Physiology Commons^™

A&P Workshop Summary—Uniting Anatomy And Physiology Through Case Studies, Angela Horner, Stuart Sumida, Tomasz Owercowicz

Q2S Enhancing Pedagogy

Introducing problem-solving based methods of pedagogy is one approach to engage students early in their careers with developing analytic and diagnostic skills. PBL approaches in anatomy and medical teaching are a logical extension of clinical case studies, wherein an example of a pathology or clinical procedure is provided, and students must ascertain the anatomical and/or physiological basis for it. Students report a deeper understanding of material presented in clinical case studies, as the ‘real world’ relevance and importance is immediately clear (Cliff and Wright, 1996).

Use Of Kalman Filtering In State And Parameter Estimation Of Diabetes Models, Cassidy Le

HMC Senior Theses

Diabetes continues to affect many lives every year, putting those affected by it at higher risk of serious health issues. Despite many efforts, there currently is no cure for diabetes. Nevertheless, researchers continue to study diabetes in hopes of understanding the disease and how it affects people, creating mathematical models to simulate the onset and progression of diabetes. Recent research by David J. Albers, Matthew E. Levine, Andrew Stuart, Lena Mamykina, Bruce Gluckman, and George Hripcsak¹ has suggested that these models can be furthered through the use of Data Assimilation, a regression method that synchronizes a model with a …

Genetic And Cellular Models For The Study Of Ptk2b And Adam10 In Adaptive Thermogenesis And Metabolism, Jared S. Farrar

Theses and Dissertations

In a cellular model, we demonstrate that the non-receptor protein tyrosine kinase 2 beta (PTK2B) plays a critical role in mouse cultured beige adipocyte differentiation. CRISPR/Cas9-mediated knock-out of Ptk2b results in non-differentiating white adipocytes and differentiated beige adipocytes with significantly reduced thermogenic gene and protein expression, enlarged lipid droplet size, and altered mitochondrial respiration. Together, these data in a cell culture system provide evidence for a role of PTK2B in the differentiation of mouse beige adipocytes.

In the process of developing a new mouse model utilizing the adipocyte selective Adipoq-Cre transgenic mouse, strong genetic linkage between a gene …

Digestive System, Janna Jann '20, Andrew Du '20, Ishan Nikam '20, Nikhilesh Gupta '20

Human Diseases Graphic Novels

No abstract provided.

Chlamydia, Lauren Pickett '20, Namit Padgaonkar '20, Vidhi Singh '20, Olivia Orobor '20, Samuel Rabideau '20

Human Diseases Graphic Novels

No abstract provided.

Alzheimer's, Sophia Pribus '20, Shivang Bhaskar '20, Pratibha Bhalla '20, Zahra Vasi '20

Human Diseases Graphic Novels

No abstract provided.

Scabies, Srilalana Appasani '21, Prarthana Prashanth '21, Krishna Thakkar '20, Esha Dani '20

Human Diseases Graphic Novels

No abstract provided.

Shingles, Pratibha Bhalla '20, Zahra Vasi '20, Shivang Bhaskar '20, Sophia Pribus '20

Human Diseases Graphic Novels

No abstract provided.

Invasion Of The Pollen, Elizabeth Murphy '20, Rachel Mason '20, Jodie Meng '20, Shouri Bochetty '21

Human Diseases Graphic Novels

No abstract provided.

Diabetes, Kailey A. Light '21, Tori Shepherd '21, Jemea Hilmara '20

Human Diseases Graphic Novels

No abstract provided.

Tuberculosis, Jodie Meng '20, Shouri Bochetty '21, Elizabeth Murphy '20, Rachel Mason '20

Human Diseases Graphic Novels

No abstract provided.

Bell's Palsy Disease, Frances Balto, Grace Federici, Bala Ramaraju, Saisu Talasu

Human Diseases Graphic Novels

No abstract provided.

Melanoma, Esha Dani '20, Krishna Thakkar '20, Prarthana Prashanth '21, Srilalana Appasani '21

Human Diseases Graphic Novels

No abstract provided.

Huntington's Disease, Frances Balto, Grace Federici, Bala Ramaraju, Saisu Talasu

Human Diseases Graphic Novels

No abstract provided.

Addisons Disease, Kailey A. Light '21, Tori Shepherd '21, Jemea Hilmara '20

Human Diseases Graphic Novels

No abstract provided.

Pneumonia, Brennan Shapiro '20

Human Diseases Graphic Novels

No abstract provided.

Rising Rural Body-Mass Index Is The Main Driver Of The Global Obesity Epidemic In Adults, Con Burns, Tara Coppinger, Janette Walton, Et Al

Publications

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3,4,5,6. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to …

Development Of A Sonically Powered Biodegradable Nanogenerator For Bone Regeneration, Avi Patel

Honors Scholar Theses

Background: Reconstruction of bone fractures and defects remains a big challenge in orthopedic surgery. While regenerative engineering has advanced the field greatly using a combination of biomaterial scaffolds and stem cells, one matter of difficulty is inducing osteogenesis in these cells. Recent works have shown electricity’s ability to promote osteogenesis in stem cell lines when seeded in bone scaffolds; however, typical electrical stimulators are either (a) externally housed and require overcomplex percutaneous wires be connected to the implanted scaffold or (b) implanted non-degradable devices which contain toxic batteries and require invasive removal surgeries.

Objective: Here, we establish a biodegradable, piezoelectric …

Cardio-Metabolic Disease Risk Factors Among South Asian Labour Migrants To The Middle East: A Scoping Review And Policy Analysis, Shiva Raj Mishra, Saruna Ghimire, Chandni Joshi, Bishal Gyawali, Archana Shrestha, Dinesh Neupane, Sudesh Raj Sharma, Yashashwi Pokharel, Salim S. Virani

School of Public Health Faculty Research

This paper aims to explore the burgeoning burden of cardiovascular and metabolic disease (CMD) risk factors among South Asian labor migrants to the Middle East. We conducted a qualitative synthesis of literature using PubMed/Medline and grey literature searches, supplemented by a policy review of policies from the South Asian countries. We found a high burden of cardio-metabolic risk factors among the migrants as well as among the populations in the home and the host countries. For example, two studies reported the prevalence of diabetes mellitus (DM) ranging between 9 and 17% among South Asian migrants. Overweight and obesity were highly …

Embryonic Lethality Of Cranial Neural Crest Deletion Of Cdc73, Lilia Shen

Honors Scholar Theses

Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a disease characterized by parathyroid tumors, renal cysts or tumors, uterine tumors, and ossifying jaw fibromas. The cause of this syndrome is linked to a tumor suppressor gene called Cdc73, which encodes the protein product parafibromin. The loss of proper expression of Cdc73/parafibromin is implicated in the development of the tumors typical of HPT-JT, although the exact mechanisms of tumorigenesis are unclear. In particular, not much is understood about the development of ossifying fibromas (OF) of the jaw in this syndrome. OF is a benign bone neoplasm that can affect the mandible and …

Aortic Stenosis, Tony Un '19

Human Diseases Graphic Novels

No abstract provided.

Cushing's And Confusion, Diana Gonzalez '20, Grace Yue '20, Amy Churchill '20, Trinity Coates '20, Annie Xu '19

Human Diseases Graphic Novels

No abstract provided.

Lights Out, Charlotte Graves '20

Human Diseases Graphic Novels

No abstract provided.

Diabetes Type I, Stroke, Arthritis And Epilepsy, Nafay Abdul '20, Danielle Lee '19, Ethan Talreja '20

Human Diseases Graphic Novels

No abstract provided.

Crohn's Disease / Myasthenia Gravis / Appendicitis / Compartment Syndrome, Maddy Chow '20, Maahum Hamayat '20, Vaishnavi Tetali '20, Milica Barac '20, Isabel Grzeskawiak '19

Human Diseases Graphic Novels

No abstract provided.

Huntington's Disease, Diana Gonzalez '20, Grace Yue '20, Amy Xxx, Trinity Coates '20, Annie Xu '19

Human Diseases Graphic Novels

No abstract provided.

Cardiac Tamponade, Eric Errampalli '19

Human Diseases Graphic Novels

No abstract provided.

Diabetes, Diana Gonzalez '19, Grace Yue '19, Amy Churchill '20, Trinity Coates '20, Annie Xu '19

Human Diseases Graphic Novels

No abstract provided.

Epilepsy, Diana Gonzalez '20, Grace Yue '20, Amy Churchill '20, Trinity Coates '20, Annie Xu '19

Human Diseases Graphic Novels

No abstract provided.

The Role Of Inflammatory Pathways In Development, Growth, And Metabolism Of Skeletal Muscle In Iugr Offspring: Blood Gene Expression Of Inflammatory Factors As Novel Biomarkers For Assessing Stress And Wellbeing In Exotic Species, Robert J. Posont

Department of Animal Science: Dissertations, Theses, and Student Research

Our first study identified the effects of maternal inflammation-induced intrauterine growth restriction (MI-IUGR) on growth and muscle glucose metabolism in offspring supplemented with curcumin. MI-IUGR lambs exhibited asymmetric growth restriction at birth and 30d of age, but normal glucose-stimulated insulin secretion. Hindlimb glucose oxidation was reduced by MI-IUGR and not improved by curcumin supplementation. Ex vivo muscle glucose oxidation was reduced by MI-IUGR but improved somewhat by curcumin. These finding indicate that fetal programming responses to MI contribute to neonatal growth and metabolic deficits. Neonatal curcumin supplementation had minimal effect on growth deficits but may improve glucose metabolism. …