Toxicology Commons^™

Medicaid Managed Care Contracting For Childhood Lead Poisoning Prevention Services, Elizabeth Wehr, Sara J. Rosenbaum

Center for Health Policy Research

This study reports on provisions relating to childhood lead poisoning prevention services in Medicaid managed care contract documents (service agreements and requests for proposals, RFPS). The provisions were extracted from the managed care contracts data base of the Center for Health Policy Research of the George Washington University Medical Center. The data base was constructed and is updated as part of the Center's ongoing analytic studies.' As with other Center studies of the contract documents, this is a descriptive study of how state Medicaid agencies addressed a series of contracting issues at a specific point in time.* In brief, we …

In Vitro Assessment Of The Toxicity Of Cocaine And Its Metabolites In The Human Umbilical Artery, Tessa L. Long

Electronic Theses and Dissertations

An in vitro model was used to assess the effect of cocaine and its metabolites on the umbilical artery. Objectives were to pharmacologically confirm the presence of adrenergic innervation using tyramine, evaluate the ability of cocaine, benzoylecgonine, norcocaine and cocaethylene to potentiate vasoconstriction by serotonin and norepinephrine, examine the ability of ketanserin to block the enhanced vasoconstriction produced by cocaine, and determine displacement of 3 H-ketanserin by serotonin, norepinephrine, tyramine and mianserin. The vasoconstrictive effect of tyramine (100 μM) was enhanced in the presence of cocaine by 257%. Vasoconstrictive effects of serotonin and norepinephrine were significantly enhanced by cocaine by …

Mouse Embryo Development In The Presence Of Capsaicin, Carlos Santiago Villar-Gosalvez

Theses and Dissertations in Biomedical Sciences

Capsaicin is the pungent agent found in hot peppers of the Capsicum genus. It is a potent neurotoxin that stimulates the degranulation and degeneration of C-afferent neurons. Capsaicin is widely used as a food condiment and medicine. Human exposure of capsaicin can exceed levels shown to be neurotoxic in laboratory animals. Additionally, capsaicin can cross the blood/placenta barrier and affect an embryo in utero. In order to assay the potential for toxicity to human embryos, mouse embryos were exposed to capsaicin and the effect of the capsaicin on embryo development was measured. Embryos were co-cultured in Krebs medium with 1% …

Sensitizing Resin Acids In Aerosol Derived From Rosin Flux Used In Electronics Soldering: Molecular Mechanistic Studies In Resin Acid/Protein Hapten Formation, Philip A. Smith

Biology

Exposure to rosin and its resin acid constituents is associated with dermal and pulmonary sensitization. Methodologies to detect resin acid compounds in aerosol from heated rosin flux included air filtration, filter extraction, and gas chromatography/mass spectrometry. Various resin acids were seen in aerosol collected under field conditions, and in the laboratory. The predominant resin acid recovered was dehydroabietic acid, with lower levels of abietic acid and oxidized resin acids, which included 7-oxodehydroabietic, 15-hydroxydehydroabietic, and 7-hydroxydehydroabietic acids. Mass balance experiments with a soldering iron and liquid rosin flux showed most of the nonvolatile mass in unheated flux to be filtrable following …

The Effects Of Retinoic Acids On The Angiogenic Growth Factors Produced By Solid Tumors, Lynn C. Burgess

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

These studies investigated the effects of retinoic acid (RA) on angiogenesis. Three human, neoplastic cell lines were used to examine angiogenic promotion and/or inhibition. The cell lines, U-373MG glioblastoma, DU-145 prostate carcinoma, and TCCSUP bladder transitional cell carcinoma, were treated with the following: all-trans, 9-cis, or 13-cis RA, at doses from 0.0001 to 100 μM. Hypoxia was used to assist the expression of the angiogenic phenotype. Conditioned media (CM) were prepared by growing the tumor cells in the presence of RA and hypoxia for 24 hours, and then the CM was transferred to bovine, capillary endothelial …

Evaluation Of Toxicity, Bioavailability And Speciation Of Lead, Zinc And Cadmium In Mine/Mill Wastewaters, Mujde Erten-Unal, Bobby G. Wixson, Nord Gale, Jerry L. Pitt

Civil & Environmental Engineering Faculty Publications

The toxicity of common compounds of lead, cadmium and zinc was evaluated in waters similar to that found in the world's largest lead producing area in Missouri. Static, acute toxicity tests were performed using fathead minnows (Pimephales promelas) and water fleas (Daphnia magna) respectively. Test organisms were subjected to varying amounts of sulfide, carbonate, chloride and sulfate salts of lead, zinc and cadmium mixed in hard, alkaline waters typical to this region. Median lethal concentrations were calculated using nominal versus measured metal concentrations. Measured metal concentrations included four different metal fractionation (extraction/filtration) techniques at different pH …

1080 Operational Procedures Manual - Second Edition, Agriculture Western Australia

Biosecurity published reports

Sodium fluoroacetate (1080) is an extremely toxic substance which can be a danger to humans if handled incorrectly. At the same time 1080 is the most effective and efficient poison for the control of Western Australia's main vertebrate pest species including rabbits, wild dogs and foxes. One of the main reasons for its usefulness in Western Australia is that many native animals have a high tolerance to it and so may not be affected by baiting.

Industry Resource Protection Program (IRPP) This program, part of Agriculture Western Australia, supports feral animal control carried out by its staff and community groups. …