision Technique Ofhigh-Velocity Arteriovenous Fistula, Ümi̇t Halici, Mehmet Ali̇ Kaygin, Özgür Dağ, Ahmet Aydin, Hüsnü Kami̇l Li̇mandal, Ümi̇t Arslan, Eyüp Serhat Çalik, Bi̇lgehan Erkut
Turkish Journal of Medical Sciences
Background/aim: The objective of this study is to report our experience with surgical revision of dialysis access-induced ischemia syndrome. Materials and methods: Between January 2005 and July 2013, 1254 patients underwent arteriovenous fistula operation, and 86 of them [53 males, mean age: 55 ± 25 (range: 25 to 75) years; 33 females, mean age: 50 ± 20 (range: 30 to 70) years] subsequently developed steal syndrome. These patients were treated with arterial pressure-controlled polytetrafluoroethylene banding or constriction with polypropylene suturing technique. Patients were followed in the outpatient clinic at regular intervals. Results: Symptoms were not relieved during the first 15 …
Investigation Of The Effect Of Changes In Muscle Strength In Gestational Ageupon Fear Of Falling And Quality Of Life, Emrah Atay, Fatma Başalan İz
Investigation Of The Effect Of Changes In Muscle Strength In Gestational Ageupon Fear Of Falling And Quality Of Life, Emrah Atay, Fatma Başalan İz
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is the investigation of the effect of changes in muscle strength in gestational age upon fear of falling and quality of life. Materials and methods: This longitudinal, descriptive study included a sample of 37 pregnant women who volunteered to participate. The research data were collected at 20 and 32 weeks of gestation. Data collection instruments included a newly developed questionnaire form, the Tinetti Falls Efficacy Scale, a visual analog scale, and the Turkish language version of the WHO Quality of Life Scale. Upper body flexibility was measured by the back scratch test, while muscle …
Risk Factors And Maximum Standardized Uptake Values Within Lymph Nodes Of Anthracosis Diagnosed By Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration, Ni̇lgün Yilmaz Demi̇rci̇, İbrahi̇m Onur Alici, Aydin Yilmaz, Funda Demi̇rağ, Ebru Tatci, Yurdanur Erdoğan
Risk Factors And Maximum Standardized Uptake Values Within Lymph Nodes Of Anthracosis Diagnosed By Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration, Ni̇lgün Yilmaz Demi̇rci̇, İbrahi̇m Onur Alici, Aydin Yilmaz, Funda Demi̇rağ, Ebru Tatci, Yurdanur Erdoğan
Turkish Journal of Medical Sciences
Background/aim: Enlarged mediastinal lymph nodes can result from serious etiologies including granulomatous disease, neoplasia, etc., and a rare condition called anthracosis . The aim of this study was to determine the incidence of risk factors and the uptake values within the anthracotic lymph nodes. Materials and methods: 106 patients who underwent endobronchial ultrasound transbronchial needle aspiration and were diagnosed as having anthracosis were analyzed retrospectively. Patients with positive confirmation by surgical biopsies or a 1-year follow-up period were enrolled. Results: 201 lymph nodes were sampled from 106 patients. Subcarinal and interlobar lymph nodes were the most commonly affected stations (36.8% …
Value Of Prealbumin In Assessment Of Nutrition For Critically Ill Patients, Mehmet Ağilli, Şafak Eki̇nci̇
Value Of Prealbumin In Assessment Of Nutrition For Critically Ill Patients, Mehmet Ağilli, Şafak Eki̇nci̇
Turkish Journal of Medical Sciences
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Cognitive Problems Related To Vertebro-Basilar Circulation, Abdulkadi̇r Koçer
Cognitive Problems Related To Vertebro-Basilar Circulation, Abdulkadi̇r Koçer
Turkish Journal of Medical Sciences
Neurodegenerative disorders are characterized by decreased regional cerebral blood flow. Supporting this concept, both cognitive training exercises and physical activity promote blood flow increase and correlate with healthy cognitive aging. The terminal branches of the posterior circulation supply blood to areas of the brain, such as the thalamus, hippocampus, occipital lobe, and cerebellum, involved with important intellectual functions, particularly recent memory, visual-spatial functioning, and visuomotor adaptations. Amnesia and visual agnosia may be a complication of not only posterior circulation infarctions but also vertebrobasilar insufficiency (VBI) without accompanying structural infarcts. The cognitive impairment may be a manifestation of transient attacks and …
Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger
Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most common progressive neurodegenerative disorder causing increased morbidity and mortality. It is characterized by accumulation of amyloid-β in neurons. As there is no known definitive treatment of this disorder, studies trying to determine its exact pathogenetic pathways and target therapies for these specific pathways are being rapidly conducted. Autophagy is one of the areas of interest in studies on the pathogenesis of AD. It is a process of self-digestion that is thought to be a response to stressors and allows cells to adapt to environmental changes. There is accumulating evidence showing an association between autophagy …
Age-Related Macular Degeneration And Alzheimer Disease, Eren Çerman, Muhsi̇n Eraslan, Osman Çeki̇ç
Age-Related Macular Degeneration And Alzheimer Disease, Eren Çerman, Muhsi̇n Eraslan, Osman Çeki̇ç
Turkish Journal of Medical Sciences
This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-β accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.
Why Is Alzheimer's Disease Confused With Other Dementias?, Dursun Aygün, İbrahi̇m Levent Güngör
Why Is Alzheimer's Disease Confused With Other Dementias?, Dursun Aygün, İbrahi̇m Levent Güngör
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most common cause of dementia. The cardinal manifestation of AD is progressive loss of memory. However, there are some nonamnestic presentations of AD, also called atypical AD. Symptoms of AD can sometimes start suddenly. In the presence of atypical symptoms or sudden onset, it may be difficult to distinguish AD from other dementias. We would like to discuss the confusing features of atypical AD that mimic other dementias. In this review, the literature associated with confusing features of AD, suggesting other dementia syndromes, is reviewed. In addition, a case of semantic dementia (SD) with the …
Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger
Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger
Turkish Journal of Medical Sciences
Dementia is an inevitable disease of aging, leading not only to diminished cognitive ability but also behavioral changes, malnutrition, pressure sores, and infections. Acknowledging common problems and their solutions is essential for any health service worker who deals with demented geriatric patients.
Postoperative Cognitive Dysfunction And Alzheimer Disease, Berri̇n Işik
Postoperative Cognitive Dysfunction And Alzheimer Disease, Berri̇n Işik
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most prevalent neurodegenerative disorder in elderly people. Patients with AD appear to be particularly at risk for cognitive deterioration following anesthesia. Some in vitro studies suggest that exposure to general anesthesia (GA) promotes the AD process. On the other hand, there are no clinical studies that clearly demonstrate that GA is a cause of cognitive dysfunction in patients with probable AD. The aim of this research was to discuss the relation between postoperative cognitive dysfunction (POCD) and AD according to the literature. In vivo studies examining AD biomarkers postoperatively and in vitro studies exploring amyloid-β …
Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar
Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is one of the most common neurodegenerative diseases and the most prevalent form of dementia. Some factors in the development of AD, age being the best-known one, have been suggested; however, no causes have been found yet. The pathophysiology of the disease is highly complex, current therapies are palliative, and a cure is still lacking. Adverse effects of anesthetics in the elderly have been reported since the 1950s; however, awareness of this old problem has recently gained importance again. Whether exposure to surgery and general anesthesia (GA) is associated with the development of AD has been questioned. …
Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul
Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul
Turkish Journal of Medical Sciences
Background/aim: Inflammation may play an important role in Alzheimer disease (AD) pathogenesis. A growing amount of evidence indicates that resistin has hallmark regulatory functions such as inflammatory states. The aim of this study was to determine whether plasma resistin levels would be useful in the diagnosis of patients with AD and to investigate the relationships between resistin and other inflammatory markers such as hs-CRP and TNF-α. Materials and methods: In this cross-sectional study, 38 AD patients and 32 control subjects with normal cognitive function aged 65 years and over were included. The diagnosis of AD was made according to DSM-IV …
Forensic Medicine Evaluation Of Alzheimer Patients: A Series From Ankara, Turkey, Mehmet Cavlak, Ramazan Akçan, Ali̇ Riza Tümer, Aysun Balseven Odabaşi, Aykut Lale, Mahmut Şeri̇f Yildirim, Eyup Ruşen Heybet
Forensic Medicine Evaluation Of Alzheimer Patients: A Series From Ankara, Turkey, Mehmet Cavlak, Ramazan Akçan, Ali̇ Riza Tümer, Aysun Balseven Odabaşi, Aykut Lale, Mahmut Şeri̇f Yildirim, Eyup Ruşen Heybet
Turkish Journal of Medical Sciences
Background/aim: Pathophysiological changes due to Alzheimer disease and increasing age might result in situations requiring forensic evaluation in the elderly. Judicial bodies might need forensic evaluation of trauma and the decision-making capacity of Alzheimer patients. This study aimed to determine the demographic and clinical characteristics of Alzheimer patients seen for forensic evaluation. Materials and methods: Forensic records issued by the Department of Forensic Medicine of Hacettepe University in 2012 and 2013 were investigated. Patients with Alzheimer disease were included in the study and were analyzed in terms of age, sex, reason for application, comorbid medical conditions, occupation, and place and …