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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
An Animal Model Of Differential Genetic Risk For Methamphetamine Intake, Tamara J. Phillips, Shkelzen Shabani
An Animal Model Of Differential Genetic Risk For Methamphetamine Intake, Tamara J. Phillips, Shkelzen Shabani
Peer Reviewed Articles
The question of whether genetic factors contribute to risk for methamphetamine (MA) use and dependence has not been intensively investigated. Compared to human populations, genetic animal models offer the advantages of control over genetic family history and drug exposure. Using selective breeding, we created lines of mice that differ in genetic risk for voluntary MA intake and identified the chromosomal addresses of contributory genes. A quantitative trait locus was identified on chromosome 10 that accounts for more than 50% of the genetic variance in MA intake in the selected mouse lines. In addition, behavioral and physiological screening identified differences corresponding …
Planarians In Pharmacology: Parthenolide Is A Specific Behavioral Antagonist Of Cocaine In The Planarian Girardia Tigrina, Oné R. Pagán, Debra Baker, Sean Deats, Erica Montgomery, Matthew Tenaglia, Clinita Randolph, Dharini Kotturu, Christopher Tallarida, Daniel Bach, Galia Wilk, Scott Rawls, Robert B. Raffa
Planarians In Pharmacology: Parthenolide Is A Specific Behavioral Antagonist Of Cocaine In The Planarian Girardia Tigrina, Oné R. Pagán, Debra Baker, Sean Deats, Erica Montgomery, Matthew Tenaglia, Clinita Randolph, Dharini Kotturu, Christopher Tallarida, Daniel Bach, Galia Wilk, Scott Rawls, Robert B. Raffa
Biology Faculty Publications
Planarians are traditional animal models in developmental and regeneration biology. Recently, these organisms are arising as vertebrate-relevant animal models in neuropharmacology. Using an adaptation of published behavioral protocols, we have described the alleviation of cocaine-induced planarian seizure-like movements (pSLM) by a naturally-occurring sesquiterpene lactone, parthenolide. Interestingly, parthenolide does not prevent the expression of pSLM induced by amphetamines; in vertebrates, amphetamines interact with the same protein target as cocaine. Parthenolide is also unable to prevent pSLM elicited by the cholinergic compounds nicotine and cytisine or by the glutamatergic agents L- or D- glutamic acid or NMDA. Thus, we conclude that parthenolide …