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2021

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Articles 121 - 150 of 383

Full-Text Articles in Physiology

Anthropometric And Leg Power Factors Affect Offensive Kinetic Patterns In Fencing, Anastasia Ntai, Charilaos Tsolakis, Athanasia Smirniotou, Giorgos Paradisis Jul 2021

Anthropometric And Leg Power Factors Affect Offensive Kinetic Patterns In Fencing, Anastasia Ntai, Charilaos Tsolakis, Athanasia Smirniotou, Giorgos Paradisis

International Journal of Exercise Science

International Journal of Exercise Science 14(4): 919-931, 2021. This study aimed to identify potential factors that may influence specific fencing offensive kinetic patterns in a large group of well-trained fencers having different ages, gender level, and training specialization. One-hundred-thirty fencers (males: n = 72) and (females: n = 58), participating in three different fencing weapons (epee, foil, and sabre), having considerable experience of national and international competitions. All members of seven national fencing teams were measured for basic anthropometric parameters, leg power performance and velocity values for three specific kinetic offensive patterns during an International Fencing camp. A multivariate analysis …


The Effect Of Freeze-Thaw Events On Dna Integrity In The Gray Treefrog (Hyla Versicolor), Georgia Ficarra Jul 2021

The Effect Of Freeze-Thaw Events On Dna Integrity In The Gray Treefrog (Hyla Versicolor), Georgia Ficarra

Masters Theses & Specialist Projects

Freeze-tolerant gray treefrogs survive winter by producing natural cryoprotectants and accommodating ice formation within extracellular spaces. While frozen, gray treefrogs endure hyperglycemia, dehydration, and anoxia due to the halt of all bodily functions. Upon thawing, the frogs’ anoxic cells receive a rapid influx of oxygen, which can cause oxidative damage to vital macromolecules including DNA. Previous studies have suggested freeze-tolerant frogs avoid oxidative damage after freeze-thaw events by elevating antioxidant activity, but recent work has shown upregulated DNA repair encoding genes in post-freeze frogs. The objective of this thesis is to assess the cellular costs of freezing by measuring oxidative …


Effect Of A 2-Week Relaxing Music Intervention On Anxiety, Stress, And Gut Symptoms In Aerobic Exercisers, Halie Marisa Maass Jul 2021

Effect Of A 2-Week Relaxing Music Intervention On Anxiety, Stress, And Gut Symptoms In Aerobic Exercisers, Halie Marisa Maass

Human Movement Studies & Special Education Theses & Dissertations

The purpose of this study was to determine the impact of a two-week relaxing music intervention on stress, anxiety, and gastrointestinal (GI) symptoms in exercisers with at least mild anxiety and exercise-related GI symptoms. Block randomization was used to allocate 15 women and two men into control (n = 8) or intervention (n = 9) groups following a one-week baseline. During the baseline period, participants recorded details of their aerobic exercise sessions and discomfort with GI symptoms (nausea, regurgitation/reflux, stomach fullness, bloating, abdominal cramps, gas, the urge to defecate). Following randomization, both groups tracked these same details for two additional …


Heat Stress And Feed Restriction Distinctly Affect Performance, Carcass And Meat Yield, Intestinal Integrity, And Inflammatory (Chemo)Cytokines In Broiler Chickens, Nima K. Emami, Elizabeth S. Greene, Michael H. Kogut, Sami Dridi Jul 2021

Heat Stress And Feed Restriction Distinctly Affect Performance, Carcass And Meat Yield, Intestinal Integrity, And Inflammatory (Chemo)Cytokines In Broiler Chickens, Nima K. Emami, Elizabeth S. Greene, Michael H. Kogut, Sami Dridi

Poultry Science Faculty Publications and Presentations

This study was conducted to distinguish the effects of heat stress (HS) and feed intake (FI) on broiler chicken’s physiological responses. Day-old male Cobb 500 broilers (n = 672) were allocated to three treatments: (1) control (CTL): birds raised under normal temperature (23°C) from day 29 to 42; (2) cyclic heat stress (CHS): birds exposed to high temperatures (8 h/day at 35°C; from 9:30 am to 5:30 pm) from day 29 to 42; (3) pair-fed (PF): birds raised under thermoneutral condition but fed the same amount of feed as CHS from day 29 to 42. On day 42, 15 …


Role Of Nhe3 In The Intestine And Thick Ascending Limb Of The Kidneys, Jianxiang Xue Jul 2021

Role Of Nhe3 In The Intestine And Thick Ascending Limb Of The Kidneys, Jianxiang Xue

USF Tampa Graduate Theses and Dissertations

The sodium-hydrogen exchanger isoform 3 (NHE3, SLC9A3) mediates most Na+/H+ exchange in the gastrointestinal tract and the kidney, where it plays crucial roles in Na+ and fluid absorption as well as acid-base homeostasis. Whole body NHE3 knockout (NHE3-/-) mice show overt absorptive defects in both the intestine and kidneys. Genetic mutations of NHE3 gene in humans are associated with congenital sodium diarrhea (CSD). In the kidneys, NHE3 is expressed in the proximal tubule (PT) and the thick ascending limb (TAL). Whole kidney-specific (PT and TAL) NHE3 knockout (NHE3Pax8cre) mice and PT-specific NHE3 knockout (PT-NHE3-/-) mice have shown the importance of …


Blood Plasma Biomarkers For Woody Breast Disease In Commercial Broilers, Byungwhi C. Kong, Bhuwan Khatri, Seong Kang, Stephanie Shouse, Hakeem J. Kadhim, Michael Thomas Kidd Jr., Kentu Lassiter, Joseph Hiltz, Barbara Mallmann, Sara Orlowski, Nicholas Anthony, Walter G. Bottje, Wayne Kuenzel, Casey Owens Jul 2021

Blood Plasma Biomarkers For Woody Breast Disease In Commercial Broilers, Byungwhi C. Kong, Bhuwan Khatri, Seong Kang, Stephanie Shouse, Hakeem J. Kadhim, Michael Thomas Kidd Jr., Kentu Lassiter, Joseph Hiltz, Barbara Mallmann, Sara Orlowski, Nicholas Anthony, Walter G. Bottje, Wayne Kuenzel, Casey Owens

Poultry Science Faculty Publications and Presentations

Woody breast (WB) myopathy results in poor muscle quality. The increasing incidence of WB over the last several years indicates a need for improved prediction or early diagnosis. We hypothesized that the use of body fluids, including blood, may be more suitable than breast muscle tissue in developing a minimally invasive diagnostic tool for WB detection. To identify potential early-age-biomarkers that may represent the potential onset of WB, blood samples were collected from 100, 4 wks old commercial male broilers. At 8 wks of age, WB conditions were scored by manual palpation. A total of 32 blood plasma samples (eight …


Computational Analysis Of Type 3 Iodothyronine Deiodinase: Potential Inhibitors, Substrate Binding, And Dimer Structure, Eric Scott Marsan Jul 2021

Computational Analysis Of Type 3 Iodothyronine Deiodinase: Potential Inhibitors, Substrate Binding, And Dimer Structure, Eric Scott Marsan

Chemistry & Biochemistry Theses & Dissertations

Thyroid hormones (THs) in mammalian tissues are crucial for development and maintaining metabolic homeostasis. Iodothyronine deiodinases (Dios) remove iodines from THs by a selenocysteine (Sec) residue, which either activates or inactivates them. Halogen bonding (XB) has been proposed to describe the interaction between the Se and I atoms of the T4-Dio complex. Disruption of TH homeostasis by xenobiotics, such as polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) can cause deleterious effects on the endocrine system. Experimental studies have indicated that PBDEs and PCBs could disrupt TH homeostasis by inhibiting Dio through XB formation. However, no current quantitative study exists …


Reduced Mitochondrial Dna And Oxphos Protein Content In Skeletal Muscle Of Children With Cerebral Palsy, Ferdinand Von Walden, Ivan J. Vechetti Jr., Davis A. Englund, Vandré C. Figueiredo, Rodrigo Fernandez-Gonzalo, Kevin A. Murach, Jessica Pingel, John J. Mccarthy, Per Stål, Eva Pontén Jun 2021

Reduced Mitochondrial Dna And Oxphos Protein Content In Skeletal Muscle Of Children With Cerebral Palsy, Ferdinand Von Walden, Ivan J. Vechetti Jr., Davis A. Englund, Vandré C. Figueiredo, Rodrigo Fernandez-Gonzalo, Kevin A. Murach, Jessica Pingel, John J. Mccarthy, Per Stål, Eva Pontén

Physiology Faculty Publications

AIM: To provide a detailed gene and protein expression analysis related to mitochondrial biogenesis and assess mitochondrial content in skeletal muscle of children with cerebral palsy (CP).

METHOD: Biceps brachii muscle samples were collected from 19 children with CP (mean [SD] age 15y 4mo [2y 6mo], range 9-18y, 16 males, three females) and 10 typically developing comparison children (mean [SD] age 15y [4y], range 7-21y, eight males, two females). Gene expression (quantitative reverse transcription polymerase chain reaction [PCR]), mitochondrial DNA (mtDNA) to genomic DNA ratio (quantitative PCR), and protein abundance (western blotting) were analyzed. Microarray data sets (CP/aging/bed rest) were …


The Neurological Asymmetry Of Self-Face Recognition, Aleksandra Janowska, Brianna Balugas, Matthew Pardillo, Victoria Mistretta, Katherine Chavarria, Janet Brenya, Taylor Shelansky, Vanessa Martinez, Kitty Pagano, Nathira Ahmad, Samantha Zorns, Abigail Straus, Sarah Sierra, Julian Keenan Jun 2021

The Neurological Asymmetry Of Self-Face Recognition, Aleksandra Janowska, Brianna Balugas, Matthew Pardillo, Victoria Mistretta, Katherine Chavarria, Janet Brenya, Taylor Shelansky, Vanessa Martinez, Kitty Pagano, Nathira Ahmad, Samantha Zorns, Abigail Straus, Sarah Sierra, Julian Keenan

Department of Biology Faculty Scholarship and Creative Works

While the desire to uncover the neural correlates of consciousness has taken numerous directions, self-face recognition has been a constant in attempts to isolate aspects of self-awareness. The neuroimaging revolution of the 1990s brought about systematic attempts to isolate the underlying neural basis of self-face recognition. These studies, including some of the first fMRI (functional magnetic resonance imaging) examinations, revealed a right-hemisphere bias for self-face recognition in a diverse set of regions including the insula, the dorsal frontal lobe, the temporal parietal junction, and the medial temporal cortex. In this systematic review, we provide confirmation of these data (which are …


Metabolic Rate, Critical Oxygen Partial Pressure, And Oxygen Supply Capacity Of Farfantepenaeus Duorarum At Their Lower Thermal Limit, Alexandra L. Burns Jun 2021

Metabolic Rate, Critical Oxygen Partial Pressure, And Oxygen Supply Capacity Of Farfantepenaeus Duorarum At Their Lower Thermal Limit, Alexandra L. Burns

USF Tampa Graduate Theses and Dissertations

Temperature and environmental oxygen availability affect oxygen supply and demand in ectotherms, which are hypothesized to control the geographic limits of many marine species. The oxygen supply capacity (α) is calculated from commonly measured metabolic traits, including the standard metabolic rate (SMR) and critical oxygen partial pressure at SMR (Pcrit). It may be used to estimate the metabolic capacity and aerobic scope across changes in temperature and oxygen partial pressures as α reflects adaptations of the cardiorespiratory system to meet maximum energy demands at a given oxygen partial pressure (PO2). In this study, α was measured for the Tampa Bay …


A Study Of Trpa1 Activation Via Covalent Electrophilic Modification Of Cysteines, Thomas A. Parks Jun 2021

A Study Of Trpa1 Activation Via Covalent Electrophilic Modification Of Cysteines, Thomas A. Parks

USF Tampa Graduate Theses and Dissertations

A subset of sensory nerves called nociceptors are stimulated by noxious stimuli and evoke nocifensive responses in different organ systems. Transient Receptor Potential Ankyrin 1 (TRPA1) is a tetrameric, nonselective, cation channel that initiates the generator potential that evokes afferent signaling in nociceptive nerves. TRPA1 is activated many harmful irritants, such as food chemicals, environmental pollutants, reactive oxygen species and other endogenous mediators. Most TRPA1 agonists have electrophilic properties, which covalently modify cysteine residues on the cytosolic side of the channel. Biochemical studies in our lab have identified four cysteines (C273, C621, C665, C1085) that rapidly bound iodoacetamide (irreversible electrophile); …


Cardiomyocyte Deletion Of Bmal1 Exacerbates Qt- And Rr-Interval Prolongation In Scn5a+/Δkpq Mice, Elizabeth A. Schroder, Jennifer L. Wayland, Kaitlyn M. Samuels, Syed F. Shah, Don E. Burgess, Tanya S. Seward, Claude S. Elayi, Karyn A. Esser, Brian P. Delisle Jun 2021

Cardiomyocyte Deletion Of Bmal1 Exacerbates Qt- And Rr-Interval Prolongation In Scn5a+/Δkpq Mice, Elizabeth A. Schroder, Jennifer L. Wayland, Kaitlyn M. Samuels, Syed F. Shah, Don E. Burgess, Tanya S. Seward, Claude S. Elayi, Karyn A. Esser, Brian P. Delisle

Physiology Faculty Publications

Circadian rhythms are generated by cell autonomous circadian clocks that perform a ubiquitous cellular time-keeping function and cell type-specific functions important for normal physiology. Studies show inducing the deletion of the core circadian clock transcription factor Bmal1 in adult mouse cardiomyocytes disrupts cardiac circadian clock function, cardiac ion channel expression, slows heart rate, and prolongs the QT-interval at slow heart rates. This study determined how inducing the deletion of Bmal1 in adult cardiomyocytes impacted the in vivo electrophysiological phenotype of a knock-in mouse model for the arrhythmogenic long QT syndrome (Scn5a+/ΔKPQ). Electrocardiographic telemetry showed inducing the …


The Effect Of Fluid Flow Shear Stress And Substrate Stiffness On Yes-Associated Protein (Yap) Activity And Osteogenesis In Murine Osteosarcoma Cells, Thomas R. Coughlin, Ali Sana, Kevin Voss, Abhilash Gadi, Upal Basu-Roy, Caroline M. Curtin, Alka Mansukhani, Oran D. Kennedy Jun 2021

The Effect Of Fluid Flow Shear Stress And Substrate Stiffness On Yes-Associated Protein (Yap) Activity And Osteogenesis In Murine Osteosarcoma Cells, Thomas R. Coughlin, Ali Sana, Kevin Voss, Abhilash Gadi, Upal Basu-Roy, Caroline M. Curtin, Alka Mansukhani, Oran D. Kennedy

Publications and Research

Osteosarcoma (OS) is an aggressive bone cancer originating in the mesenchymal lineage. Prognosis for metastatic disease is poor, with a mortality rate of approximately 40%; OS is an aggressive disease for which new treatments are needed. All bone cells are sensitive to their mechanical/ physical surroundings and changes in these surroundings can affect their behavior. However, it is not well understood how OS cells specifically respond to fluid movement, or substrate stiffness—two stimuli of relevance in the tumor microenvironment. We used cells from spontaneous OS tumors in a mouse engineered to have a bone-specific knockout of pRb-1 and p53 in …


Demographics, Activities, And Environmental Factors Impact Burnout In A National Survey Of Emergency Medicine Residents, Nicole Battaglioli, Tim P. Moran, Simiao Li-Sauerwine Jun 2021

Demographics, Activities, And Environmental Factors Impact Burnout In A National Survey Of Emergency Medicine Residents, Nicole Battaglioli, Tim P. Moran, Simiao Li-Sauerwine

Journal of Wellness

Introduction: Burnout in emergency medicine and in residency training has been well-described. The impact of demographic, individual, and programmatic factors on burnout have not previously been determined in a national survey of emergency medicine residents. This study aimed to identify personal and environmental factors impacting resident burnout in a national sample of emergency medicine residents.

Methods: A prospective Emergency Medicine Resident Wellness Survey was administered in 2017. We surveyed respondents on demographic, personal, and environmental factors; each respondent also completed the Maslach Burnout Inventory - Human Services Survey. Linear regressions were used to identify variables associated with the Maslach Burnout …


Ice Hockey Goaltender Physiology Profile And Physical Testing: A Systematic Review And Meta-Analysis, Viviane Marcotte-L'Heureux, Jérémie Charron, Robert Panenic, Alain Steve Comtois Jun 2021

Ice Hockey Goaltender Physiology Profile And Physical Testing: A Systematic Review And Meta-Analysis, Viviane Marcotte-L'Heureux, Jérémie Charron, Robert Panenic, Alain Steve Comtois

International Journal of Exercise Science

International Journal of Exercise Science 14(6): 855-875, 2021. This review aims to 1) be the first systematic review and meta-analysis of the literature examining the physiology and assessment of goaltenders, and 2) present a physiological profile of ice-hockey goaltenders. It will 1) highlight physiological differences between goaltenders and players at other positions, 2) determine strengths and weaknesses of ice hockey goaltenders, and 3) offer possible guidelines for strength and conditioning coaches. Six electronic databases were systematically searched in October 2019 using the PRISMA model. A total of twelve scientific articles published in peer-reviewed journals were included. Professional male (PM) goaltenders …


The Effect Of Set Configuration And Load On Post-Activation Potentiation On Vertical Jump In Athletes, Paolo Sirieiro, Igor Nasser, Ward C. Dobbs, Jeff Willardson, Humberto Miranda Jun 2021

The Effect Of Set Configuration And Load On Post-Activation Potentiation On Vertical Jump In Athletes, Paolo Sirieiro, Igor Nasser, Ward C. Dobbs, Jeff Willardson, Humberto Miranda

International Journal of Exercise Science

International Journal of Exercise Science 14(4): 902-911, 2021. The aim of this study was to compare the effect of post-activation potentiation (PAP) on countermovement jump (CMJ) using different set configurations and loads on conditioning activity (CA) in highly trained athletes. Sixteen national level swimmers participated in this study and performed a total of six visits to the laboratory. The first session was used for familiarization, the second session was utilized to determine five repetitions maximum (RM) in the half squat (HS), and the following four visits consisted of four CA protocols performed in a counterbalanced order. Two CAs were performed …


Are There Differences In Fitness Between Recruits From Larger (Hosting) And Smaller (Participating) Law Enforcement Agencies?, Erika Hernandez, J. Jay Dawes, Robin Marc Orr, Joseph Dulla, Robert G. Lockie Jun 2021

Are There Differences In Fitness Between Recruits From Larger (Hosting) And Smaller (Participating) Law Enforcement Agencies?, Erika Hernandez, J. Jay Dawes, Robin Marc Orr, Joseph Dulla, Robert G. Lockie

International Journal of Exercise Science

International Journal of Exercise Science 14(4): 885-901, 2021. Law enforcement agencies often conduct academy training classes that include recruits hired by both the larger hosting agency (HA), and by smaller participating agencies (PA). HAs that need to fill more positions may have recruits with a wide range of fitness levels. Smaller agencies may be more selective in their hiring as they do not have as many available positions. This study compared HA and PA recruit fitness prior to academy. Retrospective analysis was conducted on 11 academy classes, incorporating 742 HA recruits (602 males, 140 females) and 99 PA recruits (82 …


A Community-Based Boxing Program Is Associated With Improved Balance In Individuals With Parkinson’S Disease, Abbie Moore, Enoch Yee, Brad W. Willis, Evan L. Prost, Aaron D. Gray, J. Bryan Mann Jun 2021

A Community-Based Boxing Program Is Associated With Improved Balance In Individuals With Parkinson’S Disease, Abbie Moore, Enoch Yee, Brad W. Willis, Evan L. Prost, Aaron D. Gray, J. Bryan Mann

International Journal of Exercise Science

International Journal of Exercise Science 14(3): 876-884, 2021. In alignment with efforts to mitigate the negative health consequences of Parkinson’s Disease (PD), the purpose of this investigation was to examine if participation in a community-based boxing program (CBP) was associated with improvements in balance and fall risk reduction among individuals with PD. In this retrospective cross-sectional study, de-identified data from 12 individuals with PD participating in a CBP was examined. Participants included those with a Hoehn and Yahr stage between 1 and 3, averaging 2.8 ± 0.8 CBP sessions per week for 6.1 ± 0.8 months between testing. Baseline and …


Hip Flexion Angles During Supine Range Of Motion And Bodyweight Squats, Angeli J. Mata, Hidetaka Hayashi, Phillip A. Moreno, Robert I. Dudley, Eric A. Sorenson Jun 2021

Hip Flexion Angles During Supine Range Of Motion And Bodyweight Squats, Angeli J. Mata, Hidetaka Hayashi, Phillip A. Moreno, Robert I. Dudley, Eric A. Sorenson

International Journal of Exercise Science

International Journal of Exercise Science 14(1): 912-918, 2021. During the lowering phase of a squat, it has been observed that a posterior pelvic tilt (PPT) may occur when squatting to full depth. Research suggests that defaulting to compensatory movement strategies, such as PPT, during the squat may correlate with risk of lower extremity and trunk pathology. The purpose of this study was to examine hip flexion (HF) angles at the point when PPT occurs among three conditions: standard squats, heel raise squats, and supine passive HF; analyzing the differences in depth between standard and heel raise squats; and calculating differences …


The Effects Of Fasting Or Ketogenic Diet On Endurance Exercise Performance And Metabolism In Female Mice, Lola Holcomb, Caitlin O'Neill, Elizabeth Dewitt, Stephen C. Kolwicz Jr. Jun 2021

The Effects Of Fasting Or Ketogenic Diet On Endurance Exercise Performance And Metabolism In Female Mice, Lola Holcomb, Caitlin O'Neill, Elizabeth Dewitt, Stephen C. Kolwicz Jr.

Health Sciences Faculty Publications

The promotion of ketone body (KB) metabolism via ketosis has been suggested as a strategy to increase exercise performance. However, studies in humans and animals have yielded inconsistent results. The purpose of the current study was to examine the effects of ketosis, achieved via fasting or a short-term ketogenic diet (KD), on endurance exercise performance in female mice. After 8 h of fasting, serum KB significantly increased and serum glucose significantly decreased in fasted compared to fed mice. When subjected to an endurance exercise capacity (EEC) test on a motorized treadmill, both fed and fasted mice showed similar EEC performance. …


Racial And Ethnic Minority Groups Are Under-Represented And Under-Reported In Guideline-Informing Heart Failure Clinical Trials, Gerardo Gamino Jun 2021

Racial And Ethnic Minority Groups Are Under-Represented And Under-Reported In Guideline-Informing Heart Failure Clinical Trials, Gerardo Gamino

Undergraduate Honors Theses

Heart failure (HF) is a common cause of morbidity and mortality in the United States that may disproportionately affect certain racial/ethnic groups. Compared with White individuals, HF may affect Black individuals at a younger age with less favorable prognosis, and this excess risk may be partially explained by differences in HF risk factor burden. It is crucial for guideline informing HF clinical trials to adequately reflect the racial/ethnic diversity in the population. We assessed the extent of reporting and representation of race/ethnicity in HF clinical trials referenced in the 2013 ACC/AHA Guideline for the Management of Heart Failure and the …


Training On A Lower Body Positive Pressure Treadmill With Body Weight Support Does Not Improve Aerobic Capacity, David K. Lee, Natalie Maltz, James Becker, Joshua A. Cotter Jun 2021

Training On A Lower Body Positive Pressure Treadmill With Body Weight Support Does Not Improve Aerobic Capacity, David K. Lee, Natalie Maltz, James Becker, Joshua A. Cotter

International Journal of Exercise Science

International Journal of Exercise Science 14(7): 829-839, 2021. This study examined the physiological changes resulting from training on a lower body positive pressure treadmill (LBPPT) at three different levels of body weight support (BWS). Thirty-three healthy college aged students (22.3 ± 3.1 years) completed the study. Participants performed a graded exercise test (GXT) to exhaustion and were placed into one of three experimental groups corresponding to 100%, 75%, and 50% of their normal BW. Participants trained at their experimental BW levels for eight-weeks. Training speed was monitored by heart rate (HR) and speed was adjusted to elicit approximately 60% of …


The Impact Of Aquatic Based Plyometric Training On Jump Performance: A Critical Review, Pryse M. Mullenax, Quincy Johnson, Michael A. Trevino, Douglas B. Smith, Bert H. Jacobson, J. Jay Dawes Jun 2021

The Impact Of Aquatic Based Plyometric Training On Jump Performance: A Critical Review, Pryse M. Mullenax, Quincy Johnson, Michael A. Trevino, Douglas B. Smith, Bert H. Jacobson, J. Jay Dawes

International Journal of Exercise Science

International Journal of Exercise Science 14(6): 815-828, 2021. There is evidence to suggest that aquatic plyometric training (APT) may be an effective and safer alternative to traditional land-based plyometric training (LPT) when training to increase jump performance. The aim of this review was to critically examine the current literature regarding the effects of APT vs. LPT on jump performance in athletic populations. Key terms were employed in five separate databases to complete the current review. Available articles were screened for inclusion and exclusion criteria to determine which studies were deemed eligible for review. Outcome measure in these studies included those …


Resistance Training As Therapeutic Management In Women With Pcos: What Is The Evidence?, Pamela J. Wright, Cynthia F. Corbett, Bernardine M. Pinto, Robin M. Dawson, Michael Wirth Jun 2021

Resistance Training As Therapeutic Management In Women With Pcos: What Is The Evidence?, Pamela J. Wright, Cynthia F. Corbett, Bernardine M. Pinto, Robin M. Dawson, Michael Wirth

International Journal of Exercise Science

International Journal of Exercise Science 14(3): 840-854, 2021. Polycystic ovary syndrome (PCOS), the most common chronic endocrinopathy and the leading cause of infertility in women, has significant clinical consequences, including cardiovascular, endocrinological, oncological, and psychological co-morbidities. Endocrine Society Clinical Practice Guidelines on the Diagnosis and Treatment of PCOS recommend exercise and physical activity as first-line treatment to combat chronic disease risk. However, details about what type of exercise are not provided. Given the known beneficial effects of resistance training on the management of other chronic diseases, the purpose of this scoping review was to evaluate the scientific evidence about the …


Hypertrophic Cardiomyopathy Β-Cardiac Myosin Mutation (P710r) Leads To Hypercontractility By Disrupting Super Relaxed State, Alison Schroer Vander Roest, Chao Liu, Makenna M. Morck, Kristina Bezold Kooiker, Gwanghyun Jung, Dan Song, Aminah Dawood, Arnav Jhingran, Gaspard Pardon, Sara Ranjbarvaziri, Giovanni Fajardo, Mingming Zhao, Kenneth S. Campbell, Beth L. Pruitt, James A. Spudich, Kathleen M. Ruppel, Daniel Bernstein Jun 2021

Hypertrophic Cardiomyopathy Β-Cardiac Myosin Mutation (P710r) Leads To Hypercontractility By Disrupting Super Relaxed State, Alison Schroer Vander Roest, Chao Liu, Makenna M. Morck, Kristina Bezold Kooiker, Gwanghyun Jung, Dan Song, Aminah Dawood, Arnav Jhingran, Gaspard Pardon, Sara Ranjbarvaziri, Giovanni Fajardo, Mingming Zhao, Kenneth S. Campbell, Beth L. Pruitt, James A. Spudich, Kathleen M. Ruppel, Daniel Bernstein

Physiology Faculty Publications

Hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, associated with over 1,000 mutations, many in β-cardiac myosin (MYH7). Molecular studies of myosin with different HCM mutations have revealed a diversity of effects on ATPase and load-sensitive rate of detachment from actin. It has been difficult to predict how such diverse molecular effects combine to influence forces at the cellular level and further influence cellular phenotypes. This study focused on the P710R mutation that dramatically decreased in vitro motility velocity and actin-activated ATPase, in contrast to other MYH7 mutations. Optical trap measurements of single myosin molecules revealed …


Mobility Improvements After A High-Cadence Dynamic Cycling Intervention In An Individual With Motor Neuron Disease: A Case Study, Kristin Noll, Bryan T. Dowdell, Angela L. Ridgel Jun 2021

Mobility Improvements After A High-Cadence Dynamic Cycling Intervention In An Individual With Motor Neuron Disease: A Case Study, Kristin Noll, Bryan T. Dowdell, Angela L. Ridgel

International Journal of Exercise Science

International Journal of Exercise Science 14(3): 791-801, 2021. Previous exercise studies in individuals with motor neuron disease have shown some positive benefits but the stress of regular exercise could result in overuse weakness in this population. The purpose of this case study is to determine the efficacy, and tolerability of a high-cadence dynamic cycling intervention in an individual with motor neuron disease. A 67-year-old male with significant lower extremity weakness and a diagnosis of idiopathic motor neuron disease completed six 30-minute sessions of high cadence dynamic cycling over a two-week period using a custom-built motorized ergometer with the motor speed …


Head Trauma Not Associated With Long Term Effects On Autonomic Function, Carley A. Shannon, Kimberli L. Pike, Sydney R. Dejonge, Paul R. Nagelkirk, Andrew T. Del Pozzi Jun 2021

Head Trauma Not Associated With Long Term Effects On Autonomic Function, Carley A. Shannon, Kimberli L. Pike, Sydney R. Dejonge, Paul R. Nagelkirk, Andrew T. Del Pozzi

International Journal of Exercise Science

International Journal of Exercise Science 14(3): 779-790, 2021. Contact-sports can elicit concussions, which impacts autonomic function, as well as elicit repetitive head trauma, where autonomic function has not yet been assessed. The purpose of this study was to determine if differences in autonomic function exist among three groups (CTRL: healthy non-contact-sport participant, RHT: repetitive head trauma contact-sport participant, CONC: previous concussion). Forty participants (16 men and 24 women), aged 18-37 (22 ± 3), participated in the study. Participants were grouped based on their sport and concussion history (CTRL, RHT, and CONC). Body composition was measured via air displacement plethysmography. Prior …


The Influence Of A Total Body Resistance Training Program On Autonomic Modulation And Strength Variables In Young Adults, Cody Altherr, Kayla M. Soave, Paul R. Nagelkirk, Andrew T. Del Pozzi Jun 2021

The Influence Of A Total Body Resistance Training Program On Autonomic Modulation And Strength Variables In Young Adults, Cody Altherr, Kayla M. Soave, Paul R. Nagelkirk, Andrew T. Del Pozzi

International Journal of Exercise Science

International Journal of Exercise Science 14(2): 802-814, 2021. The purpose of this study was to examine autonomic modulation using multiple quantitative measures before and after a resistance training (RT) intervention. Seventeen young adults (age 18-35 years) were tested for body composition, muscular strength, and autonomic activity. The RT protocol targeted total-body large muscle groups, which were performed three days a week for eight-weeks. Autonomic assessments included respiratory sinus arrhythmia (RSA), static handgrip exercise, Valsalva maneuver, heart rate variability (HRV), and tilt-table testing. The main finding was that tilt-table duration increased by 68 seconds (p = 0.05) after RT. Upper …


Synphilin-1 And Its Effects On Pathogenesis Of Parkinson’S Disease, Mirghani Mohamed Jun 2021

Synphilin-1 And Its Effects On Pathogenesis Of Parkinson’S Disease, Mirghani Mohamed

Honors Scholar Theses

Parkinson's Disease (PD) is a progressive neurodegenerative and movement disorder primarily caused by the degradation of dopaminergic neurons. Known markers of neurodegeneration in PD are Lewy Bodies, which are fibrillar aggregates that are found in the brains of PD patients. Lewy Bodies can accumulate from specific mutations in the SNCA gene that codes for alpha-synuclein, a protein enriched in presynaptic neurons. A mutated SNCA gene can cause conformational aggregates of alpha-synuclein to form toxic species mediating neuronal death. Research into alpha-synuclein has led to the discovery of a binding partner known as synphilin-1 that is also found in protein aggregates …


Evaluating The Effects Of Match-Induced Fatigue On Landing Ability; The Case Of The Basketball Game, Nikolaos I. Liveris, Charis Tsarbou, Panagiotis D. Tsimeas, George Papageorgiou, Sofia A. Xergia, Athanasios Tsiokanos Jun 2021

Evaluating The Effects Of Match-Induced Fatigue On Landing Ability; The Case Of The Basketball Game, Nikolaos I. Liveris, Charis Tsarbou, Panagiotis D. Tsimeas, George Papageorgiou, Sofia A. Xergia, Athanasios Tsiokanos

International Journal of Exercise Science

International Journal of Exercise Science 14(6): 768-778, 2021. This paper examines the effect of match–induced fatigue on lower limb biomechanics, in the case of a basketball game. For this purpose, sixteen male basketball athletes, ages 18 to 22, performed a jump-landing task prior and post a recreational basketball game. The Landing Error Scoring System (LESS) was used to examine the biomechanics of landing. The Vertical jump (VJ) and the Borg Rating of Perceived Exertion (RPE) scale pre- and post-game were employed to assess the level of fatigue induced by the basketball game. In order to compare pre and post measurements, …