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Full-Text Articles in Systems and Integrative Physiology
Multichannel Modulation Of Depolarizing And Repolarizing Ion Currents Increases The Positive Rate-Dependent Action Potential Prolongation, Candido Cabo
Publications and Research
Prolongation of the action potential duration (APD) could prevent reentrant arrhythmias if prolongation occurs at the fast excitation rates of tachycardia with minimal prolongation at slow excitation rates (i.e., if prolongation is positive rate-dependent). APD prolongation by current anti-arrhythmic agents is either reverse (larger APD prolongation at slow rates than at fast rates) or neutral (similar APD prolongation at slow and fast rates), which may not result in an effective anti-arrhythmic action. In this report we show that, in computer models of the human ventricular action potential, the combined modulation of both depolarizing and repolarizing ion currents results in a …
Positive Rate-Dependent Action Potential Prolongation By Modulating Potassium Ion Channels, Candido Cabo
Positive Rate-Dependent Action Potential Prolongation By Modulating Potassium Ion Channels, Candido Cabo
Publications and Research
Pharmacological agents that prolong action potential duration (APD) to a larger extent at slow rates than at the fast excitation rates typical of ventricular tachycardia exhibit reverse rate dependence. Reverse rate dependence has been linked to the lack of efficacy of class III agents at preventing arrhythmias because the doses required to have an anti-arrhythmic effect at fast rates may have pro-arrhythmic effects at slow rates due to an excessive APD prolongation. In this report we show that, in computer models of the ventricular action potential, APD prolongation by accelerating phase 2 repolarization (by increasing IKs) and decelerating …
To Flex Or Rest: Does Adding No-Load Isometric Actions To The Inter-Set Rest Period In Resistance Training Enhance Muscular Adaptations? A Randomized-Controlled Trial, Brad J. Schoenfeld, Jozo Grgic, Bret Contreras, Kenneth Delcastillo, Andrew Alto, Cody Haun, Eduardo O. De Souza, Andrew D. Vigotsky
To Flex Or Rest: Does Adding No-Load Isometric Actions To The Inter-Set Rest Period In Resistance Training Enhance Muscular Adaptations? A Randomized-Controlled Trial, Brad J. Schoenfeld, Jozo Grgic, Bret Contreras, Kenneth Delcastillo, Andrew Alto, Cody Haun, Eduardo O. De Souza, Andrew D. Vigotsky
Publications and Research
We aimed to investigate the effects of resistance training (RT) combined with no-load isometric actions (iso-holds) during the inter-set recovery period versus RT that involves passive inter-set rest on muscular strength, muscular hypertrophy, and muscular endurance in resistance-trained men. Twenty-seven resistance-trained male volunteers were randomly assigned to either a traditional group (TRAD) that performed a hypertrophy-oriented RT routine with the rest intervals spent passively (n = 13) or to a group that supplemented traditional RT with iso-holds (ISO) for the working muscle group between each set (n = 14). Training for both routines consisted of three weekly sessions performed for …
Similar Muscular Adaptations In Resistance Training Performed Two Versus Three Days Per Week, Thiago Lasevicius, Brad Jon Schoenfeld, Jozo Grgic, Gilberto Laurentino, Lucas Duarte Tavares, Valmor Tricoli
Similar Muscular Adaptations In Resistance Training Performed Two Versus Three Days Per Week, Thiago Lasevicius, Brad Jon Schoenfeld, Jozo Grgic, Gilberto Laurentino, Lucas Duarte Tavares, Valmor Tricoli
Publications and Research
The purpose of the present study was to compare changes in muscle strength and hypertrophy between volume-equated resistance training (RT) performed 2 versus 3 times per week in trained men. Thirty-six resistance-trained men were randomly assigned to one of the two experimental groups: a split-body training routine (SPLIT) with muscle groups trained twice per week (n = 18) over four weekly sessions, or a total-body routine (TOTAL), with muscle groups being trained three times per week (n = 18) over three weekly sessions. The training intervention lasted 10 weeks. Testing was carried out pre- and post-study to assess maximal muscular …