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Articles 511 - 540 of 1530
Full-Text Articles in Pharmacology
Facile Derivative Uv Spectroscopy Method: Simultaneous Estimation Of Tinidazole And Fluconazole In Combined Tablet Dosage Form, Saurabh Pandey, Preeti Pandey, Shaifali Dubey, Udisha Chaturvedi, Awani K. Rai
Facile Derivative Uv Spectroscopy Method: Simultaneous Estimation Of Tinidazole And Fluconazole In Combined Tablet Dosage Form, Saurabh Pandey, Preeti Pandey, Shaifali Dubey, Udisha Chaturvedi, Awani K. Rai
The Thai Journal of Pharmaceutical Sciences
Two derivative spectrophotometric methods have been developed for simultaneous determination of tinidazole and fluconazole in pharmaceutical formulations. The first method depends on utilization of first derivative UV spectrophotometry, with zero-crossing and peak-to-base measurement at 260.57 & 264.23 nm for fluconazole and 263.86 & 318.85 nm for tinidazole. The second method, compensation technique depends on first derivative of the ratio-spectra by measurements of the amplitudes for tinidazole and fluconazole. Calibration graphs were established for tinidazole and fluconazole in the range of 10-100 μg ml-1 and 2-20 μg ml-1, respectively. All proposed methods have been extensively validated. The results were found to …
Simultaneous Estimation Of Cefixime And Cloxacillin In Human Plasma By Reversed Phase-Hplc With Uv Detection, Sommath D. Bhinge, Sharangouda M. Malipatil, Lalit V. Sonawane
Simultaneous Estimation Of Cefixime And Cloxacillin In Human Plasma By Reversed Phase-Hplc With Uv Detection, Sommath D. Bhinge, Sharangouda M. Malipatil, Lalit V. Sonawane
The Thai Journal of Pharmaceutical Sciences
An accurate, rapid and simple reversed-phase high performance liquid chromatography (RP-HPLC) method was developed and validated for simultaneous estimation of cefixime, cloxacillin and for chloramphenicol (internal standard) in human plasma. Chromatographic separation was accomplished using CAPCELL PAK C8 (4.6 mm Ó 250 mm, 5 μm) analytical column using phosphate buffer, methanol and acetonitrile (40:45:15) as eluent. Detection and quantification were performed by UV/Vis detection at 225 nm. The lower limit of detection and quantification were 0.01 μg†mL-1 and 0.25 μg†mL-1 for cefixime, 0.03 μg†mL-1 and 0.39 μg†mL-1 for cloxacillin. The calibration curves were linear over the concentration range 0.5 to …
Thrombolytic Activity Of Some Spices And Plants Available In Bangladesh, Md. Rakib Ai-Manun, Nabiha Amrin, Jahura Begum, Md. Abdul Mazid
Thrombolytic Activity Of Some Spices And Plants Available In Bangladesh, Md. Rakib Ai-Manun, Nabiha Amrin, Jahura Begum, Md. Abdul Mazid
The Thai Journal of Pharmaceutical Sciences
Thrombolytic activities of some plants, namely Tamarindus indica (Fabaceae), Flemingia congesta (Fabaceae), Lawsonia inermis (Lythraceae), Mesua nagassarium (Clusiaceae, and spices, namely Coriandrum sativum (Apiaceae), Curcuma longa (Zingiberaceae), Cinnamomum tamala (Lauraceae), Nigella sativa (Ranunculaceae), Eugenia aromaticum (Myrtaceae), available in Bangladesh, were evaluated using an in vitro model. The thrombolytic activity in terms of percentage of weight loss of in vitro formed clots were found as C. sativum 43.25 ± 7.18%, C. longa 53.32 ± 4.96%, C. tamala 22.10 ± 3.18%, N. sativa 28.49 ± 3.72%, E. aromaticum 32.18 ± 3.10%, T. indica 28.91 ± 2.29%, F. congesta 35.27 ± 7.35%, L. …
Lactobacillus Plantarum T23/3 As A Potential Probiotic Strain Isolated From Faces, Titpawan Nakpheng, Rosainee Kha, Neelam Balekar, Sanae Kaewnopparat, Teerapol Srichana
Lactobacillus Plantarum T23/3 As A Potential Probiotic Strain Isolated From Faces, Titpawan Nakpheng, Rosainee Kha, Neelam Balekar, Sanae Kaewnopparat, Teerapol Srichana
The Thai Journal of Pharmaceutical Sciences
The present study was undertaken to evaluate the properties of Lactobacillus plantarum T23/3 isolated from the feces of healthy elderly volunteer. The L. plantarum T23/3 showed better tolerance property to bile acid, simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), and exhibited antimicrobial activity against tested enteropathogens. It formed macroscopic granules with surface hydrophobicity and co-aggregated with tested microbial strain. It was resistant to some antibiotics used for treatment of diarrhea so there is possibility to co-administer L. plantarum as probiotic with antidiarrheal therapy. Furthermore, adhesion and significant potential for decreasing adhesion of pathogens (E. coli 2601 and V. …
Application Of A Stability-Indicating Hptlc Method For Simultaneous Determination Of Chloramphenicol And Dexamethasone Sodium Phosphate In Eye Drop, Yimer Seid, Araya Hymete, Adnan A. Bekhit
Application Of A Stability-Indicating Hptlc Method For Simultaneous Determination Of Chloramphenicol And Dexamethasone Sodium Phosphate In Eye Drop, Yimer Seid, Araya Hymete, Adnan A. Bekhit
The Thai Journal of Pharmaceutical Sciences
A high performance thin layer chromatography (HPTLC) method was developed and validated for the simultaneous quantification of dexamethasone sodium phosphate and chloramphenicol in eye drop. The HPTLC separation was achieved on an aluminum-backed layer of silica gel 60F254 using acetonitrile: water: ammonia (10:3:0.5 v/v/v), pH adjusted to 7.8 with 1M HCl, as a mobile phase. The densitometric determination of dexamethasone phosphate and chloramphenicol was carried out at 262 nm. Calibration curves for dexamethasone phosphate and chloramphenicol were linear in the range of 80-300 ng and 400-1400 ng, respectively. The method was validated according to International Conference on Harmonization (ICH) guidelines …
Enhancement Of Wttability And In Vitro Dissoution Properties Of Lercanidipine Hydrochloride By Solid Dispersion Technique, Suneel Pandey, Ekunkumar Chandekar, Amarnath Wattamwar, Sachin Pandit, Hemant Joshee, Arun Patil
Enhancement Of Wttability And In Vitro Dissoution Properties Of Lercanidipine Hydrochloride By Solid Dispersion Technique, Suneel Pandey, Ekunkumar Chandekar, Amarnath Wattamwar, Sachin Pandit, Hemant Joshee, Arun Patil
The Thai Journal of Pharmaceutical Sciences
The aim of the present study was to improve lercanidipine HCl solubility and in vitro dissolution rate by preparing solid dispersion with polyethylene glycol (PEG) 6000 using the solvent evaporation technique. Solid dispersions with PEG 6000 (as carriers) were prepared in drug: carrier (1:1, 1:5 and 1:10) ratios along with the corresponding physical mixtures. Analytical techniques, FT-IR spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to characterize the drug in the physical mixtures and solid dispersions. The solubility and wettability studies of solid dispersions as well as physical mixtures showed greater improvement compared to the pure drug. …
Skin Irritation Study Of Two Patented Mix Extracts From Emblica, Ma-Khwaen And Khanun, Sareeya Reungpatthanaphong, Tuanta Sematong, Buppachart Potduang, Phanukit Kunhachan, Cholticha Niwaspragrit
Skin Irritation Study Of Two Patented Mix Extracts From Emblica, Ma-Khwaen And Khanun, Sareeya Reungpatthanaphong, Tuanta Sematong, Buppachart Potduang, Phanukit Kunhachan, Cholticha Niwaspragrit
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Moisturizing Gel Formulation Containing Pueraria Mirifica Extracts As An Anti-Wrinkle Agent, Thanachod Thammachat, Sompoch Tubcharoen, Sitthiphong Soradech, Somnuk Promdang
Moisturizing Gel Formulation Containing Pueraria Mirifica Extracts As An Anti-Wrinkle Agent, Thanachod Thammachat, Sompoch Tubcharoen, Sitthiphong Soradech, Somnuk Promdang
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Quercetin And Derivatives As Butyrylcholinesterase Inhibitors, Siriluk Sontadsakul, Anchisa Prakongsantikul, Worawan Kitphati, Jaturong Pratuangdejkul, Veena Nukoolkam
Quercetin And Derivatives As Butyrylcholinesterase Inhibitors, Siriluk Sontadsakul, Anchisa Prakongsantikul, Worawan Kitphati, Jaturong Pratuangdejkul, Veena Nukoolkam
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Biological Activities Of A Patented Mix Extract From Fruits Of Phyllanthus Emblica And Zanthoxylumlimonella, Buppachart Potduang, Bundit Fungsin, Isara Keeta, Natthachest Ketmanee, Anintitha Intharungsri, Sitthiphong Soradech, Cholticha Niwaspragrit, Sayan Tanpanich
Biological Activities Of A Patented Mix Extract From Fruits Of Phyllanthus Emblica And Zanthoxylumlimonella, Buppachart Potduang, Bundit Fungsin, Isara Keeta, Natthachest Ketmanee, Anintitha Intharungsri, Sitthiphong Soradech, Cholticha Niwaspragrit, Sayan Tanpanich
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Anti-Periodontal Bacterial Activity Of Oxyresveratrol, Waranvoo Phoolcharoen, Sireerat Sooampon, Boonchoo Sritularak, Kittisak Likhitvitayawuid, Jintakom Kuvatanasuchati, Prasit Pavasant
Anti-Periodontal Bacterial Activity Of Oxyresveratrol, Waranvoo Phoolcharoen, Sireerat Sooampon, Boonchoo Sritularak, Kittisak Likhitvitayawuid, Jintakom Kuvatanasuchati, Prasit Pavasant
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Microemulsion Formulation Of Angelica Sinensis Root Extract On Clove Oil /Nonionic Surfactant/ Water Mixture, Pichaya Ukosaramik, Prasan Tangyuenyongwatana, Rathapon Asasutjarit
Microemulsion Formulation Of Angelica Sinensis Root Extract On Clove Oil /Nonionic Surfactant/ Water Mixture, Pichaya Ukosaramik, Prasan Tangyuenyongwatana, Rathapon Asasutjarit
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Effects Of Marmin Isolated From Aegle Marmelos Correa On L-Histidine Decarboxylase Enzyme In Rbl-2h3 Cells, Agung Endro Nugroho, Novrizal Abdi, Sugeng Riyanto, Kazutaka Maeyama, Zullies Ikawati
Effects Of Marmin Isolated From Aegle Marmelos Correa On L-Histidine Decarboxylase Enzyme In Rbl-2h3 Cells, Agung Endro Nugroho, Novrizal Abdi, Sugeng Riyanto, Kazutaka Maeyama, Zullies Ikawati
The Thai Journal of Pharmaceutical Sciences
Marmin or (7-(6’,7’-dihydroxygeranyl-oxy) coumarin is a compound isolated from Aegle marmelos Correa, in the study, we investigated the effects of marmin on the L-histidine decarboxylase (HDC), a rate-limiting histamine synthesizing enzyme, in rat ma...
Rapid Titrimetric And Spectrophotometric Assay Of Tramadol In Bulk Drug And In Formulation Using N-Bromosuccinimide And Methyl Orange As Reagents, K. B. Vinay, H. D., N. Rajendraprasad, M. S. Raghu, P. J. Ramesh, M. X. Cijo, K. Basavaiah
Rapid Titrimetric And Spectrophotometric Assay Of Tramadol In Bulk Drug And In Formulation Using N-Bromosuccinimide And Methyl Orange As Reagents, K. B. Vinay, H. D., N. Rajendraprasad, M. S. Raghu, P. J. Ramesh, M. X. Cijo, K. Basavaiah
The Thai Journal of Pharmaceutical Sciences
Tramadol is a centrally acting analgesic used for prevention and treatment of moderate to severe pain. Two simple, rapid and sensitive methods by titrimetric and spectrophotometric techniques are described for the determination of tramadol hydrochloride ...
Allylmercaptocaptopril Attenuates Sodium Selenite Induced Experimental Cataractogenesis: An In Vitro And In Vivo Study, K. S. Lakshmi, Shrinivas Sharma
Allylmercaptocaptopril Attenuates Sodium Selenite Induced Experimental Cataractogenesis: An In Vitro And In Vivo Study, K. S. Lakshmi, Shrinivas Sharma
The Thai Journal of Pharmaceutical Sciences
The present study sought to assess the efficacy of the allylmercaptocaptopril เท preventing seleniteinduced cataractogenesis in an experimental setting. The first, in vitro phase of the study was performed on lenses from Wistar rats incubated for 24 ...
Design And Characterization Of Bioadhesive Ophthalmic Films Of Flurbiprofen, Rashi Saroot, Ritu Mehra Gilhotra
Design And Characterization Of Bioadhesive Ophthalmic Films Of Flurbiprofen, Rashi Saroot, Ritu Mehra Gilhotra
The Thai Journal of Pharmaceutical Sciences
An attempt has been made to formulate sustained release ophthalmic films of flurbiprofen along with bioadhesive polymers. Ocular films were prepared by using polymers; sodium alginate, chitosan and HPMC; alone and in different combinations. Glycerol was ...
Influence Of Surfactants On Crystal Form Of Mefenamic Acid, Kaival P., Kulkarni P.K., Mudit Dixit, Ashwini G. Kni
Influence Of Surfactants On Crystal Form Of Mefenamic Acid, Kaival P., Kulkarni P.K., Mudit Dixit, Ashwini G. Kni
The Thai Journal of Pharmaceutical Sciences
Mefenamic acid is an anti inflammatory and poorly water-soluble drug. Since the drug powder can stick to any type of surface, and is not easy to handle in granulation and tabletting process, it is more desirable to recrystallize the mefenamic acid in suc...
Acute And Sub-Chronic Toxicity Studies Of A Standardized Extract Of Centella Asiatica Eca 233, Songpol Chivapat, Pranee Chavalittumrong, Mayuree H. Tantisira
Acute And Sub-Chronic Toxicity Studies Of A Standardized Extract Of Centella Asiatica Eca 233, Songpol Chivapat, Pranee Chavalittumrong, Mayuree H. Tantisira
The Thai Journal of Pharmaceutical Sciences
Acute toxicity study of Centella asiatica standardized extract ECa 233 was conducted by an oral administration of 10.0 g/kg extract into 10 male and 10 female mice. The extract at the given dose did not cause any toxic signs and death within the observat...
Hptlc-Densitometric Method Development And Validation For Simultaneous Determination Of Lamivudine, Nevirapine And Zidovudine In Fixed Dose Combinations, Gebremedhin Solomon, Ariaya Hymete, Abdel-Maaboud I. Mohamed, Adnan A. Bekhit
Hptlc-Densitometric Method Development And Validation For Simultaneous Determination Of Lamivudine, Nevirapine And Zidovudine In Fixed Dose Combinations, Gebremedhin Solomon, Ariaya Hymete, Abdel-Maaboud I. Mohamed, Adnan A. Bekhit
The Thai Journal of Pharmaceutical Sciences
In this study an HPTLC-densitometric method was developed for the simultaneous determination of lamivudine, nevirapine and zidovudine in pharmaceutical dosage forms which are used widely as first line HIV/AIDS treatment. Chromatographic separation of the...
Ion-Pair Titrimetric Assays Of Quetiapine Fumarate In Pharmaceuticals Using Sodium Tetraphenylboron And Sodium Lauryl Sulphate, N. Rajendraprasad, K. Basavaiah, Kanakapura B. Vinay
Ion-Pair Titrimetric Assays Of Quetiapine Fumarate In Pharmaceuticals Using Sodium Tetraphenylboron And Sodium Lauryl Sulphate, N. Rajendraprasad, K. Basavaiah, Kanakapura B. Vinay
The Thai Journal of Pharmaceutical Sciences
Two simple, rapid, precise and accurate titrim etric methods employing sodium tetraphenylboron (STPB) and sodium lauryl sulphate (SLS) as titrants are described for the quantitative determination of quetiapine fumarate (QTF) in bulk drug and tablets. The...
Simultaneous Determination Of Ampicillin Sodium And Sulbactam Sodium In Binary Mixtures And Commercial Dosage Forms Using Chemometrics - Assisted Spectrophotometric Techniques, Zelalem M, Abdel-Maaboud I., Adnan A. Bekhit, Ariaya Hymete
Simultaneous Determination Of Ampicillin Sodium And Sulbactam Sodium In Binary Mixtures And Commercial Dosage Forms Using Chemometrics - Assisted Spectrophotometric Techniques, Zelalem M, Abdel-Maaboud I., Adnan A. Bekhit, Ariaya Hymete
The Thai Journal of Pharmaceutical Sciences
The binary mixture of ampicillin sodium and sulbactam sodium is officially analyzed by HPLC but can not be simultaneously determined by the normal spectrophotometric techniques since their absorption spectra have a strong degree of overlapping. The curre...
Minocycline And Magnesium In Combination Attenuates Oxidative Stress And Decreases Ischemic Neuronal Damage In Vivo, Pallab Bhattacharya, Anand Kr., Sudip Paul
Minocycline And Magnesium In Combination Attenuates Oxidative Stress And Decreases Ischemic Neuronal Damage In Vivo, Pallab Bhattacharya, Anand Kr., Sudip Paul
The Thai Journal of Pharmaceutical Sciences
A neuroprotective strategy through a combination therapy is always being superior to any other singular therapeutic interventions, as these acts through a multifaceted approach within the brain during focal cerebral ischemia. Therefore, the development o...
Use Of Bromate - Bromide Mixture As A Reagent For The Determination Of Dothiepin Hydrochloride In Pharmaceuticals, Sameer A.M. Abdulrahman, Kanakapura Basavaiah
Use Of Bromate - Bromide Mixture As A Reagent For The Determination Of Dothiepin Hydrochloride In Pharmaceuticals, Sameer A.M. Abdulrahman, Kanakapura Basavaiah
The Thai Journal of Pharmaceutical Sciences
The present study describes one titrimetric and two spectrophotometric methods for the determination of dothiepin hydrochloride (DOTH) in bulk drug and in tablets. The methods employed bromate-bromide mixture in acid medium as an oxidimetric as well as b...
Antioxidant Properties Of Squeezed Mangosteen Juice, Monrudee Sukma, Tanasait Ngawhirunpat, Praneet Opanasopit, Pongpun Siripong
Antioxidant Properties Of Squeezed Mangosteen Juice, Monrudee Sukma, Tanasait Ngawhirunpat, Praneet Opanasopit, Pongpun Siripong
The Thai Journal of Pharmaceutical Sciences
The aim of this study was to investigate antioxidant effects of squeezed mangosteen (Garcinia mangostana) juice as preferable diet for human consumption. Mangosteen juice was prepared from the aril part. Antioxidant properties were evaluated by total ant...
Author Index, Keyword Index, N/A
Author Index, Keyword Index, N/A
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Synthesis And Antihepatotoxic Activity Of Some New Xanthones Containing 1,4-Dioxane Ring System, Shah Alam Khan, Bahar Ahmed
Synthesis And Antihepatotoxic Activity Of Some New Xanthones Containing 1,4-Dioxane Ring System, Shah Alam Khan, Bahar Ahmed
The Thai Journal of Pharmaceutical Sciences
This study was aimed at the synthesis of few xanthone derivatives containing 1,4-dioxane ring system. The reaction of 3,4-dihydroxy xanthone derivatives (3a-c) with ethylene dibromide and epichlorohydrin under approriate reaction conditions afforded xant...
Effect Of Ocimum Sanctum Extract On Sodium Nitrite - Induced Experimental Amnesia In Mice, Manoj Dokania, Kamal Kishore, P.K. Sharma
Effect Of Ocimum Sanctum Extract On Sodium Nitrite - Induced Experimental Amnesia In Mice, Manoj Dokania, Kamal Kishore, P.K. Sharma
The Thai Journal of Pharmaceutical Sciences
The present study investigated the antiamnesic effect of the extract of Ocimum sanctum (OS) on time induced amnesia and sodium nitrite-induced amnesia in mice by using two different rodent models of memory. The aqueous extract of OS was administered to m...
Feedback From Malaysian Pharmacists Who Underwent A 3-Year Period Of Compulsory Service With The Government, Ong Aik Liang, Thomas Paraidathathu
Feedback From Malaysian Pharmacists Who Underwent A 3-Year Period Of Compulsory Service With The Government, Ong Aik Liang, Thomas Paraidathathu
The Thai Journal of Pharmaceutical Sciences
Since 2004, it is mandatory for all new pharmacy graduates in Malaysia to serve the government for a period of 4 years, before they are free to work as registered pharmacists in a sector of their choice, either public or private. With the enactment of th...
Sensitive, Selective And Extraction-Free Spectrophotometric Determination Of Lamotrigine In Pharmaceuticals Using Two Sulphonthalein Dyes, K. B. Vinay, H. O., N. Rajendraprasad, K. Basavaiah
Sensitive, Selective And Extraction-Free Spectrophotometric Determination Of Lamotrigine In Pharmaceuticals Using Two Sulphonthalein Dyes, K. B. Vinay, H. O., N. Rajendraprasad, K. Basavaiah
The Thai Journal of Pharmaceutical Sciences
Two direct, simple, sensitive and rapid extraction-free spectrophotometric methods have been developed for the determination of lamotrigine (LMT) in pure form and in its dosage forms. The methods are based on formation of ion-pair complex between the dru...
Synthesis And Cytotoxicity Study Of Magnetoliposomes Loaded Doxorubicin, Surachai Ngamratanapaiboon, Issara Sramala, Wichet Leelamanit
Synthesis And Cytotoxicity Study Of Magnetoliposomes Loaded Doxorubicin, Surachai Ngamratanapaiboon, Issara Sramala, Wichet Leelamanit
The Thai Journal of Pharmaceutical Sciences
The limitation of clinical use of doxorubicin is its side effects especially a cumulative dose-dependent cardiotoxicity. To overcome this, doxorubicin can be targeted to accumulate on the site of action and limit dispersion in healthy tissue. Magnetic li...