Toxicology Commons^™

Haloperidol Paradoxical Behavior Induced Cell Proliferation Through Pkb/Akt And Abolished By Mir-Let-7c, Mounira Morgem

Dissertations (2016-Present)

Haloperidol is a typical antipsychotic drug; it is widely used for people with various psychiatric conditions such as schizophrenia, bipolar disorder, major depressive disorder, and dementia. Despite its effectiveness in controlling delusions, hallucinations, agitation, and other disruptive behavioral symptoms in these psychiatric conditions, it has adverse side effects such as extrapyramidal manifestation and endocrinologic and metabolic changes. Initial evidence shows that haloperidol has antitumor properties in several cancer types by inhibiting cell proliferation and inducing apoptosis. However, other reports indicate that haloperidol promotes cell proliferation in other cells, raising concerns about its association with an increased risk of cancer which …

Occurrence Of Emerging Contaminants In Greater Houston Watersheds, Risk Assessment, And Toxicological Effects, Sekinat Oluwakemi Atobiloye

Dissertations (2016-Present)

Rapid industrialization and urbanization within the Greater Houston area have driven a surge in anthropogenic activities that affects the burgeoning population. This region stands as one of the most densely inhabited metropolises in the United States, experiencing a substantial population growth of 9.8% from 2010 to 2020, with the population expanding from 5.92 million to 7.14 million. This population boom has been accompanied by an increased reliance on modern conveniences, leading to escalated production and utilization of chemicals such as personal care products, pharmaceuticals, pesticides, and heavy metals, all of which pose potential threats to the environment. Although these products …

Assessment Of Soil, Water Contamination And Land Cover Changes In The Urban And Suburban Watersheds Of Houston, Texas, Felica Rena Davis

Dissertations (2016-Present)

Intense urbanization and increased anthropogenic activity are two important factors contributing to the decline of soil and water quality in Houston watersheds, which poses a great environmental and human health risks. This study, therefore, was designed to: 1) determine nutrient and metal concentrations in soil and water samples along Carpenters Bayou (CaB), Cedar Bayou (CB), Sims Bayou (SB), Spring Creek Bayou (SC) and Vince Bayou (VB), 2) analyze land cover changes in watersheds using Landsat image analysis and 3) evaluate socio-economic characteristics and human health risks for each watershed. Soil and water samples were collected from three different locations with …

Amelioration Of Acrolein Effects On The Small Intestine Of Rats By Curcumin And Compound 20, Syntia Engiasa Kwende

Dissertations (2016-Present)

Acrolein is an unsaturated aldehyde which produce chemicals used as an intermediate reactive aldehyde in the chemical industry. The primary component of acrolein, is derived from the incomplete combustion of wood, plastic, fossil fuels, the main component of cigarette smoke, the burning of fats and overheating of oil. The purpose of this research is to investigate whether curcumin and compound 20 prevents the induction of inflammatory and oxidative response caused by acrolein in the small intestine. Curcumin is the yellow pigment, lipophilic polyphenol substance that gives turmeric the medicinal properties. It can also define as the primary bioactive substance in …

Investigation Of Toxic Chemicals In Plant-Based Milk Alternatives, Chukwunonso A. Anakwue

Dissertations (2016-Present)

Milk is a dietary component consumed all over the world and is known to be essential for development in children. Despite all the nutritional advantages associated with milk consumption, several issues like lactose intolerance, and high lipid content, etc., negatively affects the perception of cow milk consumption, and has grown into general health concerns. Issues with cow milk consumption drove for a healthier alternative and this led to plant-based milk alternatives (PBMA). Several studies have linked consumption of these PBMAs with other negative effects such as: allergy, poor nutrient profile and the presence of other foreign chemicals. This study’s main …

Bacteria Assessment Of Soil Samples In Houston Watersheilds; Impact Of Heavy Metal, And Stress Responses In An Eukaryotic Co-Culture System., Folasade Adedoyin

Dissertations (2016-Present)

Houston has a complex watershed in which bayous intersect one another making the city prone to flooding, as evidenced by the 2017 Hurricane Harvey flood. We sought to evaluate bacterial population dynamics in Houston watershed soils pre- and post-Hurricane Harvey; additionally, we evaluated population dynamics in neighboring, downstream bayous ~ 1 year later in the summer and winter of 2018. This study quantified bacterial loads for pre-Hurricane Harvey (June 2017) and post-hurricane Harvey (November 2017) soil samples, as well as competitive samples from one year later [summer (June 2018) and winter (November) 2018]. Unexpectedly, bayous closer to Houston’s densely populated …

Evaluating The Chronic Effect Of Food Coloring Dyes On Biological Life Functions Of Model Organism; Caenorhabditis Elegans, Demilade Adisa

Dissertations (2016-Present)

Food coloring dyes are substances known to enhance the appearance of food or drink by imparting color when it is added. They have been in large commercial food production as well as in its use in domestic food applications and non-food applications. The toxic effects of food coloring dyes have been seen in the enzymatic breakdown of the azo linkage of the dye molecule by enzyme; azo reductase. The degradation of such food dye products give rise to increased toxic effects that affect the nervous system.

Caenorhabditis elegans is a bacterial feeder, free-living soil nematode used as a model organism …