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Pharmacology, Toxicology and Environmental Health Commons™
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- Xuebijing injection (4)
- Acute graft vs. host disease (2)
- Cerebral ischemia/reperfusion injury (2)
- Chinese medicine (2)
- Integrative medicine (2)
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- Abstinence (1)
- Addiction (1)
- Allogenic hematopoietic transplantation (1)
- Amphetamine (1)
- Anti-tumor (1)
- Antivenin (1)
- Artery (1)
- Astragaloside III (1)
- Aversion (1)
- Biomarkers (1)
- Blood-activating and stasis-removing medicines (1)
- C. albicans (1)
- CXCL2/MIP-2 (1)
- Cerebral ischemia-reperfusion injury (1)
- Chinese herbal medicine (1)
- Cyclophosphamide (1)
- Cyclosporin A (1)
- Cyclosporine A (1)
- Cytokine storm (1)
- Drinking (1)
- Endoplasmic reticulum stress (1)
- Fungal infection (1)
- G-CSF (1)
- GRP78 (1)
- GVHD (1)
Articles 1 - 16 of 16
Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Galectin-3 Mediated Inflammatory Response Contributes To Neurological Recovery By Qishenyiqi In Subacute Stroke Model, Yule Wang, Shuang He, Xinyan Liu, Zhixiong Li, Lin Zhu, Guangxu Xiao, Xiaoli Du, Hongxia Du, Wen Zhang, Yiqian Zhang, John Orgah, Benjamin Feng, Boli Zhang, Yan Zhu
Galectin-3 Mediated Inflammatory Response Contributes To Neurological Recovery By Qishenyiqi In Subacute Stroke Model, Yule Wang, Shuang He, Xinyan Liu, Zhixiong Li, Lin Zhu, Guangxu Xiao, Xiaoli Du, Hongxia Du, Wen Zhang, Yiqian Zhang, John Orgah, Benjamin Feng, Boli Zhang, Yan Zhu
Peer Reviewed Articles
Effective therapies for stroke are still limited due to its complex pathological manifestations. QiShenYiQi (QSYQ), a component-based Chinese medicine capable of reducing organ injury caused by ischemia/reperfusion, may offer an alternative option for stroke treatment and post-stroke recovery. Recently, we reported a beneficial effect of QSYQ for acute stroke via modulation of the neuroinflammatory response. However, if QSYQ plays a role in subacute stroke remains unknown. The pharmacological action of QSYQ was investigated in experimental stroke rats which underwent 90 min ischemia and 8 days reperfusion in this study. Neurological and locomotive deficits, cerebral infarction, brain edema, and BBB integrity …
Paeoniflorin And Hydroxysafflor Yellow A In Xuebijing Injection Attenuate Sepsis-Induced Cardiac Dysfunction And Inhibit Proinflammatory Cytokine Production, Xin-Tong Wang, Zhen Peng, Ying-Ying An, Ting Shang, Guangxu Xiao, Shuang He, Xi Chen, Hang Zhang, Tao Wang, Jun-Hua Zhang, Xiumei Gao, Yan Zhu, Benjamin Feng
Paeoniflorin And Hydroxysafflor Yellow A In Xuebijing Injection Attenuate Sepsis-Induced Cardiac Dysfunction And Inhibit Proinflammatory Cytokine Production, Xin-Tong Wang, Zhen Peng, Ying-Ying An, Ting Shang, Guangxu Xiao, Shuang He, Xi Chen, Hang Zhang, Tao Wang, Jun-Hua Zhang, Xiumei Gao, Yan Zhu, Benjamin Feng
Peer Reviewed Articles
Sepsis-induced myocardial dysfunction is a major contributor to the poor outcomes of septic shock. As an add-on with conventional sepsis management for over 15 years, the effect of Xuebijing injection (XBJ) on the sepsis-induced myocardial dysfunction was not well understood. The material basis of Xuebijing injection (XBJ) in managing infections and infection-related complications remains to be defined. A murine cecal ligation and puncture (CLP) model and cardiomyocytes in vitro culture were adopted to study the influence of XBJ on infection-induced cardiac dysfunction. XBJ significantly improved the survival of septic-mice and rescued cardiac dysfunction in vivo. RNA-seq revealed XBJ attenuated …
Protecting Intestinal Microenvironment Alleviates Acute Graft-Versus-Host Disease, Zhengcan Zhou, Ting Shang, Xiurong Li, Hongyan Zhu, Yu-Bo Qi, Xin Zhao, Xi Chen, Zhe-Xin Shi, Guixiang Pan, Yue-Fei Wang, Guanwei Fan, Xiumei Gao, Yan Zhu, Benjamin Feng
Protecting Intestinal Microenvironment Alleviates Acute Graft-Versus-Host Disease, Zhengcan Zhou, Ting Shang, Xiurong Li, Hongyan Zhu, Yu-Bo Qi, Xin Zhao, Xi Chen, Zhe-Xin Shi, Guixiang Pan, Yue-Fei Wang, Guanwei Fan, Xiumei Gao, Yan Zhu, Benjamin Feng
Peer Reviewed Articles
Acute gut graft-versus-host disease (aGVHD) is a leading threat to the survival of allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Abnormal gut microbiota is correlated with poor prognosis in allo-HSCT recipients. A disrupted intestinal microenvironment exacerbates dysbiosis in GVHD patients. We hypothesized that maintaining the integrity of the intestinal barrier may protect gut microbiota and attenuate aGVHD. This hypothesis was tested in a murine aGVHD model and an in vitro intestinal epithelial culture. Millipore cytokine array was utilized to determine the expression of proinflammatory cytokines in the serum. The 16S rRNA sequencing was used to determine the abundance and diversity …
Shuxuening Injection Facilitates Neurofunctional Recovery Via Down-Regulation Of G-Csf-Mediated Granulocyte Adhesion And Diapedesis Pathway In A Subacute Stroke Mouse Model, Zhixiong Li, Guangxu Xiao, Ming Lyu, Yule Wang, Shuang He, Hongxia Du, Xintong Wang, Benjamin Feng, Yan Zhu
Shuxuening Injection Facilitates Neurofunctional Recovery Via Down-Regulation Of G-Csf-Mediated Granulocyte Adhesion And Diapedesis Pathway In A Subacute Stroke Mouse Model, Zhixiong Li, Guangxu Xiao, Ming Lyu, Yule Wang, Shuang He, Hongxia Du, Xintong Wang, Benjamin Feng, Yan Zhu
Peer Reviewed Articles
Post-stroke neural damage is a serious health concern which does not yet have an effective treatment. We have shown previously that Shuxuening injection (SXNI), a Ginkgo biloba extract-based natural medicine, protects brain after an acute ischemic stroke, but its efficacy for post-stroke recovery is not known. This study was to investigate whether SXNI can improve the prognosis of stroke at a subacute phase. Mice with cerebral ischemia-reperfusion injury (CIRI) were established by middle cerebral artery occlusion (MCAO), and drugs or saline were injected by the tail vein every 12 h after reperfusion. The therapeutic effect of SXNI was evaluated by …
Protection Against Acute Cerebral Ischemia/Reperfusion Injury By Qishenyiqi Via Neuroinflammatory Network Mobilization, Yule Wang, Guangxu Xiao, Xhuang He, Xinyan Liu, Lin Zhu, Xinyue Yang, Yiqian Zhang, John Orgah, Benjamin Feng, Xiaoying Wang, Boli Zhang, Yan Zhu
Protection Against Acute Cerebral Ischemia/Reperfusion Injury By Qishenyiqi Via Neuroinflammatory Network Mobilization, Yule Wang, Guangxu Xiao, Xhuang He, Xinyan Liu, Lin Zhu, Xinyue Yang, Yiqian Zhang, John Orgah, Benjamin Feng, Xiaoying Wang, Boli Zhang, Yan Zhu
Peer Reviewed Articles
Cerebral ischemia/reperfusion injury (CI/RI) is a common feature of ischemic stroke, involving a period of impaired blood supply to the brain, followed by the restoration of cerebral perfusion through medical intervention. Although ischemia and reperfusion brain damage is a complex pathological process with an unclear physiological mechanism, more attention is currently focused on the neuroinflammatory response of an ischemia/reperfusion origin, and anti-inflammatory appears to be a potential therapeutic strategy following ischemic stroke. QiShenYiQi (QSYQ), a component-based Chinese medicine with Qi-tonifying and blood-activating property, has pharmacological actions of anti-inflammatory, antioxidant, mitochondrial protectant, anti-apoptosis, and antiplatelet aggregation. We have previously reported that …
Xuebijing Injection Maintains Grp78 Expression To Prevent Candida Albicans–Induced Epithelial Death In The Kidney, Ting Shang, Qilin Yu, Tongtong Ren, Xin-Tong Wang, Hongyan Zhu, Jia-Ming Gao, Guixiang Pan, Xiumei Gao, Yan Zhu, Benjamin Feng, Ming-Chun Li
Xuebijing Injection Maintains Grp78 Expression To Prevent Candida Albicans–Induced Epithelial Death In The Kidney, Ting Shang, Qilin Yu, Tongtong Ren, Xin-Tong Wang, Hongyan Zhu, Jia-Ming Gao, Guixiang Pan, Xiumei Gao, Yan Zhu, Benjamin Feng, Ming-Chun Li
Peer Reviewed Articles
Sepsis and septic shock threaten the survival of millions of patients in the intensive care unit. Secondary fungal infections significantly increased the risk of mortality in sepsis patients. Chinese medicine Xuebijing injection (XBJ) has been routinely used as an add-on treatment to sepsis and septic shock in China. Our network pharmacology analysis predicted that XBJ also influences fungal infection, consisting with results of pioneer clinical studies. We conducted in vivo and in vitro experiments to verify this prediction. To our surprise, XBJ rescued mice from lethal Candida sepsis in a disseminated Candida albicans infection model and abolished the colonization of …
Untargeted Safety Pharmacology Screen Of Blood-Activating And Stasis-Removing Patent Chinese Herbal Medicines Identified Nonherbal Ingredients As A Cause Of Organ Damage In Experimental Models, Xinyan Liu, Rui Shao, Xinyue Yang, Guangxu Xiao, Shuang He, Benjamin Feng, Yan Zhu
Untargeted Safety Pharmacology Screen Of Blood-Activating And Stasis-Removing Patent Chinese Herbal Medicines Identified Nonherbal Ingredients As A Cause Of Organ Damage In Experimental Models, Xinyan Liu, Rui Shao, Xinyue Yang, Guangxu Xiao, Shuang He, Benjamin Feng, Yan Zhu
Peer Reviewed Articles
Blood activation and stasis removal from circulation is a central principle for treatment of syndromes related to cerebral and cardiovascular diseases in Chinese herbal medicine. However, blood-activating and stasis-removing patent Chinese herbal medicine (BASR-pCHM) widely used with or without prescription in China and elsewhere are highly variable in composition and manufacture standard, making their safety assessment a challenging task. We proposed that an integrated evaluation of multiple toxicity parameters of BASR-pCHM would provide critical reference and guidelines for their safe clinical application. Examination of standardized extracts from 58 compound BASR-pCHM in vivo in VEGFR2-luc mice and in vitro in cardiac, …
Astragaloside Iii Enhances Anti-Tumor Response Of Nk Cells By Elevating Nkg2d And Ifn-Γ, Xingmeng Chen, Xi Chen, Junxiao Gao, Han Yang, Yue Duan, Benjamin Feng, Xin He, Xiaoqun Gong, Hanjie Wang, Xiaoli Wu, Jin Chang
Astragaloside Iii Enhances Anti-Tumor Response Of Nk Cells By Elevating Nkg2d And Ifn-Γ, Xingmeng Chen, Xi Chen, Junxiao Gao, Han Yang, Yue Duan, Benjamin Feng, Xin He, Xiaoqun Gong, Hanjie Wang, Xiaoli Wu, Jin Chang
Peer Reviewed Articles
Natural killer (NK) cells play an irreplaceable role in the development of colon cancer, in which antitumor function of NK cells was impaired. Astragaloside III is a natural compound from Astragalus that has been shown to have immunomodulatory effects in various systems. However, few studies have evaluated the antitumor effects of Astragaloside III through stimulating systemic immunity and regulating NK cells. In this study, flow cytometry, immunohistochemical analysis, and immunofunctional assays were performed to elucidate the functions of Astragaloside III in restoring antitumor function of NK cells. We demonstrated that Astragaloside III significantly elevated the expression of natural killer group …
Network Pharmacology-Guided Development Of A Novel Integrative Regimen To Prevent Acute Graft-Vs.-Host Disease, Ming Lyu, Zhengcan Zhou, Xiaoming Wang, Hong Lv, Mei Wang, Guixiang Pan, Yuefei Wang, Guanwei Fan, Xiumei Gao, Benjamin Feng, Yan Zhu
Network Pharmacology-Guided Development Of A Novel Integrative Regimen To Prevent Acute Graft-Vs.-Host Disease, Ming Lyu, Zhengcan Zhou, Xiaoming Wang, Hong Lv, Mei Wang, Guixiang Pan, Yuefei Wang, Guanwei Fan, Xiumei Gao, Benjamin Feng, Yan Zhu
Peer Reviewed Articles
Lapses in the graft-vs.-host disease (GVHD) prophylaxis and side effects of current standard care following allogeneic hematopoietic stem cell transplantation (allo-HSCT) call for novel regimens. Traditional approaches targeting T cells showed limited success in preventing acute GVHD (aGVHD). System medicine showed promising results treating complex diseases such as sepsis and multi-organ dysfunction syndrome (MODS). Adapting established network pharmacology analysis methods, we aimed to develop novel integrative regimens to prevent aGVHD. Our network pharmacology analysis predicted that Xuebijing injection (XBJ) targets a series of key node proteins in aGVHD network. It also unveiled that Salviae miltiorrhizae (Danshen), an herb in Xuebijing …
Combined Mtor And Mek Inhibition Is An Effective Therapy In A Novel Mouse Model For Angiosarcoma, Michelle L. Chadwick, Adam Lane, Dana Thomas, Amanda R. Smith, Angela R. White, Dominique Davidson, Benjamin Feng, Elisa Boscolo, Yi Zheng, Denise M. Adams, Anita Gupta, Andre Veillette, Lionel M L Chow
Combined Mtor And Mek Inhibition Is An Effective Therapy In A Novel Mouse Model For Angiosarcoma, Michelle L. Chadwick, Adam Lane, Dana Thomas, Amanda R. Smith, Angela R. White, Dominique Davidson, Benjamin Feng, Elisa Boscolo, Yi Zheng, Denise M. Adams, Anita Gupta, Andre Veillette, Lionel M L Chow
Peer Reviewed Articles
Angiosarcoma is an aggressive malignancy of vascular origin that occurs de novo or in the context of previous cancer therapy. Despite multi-modal aggressive treatment including surgical resection, chemotherapy, and radiation, five-year overall survival remains poor at 35%. Due to its rarity, little is known about its molecular pathology and clinical trials have been extremely difficult to conduct. Development of animal models for rare diseases like angiosarcoma is critical to improve our understanding of tumorigenesis and to test novel treatment regimens. A genetically engineered mouse model for angiosarcoma was generated by conditional deletion of Trp53, Pten, and Ptpn12 in …
Post-Transplantation Cyclophosphamide And Ixazomib Combination Rescues Mice Subjected To Experimental Graft-Versus-Host Disease And Is Superior To Either Agent Alone, Ahmad Samer Al-Homsi, Austin Goodyke, Michael Mclane, Sarah Abdel-Mageed, Kelli Cole, Marlee Muilenburg, Benjamin Feng
Post-Transplantation Cyclophosphamide And Ixazomib Combination Rescues Mice Subjected To Experimental Graft-Versus-Host Disease And Is Superior To Either Agent Alone, Ahmad Samer Al-Homsi, Austin Goodyke, Michael Mclane, Sarah Abdel-Mageed, Kelli Cole, Marlee Muilenburg, Benjamin Feng
Peer Reviewed Articles
Lapses in the prevention of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) warrant novel approaches. Such approaches include, among others, the use of post-transplantation cyclophosphamide (PTC) and proteasome inhibitors. Although PTC alone consistently produces low rates of chronic GVHD, the incidence of acute GVHD remains significant. Inversely, prolonged post-transplantation administration of proteasome inhibitors carries a risk of paradoxical aggravation of GVHD. We examined whether the combination of cyclophosphamide and ixazomib addresses the limitations of each of these agents when used alone to prevent GVHD in mice subjected to allogeneic HSCT across MHC barriers. We chose ixazomib, an …
A Mouse Model For Binge-Level Methamphetamine Use, Shkelzen Shabani, Sydney K. Houlton, Laura Hellmuth, Erika Mojica, John R K Mootz, Zhen Zhu, Cheryl Reed, Tamara J. Phillips
A Mouse Model For Binge-Level Methamphetamine Use, Shkelzen Shabani, Sydney K. Houlton, Laura Hellmuth, Erika Mojica, John R K Mootz, Zhen Zhu, Cheryl Reed, Tamara J. Phillips
Peer Reviewed Articles
Binge/crash cycles of methamphetamine (MA) use are frequently reported by individuals suffering from MA use disorders. A MA binge is self-reported as multiple daily doses that commonly accumulate to 800 mg/day (~10 mg/kg/day for a 170 pound human). A genetic animal model with a similar vulnerability to binge-level MA intake is missing. We used selectively bred MA high drinking (MAHDR) and low drinking (MALDR) mouse lines to determine whether several procedural variations would result in binge-level MA intake. Data were also collected in two progenitor populations of the MA drinking lines, the DBA/2J (D2) strain and the F2 cross of …
An Animal Model Of Differential Genetic Risk For Methamphetamine Intake, Tamara J. Phillips, Shkelzen Shabani
An Animal Model Of Differential Genetic Risk For Methamphetamine Intake, Tamara J. Phillips, Shkelzen Shabani
Peer Reviewed Articles
The question of whether genetic factors contribute to risk for methamphetamine (MA) use and dependence has not been intensively investigated. Compared to human populations, genetic animal models offer the advantages of control over genetic family history and drug exposure. Using selective breeding, we created lines of mice that differ in genetic risk for voluntary MA intake and identified the chromosomal addresses of contributory genes. A quantitative trait locus was identified on chromosome 10 that accounts for more than 50% of the genetic variance in MA intake in the selected mouse lines. In addition, behavioral and physiological screening identified differences corresponding …
Hyperbaric Oxygen Therapy Alters Vascular Reactivity Independent Of Elevations In Atp, Benjamin M. Hake, Cole Waggener, Benjamin Eovaldi, Claude Zanetti, Francis Sylvester
Hyperbaric Oxygen Therapy Alters Vascular Reactivity Independent Of Elevations In Atp, Benjamin M. Hake, Cole Waggener, Benjamin Eovaldi, Claude Zanetti, Francis Sylvester
Peer Reviewed Articles
Hyperbaric oxygen (HBO) is a pharmacologic therapy used treat a variety of medical conditions. The underlying mechanisms of HBOs effect on vascular reactivity are poorly understood. The purpose of this study was to record the acute effects of HBO on vascular reactivity and determine the potential role of ATP in mediating these effects. Porcine mesenteric arteries were dissected and mounted in isolated organ baths to record changes in tension in response to potassium chloride (KCl, 15-60 mM), phenylephrine (PHE, 10-7-10-4 M), and sodium nitroprusside (SNP, 10-7-10-4 M) following a 2-hour exposure to HBO (1.75 ATA). HBO augmented responses to KCl …
Post-Transplant High-Dose Cyclophosphamide For The Prevention Of Graft-Versus-Host Disease, Ahmad Samer Al-Homsi, Tara S. Roy, Kelli Cole, Benjamin Feng, Ulrich Duffner
Post-Transplant High-Dose Cyclophosphamide For The Prevention Of Graft-Versus-Host Disease, Ahmad Samer Al-Homsi, Tara S. Roy, Kelli Cole, Benjamin Feng, Ulrich Duffner
Peer Reviewed Articles
Cyclophosphamide's lack of hematopoietic stem cell toxicity and its unique effects on the immune system have prompted several investigators to explore its potential for the prevention of graft-versus-host disease (GVHD). In haploidentical hematopoietic stem cell transplants, post-transplant cyclophosphamide together with standard prophylaxis reduces the incidence of GVHD to acceptable rates without the need for T cell depletion. In matched related and unrelated donor settings, cyclophosphamide alone has produced encouraging results. In particular, the low incidence of chronic GVHD is noteworthy. Here, we present a review of the current understanding of the mechanism of action of post-transplant cyclophosphamide and summarize the …
From The Kiss Of A Cobra: A Sidelong View Of Snakebite, Antivenin & Serum Sickness, Doug H. Graham
From The Kiss Of A Cobra: A Sidelong View Of Snakebite, Antivenin & Serum Sickness, Doug H. Graham
Peer Reviewed Articles
No abstract provided.