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Full-Text Articles in Systems and Integrative Physiology
Aging And Sympathetic Neurotransmission In Two Strains Of Rats That Differ In Longevity And Immune Profiles, Sam David Perez
Aging And Sympathetic Neurotransmission In Two Strains Of Rats That Differ In Longevity And Immune Profiles, Sam David Perez
Loma Linda University Electronic Theses, Dissertations & Projects
Age-related changes in sympathetic neurotransmission in immune organs may be associated with immunosenescence; however no causal relationship has been established. From previous studies in Fischer rats (F344), we have found that during middle age, sympathetic nerve activity (SNA) rises in the spleen followed by a decline in noradrenergic (NA) innervation. Also, increased sympathetic signaling via betaadrenergic receptor (β-AR) and reduced proliferation of lymphocytes are evident with increasing age. Although SNA progressively rises with age, effects of age on sympathetic factors may be different across rat strains. If causal relationships exist between sympathetic activity and immune function, they may be related …
Development Of A Model For Infective Endocarditis Via Intravenous Injection And Tooth Infection Of Rats Using Pathogenic Bacteria, Shahrokh Shabahang
Development Of A Model For Infective Endocarditis Via Intravenous Injection And Tooth Infection Of Rats Using Pathogenic Bacteria, Shahrokh Shabahang
Loma Linda University Electronic Theses, Dissertations & Projects
Historically, focal areas of infection have been linked to a number of systemic ailments. During the early part of the 20th century, patients who were suffering from inexplicable diseases and who were suspected of having infected teeth were referred to the dentist for multiple extraction of their dentition. The discovery of antibiotics provided a false sense of security that the war against microorganisms is no longer a concern for mankind. However, more recently, it has become common belief that increasing numbers of systemic diseases are linked to chronic infections. Recovery of bacteria from representative tissues has led investigators to believe …