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Articles 121 - 150 of 1530
Full-Text Articles in Pharmacology
The Study Of Physical Properties And Formulation Of Self-Assembling Nanogel From Grafted Hydrophilic Polymer Backbone As Stabilization System For Curcumin, Penpimon Charoenkanburkang, Tisana Kaewruethai, Pornchai Rojsitthisak, Jittima Amie Luckanagul
The Study Of Physical Properties And Formulation Of Self-Assembling Nanogel From Grafted Hydrophilic Polymer Backbone As Stabilization System For Curcumin, Penpimon Charoenkanburkang, Tisana Kaewruethai, Pornchai Rojsitthisak, Jittima Amie Luckanagul
The Thai Journal of Pharmaceutical Sciences
Introduction: The aim of this work is to formulate and study the thermoresponsive system with hyaluronic acid (HA) as a polysaccharide backbone grafted with poly-(N-isopropylacrylamide) (pNIPAM) for stabilization of highly sensitive molecule. Methods: The nanogel forming polymer was synthesized through EDC/NHS coupling reaction. The HA grafted pNIPAM (HA-g-pNIPAM) can be self-assembled to form gel particle. The synthesized HA-g-pNIPAM polymers were characterized by 1H NMR. Size, influence of media to forming nanogel, thermoresponsive behavior and influence of HA-g-pNIPAM nanogel network on curcumin loading capacity and stability were investigated by dynamic light scattering (DLS) and UV-VIS spectrophotometry. Result and Discussion: The results …
Quality By Design (Qbd): Principles, Underlying Concepts, And Regulatory Prospects, B.G.V.S. Jagan, P. Narasimha Murthy, Anjan Kumar Mahapatra, Ruchita Kumari Patra
Quality By Design (Qbd): Principles, Underlying Concepts, And Regulatory Prospects, B.G.V.S. Jagan, P. Narasimha Murthy, Anjan Kumar Mahapatra, Ruchita Kumari Patra
The Thai Journal of Pharmaceutical Sciences
In the past decades, with substantial growth of pharmaceutical companies and the need in enhancement of quality paradigms, adoption of systematic science based technologies was an inherent demand of regulatory agencies and one such technology is quality by design (QbD). The approved interrelated International Council on Harmonization of Technical Requirements for pharmaceuticals for Human Use guidelines, Q8 (pharmaceutical development), Q9 (quality risk management [QRM]), and Q10 (pharmaceutical quality system) drove the path in successful implementation of QbD. The primary focus of this article is made in delivering the underlying concepts that lead in framing of seven vital elements of QbD. …
Validated Ultra-Performance Chromatographic Method For Simultaneous Determination Of Andrographolide And Its Four Related Diterpenoids In Andrographis Paniculata Capsules, Jankana Burana-Osot, Panadda Phattanawasin, Uthai Sotanaphun, Chanokporn Sukonpan, Lawan Sriphong, Anchalee Kumsum
Validated Ultra-Performance Chromatographic Method For Simultaneous Determination Of Andrographolide And Its Four Related Diterpenoids In Andrographis Paniculata Capsules, Jankana Burana-Osot, Panadda Phattanawasin, Uthai Sotanaphun, Chanokporn Sukonpan, Lawan Sriphong, Anchalee Kumsum
The Thai Journal of Pharmaceutical Sciences
Introduction: Andrographis paniculata contained many pharmacologically active diterpenoids. Objectives: A simple and rapid isocratic reverse phase chromatographic method was developed using UPLC for simultaneous determination of 5 diterpenoids; andrographolide, deoxyandrographiside, neoandrographolide, 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide in A. paniculata capsules. Materials and Methods: The chromatographic separation was achieved on a Waters Acquity BEH C18, 50 × 2.1 mm, 1.7 μm column using mobile phase consisting of acetonitrile and water in a ratio of 25:75 (v/v). The flow rate was 0.4 ml/min with a runtime of 12 min. The method was validated according to the regulatory guidelines with respect to specificity, linearity, precision, …
Cost-Effectiveness Analysis Of Manidipine Versus Amlodipine As An Add-On To Renin-Angiotensin System Blockers In Hypertensive Patients With Diabetes Mellitus And Proteinuria, Kamolpat Chaiyakittisopon, Wiwat Thavornwattanayong, Jadesada Lertsirimunkong, Supitchaya Senbut
Cost-Effectiveness Analysis Of Manidipine Versus Amlodipine As An Add-On To Renin-Angiotensin System Blockers In Hypertensive Patients With Diabetes Mellitus And Proteinuria, Kamolpat Chaiyakittisopon, Wiwat Thavornwattanayong, Jadesada Lertsirimunkong, Supitchaya Senbut
The Thai Journal of Pharmaceutical Sciences
Objectives: Diabetes and hypertension are the most common causes of chronic kidney disease. Calcium channel blockers are beneficial in blood pressure reduction while also stall kidney degeneration. The aim of this study was to compare the cost-effectiveness of manidipine to amlodipine as an add-on to renin-angiotensin system blockers (RASBs) to slow down kidney degeneration in hypertensive patients with diabetes mellitus and proteinuria. Methods: A lifetime Markov decision model was used to evaluate total costs and quality-adjusted life-years (QALYs) from published data on clinical outcomes and Thai data on cost and humanistic outcomes. This study adopted a societal perspective. Results: The …
Doxorubicin Modulates P-Glycoprotein Transcription Differently During Caco-2 Differentiation, Udomsak Udomnilobol, Suree Jianmongko
Doxorubicin Modulates P-Glycoprotein Transcription Differently During Caco-2 Differentiation, Udomsak Udomnilobol, Suree Jianmongko
The Thai Journal of Pharmaceutical Sciences
P-glycoprotein (P-gp) is an efflux transporter protecting cells from various chemical threats. Upregulation of P-gp expression, mediated by reactive oxygen species (ROS), has been reported in doxorubicin-treated cells. However, during cell differentiation cellular redox status may vary. This study investigated the influence of cell differentiation on doxorubicin-mediated P-gp expression in Caco-2 cells, and its relation to cellular redox status. During 21-day culture, Caco-2 cells were divided into pre-, during-, and post-differentiation, based on total cell numbers, percentage of G0/G1 cells, and alkaline phosphatase activity. Our study demonstrated that Caco-2 cells were in a more reduced state on differentiation. At low …
Evaluation Of Acute Oral Toxicity Of Methanolic Fractions Of Sesbania Grandiflora Linn. Roots In Albino Mice, N. S. Vinay, S. Babitha, R. Nandeesh, S. Paramesh, E. Manjunath, J. P. Geetha, V. P. Veerapur, B. Swetha, H. V. Keerthi Prasanth
Evaluation Of Acute Oral Toxicity Of Methanolic Fractions Of Sesbania Grandiflora Linn. Roots In Albino Mice, N. S. Vinay, S. Babitha, R. Nandeesh, S. Paramesh, E. Manjunath, J. P. Geetha, V. P. Veerapur, B. Swetha, H. V. Keerthi Prasanth
The Thai Journal of Pharmaceutical Sciences
Introduction: Although Sesbania grandiflora Linn. roots have valuable pharmacological effects, the comprehensive awareness about its toxicity potential has been lacking. Objectives: The objectives of the study were to assess the acute oral toxicity of methanolic fraction of S. grandiflora root (MFSGR). Materials and Methods: The female albino mice were divided into two groups (n = 5), one group served as normal control while the other treated with MFSGR (2000 mg/kg, p.o). Both the groups of mice were observed for 14 days for various parameters according to the Organization for Economic Cooperative and Development guidelines 425 TG. Results: Oral administration of …
The Physico-Chemical And Filler-Binder- Disintegrant Properties Of Improved Hydrophilic Powder Derived From The Fibre Of Ipomoea Batatas Tuber In Paracetamol Tablet, Kenneth Chinedu Ugoeze, Nkemakolam Nwachukwu, Chukwudum Ejike Okeke
The Physico-Chemical And Filler-Binder- Disintegrant Properties Of Improved Hydrophilic Powder Derived From The Fibre Of Ipomoea Batatas Tuber In Paracetamol Tablet, Kenneth Chinedu Ugoeze, Nkemakolam Nwachukwu, Chukwudum Ejike Okeke
The Thai Journal of Pharmaceutical Sciences
Objectives: The physico-chemical and filler-binder-disintegrant properties of improved hydrophilic powder (HP) derived from the fibre of Ipomoea batatas tuber in a paracetamol tablet was studied.Materials and Methods: A 200 g of the powdered fibre was blended with 600 ml of 0.125 N NaOH and washed with deionized water until neutral, then stirred in 200 ml of 0.50 N HCl, washed until neutral. It was precipitated with 96 % v/v ethanol, dried in a desiccator, pulverized to 250 μm and coded as HP. It was characterized and applied as a filler-binder-disintegrant in paracetamol tablet by wet-granulation and direct- compression beside avicel® …
Subacute Toxicity Study And Clinical Trials For Ziziphus Spina-Christi Leaves Extract As An Anti-Dandruff Shampoo, Abdulkarim K.Y. Alzomor, Wafa M. Al-Madhagi, Nahlah M. Sallam, Haytham Mojamel, Mostafa M. Alawar, Abdulfattah G. Al-Hetari
Subacute Toxicity Study And Clinical Trials For Ziziphus Spina-Christi Leaves Extract As An Anti-Dandruff Shampoo, Abdulkarim K.Y. Alzomor, Wafa M. Al-Madhagi, Nahlah M. Sallam, Haytham Mojamel, Mostafa M. Alawar, Abdulfattah G. Al-Hetari
The Thai Journal of Pharmaceutical Sciences
In light of recent developments in the scientific and technological world, herbs are widely used as remedial agents. This study was aimed to formulate and evaluate the safety and the efficacy of herbal antidandruff shampoo from Ziziphus spina-christi (Sidr) leaves extract, which is used traditionally for several medical and cosmetic purposes. Sidr leaves were extracted by maceration using ethanol as a solvent. The antifungal activity of the plant extract was tested against M. furfur. In-vivo study of the extract has been evaluated with daily oral doses (50, 100, and 200 mg/kg) for 28 days for tested rats, followed by, evaluation …
Hptlc-Densitometric And Tlc-Image Analysis Method For Determination Of Alkaloids Crebanine And Dicentrine In Stephania Venosa Tuber And Their Commercial Products, Savita Chewchinda, Sumet Kongkiatpaiboon
Hptlc-Densitometric And Tlc-Image Analysis Method For Determination Of Alkaloids Crebanine And Dicentrine In Stephania Venosa Tuber And Their Commercial Products, Savita Chewchinda, Sumet Kongkiatpaiboon
The Thai Journal of Pharmaceutical Sciences
This study was aimed to develop and validate HPTLC densitometric and image analysis method for the quantification of crebanine and dicentrine in S. venosa tuber and their commercial products in Thailand. HPTLC analysis was performed on an aluminum sheet of silica gel using dichloromethane:ethyl acetate:methanol (21:6:3, v/v/v) as a mobile phase. The densitometric scanning was performed at the wavelength 290 nm, while image analysis was visualized after post-derivatization with Dragendorff’s reagent and processed by the ImageJ processing software. The proposed methods showed acceptable validation parameters. The content of crebanine and dicentrine in S. venosa tuber and their commercial product was …
Pharmacognostic And Chromatographic Evaluation Of Male And Female Flowers Of Coscinium Fenestratum For Berberine Content And Its Effect On Antioxidant Activity, T. S. Roopashree, Kuntal Das, N. Prashanth, K. Rakesh Kumar
Pharmacognostic And Chromatographic Evaluation Of Male And Female Flowers Of Coscinium Fenestratum For Berberine Content And Its Effect On Antioxidant Activity, T. S. Roopashree, Kuntal Das, N. Prashanth, K. Rakesh Kumar
The Thai Journal of Pharmaceutical Sciences
Coscinium fenestratum (CF) (Gaertn.) Colebr., [Family: Menispermaceae] is an endangered species of dioecious liana found in Western Ghats of India. The present investigation aimed with systematic analytical studies on the macroscopic, microscopic examination of male and female CF flowers, various solvent extractions, accompanied by phytochemical screening through chemical tests, identification of Berberine alkaloids, antioxidant activity, and Berberine quantification byhigh-performance thin-layer chromatography (HPTLC) process. Two different amounts of solvents (10 ml and 20 ml) with two different time intervals, that is, 15 min and 25 min, respectively, were used for extraction. Results revealed that both flowers had their own unique characters. …
High Dietary Salt Intake Alleviates Fasting Blood Glucose In Streptozotocin-Induced Diabetic Male Wistar Rats, Jerome Ndudi Asiwe, Kenneth Kelechi Anachuna, Emuesiri Goodies Moke, Kamaldeen Olalekan Sanusi, David Ehikhuemen Okonofua, Oghenerukevwe Omeru, Adesoji Adedipe Fasanmade
High Dietary Salt Intake Alleviates Fasting Blood Glucose In Streptozotocin-Induced Diabetic Male Wistar Rats, Jerome Ndudi Asiwe, Kenneth Kelechi Anachuna, Emuesiri Goodies Moke, Kamaldeen Olalekan Sanusi, David Ehikhuemen Okonofua, Oghenerukevwe Omeru, Adesoji Adedipe Fasanmade
The Thai Journal of Pharmaceutical Sciences
Objectives: Hypertension and type 2 diabetes are common comorbidities. Studies have shown that hypertension is twofold as common in diabetic patients compared with non-diabetics. Excessive intake of dietary salt has reportedly caused increase in blood pressure. This study investigated the effects of high dietary salt intake on diabetic rats. Materials and Methods: Twenty-eight animals were randomly selected into four groups (n = 7). Group 1 (normal control), fed with standard rats’ feed; Group 2 (diabetic control), streptozotocin-induced diabetic rats fed with normal diet; Group 3 (salt control), fed with 8% salt (high salt) diet; Group 4 (test group), streptozotocin-induced diabetic …
Anthraquinones Extracted From Rubia Cordifolia Linn As Potential Ligands To Treat Alzheimer’S Disease, Pottella Srinivasulu, Janga Ramesh Babu, T.N.V. Ganesh Kumar, Padarthi Pavan Kumar, S. Vidyadhara
Anthraquinones Extracted From Rubia Cordifolia Linn As Potential Ligands To Treat Alzheimer’S Disease, Pottella Srinivasulu, Janga Ramesh Babu, T.N.V. Ganesh Kumar, Padarthi Pavan Kumar, S. Vidyadhara
The Thai Journal of Pharmaceutical Sciences
Objective: The present investigation aims to predict the pharmacokinetic aspects and assessing the anti-Alzheimer’s activity using both molecular docking platform and ex vivo pharmacological studies on muscle contraction. Materials and Methods: 2-Methyl Anthraquinone (MAQ) and Quinizarine (QNZ) were isolated from Rubia cordifolia L., and evaluated for absorption, distribution, metabolism, excretion, and toxicity. Molecular docking was performed with the help of Mcule software on five drug targets acetylcholinesterase enzyme (AChE), cyclin-dependent kinase5 (CDK5), glycogen synthase kinase 3β (GSK3β), monoamine oxidase (MAO-B), and β-secretase enzyme (BACE). The pharmacological activity was screened by recording the muscle contractions of chick ileum. Results: The selected …
Anti-Senescence Activity Of Indonesian Black Pepper Essential Oil (Piper Nigrum L.) On Ovarian Cho-K1 And Fibroblast Nih-3t3 Cells, Nadzifa Nugraheni, Faradiba Nur Ahlina
Anti-Senescence Activity Of Indonesian Black Pepper Essential Oil (Piper Nigrum L.) On Ovarian Cho-K1 And Fibroblast Nih-3t3 Cells, Nadzifa Nugraheni, Faradiba Nur Ahlina
The Thai Journal of Pharmaceutical Sciences
Background: Cellular senescence or cell aging is a progressive process caused by an increase in free radicals so that cells cannot proliferate. Black pepper essential oil (BPEO) contains terpenoid compounds that perform the antioxidant activity to inhibit cell aging. Aims: This study aims to explore the potential of BPEO as an anti-senescence agent to maintain body fitness through in vitro methods on ovarian CHO-K1 and fibroblast NIH-3T3 cells. Subjects and Methods.: BPEO was obtained by hydrodistillation, then identified the compounds by gas chromatography–mass spectrometry. The cytotoxicity of BPEO was evaluated using the 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) assay. The senescence was …
Current Perspectives On The Therapeutic Potential Of Mitragyna Speciosa And Its Derivatives On Animal Model, Norsyifa Harun, Illa Syafiqah Johari, Rima Atria Japarin, Farah Wahida Suhaimi, Zurina Hassan, Mohammed Shoaib
Current Perspectives On The Therapeutic Potential Of Mitragyna Speciosa And Its Derivatives On Animal Model, Norsyifa Harun, Illa Syafiqah Johari, Rima Atria Japarin, Farah Wahida Suhaimi, Zurina Hassan, Mohammed Shoaib
The Thai Journal of Pharmaceutical Sciences
The plant Mitragyna speciosa Korth. is receiving increased attention as a therapeutic substitution for opioid use disorder (OUD). The active alkaloids constituents of the plant, particularly mitragynine and 7-hydroxymitragynine, have been shown to modulate opioid receptors, acting as agonists at mu-opioid receptors. Given this pharmacology, several studies have examined the abuse and dependence potential of M. speciosa and its alkaloids in various animal models of dependence. In addition to action on opioid receptors, the Mitragyna alkaloids also appear to exert diverse activities at other receptors in the central nervous system which may explain the complex pharmacological profile of these alkaloids. …
Synthesis And Evaluation Of Poly(Ethylene Glycol) Diacrylate-Modified Chitosan As A Mucoadhesive Polymer, Kwanputtha Arunprasert, Chaiyakarn Pornpitchanarong, Nitjawan Sahatsapan, Praneet Opanasopit, Prasopchai Patrojanasophon
Synthesis And Evaluation Of Poly(Ethylene Glycol) Diacrylate-Modified Chitosan As A Mucoadhesive Polymer, Kwanputtha Arunprasert, Chaiyakarn Pornpitchanarong, Nitjawan Sahatsapan, Praneet Opanasopit, Prasopchai Patrojanasophon
The Thai Journal of Pharmaceutical Sciences
This study aimed to synthesize a poly(ethylene glycol) diacrylate-modified chitosan (CS-PEGDA) as a mucoadhesive polymer for transmucosal drug delivery. Chitosan-cysteine (Cys-CS) was synthesized by coupling chemistry. Cys-CS was then employed for the synthesis of CS-PEGDA through a thiol-ene click reaction between the thiol groups of Cys-CS and alkene groups of PEGDA using triethanolamine as an activator. The obtained structure of the synthesized polymer was proved using Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. The mucoadhesive capability of the synthesized polymer was examined by an ex vivo mucoadhesion test using a texture analyzer. The toxicity of synthesized …
Statistical Optimization And Evaluation Of Flavoxate Hcl Gastro Retentive Floating Tablets, Raghavendra Kumar Gunda, Prasada Rao Manchineni, Rajini Sudireddy
Statistical Optimization And Evaluation Of Flavoxate Hcl Gastro Retentive Floating Tablets, Raghavendra Kumar Gunda, Prasada Rao Manchineni, Rajini Sudireddy
The Thai Journal of Pharmaceutical Sciences
Purpose: The objective of the current study is to develop gastroretentive formulation for flavoxate HCl using polymers of natural and semisynthetic origin in appropriate composition. Flavoxate HCl, a smooth muscle relaxant, mainly used for treating urinary incontinence, urgency of urination. Materials and Methods: Floating tablets of flavoxate HCl were prepared using variable amounts of hydroxypropyl methylcellulose (HPMC) K100M and Lannea coromandelica gum (LCG) with effervescent mixtures as per 32 factorial design by direct compression technique. Amount of release modifiers need to get sustained drug release was labeled as factors. On the other hand, time taken for drug dissolution were labeled …
Evaluation Of Volatile Constituents Of Fresh And Dried Herbals In Thai Traditional Compress Ball By Headspace Gas Chromatography–Mass Spectrometry Technique, Prasan Tangyuenyongwatana, Napapan Pongpoungphet, Wandee Gritsanapan
Evaluation Of Volatile Constituents Of Fresh And Dried Herbals In Thai Traditional Compress Ball By Headspace Gas Chromatography–Mass Spectrometry Technique, Prasan Tangyuenyongwatana, Napapan Pongpoungphet, Wandee Gritsanapan
The Thai Journal of Pharmaceutical Sciences
Introduction: There are two types of herbal compress balls, fresh and dried, which are normally used in combination with Thai traditional massage for relieving inflammation and pain. There is no comparing information about chemical compositions of these herbal compress balls. Objective: This research focused on analysis of chemical composition of two types of herbal compress balls using headspace (HS) gas chromatography–mass spectrometry (GC–MS) system at a temperature of 80°C. Methods: Each herbal compress sample, Cryptolepis dubia, Cymbopogon citratus, Tamarindus indica, Curcuma longa, Zingiber montanum, and Citrus hystrix, was placed in a HS vial at 80°C for 20 min, agitated at …
Drug Therapy Problems In Asthma Identified During Pharmacist-Led Educational Interventions, Kosisochi Chinwendu Amorha, Mathew Jegbefume Okonta, Chinwe Victoria Ukwe
Drug Therapy Problems In Asthma Identified During Pharmacist-Led Educational Interventions, Kosisochi Chinwendu Amorha, Mathew Jegbefume Okonta, Chinwe Victoria Ukwe
The Thai Journal of Pharmaceutical Sciences
Background: Drug therapy problems (DTPs) interfere with desired goals of therapy. This study evaluated DTPs in asthma identified during a pharmacist-led intervention in the asthma clinics of two Nigerian hospitals. Methods: This intervention study was conducted in the asthma clinics, University of Nigeria Teaching Hospital and Lagos University Teaching Hospital. Eligible participants were patients with asthma recruited into a pharmacist-led intervention study and followed up for 6 months. The Pharmaceutical Care Network Europe – Drug-related Problem Classification V6.2 in English (PCNE-DRP V6.2) was utilized to evaluate the DTPs. Results: Seventy-eight patients with asthma participated. A total of 158 DTPs were …
Analgesic, Anti-Inflammatory, And Antihyperuricemic Activities Of A Thai Herbal Remedy, Tipsuchon Aiamsa-Ard, Thidarat Phetmanee
Analgesic, Anti-Inflammatory, And Antihyperuricemic Activities Of A Thai Herbal Remedy, Tipsuchon Aiamsa-Ard, Thidarat Phetmanee
The Thai Journal of Pharmaceutical Sciences
Introduction: Moa Chub’s gout formulation (MCHGF), a traditional Thai herbal remedy, is used for the treatment of pain and swelling related to gout. Objective: This study aimed to determine MCHGF’s analgesic, anti-inflammatory, and antihyperuricemic effects. Materials and Methods: The analgesic activity of MCHGF was studied in mice using an acetic acid-induced writhing test and the hot-plate method. The anti-inflammatory activity of MCHGF was evaluated in rats using carrageenan-induced paw edema. The antihyperuricemic activity of MCHGF was tested in vivo using the model of potassium oxonate-induced hyperuricemia mice. MCHGF doses of 50, 100, and 200 mg/kg/day were used in this study. …
Evidence For Intravenous Self-Administration Of Mitragynine In Fentanyl-Dependent Rats, Norsyifa Harun, Zurina Hassan, Surash Ramanathan, Mohammed Shoaib
Evidence For Intravenous Self-Administration Of Mitragynine In Fentanyl-Dependent Rats, Norsyifa Harun, Zurina Hassan, Surash Ramanathan, Mohammed Shoaib
The Thai Journal of Pharmaceutical Sciences
Introduction: Kratom (Mitragyna speciosa Korth) is currently used as an alternative for the self-treatment of pain and management of opioid dependence and withdrawal. Due to the opioid-like effect of the plant’s active alkaloid, mitragynine (MG), the evaluation of its ability to maintain self-administration in animal models of opioid dependence appears to be great significance. Objectives: Here, the ability of MG to cross-substitute to the reinforcing effects of the synthetic narcotic fentanyl is investigated. Methods: Rats with implanted catheters were allowed to self-administer fentanyl (2.0 μg/kg/infusion) on a fixed-ratio 1 of schedule of reinforcement. Results: A significant increase in lever pressing …
Synthesis And Anti-Inflammatory Effects Evaluation Of 1,3 Substituted Isatin Derivatives, Farshid Hassanzadeh, Elham Jafari, Nahal Khayambashi, Valiollah Hajhashemi
Synthesis And Anti-Inflammatory Effects Evaluation Of 1,3 Substituted Isatin Derivatives, Farshid Hassanzadeh, Elham Jafari, Nahal Khayambashi, Valiollah Hajhashemi
The Thai Journal of Pharmaceutical Sciences
Objectives: Inflammation is a pathophysiological response of the body to a variety of agents including infections and physical injury leading to local accumulation of plasma fluid and blood cells. Isatin as a promising heterocyclic molecule has shown interesting biological profile. In this study, some derivatives of isatin containing both Schiff and mannich base fragments were synthesized in a three-step procedure. Methods: Benzohydrazide derivatives were prepared by reaction of benzoat derivatives with hydrazine hydrate. The Schiff bases were formed by treatment isatin with the benzo hydrazide derivatives. The corresponding mannich bases have been synthesized by the reaction of the Schiff bases …
Fruits Of Averrhoa Carambola Inn Protects Wistar Rats Against Indomethacin And Pylorus Ligation- Induced Ulcers, Nireeksha G. Kulal, C. S. Shastry, Sharad Chand, Sawan Mukund Ghetia
Fruits Of Averrhoa Carambola Inn Protects Wistar Rats Against Indomethacin And Pylorus Ligation- Induced Ulcers, Nireeksha G. Kulal, C. S. Shastry, Sharad Chand, Sawan Mukund Ghetia
The Thai Journal of Pharmaceutical Sciences
Background: Peptic ulcer disease is one among the major cause of hospitalization in the gastroenterology department. Objective: The study was conducted to evaluate the gastroprotective and anti-ulcerogenic activity of Averrhoa carambola L. aqueous extract and its ghritha formulation on rat models. Materials and Methods: The antiulcer activity of A. carambola L. fruit extract was assessed by inducing ulcer using indomethacin and using pylorus ligation-induced ulcer models. The drug activity was compared to standard drugs omeprazole 30 mg/kg and sucralfate at a dose of 100 mg/kg. The parameters such as gastric pH, gastric acid volume, total acidity, free acidity, and ulcer …
The Study Of Volatile Fractions Of Cabbage Leaves (Brassica Oleracea L. Convar. Capitata (L.) Alef. Var. Alba Dc.) And Determination Of Its Antibacterial And Antifungal Activity, Viktoriia Protska, Andriy Fedosov, Nadiia Burda, Oleksandr Dobrovolnyi, Moeen F. Dababneh, Marina Kuznetsova, Iryna Zhuravel, Liana Budanova
The Study Of Volatile Fractions Of Cabbage Leaves (Brassica Oleracea L. Convar. Capitata (L.) Alef. Var. Alba Dc.) And Determination Of Its Antibacterial And Antifungal Activity, Viktoriia Protska, Andriy Fedosov, Nadiia Burda, Oleksandr Dobrovolnyi, Moeen F. Dababneh, Marina Kuznetsova, Iryna Zhuravel, Liana Budanova
The Thai Journal of Pharmaceutical Sciences
Background: Along with a widespread application of cabbage as a food and fodder crop, it also possesses therapeutic properties. In traditional medicine, this plant is used in gastritis and gastric ulcer, colitis, diabetes, inflammations of upper airways, musculoskeletal system, disorders of cardiovascular system, and skin. Materials and Method: Using the method of gas chromatography, the component composition of cabbage leaves of Yaroslavna and Bilosnizhka cultivars was studied. Testing control strains of microorganisms were used for the determination of the antimicrobial activity of chloroform, ethyl acetate, and 96% ethanol extracts from cabbage cultivars leaves. Result: The general amount of volatile compounds …
Present Clinical Trial Regulatory System And Strategies For Improvement In Thailand, Charunee Krisanaphan, Rungpetch Sakulbumrungsil
Present Clinical Trial Regulatory System And Strategies For Improvement In Thailand, Charunee Krisanaphan, Rungpetch Sakulbumrungsil
The Thai Journal of Pharmaceutical Sciences
The study aimed to identify gaps and to develop strategies for improving the clinical trial regulatory system in Thailand. Two-step cross-sectional survey was conducted. The first questionnaire addressed the present situation and the expected system sent by mail. The participants were from the lists of ethics committee (EC) members available online and others obtained from Food and Drug Administration (FDA). The second questionnaire determined the strategies and methods to improve the regulatory system. The participants were the attendees at the Thailand Toward Excellence in Clinical Trials meeting. The first questionnaire with response rate of 26.9% showed that the present situation …
In Vivo And In Silico Anti-Arthritic Studies Of Chlorogenic Acid From The Rhizome Of Lasia Spinosa (L.) Thwaites (Araceae), M. Arya Lakshmi, D. S.N.B.K Prasanth, K. Gana Manjusha, B. Ganga Rao
In Vivo And In Silico Anti-Arthritic Studies Of Chlorogenic Acid From The Rhizome Of Lasia Spinosa (L.) Thwaites (Araceae), M. Arya Lakshmi, D. S.N.B.K Prasanth, K. Gana Manjusha, B. Ganga Rao
The Thai Journal of Pharmaceutical Sciences
Aim: The aim of the study was to examine the anti-arthritic function of methanol extract of Lasia spinosa (MELS) and chlorogenic acid (CA) in the rats of Freund’s complete adjuvant (FCA) mediated arthritis by in vivo and In silico studies. Materials and Methods: The MELS was subjected to acute oral toxicity in rats and tested against FCA induced arthritis in rats. Large-scale isolation and chromatographical analysis with spectral review verified that CA is responsible for the pharmacological effects reported. The efficacy of MELS and CA against CFA-induced arthritis was subsequently tested for hematological, biochemical, and in vivo anti-oxidant parameters in …
Phytochemistry And Dna˗Based Authentication Of Medicinal Lasianthus Stipularis Blume (Rubiaceae) Species Against Human Pathogenic Bacteria, Tiwtawat Napiroon, Sutee Duangjai, Srunya Vajrodaya, Markus Bacher, Henrik Balslev, Wichai Santimaleeworagun
Phytochemistry And Dna˗Based Authentication Of Medicinal Lasianthus Stipularis Blume (Rubiaceae) Species Against Human Pathogenic Bacteria, Tiwtawat Napiroon, Sutee Duangjai, Srunya Vajrodaya, Markus Bacher, Henrik Balslev, Wichai Santimaleeworagun
The Thai Journal of Pharmaceutical Sciences
Lasianthus stipularis Blume is a medicinal plant found in the tropical rainforests of peninsular Thailand and Malaysia. Its leaves are used in traditional medicine to treat a condition called “noise in the head” (i.e., ear infections). As such infections are often caused by Gram-negative bacteria; this species of Lasianthus may have antibacterial effects. In this study, we examined the non-polar fractions from the leaves and stem bark of L. stipularis using thin-layer chromatography and high-performance liquid chromatography (HPLC). The non-polar fractions exhibited a high coumarin content, while stem bark extracts showed a high concentration of 7-hydroxy-6-methoxycoumarin when isolated by column …
Investigation Of Drug Reaction With Eosinophilia And Systemic Syndrome And Its Management In A Tertiary Care Hospital Of South India, S. Shridhar, B. Suresh, S. Ojha, S. Seshadri, Mallayasamy Surulivelrajan, S. Elstin Anbu Raj, V. Rajesh
Investigation Of Drug Reaction With Eosinophilia And Systemic Syndrome And Its Management In A Tertiary Care Hospital Of South India, S. Shridhar, B. Suresh, S. Ojha, S. Seshadri, Mallayasamy Surulivelrajan, S. Elstin Anbu Raj, V. Rajesh
The Thai Journal of Pharmaceutical Sciences
Introduction: Drug reaction with eosinophilia and systemic syndrome (DRESS) is also known as drug hypersensitivity syndrome or drug-induced hypersensitivity syndrome, is a rare, potentially life-threatening drug reaction that affects multiple organ systems simultaneously. Objective: The objective of the study was to investigate the DRESS syndrome and its management in a tertiary care hospital in the department of medicine. Materials and Methods: A retrospective evaluation of 227 medical records was conducted among the patients admitted in medicine units. Causality assessment was carried out using Naranjo’s scale and two specific scoring systems. RegiSCAR 1 was utilized to confirm the diagnosis of DRESS …
Polymer As Precipitation Inhibitor Of Weak Base Drug: An Update And Brief Review, Viviane Annisa, Syaiful Choiri, Teuku Nanda Saifullah Sulaiman, Agung Endro Nugroho
Polymer As Precipitation Inhibitor Of Weak Base Drug: An Update And Brief Review, Viviane Annisa, Syaiful Choiri, Teuku Nanda Saifullah Sulaiman, Agung Endro Nugroho
The Thai Journal of Pharmaceutical Sciences
Precipitation due to supersaturation phenomenon and intraluminal solubilization behavior is mainly faced on reducing bioavailability, particularly for weak base drugs. Incomplete and extend of absorption can be avoided by modification of drug-excipient interaction namely polymers. This interaction is proposed to stabilize the amorphous form of drug through reducing nucleation followed by crystal growth. Therefore, polymers can be utilized to inhibit the precipitation phenomenon through their interaction with poorly water-soluble and weak base drugs. However, until to date, there was no recent updates on the use of polymer for precipitation inhibitor of weak base drug. This review discussed the brief and …
Non-Destructive Analysis Of Glycyrrhizin In Ummaruekvati Dispensatory Thai Traditional Medicine, Thanattaporn Charoenkittrakul, Chanamate Noi-Ang, Prathan Luecha, Jomjai Peerapattana
Non-Destructive Analysis Of Glycyrrhizin In Ummaruekvati Dispensatory Thai Traditional Medicine, Thanattaporn Charoenkittrakul, Chanamate Noi-Ang, Prathan Luecha, Jomjai Peerapattana
The Thai Journal of Pharmaceutical Sciences
Ummaruekvati is an antitussive traditional medicine. It contains licorice as the main ingredient and the major chemical component is glycyrrhizin. The conventional method for quantitative analysis of glycyrrhizin content in licorice is by high-performance liquid chromatography, which is destructive of the sample, time consuming, high cost, and has many steps in the sample preparation process. In this study, a rapid and non-destructive near-infrared spectroscopy (NIR) method was applied for quantitative analysis of glycyrrhizin content in Ummaruekvati dispensatories. A partial least squares chemometric method with various data pre-treatments was performed to establish the calibration model. The best calibration model was obtained …
Monitoring Of Crystalline Transition During Wet Granulation Process Using Probe Type Low Frequency Raman Spectrometer, Kanako Fukui, Yota Suzuki, Kazuki Haneishi, Varin Titapiwatanakun, Hiroshi Hisada, Tatsuo Koide, Toshiro Fukami
Monitoring Of Crystalline Transition During Wet Granulation Process Using Probe Type Low Frequency Raman Spectrometer, Kanako Fukui, Yota Suzuki, Kazuki Haneishi, Varin Titapiwatanakun, Hiroshi Hisada, Tatsuo Koide, Toshiro Fukami
The Thai Journal of Pharmaceutical Sciences
In recent years, real time analysis has been widely studied using various Process Analytical Technology tools particularly in the quality control of drug products. In this study, we investigated the improvement of sensitivity and the reduction of measurement time using a low frequency (LF) Raman spectrometer equipped with a new light source for in situ monitoring of crystalline transformation of active pharmaceutical ingredients (API) during wet granulation process. Three model drugs were chosen to assess the system sensitivity, hydrate transition, and cocrystal dissociation. LF Raman spectra showed the specific peaks for crystalline indomethacin and theophylline which were typical and well …