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Articles 361 - 390 of 1010
Full-Text Articles in Medicinal Chemistry and Pharmaceutics
Effects Of Fermentation Treatment On Antioxidant And Antimicrobial Activities Of Four Common Chinese Herbal Medicinal Residues By Aspergillus Oryzae, Y.-L. Wen, L.-P. Yan, C.-S. Chen
Effects Of Fermentation Treatment On Antioxidant And Antimicrobial Activities Of Four Common Chinese Herbal Medicinal Residues By Aspergillus Oryzae, Y.-L. Wen, L.-P. Yan, C.-S. Chen
Journal of Food and Drug Analysis
The feasibility of using Aspergillus oryzae NCH 42, an extracellular tannase-producing fungus, for increasing the utilization of extraction residues of Chinese herbal medicines (CHMs) was evaluated in this study. Four types of CHMs, including Trichosanthes kirilowii Maxim, Salvia miltiorrhiza Bge, Magnolia officinalis and Glycyrrhizae radix, were used. Their aqueous extraction residues were inoculated with A. oryzae NCH 42, and solid-state fermentation was performed for 5 days at 30 °C with a moisture content of 86% (ratio of solid to water 1:6, w/v). The methanolic extracts of fermentation products (F&M) were examined for their functional components and properties, such as total …
Development And Validation Of A Uplc-Dad-Ms Method For Characterization And Quantification Of Alkaloids In Menispermi Rhizoma And Its Preparations, Y. Liu, X. Song, R. Yan, T. Li, X. Chai, A. Qi, Y. Wang, Z. Jiang
Development And Validation Of A Uplc-Dad-Ms Method For Characterization And Quantification Of Alkaloids In Menispermi Rhizoma And Its Preparations, Y. Liu, X. Song, R. Yan, T. Li, X. Chai, A. Qi, Y. Wang, Z. Jiang
Journal of Food and Drug Analysis
Menispermi Rhizoma (MR), a well known traditional Chinese medicine, is widely used to prevent and treat sore throat, enteritis, dysentery and rheumatoid arthralgia clinically. However, many rhizomes of Chinese herbal medicines are mistaken as MR due to their similar appearance, which could affect MR quality and cause serious consequences for patients. To guarantee the quality of MR products, an ultra-high-performance liquid chromatography-diode array detector-tandem mass spectrometry (UPLC-DAD-MS) method was established for the characterization of major active ingredients in MR and its preparations. By comparing their retention times and characteristic fragmentations with those of authentic compounds, nine alkaloids in MR were …
Introduction To The Special Issue: Dietary Natural Compounds, M.-H. Pan
Introduction To The Special Issue: Dietary Natural Compounds, M.-H. Pan
Journal of Food and Drug Analysis
[No abstract available]
Clove (Syzygium Aromaticum) Ingredients Affect Lymphocyte Subtypes Expansion And Cytokine Profile Responses: An In Vitro Evaluation, S.P. Dibazar, S. Fateh, S. Daneshmandi
Clove (Syzygium Aromaticum) Ingredients Affect Lymphocyte Subtypes Expansion And Cytokine Profile Responses: An In Vitro Evaluation, S.P. Dibazar, S. Fateh, S. Daneshmandi
Journal of Food and Drug Analysis
Clove (Syzygium aromaticum) has been used in folk medicine in many disorders. The present work aimed to investigate effects of clove essential oil as eugenol and water soluble ingredients on mouse splenocytes. Clove extracts were harvested and in different concentrations (0.001-1000 μg/mL) were affected to splenocytes and also phytohemagglutinin (PHA = 5 μg/mL) and lipopolysaccharide (LPS = 10 μg/mL) activated splenocytes; then splenocytes proliferation assayed using the MTT ([3-(4, 5-dimethylthiazole-2-yl) -2, 5-diphenyl tetrazolium bromide]) method were done. On the culture supernatant interferon (IFN)-γ, interleukin (IL)-4, IL-10, and transforming growth factor (TGF)-β cytokines were measured. Clove ingredients (100 μg/mL and 1000 …
Total Nutritional Capacity And Inflammation Inhibition Effect Of Acalypha Alnifolia Klein Ex Wild - An Unexplored Wild Leafy Vegetable, R. Ponnusamy, P. Thangaraj
Total Nutritional Capacity And Inflammation Inhibition Effect Of Acalypha Alnifolia Klein Ex Wild - An Unexplored Wild Leafy Vegetable, R. Ponnusamy, P. Thangaraj
Journal of Food and Drug Analysis
Investigation of the nutritional as well as trace elements of a wild leafy vegetable, Acalypha alnifolia, and evaluation of the analgesic, anti-inflammatory, and antipyretic properties of acetone and methanol leaf extracts are the main objectives of the present study. The powdered A. alnifolia leaf sample was subjected to nutritional and mineral analysis. Plant leaves were extracted (using the Soxhlet apparatus) as successive solvent extractions. The extract doses of 200 and 400 mg/kg of acetone and methanol extracts were used for pharmacology study. The analgesic, anti-inflammatory, and antipyretic experiments were carried out by using animal models. The obtained result proves that …
Determination Of L-Arginine Content In Radix Isatidis By A Composite Fluorescent Probe Of Pd (Ii), D. Cheng, H. Zhu
Determination Of L-Arginine Content In Radix Isatidis By A Composite Fluorescent Probe Of Pd (Ii), D. Cheng, H. Zhu
Journal of Food and Drug Analysis
In the presence of Britton-Robinson buffer solution (pH = 9.5) and surfactant of Tween-80, fluorescence intensity of calcein was quenched by Pd2+. However, the fluorescence intensity can be enhanced after adding a certain concentration of L-arginine, and the rate of the enhancement showed a good liner relationship with the added amount of L-arginine. We then established a fluorescence spectrometry for the determination of L-arginine. In addition, the linear range, along with detection limit, was different when the slit width changed. Thus, we could use a different slit width to meet our requirements according to the samples we treated. By testing …
Binding Interactions Of Niclosamide With Serum Proteins, E. Maltas
Binding Interactions Of Niclosamide With Serum Proteins, E. Maltas
Journal of Food and Drug Analysis
A study of the binding of niclosamide (NC) to serum proteins such as human serum albumin, hemoglobin, and globulin was carried out using fluorescence and UV-visible spectroscopy. Interactions between NC and these proteins were estimated by Stern-Volmer and van't Hoff equations. The binding constants and the thermodynamic parameters, ΔH, ΔS, and ΔG at different temperatures were also determined by using these equations. Data showed that NC may exhibit a static quenching mechanism with all proteins. The thermodynamic parameters were calculated. Data showed that van der Waals interactions and hydrogen bonds are the main forces for human serum albumin and hemoglobin. …
Analytical Method Development And Validation Of Simultaneous Estimation Of Rabeprazole, Pantoprazole, And Itopride By Reverse-Phase High-Performance Liquid Chromatography, S.S. Perumal, S.P. Ekambaram, S. Raja
Analytical Method Development And Validation Of Simultaneous Estimation Of Rabeprazole, Pantoprazole, And Itopride By Reverse-Phase High-Performance Liquid Chromatography, S.S. Perumal, S.P. Ekambaram, S. Raja
Journal of Food and Drug Analysis
A simple, selective, rapid, and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of rabeprazole (RP), pantoprazole (PP), and itopride (IP) has been developed. The compounds were well separated on a Phenomenex C18 (Luna) column (250 mm × 4.6 mm, dp = 5 μm) with C18 guard column (4 mm × 3 mm × 5 μm) with a mobile phase consisting of buffer containing 10 mM potassium dihydrogen orthophosphate (adjusted to pH 6.8): Acetonitrile (70:30 v/v) at a flow rate of 1.0 mL/min and ultraviolet detection at 288 nm. The retention time of RP, PP, and IP …
Voltammetric Determination Of Chlorogenic Acid In Pharmaceutical Products Using Poly(Aminosulfonic Acid) Modified Glassy Carbon Electrode, M. Chao, X. Ma
Voltammetric Determination Of Chlorogenic Acid In Pharmaceutical Products Using Poly(Aminosulfonic Acid) Modified Glassy Carbon Electrode, M. Chao, X. Ma
Journal of Food and Drug Analysis
In this work, a poly(aminosulfonic acid) modified glassy carbon electrode was fabricated and the electrochemical behavior of chlorogenic acid (CGA) was studied by cyclic voltammetry. Compared with a bare glassy carbon electrode, the modified electrode exhibits excellent catalytic effect on the electrochemical redox of CGA. Utilizing this catalytic effect, a sensitive and selective electrochemical method for the determination of CGA was developed. The analytical parameters were optimized. Under the optimized conditions, the oxidation peak current is linearly proportional to the concentration of CGA in the range from 4.00 × 10-7 to 1.20 × 10-5 mol/L and the detection limit is …
Formulation And Evaluation Of Controlled-Release Of Telmisartan Microspheres: In Vitro/In Vivo Study, P.K. Gaur, S. Mishra, M. Bajpai
Formulation And Evaluation Of Controlled-Release Of Telmisartan Microspheres: In Vitro/In Vivo Study, P.K. Gaur, S. Mishra, M. Bajpai
Journal of Food and Drug Analysis
The aim of this work was to design a controlled-release drug-delivery system for the angiotensin-II receptor antagonist drug telmisartan. Telmisartan was encapsulated with different EUDRAGIT polymers by an emulsion solvent evaporation technique and the physicochemical properties of the formulations were characterized. Using a solvent evaporation method, white spherical microspheres with particle sizes of 629.9-792.1 μm were produced. The in vitro drug release was studied in three different pH media (pH 1.2 for 2 hours, pH 6.8 for 4 hours, and pH 7.4 for 18 hours). The formulations were then evaluated for their pharmacokinetic parameters. The entrapment efficiency of these microspheres …
Electrochemistry And Determination Of Cefdinir By Voltammetric And Computational Approaches, I.H. Taşdemir
Electrochemistry And Determination Of Cefdinir By Voltammetric And Computational Approaches, I.H. Taşdemir
Journal of Food and Drug Analysis
The oxidation and reduction behavior of cefdinir (CEF) was studied by experimental methods and computational calculations at B3LYP/6-31+G (d)//AM1. Voltammetric studies were carried out based on two irreversible reduction peaks at approximately -0.5 and -1.2 V on a hanging mercury drop electrode (HMDE) and on one irreversible oxidation peak at approximately 1.0 V on a glassy carbon electrode (GCE) versus Ag/AgCl, KCl (3.0M) in Britton-Robinson (BR) buffer at pH 4.2 and 5.0, respectively. Differential pulse adsorptive stripping voltammetric methods have been developed and validated for determination of CEF in different samples. The linear range was established as 0.25-40.0 μM for …
Sulfur Compounds Identification And Quantification From Allium Spp. Fresh Leaves, L. Gîtin, R. Dinicə, C. Neagu, L. Dumitrascu
Sulfur Compounds Identification And Quantification From Allium Spp. Fresh Leaves, L. Gîtin, R. Dinicə, C. Neagu, L. Dumitrascu
Journal of Food and Drug Analysis
Background Pyruvic acid concentration is a critical factor in determining Allium spp. pungency. This study was initiated to accurately measure the background pyruvic acid levels in Romanian Allium spp. From the pungency point of view, all analyzed plant varieties in this study are considered low pungent cultivars based on the enzymatically produced pyruvate level (between 42 μmol/g and 222 μmol/g fresh wt). Chromatographic analysis was carried out for the different varieties of the most popular fresh leaves (Allium cepa var. "Diamant", Allium cepa var. "Rubiniu", and Allium ursinum L.) in order to identify the sulfur compounds. The thin layer chromatography …
Ionic Liquid-Based Hollow Fiber-Supported Liquid-Phase Microextraction Enhanced Electrically For The Determination Of Neutral Red, S.-R. Wang, S. Wang
Ionic Liquid-Based Hollow Fiber-Supported Liquid-Phase Microextraction Enhanced Electrically For The Determination Of Neutral Red, S.-R. Wang, S. Wang
Journal of Food and Drug Analysis
A method of ionic liquid-based hollow fiber liquid-phase microextraction enhanced electrically was successfully developed and applied to the extraction and determination of neutral red (NR) dye, which was selected as the model analyte. A room temperature ionic liquid, 1-octyl-3-methylimidazolium hexafluorophosphate ([C8mim][PF6]), was placed in the pores of a polytetrafluoethylene hollow fiber, which acts as a liquid membrane and the acceptor solution. The extraction parameters affecting the enrichment factor of NR, such as pH, extraction time, elution time, stirring rate, and the voltage were optimized. In addition, UV-Visible (UV-Vis) or electrochemiluminescence spectra were also determined. The extraction rate and capacity of …
Optimization Of Fermentation Process Of Cordyceps Militaris And Antitumor Activities Of Polysaccharides In Vitro, S. Yang, L. Jin, X. Ren, J. Lu, Q. Meng
Optimization Of Fermentation Process Of Cordyceps Militaris And Antitumor Activities Of Polysaccharides In Vitro, S. Yang, L. Jin, X. Ren, J. Lu, Q. Meng
Journal of Food and Drug Analysis
The influence of medium composition and cultural conditions on simultaneous yield of mycelia, intracellular polysaccharide, adenosine, and mannitol by Cordyceps militaris CGMCC 2909 was investigated with desirability functions in this study. An optimization strategy based on the desirability function approach, together with response surface methodology (RSM) has been used to optimize medium composition, and the optimal medium was obtained via the desirability as follows: yeast extract 10.33 g/L, sucrose 27.24 g/L, KH2PO4 5.60 g/L and the optimal culture conditions are initial pH 6, 25°C, rotation speed 150 r/minute, inoculum size 4%(v/v), and medium capacity 40 mL/250 mL. Under these conditions, …
Application Of Ion Mobility Spectrometry For The Determination Of Tramadol In Biological Samples, A. Sheibani, N. Haghpazir
Application Of Ion Mobility Spectrometry For The Determination Of Tramadol In Biological Samples, A. Sheibani, N. Haghpazir
Journal of Food and Drug Analysis
In this study, a simple and rapid ion mobility spectrometry (IMS) method has been described for the determination of tramadol. The operating instrumental parameters that could influence IMS were investigated and optimized (temperature; injection: 220 and IMS cell: 190°C, flow rate; carrier: 300 and drift: 600 mL/minute, voltage; corona: 2300 and drift: 7000 V, pulse width: 100 μs). Under optimum conditions, the calibration curves were linear within two orders of magnitude with R2 ≥ 0.998 for the determination of tramadol in human plasma, saliva, serum, and urine samples. The limits of detection and the limits of quantitation were between 0.1 …
Linearity Study On Detection And Quantification Limits For The Determination Of Avermectins Using Linear Regression, R. Ismail, H.Y. Lee, N.A. Mahyudin, Bakar F. Abu
Linearity Study On Detection And Quantification Limits For The Determination Of Avermectins Using Linear Regression, R. Ismail, H.Y. Lee, N.A. Mahyudin, Bakar F. Abu
Journal of Food and Drug Analysis
In this study, linear relationships between response and concentration were used to estimate the detection limit (DL) and quantification limit (QL) for five avermectins: Emamectin, abamectin, doramectin, moxidectin, and ivermectin. Estimation of DL and QL was based on the standard deviation of residual and y-intercept of the regression line at low concentrations of avermectins, using the dispersive solid-phase extraction procedure. Avermectin extracts were analyzed using liquid chromatography tandem mass spectrometry. Based on the regression slope, DL and QL were higher at concentrations of 0.3-0.4 μg/kg and 1 μg/kg, respectively, for all avermectin compounds. Linearity assessment was performed by linear regression, …
Antioxidant Effects Of Camellia Sinensis L. Extract In Patients With Type 2 Diabetes, A. Spadiene, N. Savickiene, L. Ivanauskas, V. Jakstas, A. Skesters, A. Silova, H. Rodovicius
Antioxidant Effects Of Camellia Sinensis L. Extract In Patients With Type 2 Diabetes, A. Spadiene, N. Savickiene, L. Ivanauskas, V. Jakstas, A. Skesters, A. Silova, H. Rodovicius
Journal of Food and Drug Analysis
The prevalence of diabetes mellitus (DM) has dramatically increased in the past decade. Furthermore, increasing evidence from research shows that oxidative stress (OS) plays a crucial role in the pathogenesis of diabetes and in its complications. A search for ways to reduce oxidative damage has become the focus of interest for the majority of scientists. In this study, we determined the radical scavenging activity of single green tea constituents by using an on-line high performance liquid chromatography (HPLC)-2,2-diphenyl-1-picrylhydrazyl (DPPH) method and evaluated the antioxidant effects on type 2 diabetic patients by performing a double-blind, placebo-controlled study. Epigallocatechin gallate was identified …
Hypocholesterolemic Properties Of Grapefruit (Citrus Paradisii) And Shaddock (Citrus Maxima) Juices And Inhibition Of Angiotensin-1-Converting Enzyme Activity, G. Oboh, F.O. Bello, A.O. Ademosun
Hypocholesterolemic Properties Of Grapefruit (Citrus Paradisii) And Shaddock (Citrus Maxima) Juices And Inhibition Of Angiotensin-1-Converting Enzyme Activity, G. Oboh, F.O. Bello, A.O. Ademosun
Journal of Food and Drug Analysis
Grapefruit (Citrus paradisii) and shaddock (Citrus maxima) juices are used in folk medicine for the management of hypertension and other cardiovascular diseases, but the mechanism of action by which they exert their therapeutic action is unclear. The aim of this study was to investigate the effect of grapefruit and shaddock juices on angiotensin-1-converting enzyme (ACE) activity in vitro and the hypocholesterolemic properties of the juices in rats fed a high-cholesterol diet. Grapefruit juice had higher total phenol and flavonoid contents than shaddock juice, while both juices inhibited ACE activity in a dose-dependent manner. Furthermore, administration of the juices to rats …
Regulation Of Human Cytokines By Cordyceps Militaris, Y. Sun, Y. Shao, Z. Zhang, L. Wang, A.M. Mariga, G. Pang, C. Geng, C.-T. Ho, Q. Hu, L. Zhao
Regulation Of Human Cytokines By Cordyceps Militaris, Y. Sun, Y. Shao, Z. Zhang, L. Wang, A.M. Mariga, G. Pang, C. Geng, C.-T. Ho, Q. Hu, L. Zhao
Journal of Food and Drug Analysis
Cordyceps (Cordyceps militaris) exhibits many biological activities including antioxidant, inhibition of inflammation, cancer prevention, hypoglycemic, and antiaging properties, etc. However, a majority of studies involving C. militaris have focused only on in vitro and animal models, and there is a lack of direct translation and application of study results to clinical practice (e.g., health benefits). In this study, we investigated the regulatory effects of C. militaris micron powder (3 doses) on the human immune system. The study results showed that administration of C. militaris at various dosages reduced the activity of cytokines such as eotaxin, fibroblast growth factor-2, GRO, and …
Dolichos Biflorus Exhibits Anti-Inflammatory And Antioxidant Properties In An Acute Inflammatory Model, L.E. Mathew, G. Sindhu, A. Helen
Dolichos Biflorus Exhibits Anti-Inflammatory And Antioxidant Properties In An Acute Inflammatory Model, L.E. Mathew, G. Sindhu, A. Helen
Journal of Food and Drug Analysis
Dolichos biflorus (Muthira) is a branched, suberect, and downing herb, native to most parts of India, and found at altitudes of up to 1000 m, whose seeds can be cooked and eaten. Nutrition plays a key role in building immunity and preventing noncommunicable diseases to a certain extent. The purpose of this study was to evaluate the anti-inflammatory and antioxidant effects of 70% methanolic extract of seeds of D. biflorus (DME) in carrageenan-induced inflammation. DME exhibited maximum percentage of oedema inhibition at a dose of 50 mg/kg at the 3rd hour of carrageenan induction. The effect was higher than that …
Use Of A Failure Probability Constraint To Suggest An Initial Dose In A Phase I Cancer Clinical Trial, S.-C. Chang, C.-J. Chang, Y.-J. Lin, I.-B. Lian, C.S.J. Fann
Use Of A Failure Probability Constraint To Suggest An Initial Dose In A Phase I Cancer Clinical Trial, S.-C. Chang, C.-J. Chang, Y.-J. Lin, I.-B. Lian, C.S.J. Fann
Journal of Food and Drug Analysis
The primary objective of a Phase I cancer clinical trial is to determine the maximum tolerated dose of a drug. The "failure probability" was proposed and used as a constraint to help identify a suitable initial dose range. The maximum tolerated dose was then determined based on a 3 + 3 cohort-based escalation scheme. Multiple simulations were conducted, and the method was evaluated according to the required sample size and accuracy and precision of maximum tolerated dose estimate. The results indicated that the median of the initial dose range suggested using a failure probability is a suitable initial dose regardless …
Extraction Of Water-Soluble Polysaccharide And The Antioxidant Activity From Semen Cassiae, C. Liu, Q. Liu, J. Sun, B. Jiang, J. Yan
Extraction Of Water-Soluble Polysaccharide And The Antioxidant Activity From Semen Cassiae, C. Liu, Q. Liu, J. Sun, B. Jiang, J. Yan
Journal of Food and Drug Analysis
Water-soluble polysaccharide was isolated from Semen cassiae using water for extraction and ethanol for deposition. The optimized conditions for polysaccharide isolation by orthogonal experiments were a sample to liquid ratio of 1:30 at 80°C for 3.5 hours; the yield of polysaccharide from Semen cassiae under these conditions was 5.46%. Different polysaccharides (SCPW-1, SCPW-2, SCPW-3, SCPW-4, SCPW-5, SCPS-1, SCPS-2) were obtained from the extract (i.e., crude polysaccharide) by DEAE-cellulose column chromatography. The polysaccharides obtained showed different structures by Fourier transform infrared therein the five elected from the seven kinds separated. The antioxidant activities of the extract were evaluated. The scavenging rates …
Characterization Of Odor-Active Compounds In Cooked Meat Of Farmed Obscure Puffer (Takifugu Obscurus) Using Gas Chromatography-Mass Spectrometry-Olfactometry, N.-P. Tao, R. Wu, P.-G. Zhou, S.-Q. Gu, W. Wu
Characterization Of Odor-Active Compounds In Cooked Meat Of Farmed Obscure Puffer (Takifugu Obscurus) Using Gas Chromatography-Mass Spectrometry-Olfactometry, N.-P. Tao, R. Wu, P.-G. Zhou, S.-Q. Gu, W. Wu
Journal of Food and Drug Analysis
The volatile and odor-active compounds in cooked meat of farmed obscure puffer (Takifugu obscurus) were analyzed by gas chromatography-mass spectrometry-olfactometry (GC-MS-O). The volatile compounds were extracted by the simultaneous distillation-extraction (SDE) method, then separated and identified by GC-MS. Odor-active compounds in the SDE extract were characterized by GC-MS-O. A total of 68 volatile compounds were found, including 23 aldehydes, 10 alcohols, nine ketones, 17 N- or S-containing compounds and aromatics, three acids, three alkanes, and three esters. Of these, 31 odor-active compounds were detected and identified. Trimethylamine (fishy), octanal (grassy, leafy, green), (E)-2-octenal (roast, fatty), 1-octen-3-ol (fishy, fatty, mushroom, grassy), …
Effect Of Γ-Aminobutyric Acid And Nattokinase-Enriched Fermented Beans On The Blood Pressure Of Spontaneously Hypertensive And Normotensive Wistar-Kyoto Rats, K. Suwanmanon, P.-C. Hsieh
Effect Of Γ-Aminobutyric Acid And Nattokinase-Enriched Fermented Beans On The Blood Pressure Of Spontaneously Hypertensive And Normotensive Wistar-Kyoto Rats, K. Suwanmanon, P.-C. Hsieh
Journal of Food and Drug Analysis
In this study we have evaluated the changes in arterial blood pressure in spontaneously hypertensive rats (SHR) caused by the short-term intake of Bacillus subtilis B060-fermented beans with significant γ-aminobutyric acid (GABA) and nattokinase activity. After being weaned, 7-week-old male SHR and 7-week-old male Wistar-Kyoto (WKY) rats were randomized into seven groups. Until the 8th week of life, the rats in each group were given one of the following: Group 1, high dose of GABA and nattokinase in the SHR (SHD); Group 2, medium dose of GABA and nattokinase in the SHR (SMD); Group 3, low dose of GABA and …
A Review Of Quality Surveillance Projects On Cosmetics In Taiwan, M.-H. Chung, W.-S. Huang, Y.-C. Chang, Y.-H. Chen, M.-S. Lee, S.-C. Huang, Y.-P. Chen, D.Y.-C. Shih, H.-F. Cheng
A Review Of Quality Surveillance Projects On Cosmetics In Taiwan, M.-H. Chung, W.-S. Huang, Y.-C. Chang, Y.-H. Chen, M.-S. Lee, S.-C. Huang, Y.-P. Chen, D.Y.-C. Shih, H.-F. Cheng
Journal of Food and Drug Analysis
The Food and Drug Administration in Taiwan is responsible for the quality regulation and control of cosmetics. In order to have a clear understanding of the trends in the product quality monitoring outcomes and the regulatory control measures over the past years, this study has put together the reports of nine cosmetic surveillance projects conducted between 1982 and 2012. The findings can be used as a reference in developing a more solid quality monitoring plan and management system for cosmetic products. Results show that permanent wave products, hair dye products, and phthalate esters in cosmetic products have the highest average …
Integration Of Independent Component Analysis With Near-Infrared Spectroscopy For Analysis Of Bioactive Components In The Medicinal Plant Gentiana Scabra Bunge, Y.-K. Chuang, I.-C. Yang, Y.M. Lo, C.-Y. Tsai, S. Chen
Integration Of Independent Component Analysis With Near-Infrared Spectroscopy For Analysis Of Bioactive Components In The Medicinal Plant Gentiana Scabra Bunge, Y.-K. Chuang, I.-C. Yang, Y.M. Lo, C.-Y. Tsai, S. Chen
Journal of Food and Drug Analysis
Independent component (IC) analysis was applied to near-infrared spectroscopy for analysis of gentiopicroside and swertiamarin; the two bioactive components of Gentiana scabra Bunge. ICs that are highly correlated with the two bioactive components were selected for the analysis of tissue cultures, shoots and roots, which were found to distribute in three different positions within the domain [two-dimensional (2D) and 3D] constructed by the ICs. This setup could be used for quantitative determination of respective contents of gentiopicroside and swertiamarin within the plants. For gentiopicroside, the spectral calibration model based on the second derivative spectra produced the best effect in the …
Determination Of The Food Dye Carmine In Milk And Candy Products By Differential Pulse Polarography, U.T. Yilmaz, F. Ergun, H. Yilmaz
Determination Of The Food Dye Carmine In Milk And Candy Products By Differential Pulse Polarography, U.T. Yilmaz, F. Ergun, H. Yilmaz
Journal of Food and Drug Analysis
As a basis for the development of a sensitive analytical method for the determination of carmine food dye, a study of the differential pulse polarographic reduction of carminic acid (CA) on a dropping mercury electrode was performed. For the analytical differential pulse polarographic method running at pH 2.0 Britton-Robinson (B-R) buffer solution (peak at -489 mV), the relationship between the peak current and CA concentration was linear in the range of 1 μM to 90 μM with a detection limit of 0.16 μM. The proposed electrochemical procedure was successfully applied to the determination of carmine food dye in spiked commercially …
Comparison Of Free Radical Formation Induced By Baicalein And Pentamethyl-Hydroxychromane In Human Promyelocytic Leukemia Cells Using Electron Spin Resonance, Y.-K. Huang, T.-C. Chang, J.-R. Sheu, K.-H. Wen, D.-S. Chou
Comparison Of Free Radical Formation Induced By Baicalein And Pentamethyl-Hydroxychromane In Human Promyelocytic Leukemia Cells Using Electron Spin Resonance, Y.-K. Huang, T.-C. Chang, J.-R. Sheu, K.-H. Wen, D.-S. Chou
Journal of Food and Drug Analysis
Baicalein and pentamethyl-hydroxychromane (PMC) have been investigated for use as antioxidants. However, antioxidants may stimulate free radical formation under certain conditions. The aim of our study was to determine whether PMC and baicalein exhibit both pro-oxidant and antioxidant activities in human promyelocytic leukemia (HL-60) cells. In this study, electron spin resonance spectrometry was used to investigate the effects of baicalein and PMC on free radical formation. In HL-60 cells, baicalein and PMC produced hydroxyl and phenoxyl radicals, respectively, but each inhibited radical formation by the other. The PMC pro-oxidant activity required H2O2, whereas baicalein produced hydroxyl radicals during the cell …
Electrochemical Oxidation Behavior Of Hydrochlorothiazide On A Glassy Carbon Electrode And Its Voltammetric Determination In Pharmaceutical Formulations And Biological Fluids, A.F. Alghamdi
Journal of Food and Drug Analysis
The electrochemical oxidation behavior of hydrochlorothiazide (HCT) on a glassy carbon as a working electrode was investigated in Britton-Robinson (B-R) buffer pH 3, by using anodic stripping voltammetry (ASV) and cyclic voltammetry (CV). This drug gave a well-defined voltammetric oxidation peak at + 1200 mV versus an Ag/AgCl reference electrode. The electrochemical oxidation process was shown to be irreversible and diffusion controlled, with adsorption characterized over the entire pH range. The optimized conditions, such as accumulation time and potential, scan rate, frequency, pulse amplitude, varying of working electrodes, and instrumental parameters were studied. The calibration graph for HCT was obtained …
Flavonoid Compositions And Antioxidant Activity Of Calamondin Extracts Prepared Using Different Solvents, S.-N. Lou, Y.-S. Hsu, C.-T. Ho
Flavonoid Compositions And Antioxidant Activity Of Calamondin Extracts Prepared Using Different Solvents, S.-N. Lou, Y.-S. Hsu, C.-T. Ho
Journal of Food and Drug Analysis
Calamondin has been demonstrated to exhibit antioxidant function and tyrosinase inhibitory activity, which might be attributed to its flavonoid compounds. To improve their application, the flavonoid compositions and antioxidant activity of calamondin extracts, prepared by different solvents, were investigated. The results showed that total phenolic and flavonoid contents of extracts from peel of calamondin were higher than that from pulp, except the flavonoid content in hot water extract. The flavonoids found in extracts of calamondin were 3′,5′-di-C-β-glucopyranosylphloretin (DGPP), naringin, hesperidin, nobiletin, tangeretin, and diosmin. DGPP exhibited the highest quantity, while naringin and hesperidin were the other two major flavonoids. The …