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Full-Text Articles in Pharmacology, Toxicology and Environmental Health
Mitoxantrone Represses Markers Of Microglial Activation And Inflammation, Cameron A. Tull
Mitoxantrone Represses Markers Of Microglial Activation And Inflammation, Cameron A. Tull
Honors Theses
Multiple sclerosis (MS) is a neurodegenerative disease characterized by an autoimmune attack against myelin sheaths in the central nervous system (CNS). Resulting debilitations vary from sensory, motor, and coordination abnormalities to visual difficulties as well as bowel, bladder, sexual, and cognitive dysfunction (Fox, 2006). Mitoxantrone (Novantrone) is an FDAapproved drug used to treat the secondary-progressive form ofMS due to its demonstrated immunosuppressive properties. While the mechanism of action of mitoxantrone is not yet well understood, and is limited in its use due to cardiotoxicity, the aim of this study was to determine the effect of mitoxantrone on microglial and astrocyte …
A Broad-Spectrum Mer Operon In A Multi-Drug Resistant Strain Of The Fish Pathogen, Aeromonas Salmonicida, Erin Parry
A Broad-Spectrum Mer Operon In A Multi-Drug Resistant Strain Of The Fish Pathogen, Aeromonas Salmonicida, Erin Parry
Honors Theses
Aeromonas salmonicida AS03, a potential fish pathogen, was isolated from Atlantic salmon, Salmo salar, in 2003. This strain was found to be resistant to ≥1000 mM HgCl2 and ≥32 mM phenylmercuric acetate as well as multiple antimicrobials. Mercury (Hg) and antibiotic resistance genes are often located on the same mobile genetic elements, so the genetic determinants of both resistances and the possibility of horizontal gene transfer were examined. Specific PCR primers were used to amplify and sequence distinctive regions of the mer operon. A. salmonicida AS03 was found to have a pDU1358-like broad-spectrum mer operon, containing merB as well as …
The Presence, Prevalence And Antibiotic Resistance Of Microbes In The Pamunkey River Basin, Christina Mcdowell
The Presence, Prevalence And Antibiotic Resistance Of Microbes In The Pamunkey River Basin, Christina Mcdowell
Honors Theses
This project examined the presence, prevalence and antibiotic resistance of Coliforms (mainly Escherichia coli), Staph/occocus aureus, fecal Streptococcus, andEnterobacteriacae found in the water samples taken from three selected sites on the North Anna, South Anna, and Little Rivers of the Pamunkey River Basin. The diversity and concentration of the microbes isolated from these sites was evaluated in late January and late March allowing for a comparison of the occurrence of microbes at different times and between the different sites. Over the course of two months the concentration of colonies increased based on colony counts from Nutrient agar. The rate of …