Open Access. Powered by Scholars. Published by Universities.®
Systems and Integrative Physiology Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 6 of 6
Full-Text Articles in Systems and Integrative Physiology
Dynamic Homeostasis In Relaxation And Bursting Oscillations, Christopher J. Ryzowicz
Dynamic Homeostasis In Relaxation And Bursting Oscillations, Christopher J. Ryzowicz
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Computational Model Relating Tissue Oxygen Consumption To Oxygen Delivery In A Krogh Cylinder Model Of Skeletal Muscle, Raghad A. Alqahtani
A Computational Model Relating Tissue Oxygen Consumption To Oxygen Delivery In A Krogh Cylinder Model Of Skeletal Muscle, Raghad A. Alqahtani
Theses and Dissertations
Oxygen transport from a capillary to skeletal muscle tissue is a complex process that involves convective and diffusive mechanisms to deliver adequate oxygen to meet tissue metabolic activities. Typically, oxygen uptake in tissue is set by oxygen demand, which is set by metabolic activity. The relationship between the oxygen consumption (VO2) of an isolated perfused tissue and the rate of delivery of oxygen (QO2) to the tissue has been a subject of interest to many investigators over the past century. Experiments have shown that there is a critical value of QO2 below which tissue VO …
Branched Short Chain Fatty Acid Isovaleric Acid Causes Smooth Muscle Relaxation Via Camp/Pka Pathway, Inhibits Gastrointestinal Motility, And Disrupts Peristaltic Movement, Bryan Adam Blakeney
Branched Short Chain Fatty Acid Isovaleric Acid Causes Smooth Muscle Relaxation Via Camp/Pka Pathway, Inhibits Gastrointestinal Motility, And Disrupts Peristaltic Movement, Bryan Adam Blakeney
Theses and Dissertations
Isovaleric Acid (IVA) is a 5-carbon branched chain fatty acid present in fermented foods and produced by the fermentation of leucine by colonic bacteria. IVA activates G-protein coupled receptors such as FFAR2, FFAR3, and OR51E1 known to be expressed on enteric neurons and enteroendocrine cells. We previously reported that the shorter, straight chain fatty acids acetate, propionate and butyrate, differentially affect colonic propulsion; however, the effect of branched chain fatty acids on gastrointestinal motility is unknown. We hypothesize that IVA relaxes smooth muscle in a cAMP/PKA dependent manner by direct action on smooth muscle cells. IVA will also decrease peristalsis …
Diabetes-Induced Expression And Regulation Of Glp-1 Levels By Bile Acid Receptors (Tgr5 & Fxr), Joseph R. Spengler
Diabetes-Induced Expression And Regulation Of Glp-1 Levels By Bile Acid Receptors (Tgr5 & Fxr), Joseph R. Spengler
Theses and Dissertations
Diabetes Mellitus has continued to drastically affect the health of the world and many complications can prove fatal. As long as this metabolic disease persist, research discoveries will need to continue to be made so that patient outcomes and healthcare are dramatically enhanced. In recent years, GLP-1 has been the topic of conversation for diabetes research, due to its promising effects in promoting insulin sensitivity. Furthermore, bile acids and their receptors (TGR5 & FXR) have shown promise in their actions in the regulation of GLP-1, and thus glucose homeostasis. Here we have shown the detection and increased expression of TGR5 …
Mathematical Modeling Of Endotoxin-Induced Inflammation In Young Men, Renee Brady
Mathematical Modeling Of Endotoxin-Induced Inflammation In Young Men, Renee Brady
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Theoretical Model Of The Increase In Venous Oxygen Saturation Levels In Advanced Glaucoma Patients, Julia C. Arciero
A Theoretical Model Of The Increase In Venous Oxygen Saturation Levels In Advanced Glaucoma Patients, Julia C. Arciero
Biology and Medicine Through Mathematics Conference
No abstract provided.