Pharmacology, Toxicology and Environmental Health Commons^™

Untargeted Safety Pharmacology Screen Of Blood-Activating And Stasis-Removing Patent Chinese Herbal Medicines Identified Nonherbal Ingredients As A Cause Of Organ Damage In Experimental Models, Xinyan Liu, Rui Shao, Xinyue Yang, Guangxu Xiao, Shuang He, Benjamin Feng, Yan Zhu

Peer Reviewed Articles

Blood activation and stasis removal from circulation is a central principle for treatment of syndromes related to cerebral and cardiovascular diseases in Chinese herbal medicine. However, blood-activating and stasis-removing patent Chinese herbal medicine (BASR-pCHM) widely used with or without prescription in China and elsewhere are highly variable in composition and manufacture standard, making their safety assessment a challenging task. We proposed that an integrated evaluation of multiple toxicity parameters of BASR-pCHM would provide critical reference and guidelines for their safe clinical application. Examination of standardized extracts from 58 compound BASR-pCHM in vivo in VEGFR2-luc mice and in vitro in cardiac, …