Pharmacology, Toxicology and Environmental Health Commons^™

Outcomes Of Pharmaceutical Care Services In Promoting Rational Drug Use, Wanna Sriviriyanupap, Roungtiva Muenpa

The Thai Journal of Pharmaceutical Sciences

Pharmacists provide pharmaceutical care service in order to support rational drug use. However, still lack of evidence to show its outcomes. Therefore, this cross-sectional descriptive study and qualitative study were conducted to evaluate the outcomes o...

Calotropis Procera: A Phytochemical And Pharmacological Review, Neelam Balekar

The Thai Journal of Pharmaceutical Sciences

Medicinal plants are used from the ancient time as the major sources of drugs.The fact is that we can obtain many of the presently available drugs, either directly in the extract form or in the modified synthetic form. Naturally, plants have ability to s...

Effect Of Fat Content On Characteristics Of Ice Cream Fortified With Calcium And Vitamin D3, Rossarin Tansawat

The Thai Journal of Pharmaceutical Sciences

Calcium and vitamin D play important roles in bone homeostasis. Several studies reported inadequate intakes of these two nutrients in many population groups. Food fortification is one way to solve the problem. The objective of this study was to develop...

Exploring Knowledge Acquisition Technique For New Start-Up Community Food Enterprises, Wattanapong Luechoowong, Ruangthip Tantipidoke, Rungpetch Sakulbumrungsil

The Thai Journal of Pharmaceutical Sciences

Objective: This qualitative study is conducted to explore the knowledge acquisition techniques from five successful food enterprises at the new entry of community business. Methods: Five successful community food producers were purposively selected unde...

Stilbenoids From The Stem Of Diospyros Collinsae, The First Evidence For The Production Of Stilbene Derivatives In Ebenaceous Plants, Buntita Bumroong, Witchuda Thanakijcharoenpath

The Thai Journal of Pharmaceutical Sciences

Two stilbenoids, diptoindonesin D (1) and diptoindonesin G (2), were isolated from the stem of Diospyros collinsae Craib (Ebenaceae), together with four triterpenoids, namely friedelin, lupeol, betulin and betulinic acid. Their structures were determined...

Exploring Key Factors Affecting The Competitiveness Of Thailand’S Cosmetic Industry, Neeranard Jinachai, Win Winit-Watjana, Puree Anantachoti

The Thai Journal of Pharmaceutical Sciences

The Thai cosmetic industry has continuously grown, but relevant factors impacting on the industry remained un-assessed. This study was intended to explore key factors affecting the country competitiveness. The Diamond model was adapted as the conceptual ...

Anaphylactic Shock Caused By A Selective Allergy To Ceftriaxone: A Case Report, Wichai Santimaleeworagun

The Thai Journal of Pharmaceutical Sciences

Ceftriaxone has been wildly used due to once daily dosing. However, case with anaphylaxis secondary to ceftriaxone has been documented and the other β-lactam might be caution. We reported an 89 year-old patient who had history of type I hypersensitivity...

Comparative Evaluation Of Neuroprotective Effect Of Three Varieties Of Allium Cepa In Chronic Constriction Injury Induced Neuropathic Pain, Amit Kumar, Kundan Singh Bora, Amteshwar Singh Jaggi, Richa Shri

The Thai Journal of Pharmaceutical Sciences

Objectives: Allium cepa has been used extensively for culinary purposes as well as in traditional system of medicine. A number of varieties of A. cepa are available commercially with varietal differences in phytoconstituents and biological activities. Ho...

Effect Of Time-Dependent Polymer On The Dissolution Rate Of Flurbiprofen: Formulation And Evaluation Of Colon-Specific Matrix Tablets, Sateesh Kumar Vemula, Selamu Kebamo, Balisa Mosisa, Biniam Paulos

The Thai Journal of Pharmaceutical Sciences

An effort was made in the present study to prepare flurbiprofen matrix tablets to improve the therapeutic efficacy by increasing therapeutic drug concentrations in lower intestine i.e., site-specific release to colon. The current experiment was aimed to ...

Qsar Study On Quinolinecarbaldehyde Derivatives As Potential Anti-Tubercular Agents, Ravichandran Veerasamy, Shalini Sivadasan, Venakteskumar Krishnamoorthi, Harish Rajak, Sureshkumar Krishnan

The Thai Journal of Pharmaceutical Sciences

This study investigated the quantitative structure–activity relationships (QSAR) for a range of substituted quinolinecarbaldehyde derivatives as anti-tubercular agent by multiple linear regression analysis. The derived QSAR models have been statistical...

Synthesis And Evaluation Of Pi3kγ Enzyme Inhibitory Activity Of Novel (1h-Pyrazol-4-Yl)Methanamine, Sukumar Bepary, In Kwon Youn, Hee-Jong Lim, Ge Hyeong Lee

The Thai Journal of Pharmaceutical Sciences

A series of (1H-pyrazol-4-yl)methanamines have been synthesized and then were evaluated for the PI3Kγ enzyme inhibitory potential. Minor modification of the initially synthesized molecules offered significant improvement of the inhibitory potential from...

Cross Immediate Hypersensitivity Between Ciprofloxacin And Levofloxacin: A Case Report And Literature Review, Chotirat Nakaranurack

The Thai Journal of Pharmaceutical Sciences

Fluoroquinolones can show cross-reactivity because of the similar chemical structure. Levofloxacin is a new fluoroquinolone and can be a safe alternative due to low cross-reactivity. This is a case report showing cross-reactivity between ciprofloxacin an...

Development Of Miconazole Nitrate Loaded Micellar Gel For Improved Topical Delivery, Manish Kumar

The Thai Journal of Pharmaceutical Sciences

The objective of the present investigation was to develop micellar gel of miconazole nitrate using amphiphilic block co-polymer pluronic F-127. Miconazole nitrate was entrapped into the micelles at critical micelle concentration by dialysis method and F2...

Pharmacy Students’ Attitudes And Perceptions About Complementary And Alternative Medicine: A Systematic Review, Mohd Shahezwan Abd Wahab, Phantipa Sakthong, Win Winit-Watjana

The Thai Journal of Pharmaceutical Sciences

Complementary and alternative medicine (CAM) is extensively used worldwide. The attitudes and perceptions of pharmacy students about CAM may influence their practices upon graduation. In this work, a systematic review was conducted by searching available...

Hepatoprotective And Nephrotoxic Effects Of Methanol Leaf Extract Of Telfairia Occidentalis (Hook F.) In Adult Female Albino Rats (Rattus Norvegicus), Chidozie Nwabuisi Okoye, John Ikechukwu Ihedioha, Onyinyechukwu Ada Agina, Izuchukwu Ochiogu, David Ogwu

The Thai Journal of Pharmaceutical Sciences

The leaf extract of the plant Telfairia occidentalis, commonly known as fluted pumpkin is used as a hematinic by post-menstrual and pregnant women and for treatment of many different ailments with little consideration of their toxic potentials. This stud...

Predicting The Duration Of Antibacterial Treatment With Cell Wall Synthesis Inhibitors By Using Mathematical Models, Panit Suavansri

The Thai Journal of Pharmaceutical Sciences

This paper proposed a new mathematical model of within-host population dynamics of bacteria after cell wall synthesis inhibitors administration for practically predicting treatment duration and drug dosage. Our model deployed various concepts from differ...

Developing A Signal Triage Algorithm For Thai National Adverse Drug Reaction Database, Suntharee T. Chaisumritchoke

The Thai Journal of Pharmaceutical Sciences

There was increasing adverse drug reaction (ADR) reports submitted to the Health Product Vigilance Center under the Thai FDA. In order to find some signals, the Thai Signal Detection Program was developed to identify and filter the potential signals, cal...

Factors Affecting Community Pharmacists’ Intention To Provide Medication Management Program And Disease Screening In Bangkok, Payungjit Kangwol, Puree Anantachoti

The Thai Journal of Pharmaceutical Sciences

Objectives: To determine factors affecting community pharmacists’ intention to provide medication management program (MMP) and disease screening (DS) based on diffusion of innovations theory. Methods: A cross-sectional study using self-administered ma...

Docking And Molecular Dynamic Simulations: Study Of 1, 3, 4-Oxadiazole- Chalcone Hybrid Derivatives To Search New Active Anticancer Agents, Adel Zamri, Neni Frimayanti, Hilwan Yuda Teruna

The Thai Journal of Pharmaceutical Sciences

Chalcone hybrid derivatives are one of the anti cancer promising agents. Computational approach (i.e. molecular docking) was applied in this study to search chalcone hybrids derivatives as new anti cancer agents. Blind docking of 81 chalcone derivatives ...

One Pot Synthesis And Docking Study Of Some Tetrahydrobenzo[B]Pyran Derivatives As Extended Spectrum Class Lactamase Inhibitors For Urinary Tract Infection, Prafulla Balkrishna Choudhari

The Thai Journal of Pharmaceutical Sciences

A series of tetrahydrobenzo[b] pyran derivatives were synthesized and screened for the antimicrobial activity against Proteus vulgaris. Structures of newly synthesized compounds were confirmed by physicochemical, spectral and elemental analysis. The dock...

Comparison Of Validated Hplc Methods Using Two Derivatizing Agents For Gamma-Aminobutyric Acid Quantification, Kritchapol Panrod, Anyarporn Tansirikongkol, Vipaporn Panapisal

The Thai Journal of Pharmaceutical Sciences

Gamma-aminobutyric acid (GABA) has many advantages in physiological functions and skin benefits. Therefore, a feasible and simple method is needed for its determination. The purpose of this study was to validate and compare two HPLC analyses of GABA afte...

Bioactivity/Cytotoxicity Of Micro-/Nano-Materials And Novel Development Of Fiber-Optic Probes For Single Cell Monitoring, Qingbo Yang

Doctoral Dissertations

"Manufactured nano-/micro-materials (MNMs) have been widely used and their interactions with niche biological environment are highly concerned for both of their biohazardous and bioactive effects, whereas no available comprehensive evaluations or regulations have been provided yet. This dissertation thus focuses on three major aspects: 1) fundamental toxicity understandings of a typical MNMs (zinc oxide nanoparticles), 2) bioactivity evaluations of representative bioactive MNMs, and 3) development of novel micro-probes for high spatial resolution monitoring. Firstly, the NP's concentration, irradiation, hydrodynamic size, and the localized pH, ionic strength, NP zeta-potential as well as dissolved oxygen levels were found correlated with the production …

Phosphodiesterase Inhibition As A Mechanism Of Ion Channel Modulation By Celecoxib, Christina Jean Robakowski

Master's Theses

The overall objective of this thesis work is to determine the mechanism by which celecoxib modulates Kv7 potassium channels in vascular smooth muscle cells. The central hypothesis of the project is that celecoxib modulates Kv7 potassium channels in vascular smooth muscle cells through inhibition of phosphodiesterase 4 (PDE4, which catalyzes the breakdown of cyclic adenosine monophosphate (cAMP)), thereby activating a cAMP/protein kinase A (PKA) signaling pathway. The aims of this thesis targeted different points in the cAMP/PKA pathway with pharmacological interventions using whole cell perforated patch clamp electrophysiology and biochemical methods.

The data suggest multiple mechanisms by which celecoxib could …

Childhood Obesity, A Public Health Crisis: Narrative Review Of Public Health Interventions For Childhood Obesity, Sumera Aziz Ali, Savera Aziz Ali, Nadir Suhail, Shiyam Sunder Tikmani, Gulshan Bano

Community Health Sciences

Introduction: Child obesity is the major pediatric public health crisis of the current century and its trend is increasing in the developing countries due to nutrition and epidemiologic transition. Considering the burden of childhood obesity and its associated outcomes need for obesity prevention in children has become priority both for government and researchers.
Objective: The objective of this review is to provide the updated knowledge and evidence from various research studies, designed to provide interventions either in school or at home.
Methodology: Electronic databases like Google scholar, PubMed and Sciencedirect were used as search engines. Key terms used during the …

Neuronal Insult Either By Exposure To Lead Or By Direct Neuronal Damage Cause Genome-Wide Changes In Dna Methylation And Histone 3 Lysine 36 Trimethylation, Arko Sen

Wayne State University Dissertations

Prenatal and postnatal exposure to pervasive neuro-toxicants such as Lead (Pb) has been reported to causes extensive and diverse changes in the epigenetic profile. Among epigenetic modification, DNA methylation (5mC) is perhaps the most widely studied and has been proposed to be potential early biomarkers for Pb toxicity. Several studies have demonstrated the association between Pb-exposure and 5mC. However most of these studies are restricted to looking at a specific set of target genes or repetitive elements. Therefore, one of the main objectives of our study was to use an unbiased genome-wide approach to look at Pb-exposure associated changes in …

Discriminative Stimulus Properties Of Endogenous Cannabinoid Degradative Enzyme Inhibitors, Robert Owens Ii

Theses and Dissertations

Inhibition of fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL), the chief degradative enzymes of N-arachidonoyl ethanolamine (anandamide; AEA) and 2-arachidonoylglycerol (2-AG), respectively, elicits no or partial substitution for Δ⁹-tetrahydrocannabinol (THC) in drug discrimination procedures. However, combined inhibition of both enzymes fully substitutes for THC, as well as produces a full constellation of cannabimimetic effects. Because no published report to date have investigated whether an inhibitor of endocannabinoid hydrolysis will serve as a discriminative stimulus, the purpose of this doctoral dissertation was to investigate whether C57BL/6J mice would learn to discriminate SA-57 (4-[2-(4-Chlorophenyl)ethyl]-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl ester), a …

High Affinity Block Of Icl,Swell By Thiol-Reactive Small Molecules, Sung H. Park

Theses and Dissertations

Ebselen (Ebs) is considered as a glutathione peroxidase (GPx) mimetic and primarily thought to function by scavenging intracellular reactive oxygen species (ROS). Previous to our work, Deng et al. (2010a) demonstrated complete block of I_Cl,swell with 15 microM Ebs following endothelin-1 (ET-1) induced activation of the current in cardiomyocytes. This block was presumed to take effect mainly via the quenching of ROS. Nonetheless, our work with DI TNC1 astrocytes strongly emphasizes that Ebs might function by an alternative mechanism based on its kinetic profile in blocking I_Cl,swell. Our experiments showed that 45 nM Ebs can fully block …

Role Of Vav2 In Podocyte Inflammasome Activation And Glomerular Injury During Hyperhomocysteinemia, Sabena Conley

Theses and Dissertations

Hyperhomocysteinemia (hHcys) is a widely known pathogenic factor in the progression of end-stage renal disease (ESRD) and it is also associated with an increased risk for injurious cardiovascular pathologies during ESRD. HHcys is linked to the formation and activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, characterized as a critical early mechanism initiating the inflammatory response. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) mediate the activation of the NLRP3 inflammasome in podocytes in response to elevated levels of homocysteine (Hcys) in vitro and in vivo. However, it remains unknown how NLRP3 inflammasome activation is triggered by NOX. The …

The Role Of Oxidative Stress In The Mechanisms Of Ammonia-Induced Brain Swelling And Tolerance In The Goldfish (Carassius Auratus), David F. Jones Lisser Mr.

Theses and Dissertations (Comprehensive)

Toxic build-ups of ammonia can cause potentially fatal brain swelling in mammals, but such swelling is reversible in the anoxia- and ammonia-tolerant goldfish (Carassius auratus). The mechanisms of ammonia-induced brain swelling and tolerance remain elusive, but several studies have suggested a role for reactive oxygen species (ROS), which may damage proteins and lipids in the plasma membrane of astrocytes in the brain. As a result, osmotic gradients across cell membranes may be altered leading to water uptake by astrocytes and swelling. While a role for ROS has been proposed in mammals, no studies have addressed this question in …

The Influence Of Abiotic Factors On The Uptake And Elimination Of 3-Trifluoromethyl-4-Nitrophenol By Larval Sea Lamprey (Petromyzon Marinus), Benjamin Livingston Hlina

Theses and Dissertations (Comprehensive)

The backbone of sea lamprey (Petromyzon marinus) control in the Great Lakes is the use of the piscicide, 3-trifluoromethyl-4-nitrophenol (TFM), which is applied to streams containing larval sea lampreys. However, TFM effectiveness can be influenced by abiotic factors such as pH and temperature, which fluctuate daily and seasonally. The objectives of this thesis were to evaluate the influence of pH, temperature, and season on the toxicity, uptake, and elimination of TFM by larval sea lamprey. Radio-labeled TFM (¹⁴C-TFM) was used to determine how TFM uptake rates varied at different water pHs or temperatures during exposure to …