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Articles 1 - 4 of 4
Full-Text Articles in Systems and Integrative Physiology
Impact Of Liver-Secreted Small Extracellular Vesicles On Myotube Funcation, Tatiana Barrantes, Ioannis Tsialtas, Qing Zhang, Kevin Koronowski
Impact Of Liver-Secreted Small Extracellular Vesicles On Myotube Funcation, Tatiana Barrantes, Ioannis Tsialtas, Qing Zhang, Kevin Koronowski
Posters - 2026
Extracellular vesicles (EVs) mediate intercellular communication by transferring molecular signals between tissues. Liver-derived EVs contribute to metabolic regulation and have been implicated in tissue cross-talk during health and disease. Skeletal muscle is a highly metabolic tissue that depends on mitochondrial respiration for energy production. However, whether liver-secreted EVs influence myotube mitochondrial function remains unclear. Here, we investigate the impact of liver-derived EVs on myotube mitochondrial respiration.
Pathogenesis And Therapeutic Considerations For Nonalcoholic Fatty Liver Disease, Elijah Chung
Pathogenesis And Therapeutic Considerations For Nonalcoholic Fatty Liver Disease, Elijah Chung
Senior Honors Theses
A product of the Westernized, high-fat diet, non-alcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease, affecting one-fourth of the world's population. NAFLD is a progressive disease arising from a multisystem response to excess lipids in the blood, adipose tissue, and liver. Despite the prevalence of NAFLD and its well-studied bidirectional association with obesity and type 2 diabetes mellitus and obesity, there is a shocking scarcity of available treatments aside from diet and lifestyle changes. Thus, further research on NAFLD and potential therapies is urgently needed. This paper will illustrate the major pathways associated …
Cancer Cachexia: Metabolic Changes That Occur In Oxidative Capacity And Carbohydrate And Lipid Metabolism Of The Liver, Sarah Ramey
Health, Human Performance and Recreation Undergraduate Honors Theses
BACKGROUND: Cancer cachexia is defined as cancer-associated muscle wasting, and is a cancer side effect that dramatically affects cancer prognosis, is thought to be at least partially mediated by increased energy expenditure, and is directly responsible for the death of 20-40% of all cancer patients. Although the liver is known to be a predominant regulator of whole body metabolism, there is little known about its relationship to the development of cancer cachexia. PURPOSE: The purpose of this exploratory study was to investigate alterations in liver metabolism by examining measures of hepatic glycogen storage, oxidative phenotype and lipid content throughout the …
Maintenance Of Mitochondrial Genomic Integrity In The Absence Of Manganese Superoxide Dismutase In Mouse Liver Hepatocytes., Anthony R. Cyr, Kyle E. Brown, Michael L. Mccormick, Mitchell C. Coleman, Adam J. Case, George S. Watts, Bernard W. Futscher, Douglas R. Spitz, Frederick E. Domann
Maintenance Of Mitochondrial Genomic Integrity In The Absence Of Manganese Superoxide Dismutase In Mouse Liver Hepatocytes., Anthony R. Cyr, Kyle E. Brown, Michael L. Mccormick, Mitchell C. Coleman, Adam J. Case, George S. Watts, Bernard W. Futscher, Douglas R. Spitz, Frederick E. Domann
Journal Articles: Cellular & Integrative Physiology
Manganese superoxide dismutase, encoded by the Sod2 gene, is a ubiquitously expressed mitochondrial antioxidant enzyme that is essential for mammalian life. Mice born with constitutive genetic knockout of Sod2 do not survive the neonatal stage, which renders the longitudinal study of the biochemical and metabolic effects of Sod2 loss difficult. However, multiple studies have demonstrated that tissue-specific knockout of Sod2 in murine liver yields no observable gross pathology or injury to the mouse. We hypothesized that Sod2 loss may have sub-pathologic effects on liver biology, including the acquisition of reactive oxygen species-mediated mitochondrial DNA mutations. To evaluate this, we established …