Toxicology Commons^™

Phytoremediation Potential Of Four Heavy Metals In Soil By Chromolaena Odorata (L.) King & Robinson At The Phytotoxicity Screening Benchmarks, Gloria O. Omoregie, Beckley Ikhajiagbe, Geoffery O. Anoliefo

Tanzania Journal of Science

The remediative capacity of Chromolaena odorata with respect to heavy metal induced growth-stress was investigated. This was with a view to providing information on the adaptive mechanisms adopted by the test plant during the phytoremediation of selected heavy metals such as copper, manganese, zinc and cadmium. Stems of C. odorata were planted in soils polluted with  Mn, Zn, Cd, and Cu at the ecological screening benchmark (ESB) of 50 mg/kg (Mn and Zn), 4 mg/kg (Cd) and 100 mg/kg (Cu) of metal per kilogram of soil, in varying concentrations of 0 ESB (control), 1 ESB, 3 ESB and 5 ESB. …

Acute Exposure To Tcdd Increases Liver Disease Progression In Mice With Carbon Tetrachloride-Induced Liver Injury, Giovan N. Cholico

Boise State University Theses and Dissertations

Liver disease is a worldwide problem and the 9^th leading cause of death in the United States. Common causes of liver disease include alcohol abuse, virus infection, and nonalcoholic fatty liver. Regardless of etiology, liver damage elicits inflammation and drives the activation of hepatic stellate cells (HSCs), which deposit collagen throughout the liver. During chronic injury, excessive collagen deposition, referred to as fibrosis or “scarring”, can progress to cirrhosis, cancer, and organ failure. Emerging evidence indicates a strong association between liver disease and exposure to environmental chemicals. This research investigated mechanisms by which exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo- …

Effects Of Mercury On The Dopamine Transporter Cell Surface Expression In Pc12 Cells, Christina Hui

Student Theses

Environmental factors, such as heavy metal exposures, have been suggested to have an impact not only on neurodegenerative disease, such as Parkinson’s disease, but also on psychostimulants abuse and their toxicity. In this study, two questions were addressed: 1) effects of mercuric chloride on parkinsonian toxicant 1-methyl-4-phenylpyridinium (MPP⁺) induced cytotoxicity and 2) effects of mercuric chloride on cell surface dopamine transporter. Pheochromocytorma cells (PC12) were treated with various concentrations of mercuric chloride (0.02~2.0 ppm) for 4 hours with and without 0.1 mM MPP⁺. Significant potentiation of toxicity was observed when there was co-treatment with 0.5 ppm …

Amélioration De La Justesse Des Modèles D’Hygiène Du Travail Utilisés Pour Estimer Des Expositions Professionnelles À Des Vapeurs De Solvants, Spéro Abattan, Stéphane Hallé, Daniel Drolet, Ali Bahloul, Patrick Eddy Ryan, Wejden Chouchene, Carlos Castro Ruiz, Jérôme Lavoué, Maximilien Debia

Rapports de recherche scientifique

Chaque année, des travailleurs québécois subissent des effets sur leur santé après avoir été exposés à des substances chimiques, notamment à des solvants. La modélisation des expositions professionnelles occupe une place importante dans la prévention des risques. Cette recherche vise à étudier différents aspects de la modélisation pour estimer des expositions professionnelles à des vapeurs de solvants dans le but d’en améliorer la justesse de prédiction. Le travail de recherche a été effectué en deux volets. Grâce à la mise en œuvre de tests à petite échelle (volet I) et à échelle humaine (volet II), les travaux présentés dans cette …

The Role Of Omega-3 Polyunsaturated Fatty Acids In Blood Pressure Regulation And Secondhand Smoke-Induced Vascular Dysfunction, Emily Anna Wheeler

Biomedical Sciences ETDs

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) may lower cardiovascular disease risk by reducing blood pressure (BP). We hypothesized that fat-1 transgenic mice, which convert n-6 PUFAs to n-3 PUFAs, would have improved vascular function in BP regulation and following secondhand smoke (SHS) exposure, compared to wild type (WT) mice.

BP was recorded in mice fed an n-6 PUFA, or standard chow diet. On the n-6 PUFA diet fat-1 mice had a lower mean arterial pressure and a greater decrease in diastolic BP when treated with an ACE inhibitor, compared to WT mice. No differences were observed on the chow diet. …

Sustainable Solutions, Fall/Winter 2020, Issue 41

Sustain Magazine

No abstract provided.

Qualitative Approach To Comparative Exposure In Alternatives Assessment, William Greggs, Thomas Burns, Peter Egeghy, Michelle R. Embry, Peter Fantke, Bonnie Gaborek, Lauren Heine, Olivier Jolliet, Carolyn Lee, Derek Muir, Kathy Plotzke, Joseph Rinkevich, Neha Sunger, Jennifer Y. Tanir, Margaret Whittaker

Public Health Sciences Faculty Publications

Most alternatives assessments (AAs) published to date are largely hazard-based rankings, thereby ignoring potential differences in human and/or ecosystem exposures; as such, they may not represent a fully informed consideration of the advantages and disadvantages of possible alternatives. Building on the 2014 US National Academy of Sciences recommendations to improve AA decisions by including comparative exposure assessment into AAs, the Health and Environmental Sciences Institute's (HESI) Sustainable Chemical Alternatives Technical Committee, which comprises scientists from academia, industry, government, and nonprofit organizations, developed a qualitative comparative exposure approach. Conducting such a comparison can screen for alternatives that are expected to have …

Petri Nets As A Unifying Tool To Link Physiologically Based Toxicokinetic (Pbtk) Models To Adverse Outcome Pathways (Aops), Ian Edhlund

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Biophysical And Biomechanical Properties Of Neural Progenitor Cells As Indicators Of Developmental Neurotoxicity, Gautam Mahajan, Moo-Yeal Lee, Chandrasekhar R. Kothapalli

Chemical & Biomedical Engineering Faculty Publications

Conventional in vitro toxicity studies have focused on identifying IC50 and the underlying mechanisms, but how toxicants influence biophysical and biomechanical changes in human cells, especially during developmental stages, remain understudied. Here, using an atomic force microscope, we characterized changes in biophysical (cell area, actin organization) and biomechanical (Young's modulus, force of adhesion, tether force, membrane tension, tether radius) aspects of human fetal brain-derived neural progenitor cells (NPCs) induced by four classes of widely used toxic compounds, including rotenone, digoxin, N-arachidonoylethanolamide (AEA), and chlorpyrifos, under exposure up to 36 h. The sub-cellular mechanisms (apoptosis, mitochondria membrane potential, DNA damage, glutathione …

Environmentally Responsible Land Use, Spring/Summer 2010, Issue 22

Sustain Magazine

No abstract provided.

Sustainable Communities, Fall/Winter 2010, Issue 21

Sustain Magazine

No abstract provided.

Sustainable Building, Spring/Summer 2009, Issue 20

Sustain Magazine

No abstract provided.

Environmental History, Fall/Winter 2009, Issue 19

Sustain Magazine

No abstract provided.

Student Research, Spring/Summer 2008, Issue 18

Sustain Magazine

No abstract provided.

Evolving Pollution Prevention, Fall/Winter 2008, Issue 17

Sustain Magazine

No abstract provided.

Climate Change, Spring/Summer 2007, Issue 16

Sustain Magazine

No abstract provided.

Our Energy Future, Fall/Winter 2007, Issue 15

Sustain Magazine

No abstract provided.

Land Conservation, Spring/Summer 2006, Issue 14

Sustain Magazine

No abstract provided.

Pollution And Heart Disease, Fall/Winter 2006, Issue 13

Sustain Magazine

No abstract provided.

Green Cities, Spring/Summer 2005, Issue 12

Sustain Magazine

No abstract provided.

Global Sustainability, Fall/Winter 2005, Issue 11

Sustain Magazine

No abstract provided.

Environmental Justice, Spring/Summer 2004, Issue 10

Sustain Magazine

No abstract provided.

Kentucky's Environmental Future, Fall/Winter 2004, Issue 9

Sustain Magazine

No abstract provided.

Urban Ecology, Spring/Summer 2003, Issue 8

Sustain Magazine

No abstract provided.

Urban Regeneration, Fall/Winter 2003, Issue 7

Sustain Magazine

No abstract provided.

Urban Air Quality, Spring/Summer 2002, Issue 6

Sustain Magazine

No abstract provided.

Sustainability Of Industrialized Agriculture, Fall/Winter 2002, Issue 5

Sustain Magazine

No abstract provided.

Urban Design For Environmental Protection, Spring/Summer 2001, Issue 4

Sustain Magazine

No abstract provided.

Stream Restoration, Spring/Summer 2011, Issue 24

Sustain Magazine

No abstract provided.

Renewable Energy, Fall/Winter 2011, Issue 23

Sustain Magazine

No abstract provided.