Pharmacology, Toxicology and Environmental Health Commons^™

An Animal Model Of Differential Genetic Risk For Methamphetamine Intake, Tamara J. Phillips, Shkelzen Shabani

Peer Reviewed Articles

The question of whether genetic factors contribute to risk for methamphetamine (MA) use and dependence has not been intensively investigated. Compared to human populations, genetic animal models offer the advantages of control over genetic family history and drug exposure. Using selective breeding, we created lines of mice that differ in genetic risk for voluntary MA intake and identified the chromosomal addresses of contributory genes. A quantitative trait locus was identified on chromosome 10 that accounts for more than 50% of the genetic variance in MA intake in the selected mouse lines. In addition, behavioral and physiological screening identified differences corresponding …