Physiology Commons^™

Metabolic Response Of The Code Goby (Gobiosoma Robustum) To Estuarine Climate Change Forecasts, Karli S. Corey

All HCAS Student Capstones, Theses, and Dissertations

Forage fishes are small bodied species that form a diverse functional group, serving as a primary food source for a wide range of marine predators. This group plays a significant ecological role through energy transfer to higher trophic levels. Gobiosoma robustum (Code Goby) is a substantive diet component of several recreationally significant juvenile sportfishes in Florida estuaries. While the thermal tolerance of this species may be inferred from observational data, the absolute physiological limitations of this species remain unknown. In this study, intermittent-flow respirometry and critical thermal maxima were used to determine the response of G. robustum to chronic and …

Insights Into Cerebrovascular Health: Comparative Study Of The Common Carotid And Middle Cerebral Artery, Emma Lou

2024 Fall Honors Capstone Projects - Archive

The carotid artery, responsible for blood flow to the brain, and the middle cerebral artery (MCA), which supplies the cerebrum, are both susceptible to atherosclerosis, a condition that impairs blood flow and can lead to cognitive decline and ischemic strokes. This study investigates whether blood flow and vasodilation responses in the MCA during a hypercapnic challenge are comparable to those in the common carotid artery, which supplies the entire brain. This project aims to address limitations in current assessment methods, such as transcranial and duplex Doppler ultrasonography, to ascertain whether these two arteries exhibit consistent vasodilation patterns under hypercapnic conditions. …

Myosin Xva Isoforms Participate In The Mechanotransduction-Dependent Remodeling Of The Actin Cytoskeleton In Auditory Stereocilia, Ana I. López-Porras, Ava M. Kruse, Mark T. Mcclendon, A. Catalina Vélez-Ortega

Neurology Faculty Publications

Auditory hair cells form precise and sensitive staircase-like actin protrusions known as stereocilia. These specialized microvilli detect deflections induced by sound through the activation of mechano-electrical transduction (MET) channels located at their tips. At rest, a small MET channel current results in a constant calcium influx which regulates the morphology of the actin cytoskeleton in the shorter ‘transducing’ stereocilia. However, the molecular mechanisms involved in this novel type of activity-driven plasticity in the stereocilium cytoskeleton are currently unknown. Here, we tested the contribution of myosin XVA (MYO15A) isoforms, given their known roles in the regulation of stereocilia dimensions during hair …

High Yield Of Congenital Hypothyroidism Among Infants Attending Children Hospital, Nairobi, Kenya. Facility Based Study In The Absence Of Newborn Screening, Menbere Kahssay, Thomas Ngwiri

Paediatrics and Child Health, East Africa

Objectives: Congenital hypothyroidism (CHT) is a treatable cause of intellectual disability. Late diagnosis and delayed initiation of treatment leads to irreversible neurodevelopmental and intellectual disability. Thus, newborn screening is crucial. However, 71 % of babies are born in an area with no established newborn screening program and Kenya is not an exception. We aimed to determine the incidence of CHT, developmental outcomes of patients in the absence of newborn screening.

Methods: A retrospective data of subjects who met the inclusion criteria, newborn and infants from 3 days to 2 years whose thyroid function test (TFT) was undertaken during well baby …

Apoa2 Increases Cholesterol Efflux Capacity To Plasma Hdl By Displacing The C-Terminus Of Resident Apoa1, Snigdha Sarkar, Jamie Morris, Youngki You, Hannah Sexmith, Scott E. Street, Stephanie M. Thibert, Isaac K. Attah, Chelsea M. Hutchinson Bunch, Irina V. Novikova, James E. Evans, Amy S. Shah, Scott M. Gordon, Jere P. Segrest, Karin E. Bornfeldt, Tomas Vaisar, Jay W. Heinecke, W. Sean Davidson, John T. Melchior

Saha Cardiovascular Research Center Faculty Publications

Abstract The ability of high-density lipoprotein (HDL) to promote cellular cholesterol efflux is a more robust predictor of cardiovascular disease protection than HDL-cholesterol levels in plasma. Previously, we found that lipidated HDL containing both apolipoprotein A-I (APOA1) and A-II (APOA2) promotes cholesterol efflux via the ATP-binding cassette transporter (ABCA1). In the current study, we directly added purified, lipid-free APOA2 to human plasma and found a dose-dependent increase in whole plasma cholesterol efflux capacity. APOA2 likewise increased the cholesterol efflux capacity of isolated HDL with the maximum effect occurring when equal masses of APOA1 and APOA2 coexisted on the particles. Follow-up …

Untargeted Lipidomics Reveals Novel Hdl Metabotypes And Lipid-Clinical Correlates, Peer W. F. Karmaus, Scott M. Gordon, Marcus Y. Chen, Alison A. Motsinger-Reif, Rodney W. Snyder, Timothy R. Fennell, Suramya Waidyanatha, Reshan A. Fernando, Alan T. Remaley, Michael B. Fessler

Saha Cardiovascular Research Center Faculty Publications

Plasma high-density lipoprotein (HDL), originally studied for its role in lipid transport, is now appreciated to have wide-ranging biological functions that become defective during disease. While >200 lipids have collectively been detected in HDL, published HDL lipidomic analyses in different diseases have commonly been targeted to prespecified subsets of lipids. Here, we report the results of untargeted lipidomic analysis of HDL isolated from 101 subjects referred for computed tomographic coronary imaging for whom multiple additional clinical and lipoprotein metadata were measured. Unsupervised clustering of the total HDL lipidome revealed that the subjects fell into one of two discrete groups, herein …

Effects Of Metoprolol And Propranolol Beta-Blockers Mixture On Morphological And Physiological Responses In The American Oyster, Andrew Salinas

Theses and Dissertations

Beta-blockers are extensively used to treat human cardiovascular conditions yet pose significant risks to non-target aquatic organisms. This study aimed to investigate the effects of short-term exposure (one week) to a beta-blocker’s mixture (low-dose: 50 ng/L propranolol and 250 ng/L metoprolol, and high-dose: 250 ng/L propranolol and 650 ng/L metoprolol) in the American oysters. Histopathological assessments revealed structural damage to gills, connective tissues, and digestive glands in both low- and high-dose treatment groups. Additionally, glucose concentration and pH of the extrapallial fluid significantly declined in the high-dose treatment group. Hemocyte density within connective tissues increased proportionally with dosage. The beta-blocker …

Physiology And Genomics At The Bottom Of The World: Genome To Phenome, Amy Christine Klink

UNLV Theses, Dissertations, Professional Papers, and Capstones

Mammals are exposed to a suite of physiological challenges based on the environment in which they inhabit. Animal individuals can overcome challenges associated with the dynamic nature of their habitat through variation in phenotypic traits. The plasticity of a phenotype relies on an individual’s genome and the transcription factors that act on regulatory elements. Species living in Antarctica display physiological specializations to withstand harsh conditions, such as severe cold temperatures, shifts in available ice habitat, and annual fluctuations in daylight. To explore the connections between an individual’s genome and its phenotype, we investigated two physiologies of the Antarctic Weddell seal …

Randomized Pilot Study Examining An Online Diet Intervention To Increase Intake Of Fruits And Vegetables Among Healthy Adults, Diana Kolb, Sarah Deemer, Eva Claire Synkowski, Stephanie Silveira

International Journal of Exercise Science

International Journal of Exercise Science 17(2): 1618-1628, 2024. Intake of fruits and vegetables (F&V) is related to health outcomes. The purpose of the study was to test an online diet program promoting F&V intake among healthy adults. Twenty-three participants were randomly assigned to complete an 8-week intervention condition (#800gChallenge®) or wait-list control condition. In weeks 1-4, intervention participants were asked to interact with an application reporting (a) whether they met their daily 800g F&V goal, (b) if their 800g of F&V was from a variety of sources, and (c) reading of daily educational material. Weeks 1-4 included weekly Zoom check-in …

The Anti-Diabetic Drug Metformin Disrupts Feeding And Sleeping Behaviors In Drosophila Melanogaster, Lucas Fitzgerald

The Cardinal Edge

Dimethylbiguanide, also known as metformin, is the single most prescribed oral treatment for non-insulin dependent diabetes mellitus, or type 2 diabetes, in western countries. The primary mechanism of action that metformin acts through is the activation of AMP kinase, an important regulator of energy homeostasis. While the anti-diabetic effects of metformin are well documented, its effects on feeding and sleeping behaviors are not well characterized. Using the model organism Drosophila melanogaster, the mean daily quantity of food consumed was measured and compared between groups treated with several dosages of metformin. Feeding interactions such as meal frequency and length were …

Differences In Physiological Responses Between Two Repeated Sprint Protocols In Female Soccer Players, Emma Hörnlund, Spyridon Hadjispyrou, Apostolos Theos

International Journal of Exercise Science

International Journal of Exercise Science 17(6): 1605-1617, 2024. Soccer is a team sport characterized by repeated high-intensity sprints followed by brief periods of recovery. Repeated sprints with (RCOD) and without (RSA) change-of-direction has therefore been recognized as an important fitness component. The purpose of the present study was to examine the differences in physiological responses between RSA and RCOD, and the relationship with Yo-Yo intermittent recovery test (YYIR1), as an estimate of aerobic capacity, in female soccer players. Thirteen female soccer players (age: 20.8 ± 2.6 years) participated. All players performed an RSA and RCOD test, as well as a …

Distinct Visual Processing Patterns In Female Elite Athletes: A Comparative Study Of Gymnastics, Soccer, And Esports Using Visual P300 Event-Related Potentials, Papatsorn Ramyarangsi, Simon J. Bennett, Vorasith Siripornpanich, Ampika Nanbancha, Akachai Pokaisasawan, Prapan Noppongsakit, Amornpan Ajjimaporn

International Journal of Exercise Science

International Journal of Exercise Science 17(5): 1595-1604, 2024. Visual processing is crucial for sports performance, influencing athletes' ability to interpret and respond to visual stimuli. This study investigated distinct visual processing patterns among Thai elite athletes in gymnastics, soccer, and esports, utilizing visual P300 event-related potentials (P300 ERPs). Forty-two female athletes (14 gymnasts, 14 soccer players, and 14 esports athletes) participated. Visual P300 ERP responses were stimulated using the visual oddball paradigm. One-way ANOVA was employed to assess significant differences among the groups in P300 ERPs data, including amplitude and latency of waveforms, response time, and accuracy rate. Significant differences …

Can Lower-Body Strength And Power Alleviate Load Carriage Performance Decrements (Tactical Deficit) In Simulated Law Enforcement Job Tasks?, Ashley M. Bloodgood, Joseph Dulla, Megan Thompson, Matthew R. Moreno, Robin (Rob) Marc Orr, J. Jay Dawes, Robert G. Lockie

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 1577-1594, 2024. Law enforcement agencies typically have recruits complete fitness assessments without personal protective equipment (PPE). PPE negatively impacts performance. Greater strength and power could alleviate performance decrements due to the extra load, termed the tactical deficit (TD). The purpose of this study was to examine whether lower-body strength or power related to the TD in civilians performing police tasks. Twenty participants (12 men, 8 women) completed baseline tests, including: standing broad jump (SBJ); relative SBJ; absolute and relative isometric leg/back dynamometer (LBD) and one-repetition maximum hexagonal bar deadlift (HBD). In two other sessions, …

Heart Rate And Blood Pressure Responses Vary Between Blood Flow Restriction Cuff Type, Daniela Rincon Garcia, Abbey C. Hafler, Rebecca F. Rodriguez, Erica M. Marshall

International Journal of Exercise Science

International Journal of Exercise Science 17(2): 1568-1576, 2024. The purpose of the study was to compare heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) following high load resistance exercise (HLRE) and blood flow restriction exercise (BFRE) with a knee wrap (kBFRE) and pneumatic cuff (pBFRE). Eleven men (N = 9) and women (N = 2) participated. HR, SBP, and DBP were collected at Rest, immediately post exercise (IP), 10-, 30-, and 45-minutes post exercise. Repeated measures ANOVAs assessed the effects of condition across time on all variables. Significant effects were examined with pairwise comparisons and a …

Life Course Stressors, Latent Coping Strategies, Alcohol Use, And Adherence Among People With Hiv, Amrita Gill, Gretchen Clum, Patricia Molina, David Welsh, Tekeda Ferguson, Katherine P. Theall

School of Medicine Faculty Publications

People with HIV (PWH) have often experienced chronic stressors across their lifespan, including adverse childhood experiences (ACES), lifetime economic hardship (LEH), and concurrent stressors associated with living in urban areas (urban stress). Prolonged exposure to stressors might result in differential coping patterns among PWH that can impact care trajectories. We utilized a life course-informed approach to examine chronic stressors as antecedents of latent coping strategies among PWH in care. High-risk alcohol use and non-adherence to anti-retroviral therapy (ART) were examined as consequences of latent coping strategies. Data were utilized from the baseline and interim follow-up visit of the New Orleans …

Relative Age Effect For Different Playing Positions In Adolescent Female Volleyball Players, Christos Ntozis, Karolina Barzouka, Apostolos Z. Skouras, Evgenia Cherouveim, Flora Papitsi, Nikolaos Apostolidis, Charilaos Tsolakis

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 1553-1567, 2024. Understanding the Relative Age Effect (RAE) in female volleyball can provide a deeper insight into potential developmental advantages and selection biases between playing positions and volleyball-related performance characteristics. This study aimed to investigate the occurrence of the RAE in adolescent female volleyball players according to the playing position and the possible differences in anthropometric and performance characteristics between the relative age groups. The study involved 193 young female volleyball players from 12 different regions and 108 sports clubs from all over Greece, with an average age of 14.53 ± 0.31 years, height …

The Effects Of Mental Fatigue Induced By The Stroop Test On Muscular Endurance Performance And Neuromuscular Activation In Division Iii Female Athletes, Francesca Cuchna, Jeffrey Herrick, Price Blair, Sean Collins

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 1540-1552, 2024. The purpose of this study was to investigate the effect that mental fatigue, as induced by a Stroop test, has on resistance training performance outcomes such as muscular endurance, power output, and neuromuscular activation. Seven female college-aged NCAA Division III student-athletes with at least one year of resistance training experience and were within the 50th percentile for maximal aerobic capacity provided informed consent for participation. During two separate visits, using a within-subject crossover experimental design, subjects completed either the experimental or control condition. Subjects then completed a to-failure leg press test at …

Use Of Electrical Bone Growth Stimulators In High-Risk Patients Following Spinal Fusion, Soumya Malhotra, Khavir Sharieff

HCA-NSU MD Research Day

Title: Use of Electrical Bone Growth Stimulators in High-Risk Patients Following Spinal Fusion Authors: Soumya Malhotra, BA., MS1 & Khavir Sharieff, DO, MBA2 1Class of 2027, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, FL 2Assistant Professor of Surgery, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Tampa Bay, FLNova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine Objective: This study aimed to elucidate the advantages of EBGSs following high-risk spinal fusions. Background: Pseudarthrosis is a condition where bones fail to fuse after an injury or surgery. It causes significant …

Effects Of Different Warm-Up Protocols On The Cardiopulmonary Responses To Exercise Testing In Youth, Avery D. Faigenbaum, Jie Kang, Jenna Ingui, Aidan Fish, Jessica Dimatteo, Izzy Leazier, Jill Bush, Nicholas Ratamess

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 1530-1539, 2024. The aim of this study was to compare the warm-up effects of a treadmill walking warm-up (TW) with a dynamic warm-up (DW) on the responses to cardiopulmonary exercise testing (CPET) in youth. A sample of 16 active youth (age 13.6 ± 1.8 yr) were tested for peak oxygen uptake (VO₂ peak) using the Fitkids treadmill test protocol on 2 nonconsecutive days following different 6-min warm-up procedures. The TW consisted of walking on a treadmill at 2.2 mph and 0% grade whereas the DW consisted of 12 bodyweight exercises with a 2 …

A Comparison Of Achilles Tendon Morphological Characteristics Based Upon Visa-A Score In Active Adults Over Age 50, Joshua Sponbeck, Brie Gisseman, Christian Lefevre, Emily Shuler, Ron Hager, A. Wayne Johnson

International Journal of Exercise Science

International Journal of Exercise Science 17(3): 1517-1529, 2024. Morphologic Achilles tendon properties obtained via diagnostic ultrasound imaging are valuable in understanding Achilles tendon health and injury. Currently, limited information exists regarding Achilles tendon morphological properties amongst active aging adults based upon Victorian Institute of Sport Assessment (VISA-A) scores. Achilles tendon morphologic properties defined by VISA-A score groupings allow clinicians and researchers to compare data values amongst current patients. Purpose: Comparison of physically active aging adults Achilles tendon morphological properties with various VISA-A scores or a previous Achilles tendon rupture. A convenience sample of 121 participants (71 females, 50 males) at …

Leisure-Time Physical Activity And Motivation In Police Cadets: A Self-Determination Study, Sébastien Poirier, François Trudeau, Julie Houle

International Journal of Exercise Science

International Journal of Exercise Science 17(5): 1504-1516, 2024. Several studies have highlighted the importance of leisure-time physical activity (LTPA) for the health and performance of law enforcement officers. Nevertheless, a considerable proportion of officers still fail to engage in any LTPA. There is a clear need to identify correlates of physical activity among this specific occupational group to help the design of workplace physical activity interventions. Rooted in the self-determination theory, this study seeks to assess the LTPA level of police cadets and examine its relationship with the different regulatory forms of motivation. In this cross-sectional study, 188 police cadets …

High-Intensity Exercise In Community-Based Boxing Improves Functional Limitations In Individuals With Parkinson’S Disease, Linnette Ramos, Jessica Watson, Ryan Macalintal, Carrie Ellis

International Journal of Exercise Science

International Journal of Exercise Science 17(3): 1493-1503, 2024. Various exercise types may slow disease progression and improve physical function for people with Parkinson’s disease (PWP), including community-based boxing programs (CBP). Recent research suggests that high-intensity exercise may result in greater benefits for PWP. Participants in CBP, which are typically self-paced, may not be reaching this optimal intensity. This study examines if it is feasible and beneficial for PWP to perform high-intensity exercise in a CBP. Seven subjects diagnosed with Parkinson’s disease participated in a multimodal CBP twice a week for six weeks while wearing heart rate (HR) monitors to help …

A Genome-Wide Association Study Identifies Genetic Determinants Of Hemoglobin Glycation Index With Implications Across Sex And Ethnicity, John S. House, Joseph H. Breeyear, Farida S. Akhtari, Violet Evans, John B. Buse, James Hempe, Alessandro Doria, Josyf C. Mychaleckyi, Vivian Fonseca, Mengyao Shi, Changwei Li, Shuqian Liu, Tanika N. Kelly, Daniel Rotroff, Alison A. Motsinger-Reif

School of Medicine Faculty Publications

Introduction: We investigated the genetic determinants of variation in the hemoglobin glycation index (HGI), an emerging biomarker for the risk of diabetes complications. Methods: We conducted a genome-wide association study (GWAS) for HGI in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (N = 7,913) using linear regression and additive genotype encoding on variants with minor allele frequency greater than 3%. We conducted replication analyses of top findings in the Atherosclerosis Risk in Communities (ARIC) study with inverse variance-weighted meta-analysis. We followed up with stratified GWAS analyses by sex and self-reported race. Results: In ACCORD, we identified single …

Core Concepts: Views From Physiology And Neuroscience, Jennifer E. Schaefer, Joel Michael

Biology Faculty Publications

Core concepts are “big ideas” that are central to a discipline, provide frameworks of understanding for disciplinary content, and aid student transfer of learning. Core concept lists have been developed for increasing numbers of higher education STEM disciplines. This mini-review uses physiology and neuroscience core concepts as examples to inform core concept pedagogies in these and other disciplines. The article reviews the development of physiology and neuroscience core concepts and compares the resulting concept lists. It then provides suggestions or “lessons learned” for educators and researchers who wish to utilize core concept pedagogies or who wish to develop core concepts …

The Interaction Of Treadmill Type And Incline Slope On Biomechanics And Muscle Activation During Human Locomotion, Rohit Kundu, Ricardo Sanchez, Taj Krieger, Eli Lankford

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 1478-1492, 2024. To investigate the effects of differing treadmills on impact acceleration and muscle activation. Methods: 15 males and 7 females (27.8 ± 7.7yrs), engaged in two sessions of high-incline walking (HIW), and low-incline jogging (LIJ) on different deck systems (cushioned) treadmills (TM1 and TM2). Sessions lasted 5-minutes, and participants maintained a self-selected pace matched for each session. EMG markers were placed over the Tibialis Anterior (TA), Soleus (SOL), Lateral Gastrocnemius (LG), Biceps Femoris (BF), Gluteus Maximus (GM), Anterior Deltoid (AD), Vastus Lateralis (VL), and the Erector Spinae (ES). Trident Inertial Measurement Units (IMU) …

Effect Of Sex And Age On Knee Strength In Young Athletes: A Systematic Review And Meta-Analysis, Hui Gao, Xiaoquan Luo

International Journal of Exercise Science

International Journal of Exercise Science 17(6): 1461-1477, 2024. The purpose was to summarize the studies examining knee strength in young athletes and provide valuable insights into the magnitude of changes in knee flexion and extension strength during the transition from pre-puberty to puberty among male and female athletes. The literature search was conducted through Cochrane Library, Embase, PubMed, Web of Science. Cohen’s effect size (ES) and 95% confidence intervals (CIs) were computed using a random effects model. While comparing males and females, as well as pre-puberty and puberty stages, we conducted subgroup analyses for pre-puberty versus puberty and for males …

Acute Effects Of Serial And Integrated Concurrent Exercise On Circulating Micrornas -126 And -222 In Sedentary Adults, Matthew F. Brisebois, Ryan A. Gordon, Emily L. Zumbro, Matthew L. Sokoloski, Anthony A. Duplanty, Shanil Juma, Brandon R. Rigby

International Journal of Exercise Science

International Journal of Exercise Science 17(2): 1444-1460, 2024. The purpose of this study was to compare changes in circulating microRNAs -126 (c-miR-126) and -222 (c-miR-222) following acute serial concurrent exercise (SCE) and integrated concurrent exercise (ICE) sessions among young, sedentary adults. Ten males and 9 females completed the study procedures. For SCE, participants performed resistance exercise (RE) followed by aerobic exercise (AE), without mixing the two. For ICE, participants performed a brief bout of AE before each set of RE. Blood was collected before, immediately after (IP), and 1 h (1HR) after each exercise session. Expression of c-miR-126 significantly increased …

Hepatic Targets To Control Blood Glucose And Potentially Aid In The Treatment Of Diabetes, Rena A. Velissarios

PANDION: The Osprey Journal of Research and Ideas

Maintaining glucose homeostasis is extremely important to remain in good health and prevent disease. This homeostasis is achieved via the regulation of hepatic metabolic pathways like gluconeogenesis and glycogenesis by insulin, which is expressed during high blood glucose. Insulin is responsible for facilitating the uptake of glucose into other tissues from the blood, as well as signaling whether to stimulate or slow glucose metabolism in the liver. Hyperglycemia is one of the main effects of diabetes, a disease characterized by the body’s inability to produce or respond to insulin. Without insulin, hepatic glucose output continues and blood glucose accumulates, causing …

Two Lives, Shruti Trehan Mbbs

Journal of Wellness

A busy oncologist makes a decision to leave her busy, thriving, community practice in the Mid-West and moves to a Veterans Affairs hospital in South Florida in the quest for a better work-life balance.

Effects Of Lactate On Corticospinal Excitability: A Scoping Review, Jess T. Gibson, Hudson J. Barr, Shaun G. Boe

International Journal of Exercise Science

International Journal of Exercise Science 17(2): 1429-1443, 2024. Aerobic exercise has been shown to impact corticospinal excitability (CSE), however the mechanism(s) by which this occurs is unclear. Some evidence suggests an increase in blood lactate concentration resulting from exercise may be what is driving these changes in corticospinal excitability. The extent of literature examining this effect and whether it is consistent across the literature is unknown. As such, the objective of this scoping review was to summarize the existing literature examining the effect of lactate on corticospinal excitability and to determine any trend(s) in the effect. Embase, CINAHL, Medline, SPORTDiscus, …