Medicinal Chemistry and Pharmaceutics | Open Access Articles

Mulberry Fruits Extracts Induce Apoptosis And Autophagy Of Liver Cancer Cell And Prevent Hepatocarcinogenesis In Vivo, Kwok-Chui Cheng, Chau-Jong Wang, Yun-Ching Chang, Tung-Wei Hung, Chun-Jung Lai, Chi-Wen Kuo, Hui-Pei Huang

Journal of Food and Drug Analysis

No abstract provided.

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Biotransformation Of Mogrosides From Siraitia Grosvenorii By Ganoderma Lucidum Mycelium And The Purification Of Mogroside Iii E By Macroporous Resins, Chun-Hui Chiu, Reuben Wang, Shasha Zhuang, Pei-Yin Lin, Yi-Chen Lo, Ting-Jang Lu

Journal of Food and Drug Analysis

No abstract provided.

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Gas Chromatography-Mass Spectrometry-Based Analytical Strategies For Fatty Acid Analysis In Biological Samples, H.-H. Chiu, C.-H. Kuo

Journal of Food and Drug Analysis

Over the past few decades, phytochemicals widely present in edible plants have exhibited compelling positive biological impact on human health, including treating some cancers. In some cases, metabolites and artificially modified products of these natural compounds have shown better chemopreventive effects than their natural counterparts. Along with direct chemopreventive strategies using phytochemicals to treat cancer by leading to cell cycle arrest, autophagy and apoptosis, natural compounds have been shown to reverse adverse epigenetic regulation, including altering DNA methylation and histone modification, modulating miRNA expression, promoting expression of phase II enzyme for detoxification, balancing inflammation responses, recovering circadian rhythm from misalignment, …

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A Mechanistic And Empirical Review Of Antcins, A New Class Of Phytosterols Of Formosan Fungi Origin, Kumar K.J. Senthil, Vani M. Gokila, Chieh-Yin Chen, Wen-Wei Hsiao, Jing Li, Zhan-Xi Lin, Fang-Hua Chu, Gow-Chin Yen, Sheng-Yang Wang

Journal of Food and Drug Analysis

Tumor cell-induced platelet aggregation (TCIPA) is a mechanism that involves the protection of tumor cells in the circulation and the promotion of tumor cell invasion and metastases. The C-type lectin-like receptor 2 (CLEC-2) that binds podoplanin (PDPN) is on the platelet surface and facilitates the TCIPA. Selective blockage of the PDPN-mediated platelet-tumor cell interaction is thereby a plausible strategy for inhibiting metastases. In a search for antagonists of PDPN- and tumor cell-induced platelet aggregation, traditional Chinese medicines were screened and it was found that the water extract of Artemisia argyi leaves selectively inhibited the PDPN-induced platelet aggregation. Bioactivity-guided fractionation analysis …

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Recent Advances In Cancer Chemoprevention With Phytochemicals, Yen-Chun Koh, Chi-Tang Ho, Min-Hsiung Pan

Journal of Food and Drug Analysis

In the present study, we investigated the effects of Probiotic mix 1 (Pm1) with Lactobacillus plantarum subsp. plantarum, Lactobacillus paracasei subsp. paracasei, and Streptococcus salivarius subsp. thermophilus on preventing renal injury using a chronic kidney disease (CKD) minipig model previously developed in our lab using cisplatin-induced CKD in Lanyu pigs. The results indicated that the high dosage Pm1 (H.Pm1) group demonstrated lower incidence of lesions, including atrophy, mononuclear inflammation, cell infiltration, and interstitial fibrosis in renal tubules in hematoxylin and eosin (H&E) and Masson's trichrome stain. We further systematically investigated the preventing effect of Pm1. The H.Pm1 group decreased inflammatory …

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Hyaluronic Acid Coated Targeted Lipid Micellar Nanoparticle As A Delivery Vehicle For Lapatinib And Ketoconazole In Egfr Mutated Lung Cancer, Nadia Tasnim Ahmed

USF Tampa Graduate Theses and Dissertations

Background: According to the American Cancer Society, lung cancer was accountable for over 142,000 deaths in the USA in 2019. Common mutations related to lung cancer mainly occur in TP53, EGFR, and KRAS genes. Lapatinib is a small molecule tyrosine kinase inhibitor which acts reversibly on both epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). Overexpression of EGFR leads to increased production and signaling of proteins that cause upregulation of cellular proliferation, cholesterol synthesis and resistance to apoptosis. Ketoconazole is an imidazole antifungal agent which works principally by inhibiting the enzyme cytochrome P450 14α-demethylase (CYP51A1) …

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Evaluation Of Analysis Of Cholesterol Oxidation Products And Heterocyclic Amines In Duck And Their Formation As Affected By Roasting Methods, Kai-Yu Hsu, Baskaran Stephen Inbaraj, Bing-Huei Chen

Journal of Food and Drug Analysis

Roast duck, a popular meat commodity in Asian countries especially Taiwan and China, can produce many types of toxic compounds such as cholesterol oxidation products (COPs) and heterocyclic amines (HAs). The objectives of this study were to evaluate analysis of COPs and HAs in duck by GCeMS and UPLC-MS/MS respectively, and study their formation as affected by roasting methods including traditional oven, fan oven and superheated steam oven. Results showed that both high precision and accuracy was attained by using the QuEChERS method with reduced separation time of 14 min for 7 COPs and 4.5 min for 21 HAs by …

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Preparation, Evaluation And Metabolites Study In Rats Of Novel Isoginkgetin-Loaded Tpgs/Soluplus Mixed Nanomicelles, Xue Feng, Yu-Ting Chen, Lu-Ya Li, Yu-Peng Sun, Hai-Rong Wang, Lan-Tong Zhang

Journal of Food and Drug Analysis

At present, cancer is one of the most lethal diseases in the world, and researchers are committed to developing effective anticancer drugs. Isoginkgetin (IGG) is a kind of biflavone with the potential to treat cancer due to the features of altering the cell cycle and inhibiting tumor cell infiltration. However, its solubility, absorbability and bioavailability are poor, so in this study, IGG was prepared into mixed nanomicelles and evaluated in vitro and in vivo. After condition optimization, IGG-loaded TPGS/soluplus mixed nanomicelles with particle size of 62.34 ± 1.10 nm, entrapment efficiency of 96.92 ± 0.66% and drug loading of 2.42 …

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Rapid Identification Of Nicotine In Electronic Cigarette Liquids Based On Surface-Enhanced Raman Scattering, Jun-Yi Chien, Yong-Chun Gu, Hsin-Mei Tsai, Chun-Hao Liu, Chia-Yuan Yen, Yuh-Lin Wang, Juen-Kai Wang, Chi-Hung Lin

Journal of Food and Drug Analysis

Nicotine-containing electronic cigarette liquid (e-liquid) is prohibited in many countries, creating requirements for rapid detection approaches for on-site inspection or screening for large amounts of samples. Here, we demonstrate a simple way to identify nicotine using surface-enhanced Raman scattering (SERS) with substrates made of silver nanoparticle arrays imbedded in anodic aluminum oxide nanochannels (Ag/AAO). Compared with the reported colloidal nanoparticle-based SERS, that required serial dilutions to enable colloid aggregation in the viscous e-liquid, a small amount of undiluted e-liquid sample can be directly added onto our solid-phase Ag/AAO substrate without any pre-treatment. The sensitivity of our SERS measurements is 2e3 …

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A Multi-Analyte Lc-Ms/Ms Method For Screening And Quantification Of Nitrosamines In Sartans, Shu-Han Chang, Ching-Chia Chang, Li-Jing Wang, Wei-Ching Chen, Shu-Yu Fan, Chi-Zong Zang, Ya-Hui Hsu, Mei-Chih Lin, Su-Hsiang Tseng, Der-Yuan Wang

Journal of Food and Drug Analysis

An incident of sartan medicine contamination was notified by Europe in June 2018. The contaminant was identified as a probable carcinogenic nitrosamine and the recalls of sartan medicines were soon made. Since then, more nitrosamine contaminants in sartan medicines were reported. To broaden the applicability and variety in nitrosamine determination, a multi-analyte method is required. In this study, a feasible and sensitive multi-analyte LC-MS/MS method for determination of 12 nitrosamines in sartans was established, where the active pharmaceutical ingredients and final products merchandised in Taiwan were also examined. Chromatographic separation was achieved on an Xselect® HSS T3 column (15 cm …

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Anti-Inflammatory Effects Of Peptides From A Marine Algicolous Fungus Acremonium Sp. Ntu492 In Bv-2 Microglial Cells, George Hsiao, Shih-Wei Wang, Yin-Ru Chiang, Wei-Chiung Chi, Yueh-Hsiung Kuo, Do Anh Phong, Chia-Yu Chen, Tzong-Huei Lee

Journal of Food and Drug Analysis

Located in tropical and subtropical region, Taiwan is an island with high algal species diversity. In this study, a number of fungal strains were isolated from marine macroalgae collected from northeastern intertidal zone of Taiwan. Preliminary anti-inflammatory screening has shown that the methanolic extracts of solid fermented products of the red alga Mastophora rosea-derived fungal strain Acremonium sp. NTU492 exhibited significant bioactivity. In an attempt to disclose the active principles from this fungal strain, a series of separation and purification was thus undertaken, which has led to the isolation and characterization of seven compounds including four new peptides, namely acrepeptins …

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A Rapid Strategy For Screening High-Efficiency Pcsk9 Inhibitors From Ginkgo Biloba Leaves By Ligand Fishing, Hplc-Q-Tof-Ms And Interdisciplinary Assay, Li Li, Meng-Lin Fan, Ya-Nan Li, Ya-Xuan Huang, Xiu-Feng Liu, Ji-Hua Liu

Journal of Food and Drug Analysis

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an attractive target for new cholesterol-lowering drug development. Here, we developed a method integrating ligand fishing, HPLC-Q-TOF-MS and interdisciplinary assay, aiming to explore potential PCSK9 inhibitors from mixtures rapidly and accurately. PCSK9 was expressed and purified firstly, and then the recombined PCSK9 was coated on the surface of magnetic beads (MBs). The PCSK9-immobilized MBs (PCSK9-MBs) were used for ligand fishing combined with HPLC and Q-TOF-MS/MS. Ginkgo biloba leaves (GBL), an herbal medicine widely used in Asia and Europe with good efficacy in treatment of hypercholesterolemia, were chosen as an illustration for ligand fishing. …

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Analysis Of Flavor And Other Metabolites In Lemon Juice (Citrus Limon) From Huanglongbing-Affected Trees Grafted On Different Rootstocks, Laura Reuss, Shi Feng, Wei-Lun Hung, Qibin Yu, Frederick G. Gmitter Jr, Yu Wang

Journal of Food and Drug Analysis

Flavor perception integrates sensory input from chemical receptors triggered by taste- and aroma-active metabolites to contribute to food flavor quality. Many factors alter flavor quality. Disease affects aroma and flavonoid constituents, causing off-flavors in plants. Huanglongbing (HLB) disease negatively affects citrus, although lemons are more tolerant. Lemon juice quality of HLB-affected fruits is not well studied. Lemon juice aroma-active compounds were profiled in this study using gas chromatography/mass spectrometry-olfactometry, and other metabolites contributing to overall flavor quality were investigated. Lemon juice from different rootstocks was discriminated using the metabolic profile. Flavor and other lemon juice metabolites also distinguished symptomatic from …

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Chemometric Authentication Of Pu'er Teas In Terms Of Multielement Stable Isotope Ratios Analysis By Ea-Irms And Icp-Ms, Honglin Liu, Yitao Zeng, Xin Zhao, Huarong Tong

Journal of Food and Drug Analysis

In this work, the stable isotope ratios of carbon, nitrogen, hydrogen, oxygen, and mineral elements and their stoichiometric methods were examined as possible factors that could certify Chinese tea based on its production years. A total of 43 multi-element stable isotope ratios of Xiangzhujing Pu'er tea in five production years were determined through inductively coupled plasma mass spectrometry (ICP-MS) and elemental analyzer-isotope ratio mass spectrometry (EA-IRMS) methods. Two unsupervised learning techniques (principal component analysis and hierarchical clustering analysis) and three supervised learning techniques (partial least squares discriminant analysis [PLS-DA], back-propagation artificial neural network [BP-ANN], and linear discriminant analysis [LDA]) were …

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The Chemical Aspects Of Raman Spectroscopy: Statistical Structure-Spectrum Relationship In The Analyses Of Bioflavonoids, Chih-Hsien Wang, Chia-Chi Huang, Wenlung Chen, Yen-Shi Lai

Journal of Food and Drug Analysis

Raman spectroscopy has been accepted as a useful tool for the characterization of natural products. However, to identify a specific compound in a mixture sample of natural products using Raman spectra alone is highly challenging if not impossible. We demonstrated an effective solution to such issues using a method combining statistical Raman spectroscopy and Mass spectrometry. The method was validated with a successful application to the identification of the major anthocyanin components in a purple yam (Dioscorea purpurea) extract. Of particular interest is that statistical grouping of the bioflavonoid standards that formed the database of this study was found to …

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Screening For Malachite Green Contamination On Live Fish Skin With Chewing Gum Based Viscoelastic Sers Sensor, Wan-Li Fan, Shi-Wei Yang, Dong-Mei Wang, Zheng-Jun Gong, Mei-Kun Fan

Journal of Food and Drug Analysis

Malachite green (MG), a prohibited but still found antimicrobial in aquafarm and during live fish shipping, is a hot target in food safety screening. Herein, a novel chewing gum based flexible SERS (G-SERS) sensor was proposed for rapid sampling and detection of MG on live fish skin. The whole analysis takesmin, while the limit of detection for MG is 0.73 pg. Different from other reports, MG contaminated live fish was monitored daily with the G-SERS sensor, during which the fish was firstly raised in 0.5 ppm MG solution for one day, followed by freshwater for a week. It was found …

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Uplc-Qtof-Ms Fingerprinting Combined With Chemometrics To Assess The Solvent Extraction Efficiency, Phytochemical Variation, And Antioxidant Activities Of Beta Vulgaris L., Junyi Wang, Guddadarangavvanahally Krishnareddy Jayaprakasha, Bhimanagouda S. Patil

Journal of Food and Drug Analysis

Accurate assays of plant antioxidants and other phytochemicals require efficient extraction conditions and enable rigorous assessments of crop varieties and production systems. This study assessed the extraction of phytochemicals and antioxidants from conventionally or organically grown red and golden beets (Beta vulgaris L.), using twenty solvent (S1eS20) mixtures containing water, methanol, and ethanol alone or with acids (ascorbic, formic, acetic). Red beetroot extracted with methanol with or without acid had the highest betanin content (2791.0 mg/g and 8222.3 mg/g of fresh weight [FW], respectively) and golden beetroot extracted with methanol/ascorbic acid/water had the highest vulgaxanthin I (193.7 mg/g and 15.0 …

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Food Preservative Sorbic Acid Deregulates Hepatic Fatty Acid Metabolism, Chia-Hui Chen, Sin-Ni Ho, Po-An Hu, Yu Ru Kou, Tzong-Shyuan Lee

Journal of Food and Drug Analysis

Sorbic acid (SA) is one of the most commonly used food preservatives worldwide. Despite SA having no hepatotoxicity at legal dosages, its effect on hepatic lipid metabolism is still unclear. We investigated the effect of SA on hepatic lipid metabolism and its mechanism of action in C57BL/6 mice. Daily treatment with SA (1 g/kg in diet) for 4 weeks did not alter the body weight, organ weight, and blood lipids in mice. However, hepatic lipid accumulation, particularly that of triglycerides, fatty acids, and glycerol, but not cholesteryl ester and free cholesterol, was increased with SA treatment. Mechanistically, SA decreased the …

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The Potential Role Of Phenolic Compounds On Modulating Gut Microbiota In Obesity, Gow-Chin Yen, Hsin-Lin Cheng, Li-Yu Lin, Shiuan-Chih Chen, Chin Lin Hsu

Journal of Food and Drug Analysis

Obesity is a rising public health issue and challenge which is tightly correlated with socio-economic development paralleled with increased energy intake and sedentary behavior that subsequently cause adipose tissue accumulation. Physiological and metabolic status changes during obesity development have been suggested with low grade inflammation of gastrointestinal tract. The gut microbiota plays an essential role in regulating whole body energy metabolism and also lipid accumulation, and immunity of host. However, the detail mechanism of which the gut microbiota composition influence obesity development in humans still need deeper investigation owing to the complex pathophysiology of such disease. Recently, the consumption of …

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Transcriptome Studies On The Toxicity Of Silica Nanoparticles, Shih-Yi Hsu

USF Tampa Graduate Theses and Dissertations

Nanotechnology enables more precise harmony in health condition via reducing the dosage amount, improving the delivery of hydrophobic drugs, more specific targeting to the cancerous sites, and so on. Nevertheless, issues regarding the toxicity of nanotechnology have begun to call for attention several decades later after the innovation of nanotechnology. Tools about risk management of nanotechnology have been developed, but recently not much evidence recognizes the toxicity of nanoparticles (NPs) except for some animal studies, which demonstrated organ damage after the exposure to NPs. Toxicogenomic approach refers to the method utilizing gene expression to evaluate the chemical toxicity. Databases as …

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Development Of A Pharmaceutical Tablet Authentication System Using Spectroscopic Techniques In Combination With Multivariate Chemometric Methods, Md Nayeem Hossain

Electronic Theses and Dissertations

The spread of falsified drugs is increasing worldwide. Currently, 10%-30% of drugs in the world are falsified. Unfortunately, the supply chain system of developing countries (from manufacturers to customers) is not well monitored and suffers the highest rates of fraudulent activities. Also, the rise of product procurement from the internet increases the chance of American consumers' exposure to poor quality drugs. To combat this horrendous activity, surveillance of pharmaceutical materials is required in the supply chain system. Spectroscopic techniques (e.g., Near-Infrared and Raman spectroscopies) can be a potential solution to authenticate samples in different locations; they are non-destructive, safe, rapid, …

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Study Of Pharmaceutical Tablets Using Raman Mapping, Kyle Joseph Pauly

Honors Theses

Covalent bonds are the strongest type of bonds holding molecules together. Based on the pattern of bonding of the molecule, the atoms associated with the bond will vibrate at a specific frequency. Utilizing vibrational spectroscopy, such as Raman spectroscopy, these unique vibrational frequencies can be used to detect the presence of analytes over a selected area. Furthermore, the intensities of the vibrational modes can be tracked to comparatively quantify the concentration of analytes at various locations. This is a method of great importance due to its ability to compare pharmaceutical tablets synthesized with different techniques. Here, the presence and concentration …

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Long-Distance Phasing Of A Tentative "Enhancer" Single-Nucleotide Polymorphism With Yp2d6 Star Allele Definitions, Erin C. Boone, Wendy Y. Wang, R Gaedigk, Mariana Cherner, Anick Bérard, J Steven Leeder, Neil A. Miller, Andrea Gaedigk

Manuscripts, Articles, Book Chapters and Other Papers

Background: The CYP2D6 gene locus has been extensively studied over decades, yet a portion of variability in CYP2D6 activity cannot be explained by known sequence variations within the gene, copy number variation, or structural rearrangements. It was proposed that rs5758550, located 116 kb downstream of the CYP2D6 gene locus, increases gene expression and thus contributes to variability in CYP2D6 activity. This finding has, however, not been validated. The purpose of the study was to address a major technological barrier, i.e., experimentally linking rs5758550, also referred to as the "enhancer" single-nucleotide polymorphism (SNP), to CYP2D6 haplotypes >100 kb away. To overcome …

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Design And Synthesis Of Novel Analogs As Potential Antitubercular Agents, Peggy Mccluggage

Honors Theses

Tuberculosis (TB) is an infectious, airborne disease which primarily infects the lungs. One-third of the world’s population is currently estimated to be infected with Mycobacterium tuberculosis (Mtb), the causative agent for TB [1]. Current treatment for this disease requires at least six months of taking multiple antibiotics with undesirable side effects [2]. Difficulty in complying to this regimen as well as the prevalence of HIV/AIDS has led to antimicrobial resistance seen in Mtb. In order to combat the Multi-Drug Resistant and Extensively-Drug Resistant strains of the disease-causing bacteria, preventative care and novel antibiotics are urgently needed [3]. The purpose for …

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Therapeutic Drug Monitoring Of Apixaban Using Chromogenic Kits, Brooke Vogel

Undergraduate Honors Theses

Apixaban is a novel oral anticoagulant that prevents clotting by directly inhibiting Factor Xa in the coagulation cascade. Due to its different pharmacokinetics, previous standards for testing anticoagulant concentrations are ineffective at measuring apixaban. In this study, Hyphen Biomed Biophen Direct Xa Inhibitor and Biophen Heparin chromogenic kits from Aniara Diagnostica were used along with a NanoDrop™ One/One^C Microvolume UV-Vis Spectrophotometer to see if either of these kits provide acceptable precision and accuracy for the quantification of apixaban in plasma samples, as well as if there is a significant difference in these two kits at varying concentrations of apixaban. …

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Antidepressants Versus Music Therapy: Which Treatment Is Better For Treating Depression In Parkinson's Disease?, Emaan Dawood

Virginias Collegiate Honors Council Conference

Music and medicine are merging to treat depression in Parkinson’s disease (PD). Antidepressants, the current standard, demonstrate mixed effects in clinical trials, warranting other treatment options. Here, I compare music therapy to antidepressants in the treatment of depression in PD via literature review. Studies of depressed PD patients undergoing music therapy and/or antidepressants were reviewed with attention to variables including depression (on a patient-reported outcome) that were measured pre- and post- therapy. In the music studies, improvements were seen in depression. Methodological inconsistencies across these studies, a paucity of studies, and small sample sizes, however, necessitate more research to reach …

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Orally Administered Nanoscale Drug Delivery System For Colorectal Cancer, Bhavya Shah

USF Tampa Graduate Theses and Dissertations

Mithramycin-A (Mit-A) is a US Food and Drug Administration (FDA) approved chemotherapeutic agent that is used for the treatment of testicular cancer. According to previous studies, Mit-A has shown promising results in targeting colorectal cancer (CRC) and cancer stem cells (CSCs) which are responsible for a highly invasive and metastatic forms of CRC. The use of Mit-A as chemotherapy is limited in CRC due to its toxicity. To minimize its toxicity, we have developed an orally delivered nanoscale drug delivery system by which Mit-A can be delivered using biocompatible and biodegradable materials. Mit-A nanoparticles were prepared using Poly(lactic-co-glycolic acid) as …

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Luciferase Reporter Crc Cell Line For Bioluminescence Imaging In Orthotopic Tumor Model, Pratik Chopade

USF Tampa Graduate Theses and Dissertations

CRC is the second most common type of cancer in women and the third most common type of cancer in men. It accounts for 9.7% of all cancers in terms of people diagnosed. Measuring the real-time effect of chemotherapeutic drugs has been a major obstacle in developing a tumor model mouse. Tracking the regression of cancer cells after chemotherapy could be an effective way to resolve this issue. Therefore, cancer cells expressing the constitutive luciferase reporter gene can be a potential solution. The biggest advantage of the luciferase (Luc) reporter is that it is detectable at very low concentrations in …

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Identification Of Snps Associated With Multiple Antibiotic Resistance Genes In Eight Clinical Variants Of Enterococcus Faecium., Krishna S. Karia

USF Tampa Graduate Theses and Dissertations

The evolution of multi drug resistant (MDR) bacteria has been well documented these last decade, suggesting that resistance to antibiotics is most commonly associated to single nucleotide polymorphism (SNPs) mutation. To this aim, several molecular methods have been performed to elucidate SNPs in the increasing number of resistant microorganisms. Early detection of MDR bacteria has become of prime necessity in order to combat the disease and ensure public health. Therefore, this research was conducted to screen for SNP mutations correlated to drug resistance in some nosocomial MDR bacteria strains donated from Moffitt Cancer Center (MCC) hospital. Blood, stool, urine, and …

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A Micro-Nano Particle System For Sustained Drug Release In Lung Cancer Therapy, Heta N. Jadhav

USF Tampa Graduate Theses and Dissertations

Lung cancer remains the leading cause of cancer-related mortality in men and women worldwide (National Comprehensive Cancer Network). Hence, developing an effective new therapy to treat lung cancer is under intense investigation. Specifically, the sustained release of a drug in lung tumors is critically important. Previous studies at the USF have shown that telmisartan exhibits synergistic properties when combined with Actinomycin-D for lung cancer treatment. The objective of this study is to develop a novel micro/nano system consisting of lipids and chitosan polymers that would be able to deliver Tel directly to the lungs and release its payloads in a …

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Full-Text Articles in Medicinal Chemistry and Pharmaceutics

Mulberry Fruits Extracts Induce Apoptosis And Autophagy Of Liver Cancer Cell And Prevent Hepatocarcinogenesis In Vivo, Kwok-Chui Cheng, Chau-Jong Wang, Yun-Ching Chang, Tung-Wei Hung, Chun-Jung Lai, Chi-Wen Kuo, Hui-Pei Huang

Journal of Food and Drug Analysis

Biotransformation Of Mogrosides From Siraitia Grosvenorii By Ganoderma Lucidum Mycelium And The Purification Of Mogroside Iii E By Macroporous Resins, Chun-Hui Chiu, Reuben Wang, Shasha Zhuang, Pei-Yin Lin, Yi-Chen Lo, Ting-Jang Lu

Journal of Food and Drug Analysis

Gas Chromatography-Mass Spectrometry-Based Analytical Strategies For Fatty Acid Analysis In Biological Samples, H.-H. Chiu, C.-H. Kuo

Journal of Food and Drug Analysis

A Mechanistic And Empirical Review Of Antcins, A New Class Of Phytosterols Of Formosan Fungi Origin, Kumar K.J. Senthil, Vani M. Gokila, Chieh-Yin Chen, Wen-Wei Hsiao, Jing Li, Zhan-Xi Lin, Fang-Hua Chu, Gow-Chin Yen, Sheng-Yang Wang

Journal of Food and Drug Analysis

Recent Advances In Cancer Chemoprevention With Phytochemicals, Yen-Chun Koh, Chi-Tang Ho, Min-Hsiung Pan

Journal of Food and Drug Analysis

Hyaluronic Acid Coated Targeted Lipid Micellar Nanoparticle As A Delivery Vehicle For Lapatinib And Ketoconazole In Egfr Mutated Lung Cancer, Nadia Tasnim Ahmed

USF Tampa Graduate Theses and Dissertations

Evaluation Of Analysis Of Cholesterol Oxidation Products And Heterocyclic Amines In Duck And Their Formation As Affected By Roasting Methods, Kai-Yu Hsu, Baskaran Stephen Inbaraj, Bing-Huei Chen

Journal of Food and Drug Analysis

Preparation, Evaluation And Metabolites Study In Rats Of Novel Isoginkgetin-Loaded Tpgs/Soluplus Mixed Nanomicelles, Xue Feng, Yu-Ting Chen, Lu-Ya Li, Yu-Peng Sun, Hai-Rong Wang, Lan-Tong Zhang

Journal of Food and Drug Analysis

Rapid Identification Of Nicotine In Electronic Cigarette Liquids Based On Surface-Enhanced Raman Scattering, Jun-Yi Chien, Yong-Chun Gu, Hsin-Mei Tsai, Chun-Hao Liu, Chia-Yuan Yen, Yuh-Lin Wang, Juen-Kai Wang, Chi-Hung Lin

Journal of Food and Drug Analysis

A Multi-Analyte Lc-Ms/Ms Method For Screening And Quantification Of Nitrosamines In Sartans, Shu-Han Chang, Ching-Chia Chang, Li-Jing Wang, Wei-Ching Chen, Shu-Yu Fan, Chi-Zong Zang, Ya-Hui Hsu, Mei-Chih Lin, Su-Hsiang Tseng, Der-Yuan Wang

Journal of Food and Drug Analysis

Anti-Inflammatory Effects Of Peptides From A Marine Algicolous Fungus Acremonium Sp. Ntu492 In Bv-2 Microglial Cells, George Hsiao, Shih-Wei Wang, Yin-Ru Chiang, Wei-Chiung Chi, Yueh-Hsiung Kuo, Do Anh Phong, Chia-Yu Chen, Tzong-Huei Lee

Journal of Food and Drug Analysis

A Rapid Strategy For Screening High-Efficiency Pcsk9 Inhibitors From Ginkgo Biloba Leaves By Ligand Fishing, Hplc-Q-Tof-Ms And Interdisciplinary Assay, Li Li, Meng-Lin Fan, Ya-Nan Li, Ya-Xuan Huang, Xiu-Feng Liu, Ji-Hua Liu

Journal of Food and Drug Analysis

Analysis Of Flavor And Other Metabolites In Lemon Juice (Citrus Limon) From Huanglongbing-Affected Trees Grafted On Different Rootstocks, Laura Reuss, Shi Feng, Wei-Lun Hung, Qibin Yu, Frederick G. Gmitter Jr, Yu Wang

Journal of Food and Drug Analysis

Chemometric Authentication Of Pu'er Teas In Terms Of Multielement Stable Isotope Ratios Analysis By Ea-Irms And Icp-Ms, Honglin Liu, Yitao Zeng, Xin Zhao, Huarong Tong

Journal of Food and Drug Analysis

The Chemical Aspects Of Raman Spectroscopy: Statistical Structure-Spectrum Relationship In The Analyses Of Bioflavonoids, Chih-Hsien Wang, Chia-Chi Huang, Wenlung Chen, Yen-Shi Lai

Journal of Food and Drug Analysis

Screening For Malachite Green Contamination On Live Fish Skin With Chewing Gum Based Viscoelastic Sers Sensor, Wan-Li Fan, Shi-Wei Yang, Dong-Mei Wang, Zheng-Jun Gong, Mei-Kun Fan

Journal of Food and Drug Analysis

Uplc-Qtof-Ms Fingerprinting Combined With Chemometrics To Assess The Solvent Extraction Efficiency, Phytochemical Variation, And Antioxidant Activities Of Beta Vulgaris L., Junyi Wang, Guddadarangavvanahally Krishnareddy Jayaprakasha, Bhimanagouda S. Patil

Journal of Food and Drug Analysis

Food Preservative Sorbic Acid Deregulates Hepatic Fatty Acid Metabolism, Chia-Hui Chen, Sin-Ni Ho, Po-An Hu, Yu Ru Kou, Tzong-Shyuan Lee

Journal of Food and Drug Analysis

The Potential Role Of Phenolic Compounds On Modulating Gut Microbiota In Obesity, Gow-Chin Yen, Hsin-Lin Cheng, Li-Yu Lin, Shiuan-Chih Chen, Chin Lin Hsu

Journal of Food and Drug Analysis

Transcriptome Studies On The Toxicity Of Silica Nanoparticles, Shih-Yi Hsu

USF Tampa Graduate Theses and Dissertations

Development Of A Pharmaceutical Tablet Authentication System Using Spectroscopic Techniques In Combination With Multivariate Chemometric Methods, Md Nayeem Hossain

Electronic Theses and Dissertations

Study Of Pharmaceutical Tablets Using Raman Mapping, Kyle Joseph Pauly

Honors Theses

Long-Distance Phasing Of A Tentative "Enhancer" Single-Nucleotide Polymorphism With Yp2d6 Star Allele Definitions, Erin C. Boone, Wendy Y. Wang, R Gaedigk, Mariana Cherner, Anick Bérard, J Steven Leeder, Neil A. Miller, Andrea Gaedigk

Manuscripts, Articles, Book Chapters and Other Papers

Design And Synthesis Of Novel Analogs As Potential Antitubercular Agents, Peggy Mccluggage

Honors Theses

Therapeutic Drug Monitoring Of Apixaban Using Chromogenic Kits, Brooke Vogel

Undergraduate Honors Theses

Antidepressants Versus Music Therapy: Which Treatment Is Better For Treating Depression In Parkinson's Disease?, Emaan Dawood

Virginias Collegiate Honors Council Conference

Orally Administered Nanoscale Drug Delivery System For Colorectal Cancer, Bhavya Shah

USF Tampa Graduate Theses and Dissertations

Luciferase Reporter Crc Cell Line For Bioluminescence Imaging In Orthotopic Tumor Model, Pratik Chopade

USF Tampa Graduate Theses and Dissertations

Identification Of Snps Associated With Multiple Antibiotic Resistance Genes In Eight Clinical Variants Of Enterococcus Faecium., Krishna S. Karia

USF Tampa Graduate Theses and Dissertations

A Micro-Nano Particle System For Sustained Drug Release In Lung Cancer Therapy, Heta N. Jadhav

USF Tampa Graduate Theses and Dissertations