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Articles 91 - 120 of 1187
Full-Text Articles in Pharmacology
Fluorescent “On–Off–On” Sensor Based On N, P Co-Doped Carbon Nanoparticles For Specific Detection Of Fe3+ And Ascorbic Acid, Li Li, Ming Zhang, Xiang Liu, Shaoqing Zhu
Fluorescent “On–Off–On” Sensor Based On N, P Co-Doped Carbon Nanoparticles For Specific Detection Of Fe3+ And Ascorbic Acid, Li Li, Ming Zhang, Xiang Liu, Shaoqing Zhu
Journal of Food and Drug Analysis
Ascorbic acid (AA) is used as a food additive for its antibacterial and antioxidant properties. However, excessive intake of AA is harmful to humans. Therefore, the detection of Fe3+ and AA is generally recognized to be meaningful. In this work, a one-step hydrothermal tactics is developed for the preparing nitrogen and phosphorus co-doped carbon nanoparticles (N, P-CNPs) by using sucrose and ammonium orthophosphate as raw materials. The N, P-CNPs not only exhibited an enhanced fluorescent efficiency with a relatively high quantum yield up to 28%, but also showed satisfactory stability, water solubility and photostability. The fluorescence of N, P-CNPs …
Aromatic Compounds And Organic Acids Identified From Ganoderma Formosanum Exhibit Synergistic Anti-Melanogenic Effects, Chen-Che Hsieh, Chih-Yao Hou, Hsiao-Yun Lei, Darin Khumsupan, Huey-Jine Chai, Pek-Kui Lim, Cheng-Chih Hsu, Sz-Jie Wu, Kai-Wen Cheng, Yi-Chen Chen, Kuan-Chen Cheng
Aromatic Compounds And Organic Acids Identified From Ganoderma Formosanum Exhibit Synergistic Anti-Melanogenic Effects, Chen-Che Hsieh, Chih-Yao Hou, Hsiao-Yun Lei, Darin Khumsupan, Huey-Jine Chai, Pek-Kui Lim, Cheng-Chih Hsu, Sz-Jie Wu, Kai-Wen Cheng, Yi-Chen Chen, Kuan-Chen Cheng
Journal of Food and Drug Analysis
This study reveals the anti-tyrosinase activity of Ganoderma formosanum extracts, pinpointing compounds including gluconic acid, mesalamine, L-pyroglutamic acid, esculetin, 5-hydroxyindole, and salicylic acid, as effective melanin production inhibitors in melanoma cells and zebrafish embryos. Furthermore, multiple molecular docking simulations provided insights into interactions between the identified compounds and tyrosinase, increasing binding affinity up to -16.36 kcal/mol. The enhanced binding of identified compounds to tyrosinase facilitated synergistic inhibitory effects on melanin production. This study highlights the potential of GFE-EA as a source of natural tyrosinase inhibitors and contributes to understanding the role of active compounds extracted from G. formosanum.
Bio-Inspired Chitosan/Polydopamine-Nanoparticle Based Sorbent Bead: A Versatile Platform For Separation And Hplc Analysis Of Tetracycline Antibiotics From Various Sample Matrix, Emmanuvel Arputharaj, Yu-Hui Huang, Shivangi Singh, Chen-Han Zhuang, Kuei-Ying Lin, Sri Sudewi, You-Rong Wu, Yeou-Lih Huang
Bio-Inspired Chitosan/Polydopamine-Nanoparticle Based Sorbent Bead: A Versatile Platform For Separation And Hplc Analysis Of Tetracycline Antibiotics From Various Sample Matrix, Emmanuvel Arputharaj, Yu-Hui Huang, Shivangi Singh, Chen-Han Zhuang, Kuei-Ying Lin, Sri Sudewi, You-Rong Wu, Yeou-Lih Huang
Journal of Food and Drug Analysis
This study introduces an innovative bio-based sorbent bead crafted by integrating chitosan (CS) biopolymers, Fe(NO3)3 and polydopamine nanoparticles (PDA NPs) via glutaraldehyde crosslinking. The primary focus of this study was the concurrent separation of diverse tetracycline antibiotics (TCs), followed by rigorous reversed-phase liquid chromatography analysis. The fabricated CS/Fe@PDA sorbent beads were comprehensively characterized using scanning electron microscopy and energy-dispersive X-ray spectroscopy, revealing a surface rich in active carbon (C), nitrogen (N), and oxygen (O) moieties. The proposed method demonstrated substantial analytical robustness, enabling the sorbent bead to detect low concentrations of TCs, with limit of detection values …
Bitter Acids From Humulus Lupulus L. Alleviate D-Galactose Induced Osteoblastic Senescence And Bone Loss Via Regulating Akt/Mtor-Mediated Autophagy, Tian-Shuang Xia, Sheng-Yan Xu, Li-Yong Lai, Yi-Ping Jiang, Na-Ni Wang, Hai-Liang Xin
Bitter Acids From Humulus Lupulus L. Alleviate D-Galactose Induced Osteoblastic Senescence And Bone Loss Via Regulating Akt/Mtor-Mediated Autophagy, Tian-Shuang Xia, Sheng-Yan Xu, Li-Yong Lai, Yi-Ping Jiang, Na-Ni Wang, Hai-Liang Xin
Journal of Food and Drug Analysis
Bitter acids (BA) are main component of Humulus lupulus L. (hops). They are known for beer brewing and have various biological and pharmacological properties, especially the bone-protective effect confirmed by our previous in vivo study. Here we aimed to elucidate the anti-senior osteoporosis (SOP) effect of BA on osteoblasts and explore its underlying mechanism. In vitro SOP model was established by D-galactose (D-gal) injured osteoblasts, and the bone formation markers and apoptosis level were measured. mCherry-EGFP-LC3 adenovirus infection and autophagic markers including beclin1 and LC3 proteins were detected to investigate the autophagy level in osteoblasts. To further verify whether BA …
Development And Industrial Application Of Geographical Origin Identification For Taiwanese Oolong Tea, Tien-Lin Liu, Jia-Ru Dai, Tsung-Chen Su, Chun-Huo Chiu, Hsien-Tsung Tsai, Chui-Feng Chiu, Jin-Chih Lin, Chih-Yi Hu
Development And Industrial Application Of Geographical Origin Identification For Taiwanese Oolong Tea, Tien-Lin Liu, Jia-Ru Dai, Tsung-Chen Su, Chun-Huo Chiu, Hsien-Tsung Tsai, Chui-Feng Chiu, Jin-Chih Lin, Chih-Yi Hu
Journal of Food and Drug Analysis
Taiwanese oolong tea is renowned for its excellent quality and enjoys a prestigious reputation both domestically and internationally. In recent years, there has been an issue with imported Taiwanese-style oolong tea being sold as genuine Taiwanese oolong tea, which has adversely affected the brand value of Taiwanese oolong tea. In this study, samples of domestic oolong tea (Taiwanese oolong tea) and Taiwanese-style oolong tea produced abroad (including China, Vietnam, Indonesia, Thailand, etc.) were collected. A multi-elements analysis method was applied to establish an elemental database of tea leaf samples. Subsequently, various widely used classification methods were employed to develop a …
The Effects Of Fermentation By Different Species Oflactic Acid Bacteria On Betalains And Polyphenol Profile And In Vitro Bioactive Potential Of Red Beetroot Juice, Tomasz Sawicki, Monika Jabłońska, Małgorzata Starowicz, Lucyna Kłębukowska, Wioletta Błaszczak
The Effects Of Fermentation By Different Species Oflactic Acid Bacteria On Betalains And Polyphenol Profile And In Vitro Bioactive Potential Of Red Beetroot Juice, Tomasz Sawicki, Monika Jabłońska, Małgorzata Starowicz, Lucyna Kłębukowska, Wioletta Błaszczak
Journal of Food and Drug Analysis
In the current study, the effects of fermentation by Lactobacillus acidophilus, Levilactobacillus brevis or Lactiplantibacillus plantarum (La/Lb/Lp, 1-2.5%) and incubation (30/37℃, C1/C2) of red beetroot juice on the profile of betalains and polyphenols (UHPLC-DAD-MS), and antioxidant capacity using photochemiluminescence (PCL) and spectrophotometric assays (DPPH/ABTS) was investigated. Additionally, anti-glycaemic (anti-AGEs) and anti-cholinergic (anti-AChE) potential in vitro was analysed. Fermentation distinctly initiated isobetanin and neobetaninformation and enhanced flavonoid concentration, emphasising rutin, kaempferol and (+)-catechin. The fermented juices inhibited protein glycation in the BSA-GLU model and showed high DPPH and ABTS values. LP2.5% juice was the only one indicating anti-AChE potential.
Determination And Validation Of Polycyclic Aromatichydrocarbons (Pah4) In Katsuobushi, Plant-Basedfood Supplements, And Cocoa Bean Shells Using Gc-Ms/Ms, Chia-Hsin Liu, Yu-Ning Shin, Ya-Chun Chou, Guan-Jhih Peng, Ying-Ru Shen, Nu-Ching Lin, Shu-Han Chang, Ya-Min Kao, Su-Hsiang Tseng, Der-Yuan Wang
Determination And Validation Of Polycyclic Aromatichydrocarbons (Pah4) In Katsuobushi, Plant-Basedfood Supplements, And Cocoa Bean Shells Using Gc-Ms/Ms, Chia-Hsin Liu, Yu-Ning Shin, Ya-Chun Chou, Guan-Jhih Peng, Ying-Ru Shen, Nu-Ching Lin, Shu-Han Chang, Ya-Min Kao, Su-Hsiang Tseng, Der-Yuan Wang
Journal of Food and Drug Analysis
Polycyclic aromatic hydrocarbons (PAHs) are primarily generated through the incomplete combustion or pyrolysis oforganic materials in various industrial processes. Foods may become contaminated with environmental PAHs found inair, soil, or water, or through industrial food processing methods such as smoking, roasting, drying, and grilling. The Ministry of Health and Welfare in Taiwan has established maximum levels for benzo[a]pyrene (BaP) and indicativevalues for BaP as well as PAH4 (the sum of benz[a]anthracene, chrysene, benzo[b]fluoranthene, and benzo[a]pyrene) infoods as operational guidelines. The current study developed an analytical method for simultaneous determination of PAH4 levels in katsuobushi (dried bonito flakes), cocoa bean shells, …
A Novel Selective Medium For Isolation Of Limosilactobacillus Reuteri From Dietary Supplements, Yu-Ting Wang, Jyue-Wei Chuang, Ming-Sian Wu, Min-Cheng Wang, Yu-Cheng Yang, Jun-Jie Yang, Shih-Ting Chiou, Chun-Hsien Li, Che-Yang Lin, Shou-Chieh Huang, Su-Hsiang Tseng, Der-Yuan Wang
A Novel Selective Medium For Isolation Of Limosilactobacillus Reuteri From Dietary Supplements, Yu-Ting Wang, Jyue-Wei Chuang, Ming-Sian Wu, Min-Cheng Wang, Yu-Cheng Yang, Jun-Jie Yang, Shih-Ting Chiou, Chun-Hsien Li, Che-Yang Lin, Shou-Chieh Huang, Su-Hsiang Tseng, Der-Yuan Wang
Journal of Food and Drug Analysis
Limosilactobacillus reuteri is a probiotic bacterium known for its numerous beneficial effects on human health and is commonly utilized in various dietary supplements. Previously, we encountered difficulties in isolating L. reuteri from retail dietary supplements containing complex probiotic compositions by using non-selective media such as de Man, Rogosa, and Sharpe (MRS) agar. Our findings reveal that MRS agar using D-gluconic acid as the carbon source and peptone from soymeal as the nitrogen source provid a growth advantage for L. reuteri. Furthermore, all the tested L. reuteri strains exhibit higher resistance to oxacillin compared to non-L. reuteri strains and …
Herbal Nanoemulsions In Cosmetic Science: A Comprehensive Review Of Design, Preparation, Formulation, And Characterization, Benni Iskandar, Ta-Wei Liu, Hui-Ching Mei, I-Chih Kuo, Meircurius Dwi Condro Surboyo, Hsiu-Mei Lin, Ching-Kuo Lee
Herbal Nanoemulsions In Cosmetic Science: A Comprehensive Review Of Design, Preparation, Formulation, And Characterization, Benni Iskandar, Ta-Wei Liu, Hui-Ching Mei, I-Chih Kuo, Meircurius Dwi Condro Surboyo, Hsiu-Mei Lin, Ching-Kuo Lee
Journal of Food and Drug Analysis
The rapid development of delivery systems for cosmetics has revealed two critical challenges in the field: enhancing the solubility of active ingredients and ensuring the stability of natural materials used in cosmetics. Nanoemulsion technology has emerged as an indispensable solution for addressing these challenges, not only enhancing the stability of cosmetics but also improving the solubility of pharmaceuticals and active ingredients with poor solubility. Nanoemulsion formulations have reinforced stability and amended the bioavailability of hydrophobic drugs. Moreover, nanoemulsion exhibit excellent skin penetration and long-lasting effects, making them particularly appealing to consumers, especially in the cosmetic industry. This article aims to …
Therapeutic Approach Of Carbon Nanotube: Revolutionize Nanomaterial In Biomedical And Pharmaceutical Sector, Shovan Ghosh, Vivek Dave, Pranay Wal
Therapeutic Approach Of Carbon Nanotube: Revolutionize Nanomaterial In Biomedical And Pharmaceutical Sector, Shovan Ghosh, Vivek Dave, Pranay Wal
Journal of Food and Drug Analysis
Carbon nanotubes (CNTs) has emerged as a promising nanomaterial with a wide range of potential applications due to their unique structural, mechanical, electrical, and thermal properties. However, numerous obstacles must be overcome for CNTs to be used successfully, including low solubility, aggregation, and a lack of specialized functions. Diverse techniques have been developed for the manufacture, purification, and functionalization of CNTs in order to overcome these issues. The main aim of this review article is to provide brief knowledge about CNTs and strategies to use this revolutionized nanomaterial in drug delivery. Prepare CNTs cannot be directly used as drug carrier …
Updates On The Conversion Of Nanosuspensions To Solid Oral Dosage Forms, Anastasia Tsiaxerli, Elisavet Vardaka, Christos Moutroupidis, Kevin M.G. Taylor, Kyriakos Kachrimanis, Maria Malamatari
Updates On The Conversion Of Nanosuspensions To Solid Oral Dosage Forms, Anastasia Tsiaxerli, Elisavet Vardaka, Christos Moutroupidis, Kevin M.G. Taylor, Kyriakos Kachrimanis, Maria Malamatari
Journal of Food and Drug Analysis
Pharmaceutical nanosuspensions, also called nanocrystals, are heterogeneous mainly aqueous dispersions of insoluble drug particles stabilised by surfactants and/or polymers. Nanosuspensions as liquid formulations suffer from instability. Solidification of nanosuspensions to solid dosage forms is a way to combine the advantages of nanocrystals with the advantages of the solid state. In this review, advances regarding stabilisation and production of nanosuspensions are briefly covered. Updates on the methods used to convert nanosuspensions to solid oral dosage forms (e.g., powder, granules, pellets, tablets, and films) are presented in depth. From these methods, spray drying and freeze drying are widely used. Granulation and hot-melt …
Mechanobactericidal Nanotopographies For Food Industry: A Promising Strategy For Eradicating Foodborne Pathogens - Progress And Challenges, Deepak Patil
Journal of Food and Drug Analysis
Nowadays, food preservation, quality maintenance, and safety are major emerging concerns in the food industry. Methods for removing pathogens from the outside surfaces of food products would be an effective way to prevent bacterial contamination. Nanotopographies found on natural surfaces have been shown to mechanically damage the membranes of foodborne bacteria. Thus, using bioinspired mechanobactericidal nanostructures in food packaging and processing materials has the potential to lower surface bacterial contamination while increasing food safety. However, putting this concept into practice remains a challenge. This review discussed recent advances in understanding mechanobactericidal mechanisms, issues concerning the durability of nanotopography under external …
Corrigendum To "Chemical Constituents From A Marine Medicinal Brown Alga-Derived Xylaria Acuta Sc1019," Journal Of Food And Drug Analysis: Vol. 32 : Iss. 2 , Article 3.
Journal of Food and Drug Analysis
No abstract provided.
Corrigendum To “Composition Decipherment Of Ficus Pumila Var. Awkeotsang And Its Potential On Covid-19 Symptom Amelioration And In Silico Prediction Of Sars-Cov-2 Interference.”
Journal of Food and Drug Analysis
No abstract provided.
Characterization Of Carbon Dots From Fructus Gardeniae (Zhi-Zi) And Gardenia Charcoal (Black Zhi-Zi) Via Microwave-Assisted Extraction, Hung-Wen Tsai, Nelly Fitri Tampubolon, Tsunghsueh Wu, Mei-Yao Wu, Yang-Wei Lin
Characterization Of Carbon Dots From Fructus Gardeniae (Zhi-Zi) And Gardenia Charcoal (Black Zhi-Zi) Via Microwave-Assisted Extraction, Hung-Wen Tsai, Nelly Fitri Tampubolon, Tsunghsueh Wu, Mei-Yao Wu, Yang-Wei Lin
Journal of Food and Drug Analysis
We employed a straightforward microwave-assisted extraction technique to investigate the presence of carbon dots (CDs) in Chinese herbal extracts derived from fructus gardeniae and gardenia charcoal, designated as CDs-1 and CDs-2, respectively. The found CDs exhibited unique photoluminescence with quantum yields of 0.95% for CDs-1 and 1.81% for CDs-2, indicating significant potential for bioimaging applications. Both CD types maintain approximately 80% of their fluorescence intensity after 120 minutes of continuous 365 nm UV exposure, underscoring their stability and suitability for prolonged biological studies. Moreover, antioxidant activity tests showed that CDs-2 have a higher scavenging capacity, with an SC-50 value of …
Optimization, Physicochemical Stability And In Vivo Study Of Alginate-Chitosan Composites As Nanocarriers For Low Molecular Weight Angiotensin I-Converting Enzyme (Ace)-Inhibitory Peptide, Shehu Muhammad Auwal, Siti Balqis Muhammad Ghanisma, Nazamid Saari
Optimization, Physicochemical Stability And In Vivo Study Of Alginate-Chitosan Composites As Nanocarriers For Low Molecular Weight Angiotensin I-Converting Enzyme (Ace)-Inhibitory Peptide, Shehu Muhammad Auwal, Siti Balqis Muhammad Ghanisma, Nazamid Saari
Journal of Food and Drug Analysis
Chitosan and alginate, are non-toxic and biodegradable polymers used to enhance the stability of biotherapeutics by loading them into nanocarriers. In this study, the stone fish-derived low molecular weight peptide (Ala-Leu-Gly-Pro-Gln-Phe-Tyr), exhibited an in vitro ACE-inhibitory activity of 94.43 ± 2.05% and an IC50 of 0.012 ± 0.001 mM. The peptide was encapsulated via ionic gelation with alginate followed by polyelectrolyte complexation with chitosan. The resulting ACE-inhibitory peptide-loaded alginate-chitosan nanoparticles (ACE-I-ALG-CS NPs) were optimized to achieve small particle size (212.60 nm) and high encapsulation efficiency (EE, 74.48%). This was based on an optimum chitosan concentration (0.420%w/v), homogenization speed (6000 …
Sensitive Electrochemical Sensor Of Levofloxacin Using Boron-Doped Diamond (Bdd) Electrode Modified With Ti3c2tx (Mxene) Material, Prastika Krisma Jiwanti, Indah Harindy Putri, Grandprix T.M. Kadja, Yasuaki Einaga, Laurencia Gabrielle Sutanto, Siti Wafiroh, Dewi Kartika Azizah Sukardi, Anis Puspita Sari, Tahta Amrillah, Ilma Amalina, Qonita Kurnia Anjani, Wan Jeffrey Basirun
Sensitive Electrochemical Sensor Of Levofloxacin Using Boron-Doped Diamond (Bdd) Electrode Modified With Ti3c2tx (Mxene) Material, Prastika Krisma Jiwanti, Indah Harindy Putri, Grandprix T.M. Kadja, Yasuaki Einaga, Laurencia Gabrielle Sutanto, Siti Wafiroh, Dewi Kartika Azizah Sukardi, Anis Puspita Sari, Tahta Amrillah, Ilma Amalina, Qonita Kurnia Anjani, Wan Jeffrey Basirun
Journal of Food and Drug Analysis
Overuse of levofloxacin (LEV) is often associated with bacterial resistance and serious health problems, underscoring the need for reliable sensing and monitoring of LEV molecules. Therefore, this study aimed to investigate LEV using boron-doped diamond (BDD) and boron-doped diamond modified with MXene (Ti3C2TX) (BDD-MXene) electrode. The successful deposition of MXene on the BDD surface was confirmed using scanning electron microscope (SEM). Cyclic voltammetry (CV) and square wave voltammetry (SWV) methods were also applied to evaluate the electrochemical behavior. The results showed that both electrodes had a linear response in the range of 30-100 µM. …
Production And Characterization Of Encapsulated Thymoquinone Loaded Bacterial Cellulose/Chitosan Composite Nano Film And Investigation Of Its In Vitro Antibacterial Activity, Aytul Bayraktar, Tunc Tuba
Production And Characterization Of Encapsulated Thymoquinone Loaded Bacterial Cellulose/Chitosan Composite Nano Film And Investigation Of Its In Vitro Antibacterial Activity, Aytul Bayraktar, Tunc Tuba
Journal of Food and Drug Analysis
In this study, nanostructured thin films were produced from thymoquinone (TQ)-loaded composites encapsulated with different ratios of bacterial nanocellulose (BNC) to chitosan (CS). The study aimed to investigate their characterization, antibacterial effects, and potential as drug film coating materials. Chemical features and morphological characteristics were determined, and release tests and antibacterial assays were conducted on the thin film layers. As a result, BNC/CS-thymoquinone composite films obtained at different ratios were found to exhibit the highest antibacterial effect, particularly films with a 70% BNC/CS to 30% thymoquinone ratio, against Salmonella typhimurium bacteria.
Enhancing Mango Shelf Life Through Natural Preservation: Investigating The Efficacy Of Polysaccharide Edible Coating And Leaf Extracts, Binh Minh Nguyen Dac, Khoa Hai Le, Van Anh Phan Thi, Van Minh Dao, Trung Dinh Do, Phuong Nguyen-Tri, S. Woong Chang, D. Duc Nguyen, Duong Duc La
Enhancing Mango Shelf Life Through Natural Preservation: Investigating The Efficacy Of Polysaccharide Edible Coating And Leaf Extracts, Binh Minh Nguyen Dac, Khoa Hai Le, Van Anh Phan Thi, Van Minh Dao, Trung Dinh Do, Phuong Nguyen-Tri, S. Woong Chang, D. Duc Nguyen, Duong Duc La
Journal of Food and Drug Analysis
A sustainable solution to prevent the waste of fruits and vegetables from spoilage is the use of edible coatings or films. This research project aimed to create a fresh coating recipe that could effectively extend the shelf life of mangoes. The coating was composed of chitosan, glycerol, and gum Arabic mixed with the extract obtained from the extraction of Cleistocalyx operculatus plant. The prepared exact has a total polyphenol content of 17% and showed potent free radical scavenging abilities in a dose-dependent manner. The chitosan/gum Arabic/Glycerol/extract edible coatings were analyzed using SEM and FTIR spectroscopy, revealing a smooth and uniform …
Unlocking Early Detection Of Alzheimer's Disease: The Emerging Role Of Nanomaterial-Based Optical Sensors, Chun-Hsien Chen, Hsin-Hua Liang, Chun-Chi Wang, Yi-Ting Yang, Yi-Hui Lin, Yen-Ling Chen
Unlocking Early Detection Of Alzheimer's Disease: The Emerging Role Of Nanomaterial-Based Optical Sensors, Chun-Hsien Chen, Hsin-Hua Liang, Chun-Chi Wang, Yi-Ting Yang, Yi-Hui Lin, Yen-Ling Chen
Journal of Food and Drug Analysis
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder that affects millions of individuals worldwide. Researchers have conducted numerous studies to find accurate biomarkers for early AD diagnosis and develop more effective treatments. The main pathological hallmarks of AD are amyloid beta and Tau proteins. Other biomarkers, such as DNA, RNA, and proteins, can also be helpful in early AD diagnosis. To diagnose and treat AD promptly, it is essential to accurately measure the concentration of biomarkers in the cerebrospinal fluid or blood. However, due to the low concentrations of these biomarkers in the body, highly sensitive analytical techniques …
Harnessing Gold Nanomaterials For Advanced Multicolor Colorimetric Biosensors In Food Hazards Detection, Longyingzi Xie, Chenxi Guo, Lu Yang, Yue He
Harnessing Gold Nanomaterials For Advanced Multicolor Colorimetric Biosensors In Food Hazards Detection, Longyingzi Xie, Chenxi Guo, Lu Yang, Yue He
Journal of Food and Drug Analysis
Hazards such as pathogenic bacteria, mycotoxins, pesticides, antibiotics, heavy metal ions, etc., cause serious food safety problems worldwide due to their toxicity and frequent contamination. Rapid screening is an effective way for food safety control, which highly relies on the development of sensitive, specific, and convenient detection methods. The multicolor colorimetric biosensors based on gold nanomaterials have evolved into advanced tools for detecting various hazards in food, with intuitive readout. The excellent localized surface plasmon resonance (LSPR) properties of gold nanomaterials enable them to exhibit bright colors when used as chromophores. In addition, the small changes in the morphology of …
Functional Gold Nanoparticles For Analysis And Delivery Of Nucleic Acids, Po-Tsang Huang, Yen-Ling Chen, Yi-Hui Lin, Chun-Chi Wang, Huan-Tsung Chang
Functional Gold Nanoparticles For Analysis And Delivery Of Nucleic Acids, Po-Tsang Huang, Yen-Ling Chen, Yi-Hui Lin, Chun-Chi Wang, Huan-Tsung Chang
Journal of Food and Drug Analysis
Gold nanoparticles (AuNPs) have become the rising stars in the field of nanotechnology and made a revolution in exploiting the profundity of genomics due to their distinguished properties such as stability, ease in preparation and conjugation, biocompatibility, and unique optical properties. These characteristics have greatly expanded their applications such as sensitive and selective quantitation of nucleic acids and as effective carriers for specifically delivering various important molecules/biomolecules to various targets, which are the cornerstone in treating genetic disorders. This review comprehensively discusses the most recent progress in utilization of AuNPs in quantitation and delivery of nucleic acids. The future prospects …
Preface, Chih-Ching Huang, Yang-Wei Lin, Amit Nain
Preface, Chih-Ching Huang, Yang-Wei Lin, Amit Nain
Journal of Food and Drug Analysis
No abstract provided.
Fluorescent Carbon Nanodot-Based Rapid Cell Nucleus Staining And Application For Diagnosis, Daiming Zhong, Huamin Yuan, Qiuyan Tian, Gongping Deng, Yanhong Ouyang, Yi Chen, Yang Wang, Zhiqin Yuan
Fluorescent Carbon Nanodot-Based Rapid Cell Nucleus Staining And Application For Diagnosis, Daiming Zhong, Huamin Yuan, Qiuyan Tian, Gongping Deng, Yanhong Ouyang, Yi Chen, Yang Wang, Zhiqin Yuan
Journal of Food and Drug Analysis
Cell nucleus status decides the activities of corresponding cells, making its rapid and effective staining important for revealing the actual condition of biological environment in life science and related fields. In this study, fast staining of cell nucleus is realized by fluorescent carbon nanodots (CDs). The staining mechanism is due to the positively charged CD surface-induced cell membrane penetration, which facilitates the CD-nucleus binding via electrostatic attraction. The size of cell nucleus is easily measured with fluorescence imaging technique. In addition, the CD-based cell nucleus stain is applied for discriminating the normal and cancer cells by determining the cell-to-nucleus ratio …
Effects Of Ibuprofen In The Zdf Rat Model Of Type 2 Diabetes, Alexander Gosslau, Unsal Ozdogru, Emmanuel Zachariah, Shiming Li, Chi-Tang Ho
Effects Of Ibuprofen In The Zdf Rat Model Of Type 2 Diabetes, Alexander Gosslau, Unsal Ozdogru, Emmanuel Zachariah, Shiming Li, Chi-Tang Ho
Journal of Food and Drug Analysis
We aimed to investigate the therapeutic potential of ibuprofen against type 2 diabetes (T2D) using obese Zucker diabetic fatty (ZDF) rats as type 2 diabetes model. ZDF rats were hyperglycemic, dyslipidemic and expressed pro-inflammatory markers in contrast to lean controls, thus reflecting the relationship between obesity and chronic inflammation promoting T2D. Chronic treatment with ibuprofen (2-(4-Isobutylphenyl)propanoic acid) was used to study the impact on pathological T2D conditions as compared to metformin (1,1-dimethylbiguanide) treated ZDF as well as lean controls. Ibuprofen decreased A1c but induced a high insulin release with improved glucose tolerance only after early time points (i.g., 15 and …
Citrus Depressa Peel Extract Act As A Prebiotic To Reduce Lipid Accumulation And Modulate Gut Microbiota In Obese Mice, Zheng-Yuan Su, Jie-An Liao, Ching-Ting Lin, Guor-Jien Wei, Yen-Chen Tung
Citrus Depressa Peel Extract Act As A Prebiotic To Reduce Lipid Accumulation And Modulate Gut Microbiota In Obese Mice, Zheng-Yuan Su, Jie-An Liao, Ching-Ting Lin, Guor-Jien Wei, Yen-Chen Tung
Journal of Food and Drug Analysis
Citrus peels contain abundant polyphenols, particularly flavonoids, and have been shown to exert lipid accumulation decreasing ability. In this study, Citrus depressa peel applied to oven drying and extracted with ethanol extract as CDEE to analyze its flavonoids compositions and investigated its effects on a high-fat diet (HFD)-induced obese mice model. CDEE contained several flavonoids such as hesperidin, sinesentin, nobiletin, tangeretin, 5-demethylnobiletin, and 5-demethyltangeretin. The mice fed an HFD, and administration of 2% CDEE to could decrease weight gain, abdominal fat weight, inguinal fat weight, and the adipocyte size, and CDEE also reduced serum total cholesterol (TCHO), triacylglycerol (TG) compared …
Antityrosinase Activity And Lc-Ms/Ms Analysis Of Optimized Ultrasound-Assisted Condition Extracts And Fractions From Strawberry Tree (Arbutus Unedo L.), Serdar Demir, Halil Koyu, Mustafa Abdullah Yilmaz, Abbas Tarhan, Sura Baykan Ozturk
Antityrosinase Activity And Lc-Ms/Ms Analysis Of Optimized Ultrasound-Assisted Condition Extracts And Fractions From Strawberry Tree (Arbutus Unedo L.), Serdar Demir, Halil Koyu, Mustafa Abdullah Yilmaz, Abbas Tarhan, Sura Baykan Ozturk
Journal of Food and Drug Analysis
Investigation of utilization possibilities of natural sources has been an important area for research. Tyrosinase inhibitory activity plays a key role in food and medicine industry. Strawberry tree (Arbutus unedo), a widely distributed plant among Mediterranean countries, possess fruits and leaves with rich bioactive phytochemicals, especially polyphenolic compounds. In this study, we aimed to investigate the antityrosinase activity of the fruit and leaf extracts of the plant, and to determine the phenolic compounds that contribute to the antityrosinase activity. In this regard, we evaluated the effect of solvent composition on the extraction of phenolic compounds from A. unedo …
Detection Of Aflatoxin B1 In Chili Powder Using Attenuated Total Reflectance–Fourier Transform Infrared Spectroscopy, Thin Thin Sein, Urairat Mongmonsin, Patutong Chatchawal, Molin Wongwattanakul, Oranee Srichaiyapol, Rungrueang Pattanakul, Patcharaporn Tippayawat
Detection Of Aflatoxin B1 In Chili Powder Using Attenuated Total Reflectance–Fourier Transform Infrared Spectroscopy, Thin Thin Sein, Urairat Mongmonsin, Patutong Chatchawal, Molin Wongwattanakul, Oranee Srichaiyapol, Rungrueang Pattanakul, Patcharaporn Tippayawat
Journal of Food and Drug Analysis
Aflatoxin B1, a major global food safety concern, is produced by toxigenic fungi during crop growing, drying, and storage, and shows increasing annual prevalence. This study aimed to detect aflatoxin B1 in chili samples using ATR–FTIR coupled with machine learning algorithms. We found that 83.6% of the chili powder samples were contaminated with Aspergillus and Penicillium species, with aflatoxin B1 levels ranging from 7.63 to 44.32 µg/kg. ATR–FTIR spectroscopy in the fingerprint region (1800−400 cm-1) showed peak intensity variation in the bands at 1587, 1393, and 1038 cm-1, which are mostly related …
Comparative Bioactivity Assessment Of Bixin Pigment And Associated Phytochemicals Extracted From Annatto Seeds Using Conventional And Green Solvents, Sonakshi Puri, Sumit Kumar Mandal, Harshit Jain, Pankaj Kumar Sharma, Perinkulam Ravi Deepa
Comparative Bioactivity Assessment Of Bixin Pigment And Associated Phytochemicals Extracted From Annatto Seeds Using Conventional And Green Solvents, Sonakshi Puri, Sumit Kumar Mandal, Harshit Jain, Pankaj Kumar Sharma, Perinkulam Ravi Deepa
Journal of Food and Drug Analysis
Nutraceuticals, that include food ingredients and bioactives from natural products, confer physiological health benefits and protection against chronic diseases. Annatto is a tropical shrub grown in Central and South America and parts of India. Its seeds are rich in the edible carotenoid-derived apocarotenoid pigment, bixin, which is used as a natural colorant in food, textiles, and cosmetics, and is now gaining attention for its potential health-promoting attributes. Here, we compared a green solvent (ethyl lactate) based extraction of bixin and associated metabolites in annatto seeds (crushed and seed coat) with two other conventional solvents (acetone and acid-base). Bixin was characterized …
Chemical Constituents From A Marine Medicinal Brown Alga-Derived Xylaria Acuta Sc1019, Hsiao-Yang Hsi, Shih-Wei Wang, George Hsiao, Li-Kwan Chang, Yuan-Chung Cheng, Shu-Jung Huang, Yi-Shan Lu, Tzong-Huei Lee
Chemical Constituents From A Marine Medicinal Brown Alga-Derived Xylaria Acuta Sc1019, Hsiao-Yang Hsi, Shih-Wei Wang, George Hsiao, Li-Kwan Chang, Yuan-Chung Cheng, Shu-Jung Huang, Yi-Shan Lu, Tzong-Huei Lee
Journal of Food and Drug Analysis
In this study, a marine medicinal brown alga Sargassum cristaefolium-derived fungal strain Xylaria acuta SC1019 was isolated and identified. Column chromatography of the extracts from liquid- and solid-fermented products of the fungal strain was carried out, and led to the isolation of twenty-one compounds. Their structures were characterized by spectroscopic analysis, and the absolute configurations were further established by single X-ray diffraction analysis or modified Mosher’s method as nine previously undescribed compounds, namely xylarilactones A–C (1–3), ent-gedebic acid 8-O-α-D-glucopyranoside (4), 5R-hydroxylmethylmellein 11-O-α-D-glucopyranoside (5), ent …