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Full-Text Articles in Medicine and Health Sciences
Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz
Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population. Materials and methods: Fifty-three AD patients and 56 controls were included to examine polymorphism and allele frequency of the APOE and BIN1 …
The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz
The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease (AD) is characterized by the accumulation of senile plaques composed of amyloid β-peptide, which is derived from β-amyloid precursor protein through degradation by β-secretase and γ-secretase complexes. One of the major components of γ-secretase complex, anterior pharynx-defective-1 (APH-1), is responsible for the activity of the γ-secretase complex. In this study, we searched for not only the most known common genetic risk factor, APOE, but also the APH-1a gene polymorphism in AD patients in a Turkish population. Materials and methods: In this study, 49 AD patients and 45 healthy controls were included. The genetic polymorphisms and allele frequencies …