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Articles 811 - 840 of 1010
Full-Text Articles in Medicinal Chemistry and Pharmaceutics
Transporter-Mediated Interaction Of Indican And Methotrexate In Rats, S.-P. Lin, C.-P. Yu, Y.-C. Hou, C.-Y. Huang, L.-C. Ho, S.-L. Chan
Transporter-Mediated Interaction Of Indican And Methotrexate In Rats, S.-P. Lin, C.-P. Yu, Y.-C. Hou, C.-Y. Huang, L.-C. Ho, S.-L. Chan
Journal of Food and Drug Analysis
Indican (indoxyl-β-D-glucoside) is present in several Chinese herbs e.g. Isatis indigotica, Polygonum tinctorium and Polygonum perfoliatum. The major metabolite of indican was indoxyl sulfate (IS), an uremic toxin which was a known substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4. Methotrexate (MTX), an important immunosuppressant with narrow therapeutic window, is a substrate of OAT 1, 2, 3, 4 and MRP 1, 2, 3, 4. We hypothesized that IS, the major metabolite of oral indican, might inhibit the renal excretion of MTX mediated by OAT 1, OAT 3 and MRP 4. Therefore, this study …
Transporter-Mediated Natural Product–Drug Interactions For The Treatment Of Cardiovascular Diseases, W. Zha
Transporter-Mediated Natural Product–Drug Interactions For The Treatment Of Cardiovascular Diseases, W. Zha
Journal of Food and Drug Analysis
The growing use of natural products in cardiovascular (CV) patients has been greatly raising the concerns about potential natural product–CV drug interactions. Some of these may lead to unexpected cardiovascular adverse effects and it is, therefore, essential to identify or predict potential natural product–CV drug interactions, and to understand the underlying mechanisms. Drug transporters are important determinants for the pharmacokinetics of drugs and alterations of drug transport has been recognized as one of the major causes of natural product–drug interactions. In last two decades, many CV drugs (e.g., angiotensin II receptor blockers, beta-blockers and statins) have been identified to be …
Activation Of P-Glycoprotein And Cyp 3a By Coptidis Rhizoma In Vivo: Using Cyclosporine As A Probe Substrate In Rats, C.-P. Yu, C.-Y. Huang, S.-P. Lin, Y.-C. Hou
Activation Of P-Glycoprotein And Cyp 3a By Coptidis Rhizoma In Vivo: Using Cyclosporine As A Probe Substrate In Rats, C.-P. Yu, C.-Y. Huang, S.-P. Lin, Y.-C. Hou
Journal of Food and Drug Analysis
Coptidis Rhizoma (CR), the rhizome of Coptis chinensis FRANCH, is a popular Chinese herb. CR contains plenty of isoquinoline alkaloids such as berberine, coptisine and palmatine. Cyclosporine (CSP), an important immunosuppressant with narrow therapeutic window, is employed as a probe substrate of P-glycoprotein (P-gp) and CYP3A4 in order to investigate the in vivo modulation effect of CR on P-gp and CYP3A4. Three groups of rats were orally administered CSP without and with single dose or repeated dosing of CR in a parallel design. Blood samples were collected at specific time points and the blood CSP concentration was determined by a …
Risk Undermined In The Bilateral Pharmaceutical Regulatory System In Taiwan, H.-P. Wang, C.-L. Wang
Risk Undermined In The Bilateral Pharmaceutical Regulatory System In Taiwan, H.-P. Wang, C.-L. Wang
Journal of Food and Drug Analysis
The concept of Pharmacovigilance Planning and Risk Minimization Planning (PVP/RMP), initiated by the International Conference on Harmonization (ICH), addressed an important conceptual change from monitoring the safety of individual medicine to proactively conducting risk prevention for the minimization of medication error. However, the implementation of PVP/RMP is a challenge in societies like Taiwan where irrational medication and co-medication is prevalent. It is even more difficult in Taiwan where two regulatory bodies are governing pharmaceutical affairs, namely Taiwan Food and Drug Administration (TFDA) in charge of Western Medicine (WM) and the Department of Chinese Medicine and Pharmacy (DCMP) in charge of …
Excipient-Drug Pharmacokinetic Interactions: Effect Of Disintegrants On Efflux Across Excised Pig Intestinal Tissues, W. Gerber, J.H. Hamman, J.D. Steyn
Excipient-Drug Pharmacokinetic Interactions: Effect Of Disintegrants On Efflux Across Excised Pig Intestinal Tissues, W. Gerber, J.H. Hamman, J.D. Steyn
Journal of Food and Drug Analysis
Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics. Pharmacokinetic interactions may be caused by modulation of efflux transporter proteins, intercellular tight junctions and/or metabolic enzyme amongst others. In this study, five disintegrants from different chemical classes were evaluated for P-glycoprotein (P-gp) related inhibition and tight junction modulation effects. Bi-directional transport studies of the model compound, Rhodamine 123 (R123) were conducted in the absence (control group) and presence (experimental groups) of four concentrations of each selected disintegrant across excised pig jejunum tissue. The results showed that …
Update Of Green Tea Interactions With Cardiovascular Drugs And Putative Mechanisms, J.P. Werba, S. Misaka, M.G. Giroli, K. Shimomura, M. Amato, N. Simonelli, L. Vigo, E. Tremoli
Update Of Green Tea Interactions With Cardiovascular Drugs And Putative Mechanisms, J.P. Werba, S. Misaka, M.G. Giroli, K. Shimomura, M. Amato, N. Simonelli, L. Vigo, E. Tremoli
Journal of Food and Drug Analysis
Many patients treated with cardiovascular (CV) drugs drink green tea (GT), either as a cultural tradition or persuaded of its putative beneficial effects for health. Yet, GT may affect the pharmacokinetics and pharmacodynamics of CV compounds. Novel GT-CV drug interactions were reported for rosuvastatin, sildenafil and tacrolimus. Putative mechanisms involve inhibitory effects of GT catechins at the intestinal level on influx transporters OATP1A2 or OATP2B1 for rosuvastatin, on CYP3A for sildenafil and on both CYP3A and the efflux transporter p-glycoprotein for tacrolimus. These interactions, which add to those previously described with simvastatin, nadolol and warfarin, might lead, in some cases, …
Food-Drug Interactions Precipitated By Fruit Juices Other Than Grapefruit Juice: An Update Review, M. Chen, S.-Y. Zhou, E. Fabriaga, P.-H. Zhang, Q. Zhou
Food-Drug Interactions Precipitated By Fruit Juices Other Than Grapefruit Juice: An Update Review, M. Chen, S.-Y. Zhou, E. Fabriaga, P.-H. Zhang, Q. Zhou
Journal of Food and Drug Analysis
This review addressed drug interactions precipitated by fruit juices other than grapefruit juice based on randomized controlled trials (RCTs). Literature was identified by searching PubMed, Cochrane Library, Scopus and Web of Science till December 30 2017. Among 46 finally included RCTs, six RCTs simply addressed pharmacodynamic interactions and 33 RCTs studied pharmacokinetic interactions, whereas seven RCTs investigated both pharmacokinetic and pharmacodynamic interactions. Twenty-two juice-drug combinations showed potential clinical relevance. The beneficial combinations included orange juice-ferrous fumarate, lemon juice-99mTc-tetrofosmin, pomegranate juice-intravenous iron during hemodialysis, cranberry juice-triple therapy medications for H. pylori, blueberry juice-etanercept, lime juice-antimalarials, and wheat grass juice-chemotherapy. The potential …
Volatile Sulfur Compounds In Tropical Fruits, R.J. Cannon, C.-T. Ho
Volatile Sulfur Compounds In Tropical Fruits, R.J. Cannon, C.-T. Ho
Journal of Food and Drug Analysis
Global production and demand for tropical fruits continues to grow each year as consumers are enticed by the exotic flavors and potential health benefits that these fruits possess. Volatile sulfur compounds (VSCs) are often responsible for the juicy, fresh aroma of tropical fruits. This poses a challenge for analytical chemists to identify these compounds as most often VSCs are found at low concentrations in most tropical fruits. The aim of this review is to discuss the extraction methods, enrichment techniques, and instrumentation utilized to identify and quantify VSCs in natural products. This will be followed by a discussion of the …
A Regulatory Science Viewpoint On Botanical–Drug Interactions, M. Grimstein, S.-M. Huang
A Regulatory Science Viewpoint On Botanical–Drug Interactions, M. Grimstein, S.-M. Huang
Journal of Food and Drug Analysis
There is a continued predisposition of concurrent use of drugs and botanical products. Consumers often self-administer botanical products without informing their health care providers. The perceived safety of botanical products with lack of knowledge of the interaction potential poses a challenge for providers and both efficacy and safety concerns for patients. Botanical–drug combinations can produce untoward effects when botanical constituents modulate drug metabolizing enzymes and/or transporters impacting the systemic or tissue exposure of concomitant drugs. Examples of pertinent scientific literature evaluating the interaction potential of commonly used botanicals in the US are discussed. Current methodologies that can be applied to …
General Survey Of Fructus Psoraleae From The Different Origins And Chemical Identification Of The Roasted From Raw Fructus Psoraleae, J. Yang, J. Yang, J. Du, Y. Feng, X. Chai, M. Xiao, Y. Wang, X. Gao
General Survey Of Fructus Psoraleae From The Different Origins And Chemical Identification Of The Roasted From Raw Fructus Psoraleae, J. Yang, J. Yang, J. Du, Y. Feng, X. Chai, M. Xiao, Y. Wang, X. Gao
Journal of Food and Drug Analysis
Fructus Psoraleae, a traditional Chinese medicine, is widely used for preventing and treating various diseases such as vitiligo, osteoporosis and psoriasis. Coumarin, such as psoralenoside, isopsoralenoside, psoralen and isopsoralen, are important compounds in Fructus Psoraleae. In our study, ultra performance liquid chromatography coupled with diode array detector was employed for an excellent method validation for simultaneous quantification of psoralenoside, isopsoralenoside, psoralen and isopsoralen, which was further applied in performing general survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae in the light of illuminating the transformed rule of psoralenoside and isopsoralenoside. …
Oxidative Stress Evoked Damages Leading To Attenuated Memory And Inhibition Of Nmdar–Camkii–Erk/Creb Signalling On Consumption Of Aspartame In Rat Model, A. Iyaswamy, A.K. Kammella, C. Thavasimuthu, W. Wankupar, W. Dapkupar, S. Shanmugam, R. Rajan, S. Rathinasamy
Oxidative Stress Evoked Damages Leading To Attenuated Memory And Inhibition Of Nmdar–Camkii–Erk/Creb Signalling On Consumption Of Aspartame In Rat Model, A. Iyaswamy, A.K. Kammella, C. Thavasimuthu, W. Wankupar, W. Dapkupar, S. Shanmugam, R. Rajan, S. Rathinasamy
Journal of Food and Drug Analysis
Many controversial reports are available on the use of aspartame as it releases methanol as one of its metabolite during metabolism. The present study proposes to investigate whether long term (90 days) aspartame (40 mg/kg b.wt) administration could induce oxidative stress and alter the memory in Wistar strain male albino rats. To mimic the human methanol metabolism, methotrexate (MTX)-treated rats were included as a model to study the effects of aspartame. Wistar strain albino rats were administered with aspartame (40 mg/kg b.wt) orally and studied along with controls and MTX-treated controls. Aspartame interfered in the body weight and corticosterone levels …
Mulberry Leaf Extracts Prevent Obesity-Induced Nafld With Regulating Adipocytokines, Inflammation And Oxidative Stress, C.-H. Peng, H.-T. Lin, D.-J. Chung, C.-N. Huang, C.-J. Wang
Mulberry Leaf Extracts Prevent Obesity-Induced Nafld With Regulating Adipocytokines, Inflammation And Oxidative Stress, C.-H. Peng, H.-T. Lin, D.-J. Chung, C.-N. Huang, C.-J. Wang
Journal of Food and Drug Analysis
Mulberry (Morus alba) leaf has been used in Chinese medicine as the remedy for hyperlipidemia and metabolic disorders. Recent report indicated Mulberry leaf extract (MLE) attenuated dyslipidemia and lipid accumulation in high fat diet (HFD)-fed mice. Non-alcoholic fatty liver (NAFLD) is generally considered as the liver component of metabolic syndrome. The hepatic lipid infiltration induces oxidative stress, and is associated with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) which are regulated by the leptin and adiponectin. MLE could prevent obesity-related NAFLD via downregulating the lipogenesis enzymes while upregulating the lipolysis markers. Treatment of MLE, especially at 2%, enhanced the expression …
Organic Solute Carrier 22 (Slc22) Family: Potential For Interactions With Food, Herbal/Dietary Supplements, Endogenous Compounds, And Drugs, R.E. Lai, C.E. Jay, D.H. Sweet
Organic Solute Carrier 22 (Slc22) Family: Potential For Interactions With Food, Herbal/Dietary Supplements, Endogenous Compounds, And Drugs, R.E. Lai, C.E. Jay, D.H. Sweet
Journal of Food and Drug Analysis
Many drugs, hormones, components of herbal medicines, environmental pesticides and toxins are Solute Carrier family 22 (SLC22) substrates. The last twenty years has seen great progress in determining SLC22 tissue expression profiles, membrane localization, energetics, substrate profiles and biopharmaceutical significance. However, much still remains to be answered in terms of SLC22 family member's roles in ‘normal’ physiology as compared to pathophysiological states, as well as in drug interactions that impact pharmacokinetics, efficacy and toxicity. This review begins with a brief synopsis of SLC22 family discovery, function and tissue expression. Subsequent sections provide examples establishing a role for SLC22 transporters in …
Effects Of Processing Adjuvants On Traditional Chinese Herbs, L.-L. Chen, R. Verpoorte, H.-R. Yen, W.-H. Peng, Y.-C. Cheng, J. Chao, L.-H. Pao
Effects Of Processing Adjuvants On Traditional Chinese Herbs, L.-L. Chen, R. Verpoorte, H.-R. Yen, W.-H. Peng, Y.-C. Cheng, J. Chao, L.-H. Pao
Journal of Food and Drug Analysis
Processing of Chinese medicines is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces for use in different therapies. Various adjuvants, such as vinegar, wine, honey, and brine, are used in the processing to enhance the efficacy and reduce the toxicity of crude drugs. Proper processing is essential to ensure the quality and safety of traditional Chinese medicines (TCMs). Therefore, sound knowledge of processing principles is crucial to the standardized use of these processing adjuvants and to facilitate the production and clinical use of decoction pieces. Many scientific reports have indicated the synergistic effects of processing mechanisms on …
Concurrent Administration Of Anticancer Chemotherapy Drug And Herbal Medicine On The Perspective Of Pharmacokinetics, Y.-Y. Cheng, C.-H. Hsieh, T.-H. Tsai
Concurrent Administration Of Anticancer Chemotherapy Drug And Herbal Medicine On The Perspective Of Pharmacokinetics, Y.-Y. Cheng, C.-H. Hsieh, T.-H. Tsai
Journal of Food and Drug Analysis
With an increasing number of cancer patients seeking an improved quality of life, complementary and alternative therapies are becoming more common ways to achieve such improvements. The potential risks of concurrent administration are serious and must be addressed. However, comprehensive evidence for the risks and benefits of combining anticancer drugs with traditional herbs is rare. Pharmacokinetic investigations are an efficient way to understand the influence of concomitant remedies. Therefore, this study aimed to collect the results of pharmacokinetic studies relating to the concurrent use of cancer chemotherapy and complementary and alternative therapies. According to the National Health Insurance (NHI) database …
Corrigendum To “Chemopreventive Effect Of Natural Dietary Compounds On Xenobiotic-Induced Toxicity” [J Food Drug Anal 25 (2017) 176–186] (S1021949816301818) (10.1016/J.Jfda.2016.10.019)), J.-C. Wu, C.-S. Lai, M.-L. Tsai, C.-T. Ho, Y.-J. Wang, M.-H. Pan
Corrigendum To “Chemopreventive Effect Of Natural Dietary Compounds On Xenobiotic-Induced Toxicity” [J Food Drug Anal 25 (2017) 176–186] (S1021949816301818) (10.1016/J.Jfda.2016.10.019)), J.-C. Wu, C.-S. Lai, M.-L. Tsai, C.-T. Ho, Y.-J. Wang, M.-H. Pan
Journal of Food and Drug Analysis
The affiliations of Min-Hsiung Pan were missing. The affiliations should be corrected to: fDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan gDepartment of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan hInstitute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan © 2017
A Novel Uv-Photolysis Approach With Acetone And Isopropyl Alcohol For The Rapid Determination Of Fluoride In Organofluorine-Containing Drugs By Spectrophotometry, V.B.K. Mullapudi, K. Dheram
A Novel Uv-Photolysis Approach With Acetone And Isopropyl Alcohol For The Rapid Determination Of Fluoride In Organofluorine-Containing Drugs By Spectrophotometry, V.B.K. Mullapudi, K. Dheram
Journal of Food and Drug Analysis
A UV photolysis decomposition (UVPD) method for the determination of fluoride in fluorine containing pharmaceuticals by spectrophotometry is reported. It is based on the use of high intensity UV-irradiation in the presence of a digesting solution comprising a mixture of acetone and isopropanol. For the optimization of the UVPD procedure, three bulk drugs (levofloxacin, nebivolol and efavirenz) were chosen as representatives of three diverse compounds containing a single fluorine atom, two fluorine atoms, and trifluoromethyl groups respectively. Operational conditions of the UVPD method, such as concentration and volume of reagents (acetone and isopropyl alcohol), and UV irradiation time (1–6 minutes) …
Investigation Of Borneols Sold In Taiwan By Chiral Gas Chromatography, T.-J. Ho, C.-C. Hung, T.-L. Shih, L.-M. Yiin, H.-P. Chen
Investigation Of Borneols Sold In Taiwan By Chiral Gas Chromatography, T.-J. Ho, C.-C. Hung, T.-L. Shih, L.-M. Yiin, H.-P. Chen
Journal of Food and Drug Analysis
Borneol is a monoterpene that is widely used in traditional Chinese medicine. There are two different products sold in Taipei's traditional Chinese medicine market, natural and chemically synthesized borneol. Chemically synthesized borneol contains four stereoisomers, (+)-isoborneol, (−)-isoborneol, (−)-borneol, and (+)-borneol. The ratio of these four isomers in chemically synthesized and natural borneol products was determined by gas chromatography mass spectrometry. A huge variation between these products is highlighted in this survey. The results suggest that the Food and Drug Administrations in Asian countries should establish a regulatory standard regarding the ratio of the four different borneol isomers in both natural …
Comprehensive Analysis Of Polygoni Multiflori Radix Of Different Geographical Origins Using Ultra-High-Performance Liquid Chromatography Fingerprints And Multivariate Chemometric Methods, L.-L. Sun, M. Wang, H.-J. Zhang, Y.-N. Liu, X.-L. Ren, Y.-R. Deng, A.-D. Qi
Comprehensive Analysis Of Polygoni Multiflori Radix Of Different Geographical Origins Using Ultra-High-Performance Liquid Chromatography Fingerprints And Multivariate Chemometric Methods, L.-L. Sun, M. Wang, H.-J. Zhang, Y.-N. Liu, X.-L. Ren, Y.-R. Deng, A.-D. Qi
Journal of Food and Drug Analysis
Polygoni Multiflori Radix (PMR) is increasingly being used not just as a traditional herbal medicine but also as a popular functional food. In this study, multivariate chemometric methods and mass spectrometry were combined to analyze the ultra-high-performance liquid chromatograph (UPLC) fingerprints of PMR from six different geographical origins. A chemometric strategy based on multivariate curve resolution–alternating least squares (MCR–ALS) and three classification methods is proposed to analyze the UPLC fingerprints obtained. Common chromatographic problems, including the background contribution, baseline contribution, and peak overlap, were handled by the established MCR–ALS model. A total of 22 components were resolved. Moreover, relative species …
Preparation, Characterization, And Antimicrobial Activity Of Nanoemulsions Incorporating Citral Essential Oil, W.-C. Lu, D.-W. Huang, C.-C.R. Wang, C.-H. Yeh, J.-C. Tsai, Y.-T. Huang, P.-H. Li
Preparation, Characterization, And Antimicrobial Activity Of Nanoemulsions Incorporating Citral Essential Oil, W.-C. Lu, D.-W. Huang, C.-C.R. Wang, C.-H. Yeh, J.-C. Tsai, Y.-T. Huang, P.-H. Li
Journal of Food and Drug Analysis
Citral is a typical essential oil used in the food, cosmetic, and drug industries and has shown antimicrobial activity against microorganisms. Citral is unstable and hydrophobic under normal storage conditions, so it can easily lose its bactericide activity. Nanoemulsion technology is an excellent way to hydrophilize, microencapsulate, and protect this compound. In our studies, we used a mixed surfactant to form citral-in-water nanoemulsions, and attempted to optimize the formula for preparing nanoemulsions. Citral-in-water nanoemulsions formed at S o 0.4 to 0.6 and ultrasonic power of 18 W for 120 seconds resulted in a droplet size of < 100 nm for nanoemulsions. The observed antimicrobial activities were significantly affected by the formulation of the nanoemulsions. The observed relationship between the formulation and activity can lead to the rational design of nanoemulsion-based delivery systems for essential oils, based on the desired function of antimicrobials in the food, cosmetics, and agrochemical industries. © 2017
A Comparative Analysis For The Volatile Compounds Of Various Chinese Dark Teas Using Combinatory Metabolomics And Fungal Solid-State Fermentation, L. Cao, X. Guo, G. Liu, Y. Song, C.-T. Ho, R. Hou, L. Zhang, X. Wan
A Comparative Analysis For The Volatile Compounds Of Various Chinese Dark Teas Using Combinatory Metabolomics And Fungal Solid-State Fermentation, L. Cao, X. Guo, G. Liu, Y. Song, C.-T. Ho, R. Hou, L. Zhang, X. Wan
Journal of Food and Drug Analysis
A total of 98 compounds including 20 aldehydes, eight arenes, six acids, 17 alcohols, 13 ketones, nine esters, nine methoxyphenolics, three alkenes, seven alkanes, and six other components were tentatively identified in six Chinese dark teas (CDTs) using gas chromatography–mass spectrometry. Multivariate statistical analysis revealed that dark teas from Yunnan and Guangxi provinces could be classified into one group, and other CDTs belonged to the other cluster. The diagnostic volatile compounds being responsible for CDTs' discrimination were observed as (E,E)-2,4-decadienal, methoxyphenolics, geraniol, α-terpineol, 2,4-heptadienal, cis-jasmone, linalool oxides, and 2-nonenal. Furthermore, mature tea leaves were separately fermented using Eurotium cristatum and …
Optimization Of Culture Conditions For Gamma-Aminobutyric Acid Production In Fermented Adzuki Bean Milk, H.Y. Song, R.C. Yu
Optimization Of Culture Conditions For Gamma-Aminobutyric Acid Production In Fermented Adzuki Bean Milk, H.Y. Song, R.C. Yu
Journal of Food and Drug Analysis
γ-Aminobutyric acid (GABA), a nonprotein amino acid, is widely distributed in nature and fulfills several physiological functions. In this study, various lactic acid strains commonly used to produce fermented milk products were inoculated into adzuki bean milk for producing GABA. The high GABA producing strain was selected in further experiment to improve the GABA production utilizing culture medium optimization. The results demonstrated that adzuki bean milk inoculated with Lactobacillus rhamnosus GG increased GABA content from 0.05 mg/mL to 0.44 mg/mL after 36 hours of fermentation, which showed the greatest elevation in this study. Furthermore, the optimal cultural condition to adzuki …
Evaluation Of Synergistic Anticandidal And Apoptotic Effects Of Ferulic Acid And Caspofungin Against Candida Albicans, Z. Canturk
Journal of Food and Drug Analysis
This study aimed to investigate the synergy between anticandidal and apoptotic effects of ferulic acid and caspofungin against Candida albicans and Candida glabrata, with the help of a quantitative checkerboard microdilution assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) as a viability dye. Apoptotic effects of caspofungin and ferulic acid concentrations (alone and combined) were analyzed for C. albicans and C. glabrata based on annexin V–propidium iodide binding capacities using flow cytometric analysis. C. albicans showed a synergistic effect, represented by a fractional inhibitory concentration index of < 0.5, but C. glabrata showed no synergistic effect (fractional inhibitory concentration index > 0.5). Early and late apoptotic effects of caspofungin and ferulic acid concentrations (1 μg/mL and 1000 …
Fatty Acid Composition And Antibacterial Potential Of Cassia Tora (Leaves And Stem) Collected From Different Geographic Areas Of India, S. Shukla, S. Hegde, A. Kumar, G. Chaudhary, S.K. Tewari, D.K. Upreti, M. Pal
Fatty Acid Composition And Antibacterial Potential Of Cassia Tora (Leaves And Stem) Collected From Different Geographic Areas Of India, S. Shukla, S. Hegde, A. Kumar, G. Chaudhary, S.K. Tewari, D.K. Upreti, M. Pal
Journal of Food and Drug Analysis
The comparative analysis of the fatty acid composition of Cassia tora (leaves and stem) was determined using gas chromatography–mass spectrometry. Twenty-seven fatty acids were identified in C. tora (leaves and stem) which was collected from three different geographical areas of India: Lucknow (Uttar Pradesh), Nainital (Uttarakhand), and Bhavnagar (Gujarat), coded as CT-1, CT-2, and CT-3, respectively. The gas chromatography–mass spectrometry analysis showed the presence of various saturated and unsaturated fatty acids. The major fatty acids found were palmitic acid, linoleic acid, linolenic acid, margaric acid, melissic acid, and behenic acid. The highest amounts of saturated fatty acids were found in …
Metabolite Profiling, Antioxidant, And Α-Glucosidase Inhibitory Activities Of Germinated Rice: Nuclear-Magnetic-Resonance-Based Metabolomics Study, P. Pramai, Hamid N.A. Abdul, A. Mediani, M. Maulidiani, F. Abas, S. Jiamyangyuen
Metabolite Profiling, Antioxidant, And Α-Glucosidase Inhibitory Activities Of Germinated Rice: Nuclear-Magnetic-Resonance-Based Metabolomics Study, P. Pramai, Hamid N.A. Abdul, A. Mediani, M. Maulidiani, F. Abas, S. Jiamyangyuen
Journal of Food and Drug Analysis
In an attempt to profile the metabolites of three different varieties of germinated rice, specifically black (GBR), red, and white rice, a 1 H-nuclear-magnetic-resonance-based metabolomics approach was conducted. Multivariate data analysis was applied to discriminate between the three different varieties using a partial least squares discriminant analysis (PLS-DA) model. The PLS model was used to evaluate the relationship between chemicals and biological activities of germinated rice. The PLS-DA score plot exhibited a noticeable separation between the three rice varieties into three clusters by PC1 and PC2. The PLS model indicated that α-linolenic acid, γ-oryzanol, α-tocopherol, γ-aminobutyric acid, 3-hydroxybutyric acid, fumaric …
The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice, J.-F. Yang, Y.-R. Liu, C.-C. Huang, Y.-F. Ueng
The Time-Dependent Effects Of St John's Wort On Cytochrome P450, Uridine Diphosphate-Glucuronosyltransferase, Glutathione S-Transferase, And Nad(P)H-Quinone Oxidoreductase In Mice, J.-F. Yang, Y.-R. Liu, C.-C. Huang, Y.-F. Ueng
Journal of Food and Drug Analysis
Hypericum perforatum [St. John's wort (SJW)] is known to cause a drug interaction with the substrates of cytochrome P450 (P450, CYP) isoforms, mainly CYP3A. This study aims to determine the dose response and time course of the effects of SJW extract on P450s, UDP-glucuronosyltransferase (UGT), glutathione S-transferase (GST), and NAD(P)H-quinone oxidoreductase (NQO) in mice. The oral administration of SJW extract to male mice at 0.6 g/kg/d for 21 days increased hepatic oxidation activity toward a Cyp3a substrate nifedipine. By extending the SJW treatment to 28 days, hepatic nifedipine oxidation (NFO) and warfarin 7-hydroxylation (WOH) (Cyp2c) activities were increased by 95% …
Optimal Conditions For Cordycepin Production In Surface Liquid-Cultured Cordyceps Militaris Treated With Porcine Liver Extracts For Suppression Of Oral Cancer, L.-T. Lin, Y.-J. Lai, S.-C. Wu, W.-H. Hsu, C.-J. Tai
Optimal Conditions For Cordycepin Production In Surface Liquid-Cultured Cordyceps Militaris Treated With Porcine Liver Extracts For Suppression Of Oral Cancer, L.-T. Lin, Y.-J. Lai, S.-C. Wu, W.-H. Hsu, C.-J. Tai
Journal of Food and Drug Analysis
Cordycepin is one of the most crucial bioactive compounds produced by Cordyceps militaris and has exhibited antitumor activity in various cancers. However, industrial production of large amounts of cordycepin is difficult. The porcine liver is abundant in proteins, vitamins, and adenosine, and these ingredients may increase cordycepin production and bioconversion during C. militaris fermentation. We observed that porcine liver extracts increased cordycepin production. In addition, air supply (2 h/d) significantly increased the cordycepin level in surface liquid-cultured C. militaris after 14 days. Moreover, blue light light-emitting diode irradiation (16 h/d) increased cordycepin production. These findings indicated that these conditions are …
Nutritional Composition In The Chia Seed And Its Processing Properties On Restructured Ham-Like Products, Y. Ding, H.-W. Lin, Y.-L. Lin, D.-J. Yang, Y.-S. Yu, J.-W. Chen, S.-Y. Wang, Y.-C. Chen
Nutritional Composition In The Chia Seed And Its Processing Properties On Restructured Ham-Like Products, Y. Ding, H.-W. Lin, Y.-L. Lin, D.-J. Yang, Y.-S. Yu, J.-W. Chen, S.-Y. Wang, Y.-C. Chen
Journal of Food and Drug Analysis
Low-fat meat products always have harder texture, lower juiciness, and worse flavor. Due to their higher water-holding, water absorption, and organic molecule absorption, chia seeds (CHIA) have been applied in powders, nutrition bars, breads, and cookies. Hence, the objectives of this study were to: (1) analyze the nutritional compositions in CHIA; and (2) look for the possible application of CHIA on restructured ham-like products. CHIA has high amounts of α-linolenic acid, crude polysaccharides, and also contains essential amino acids, minerals, and polyphenols. Regarding processing properties of CHIA, a combination of CHIA and carrageenan (CA) increased (p < 0.05) production yield of restructured ham-like products. A scanning electron microscope observation indicated that CHIA and CA addition can assist an emulsification in this ham-like product. Addition of 0.5% CA and 1.0% CHIA in this ham-like product showed the similar overall acceptance as products with added fat. Following storage at 4°C, higher (p < 0.05) purge and centrifugation losses, as well as hardness of this ham-like product can be improved by adding CHIA and CA. CHIA addition also resulted in lower (p < 0.05) lipid and protein oxidation, especially a 1.0% addition. In summary, due to both nutritional addition and improvements on physicochemical and sensorial properties of restructured ham-like products, CHIA seeds have great potential on the development of healthy and good-quality meat products. © 2017
Hypocholesterolemic Activity Of Indigenous Probiotic Isolate Saccharomyces Cerevisiae Ardmc1 In A Rat Model, D. Saikia, A.K. Manhar, B. Deka, R. Roy, K. Gupta, N.D. Namsa, P. Chattopadhyay, R. Doley, M. Mandal
Hypocholesterolemic Activity Of Indigenous Probiotic Isolate Saccharomyces Cerevisiae Ardmc1 In A Rat Model, D. Saikia, A.K. Manhar, B. Deka, R. Roy, K. Gupta, N.D. Namsa, P. Chattopadhyay, R. Doley, M. Mandal
Journal of Food and Drug Analysis
The aim of this study was to investigate probiotic attributes of Saccharomyces cerevisiae ARDMC1 isolated from traditional rice beer starter cake and its hypocholesterolemic effects on Wistar rats fed a high-cholesterol diet. The indigenous isolate ARDMC1 showed potential probiotic characteristics such as tolerance to simulated gastrointestinal stress conditions, autoaggregation properties, and adhesion to intestinal epithelium Caco-2 cell line. In addition, ARDMC1 isolate exhibited in vitro cholesterol assimilation properties in media supplemented with cholesterol. Furthermore, administration of probiotic isolate to rats fed a hypercholesterolemic diet resulted in significant reduction of serum total cholesterol, low-density lipoprotein cholesterol, and triglyceride at the end …
Ceratonia Siliqua Honeys From Morocco: Physicochemical Properties, Mineral Contents, And Antioxidant Activities, R. El-Haskoury, W. Kriaa, B. Lyoussi, M. Makni
Ceratonia Siliqua Honeys From Morocco: Physicochemical Properties, Mineral Contents, And Antioxidant Activities, R. El-Haskoury, W. Kriaa, B. Lyoussi, M. Makni
Journal of Food and Drug Analysis
Physicochemical properties, main mineral content, and antioxidant activity were determined for eight floral carob honeys collected from different geographical regions of Morocco. Moroccan honeys showed good chemical and nutritional qualities, fulfilling the criteria described in the standard codex for honey. The percentages obtained for ashes were (0.13–0.69%), electrical conductivity (0.36–1.35 mS/cm), water content (17.30–22.80%), pH (4.17–5.05), free acidity (11.0–42.50 meq/kg), lactone acidity (4.0–16.50 meq/kg), and for total acidity (16.50–59.50 meq/kg). In addition, minerals such as K, Na, Mg, Cu, Zn, and Ca of honey samples were determined and potassium was the major mineral in all samples. The antioxidant activities based …